At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.
|GO Biological Process||regulation of interferon-gamma-mediated signaling pathway (0060334)|
|10526574||Negative regulators of cytokine signal transduction||Cell Mol Life Sci||1999|
|12645661||Suppressors of cytokine signalling: SOCS||APMIS||2002|
|18031232||PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription||Biochem Soc Trans||2007|