Reactome: A Curated Pathway Database

Regulation of IFNG signaling (R-HSA-877312) [Homo sapiens]


At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.

Additional Information
GO Biological Process regulation of interferon-gamma-mediated signaling pathway (0060334)
Cross References
Database Identifier
BioModels Database BIOMD0000000477
Literature References
pubMedId Title Journal Year
10526574 Negative regulators of cytokine signal transduction Cell Mol Life Sci 1999
12645661 Suppressors of cytokine signalling: SOCS APMIS 2002
18031232 PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription Biochem Soc Trans 2007