Reactome: A Curated Pathway Database

Regulation of IFNG signaling

Stable Identifier
R-HSA-877312
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database