Reactome | Pyrin binds ASC

Pyrin binds ASC

Stable Identifier

R-HSA-877361

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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- Infectious disease (Homo sapiens)
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        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Pyrin binds ASC (Homo sapiens)

General

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Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11498534	Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis Schaner, P, Richards, N, Shelden, E, Wadhwa, A, Stuckey, J, Diaz, A, Gumucio, DL	J Biol Chem	2001
12615073	Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product Dowds, TA, Masumoto, J, Nunez, G, Inohara, N, Ogura, Y, Chen, FF	Biochem Biophys Res Commun	2003