Reactome: A Curated Pathway Database

Pyrin binds ASC

Stable Identifier
R-HSA-877361
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003).

Literature References
Participants
Participant Of
Orthologous Events