Reactome: A Curated Pathway Database

Pyrin binds ASC (R-HSA-877361)

Species Homo sapiens

Summation

Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol