Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003).
|11498534||Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis||J Biol Chem||2001|
|12615073||Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product||Biochem Biophys Res Commun||2003|