Reactome: A Curated Pathway Database

AGER binds ERK1/2 (R-HSA-879362) [Homo sapiens]


Binding of ligand to AGER results in the activation of multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade (Lander et al. 1997), cdc42/Rac (Huttunen et al. 1999), and activation of NF-?B (Tanaka et al. 2000). A membrane-proximal cytoplasmic region of the advanced glycation end-products receptor (AGER) is responsible for binding to extracellular signal-regulated protein kinase-1 and -2 (ERK1/2 or MAPK3/1). This region is similar to the D-domain, an ERK docking site which is conserved in some ERK substrates (Ishihara et al. 2003).

Additional Information
Compartment plasma membrane , cytosol
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Literature References
pubMedId Title Journal Year
12935895 The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site FEBS Lett 2003
Inferred Entries
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