Reactome: A Curated Pathway Database

Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)

Species Homo sapiens

Summation

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
7491953 Cholecystokinin receptors Am J Physiol 1995
10413847 [Receptors for cholecystokinin and gastrin] Z Gastroenterol 1999
17698287 Role of gastrin peptides in carcinogenesis Cancer Lett 2007