Reactome: A Curated Pathway Database

AURKA Activation by TPX2

Stable Identifier
R-HSA-8854518
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

TPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. 2003, Xu et al. 2011, Giubettini et al. 2011, Dodson and Bayliss 2012).

Literature References
Participants
Participant Of
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Orthologous Events