VLDLR internalisation and degradation

Stable Identifier
R-HSA-8866427
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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VLDLR internalisation and degradation
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The steps involved in proprotein convertase PCSK9-induced degradation of VLDLR are described here (Poirier et al. 2008). The rate of this catabolic process plays a clinically significant role in determining the efficiency of lipoprotein clearance from the blood.
Literature References
PubMed ID Title Journal Year
18039658 The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H

J. Biol. Chem. 2008
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Events
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as an event of
Event Information
Go Biological Process
low-density lipoprotein particle receptor catabolic process (0032802)
Orthologous Events
VLDLR internalisation and degradation (Bos taurus)
VLDLR internalisation and degradation (Caenorhabditis elegans)
VLDLR internalisation and degradation (Canis familiaris)
VLDLR internalisation and degradation (Dictyostelium discoideum)
VLDLR internalisation and degradation (Drosophila melanogaster)
VLDLR internalisation and degradation (Gallus gallus)
VLDLR internalisation and degradation (Mus musculus)
VLDLR internalisation and degradation (Rattus norvegicus)
VLDLR internalisation and degradation (Saccharomyces cerevisiae)
VLDLR internalisation and degradation (Schizosaccharomyces pombe)
VLDLR internalisation and degradation (Sus scrofa)
VLDLR internalisation and degradation (Xenopus tropicalis)
Authored
Jassal, B  (2016-04-01)
Reviewed
D'Eustachio, P  (2016-04-05)
Created
Jassal, B  (2016-04-01)
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