Reactome: A Curated Pathway Database

Phosphorylation of STAT1 at Ser727 (R-HSA-909552) [Homo sapiens]


Kinases like Protein kinase C delta (PKC-delta) and Calcium/calmodulin-dependent protein kinase II (CaMK II ) can phosphorylate STAT1 at serine 727 (S727). This phosphorylation is not required for STAT1 homodimer formation, nuclear translocation and DNA binding. However, it is essential for the full transcriptional activation of STAT1.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
CaMKII and PKC-delta protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
15322115 Protein kinase Cdelta regulates apoptosis via activation of STAT1 J Biol Chem 2004
11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma Proc Natl Acad Sci U S A 2002