Reactome: A Curated Pathway Database

Phosphorylation of STAT1 at Ser727

Stable Identifier
R-HSA-909552
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Kinases like Protein kinase C delta (PKC-delta) and Calcium/calmodulin-dependent protein kinase II (CaMK II ) can phosphorylate STAT1 at serine 727 (S727). This phosphorylation is not required for STAT1 homodimer formation, nuclear translocation and DNA binding. However, it is essential for the full transcriptional activation of STAT1.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of CaMKII and PKC-delta [cytosol] CaMKII and PKC-delta [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events