Reactome: A Curated Pathway Database

Telomeres cluster at the nuclear membrane (R-HSA-912408) [Homo sapiens]

Black Box Event

As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with SUN1 and SUN2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin. Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane.

Additional Information
Compartment nucleoplasm , nuclear envelope