Reactome: A Curated Pathway Database

Telomeres cluster at the nuclear membrane

Stable Identifier
R-HSA-912408
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Formation of the telomere bouquet
Locations in the PathwayBrowser
Summation

As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with SUN1 and SUN2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin. Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane.

Literature References
Participants
Participant Of
hasEvent
Inferred From