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Formation of meiotic heteroduplex

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Meiotic Strand Invasion
Locations in the PathwayBrowser

Following double strand break (DSB) formation and strand resection, RAD51 and DMC1 coat single-stranded 3' ends of DNA and catalyze the search for homology and strand invasion into the DNA duplex of the chromosomal homolog (Baumann et al. 1996, Barlow et al. 1997, Benson et al. 1998, Baumann and West 1999, Masson et al. 1999, Sehorn et al. 2004, Murayama et al. 2008). The invading strand displaces the original strand of the chromosomal homolog creating a D-loop structure. Other proteins present in the complex are inferred from cytology (Barlow et al. 1997, Oliver-Bonet et al. 2005, Oliver-Bonet et al. 2007).

Participant Of
Catalyst Activity
Catalyst Activity
recombinase activity of Meiotic single-stranded DNA complex [nucleoplasm]
Physical Entity
This entity is regulated by
Inferred From