Reactome: A Curated Pathway Database

SHC1 mediates cytokine-induced phosphorylation of GAB2

Stable Identifier
R-HSA-912527
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).

Literature References
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Orthologous Events