Reactome: A Curated Pathway Database

ESCRT Disassembly

Stable Identifier
R-HSA-917693
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Disassembly Phase
The AAA-ATPase, Vps4 disassembles ESCRT-III and catalyzes the final step of the MVB pathway. The microtubule interacting and trafficking (MIT) domain of Vps4 interacts directly with the C-terminal region of Vps2 (MIM1) and Vps20 (MIM2). The association of Vta1, which contains two MIT domains, greatly enhances the activity of Vps4. Please note that the recomended names of the Vacuolar protein sorting-associated proteins (Vps) are Charged multivesicular body proteins or CHMPs.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ATPase activity of Vps/Vta1 [cytosol] Vps/Vta1 [cytosol] ATPase activity (0016887)
Orthologous Events