Reactome: A Curated Pathway Database

ESCRT Disassembly (R-HSA-917693) [Homo sapiens]


Disassembly Phase
The AAA-ATPase, Vps4 disassembles ESCRT-III and catalyzes the final step of the MVB pathway. The microtubule interacting and trafficking (MIT) domain of Vps4 interacts directly with the C-terminal region of Vps2 (MIM1) and Vps20 (MIM2). The association of Vta1, which contains two MIT domains, greatly enhances the activity of Vps4. Please note that the recomended names of the Vacuolar protein sorting-associated proteins (Vps) are Charged multivesicular body proteins or CHMPs.

Additional Information
Compartment endosome membrane
Catalyst Activity
PhysicalEntity Activity Active Units
Vps/Vta1 ATPase activity (0016887)