Reactome: A Curated Pathway Database

MCOLN1 transports Fe2+ from endosome lumen to cytosol (R-HSA-917936)

Species Homo sapiens


Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

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Additional Information
Compartment endosome membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
MCOLN1 iron ion transmembrane transporter activity (0005381)
Literature References
pubMedId Title Journal Year
18794901 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel Nature 2008