Reactome: A Curated Pathway Database

MCOLN1 transports Fe2+ from endosome lumen to cytosol (R-HSA-917936) [Homo sapiens]


Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Additional Information
Compartment endosome membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
MCOLN1 iron ion transmembrane transporter activity (0005381)  
Literature References
pubMedId Title Journal Year
18794901 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel Nature 2008