Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

MCOLN1 transports Fe2+ from endosome lumen to cytosol

Stable Identifier
R-HSA-917936
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Iron diffuses out of the endosome
Locations in the PathwayBrowser
Summation

Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
iron ion transmembrane transporter activity of MCOLN1 [endosome membrane] MCOLN1 [endosome membrane] iron ion transmembrane transporter activity (0005381)
Orthologous Events