Reactome: A Curated Pathway Database

MCOLN1 transports Fe2+ from endosome lumen to cytosol

Stable Identifier
R-HSA-917936
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Iron diffuses out of the endosome
Locations in the PathwayBrowser
Summation

Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
iron ion transmembrane transporter activity of MCOLN1 [endosome membrane] MCOLN1 [endosome membrane] iron ion transmembrane transporter activity (0005381)
Orthologous Events