Reactome: A Curated Pathway Database

Iron uptake and transport

Stable Identifier
R-HSA-917937
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).

Literature References
Participants
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Orthologous Events