Reactome: A Curated Pathway Database

Transferrin endocytosis and recycling

Stable Identifier
R-HSA-917977
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a lysosome but recycles its content back to the cell surface where soon transferrin dissociates from its receptor (Dautry-Varsat, 1986).

Literature References
Participants
Participant Of
Orthologous Events