Reactome: A Curated Pathway Database

Transferrin endocytosis and recycling (R-HSA-917977)

Species Homo sapiens

Summation

Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a lysosome but recycles its content back to the cell surface where soon transferrin dissociates from its receptor (Dautry-Varsat, 1986).

Locations in the PathwayBrowser
Additional Information
GO Biological Process transferrin transport (0033572)
Literature References
pubMedId Title Journal Year
2874839 Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor Biochimie 1986