Reactome: A Curated Pathway Database

Phosphorylated STAT5 is released (R-HSA-919404) [Homo sapiens]


Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).

Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
9030599 A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation J Biol Chem 1997