SMG6 hydrolyzes mRNA with premature termination codon

Stable Identifier
R-HSA-927836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SMG6 hydrolyzes mRNA with premature termination codon
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SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).
Literature References
PubMed ID Title Journal Year
17053788 Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

Conti, E, Behm-Ansmant, I, Glavan, F, Izaurralde, E

EMBO J 2006
18974281 SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

Saulière, J, Fauser, M, Huntzinger, E, Izaurralde, E, Kashima, I

RNA 2008
19060897 SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

Jensen, TH, Eberle, AB, Lykke-Andersen, S, Muhlemann, O

Nat Struct Mol Biol 2009
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Catalyst Activity

endoribonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

Physical Entity
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Activity
endoribonuclease activity (GO:0004521)
Orthologous Events
SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
Authored
May, B  (2010-08-06)
Reviewed
Neu-Yilik, G  (2011-05-19)
Created
May, B  (2010-08-10)
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