SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).
|Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP||endoribonuclease activity (0004521)|
|19060897||SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells||Nat Struct Mol Biol||2009|
|17053788||Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex||EMBO J||2006|
|18974281||SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan||RNA||2008|