Reactome: A Curated Pathway Database

SMG6 hydrolyzes mRNA with premature termination codon

Stable Identifier
R-HSA-927836
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endoribonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] endoribonuclease activity (0004521)
Orthologous Events