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SMG6 hydrolyzes mRNA with premature termination codon

Stable Identifier
R-HSA-927836
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endoribonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
Physical Entity
Activity
Orthologous Events