Reactome: A Curated Pathway Database

SMG6 hydrolyzes mRNA with premature termination codon (R-HSA-927836) [Homo sapiens]

Black Box Event
Summation

SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).

Additional Information
Compartment cytosol