Reactome: A Curated Pathway Database

CYLD mediated deubiquitination of DDX58 (RIG-I)

Stable Identifier
R-HSA-936390
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of DDX58 (RIG-I) mediated antiviral signaling. CYLD associates with the CARD domain of DDX58 and removes K63-linked ubiquitin from the DDX58 CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Lys63-specific deubiquitinase activity of CYLD [cytosol] CYLD [cytosol] Lys63-specific deubiquitinase activity (0061578)
Orthologous Events