CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of RIG-I mediated antiviral signaling. CYLD associates with the CARD domain of RIG-I and removes K63-linked ubiquitin from the RIG-I CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.
|CYLD||protein K63-linked deubiquitination (0070536)|
|18636086||The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response||EMBO Rep||2008|
|18467330||Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD||J Biol Chem||2008|