Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

CYLD mediated deubiquitination of DDX58 (RIG-I)

Stable Identifier
R-HSA-936390
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of DDX58 (RIG-I) mediated antiviral signaling. CYLD associates with the CARD domain of DDX58 and removes K63-linked ubiquitin from the DDX58 CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Lys63-specific deubiquitinase activity of CYLD [cytosol] CYLD [cytosol] Lys63-specific deubiquitinase activity (0061578)
Orthologous Events