Reactome: A Curated Pathway Database

Negative regulators of RIG-I/MDA5 signaling

Stable Identifier
R-HSA-936440
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.

Literature References
Participants
Participant Of
Orthologous Events