Reactome: A Curated Pathway Database

Negative regulators of RIG-I/MDA5 signaling (R-HSA-936440) [Homo sapiens]


As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.

Additional Information
GO Biological Process negative regulation of type I interferon production (0032480)
Literature References
pubMedId Title Journal Year
18703349 Negative regulation of cytoplasmic RNA-mediated antiviral signaling Cytokine 2008
18549796 Regulation of mitochondrial antiviral signaling pathways Immunity 2008