Reactome: A Curated Pathway Database

Ion transport by P-type ATPases (R-HSA-936837) [Homo sapiens]


The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).

Additional Information
GO Biological Process ion transmembrane transport (0034220)
Literature References
pubMedId Title Journal Year
15071553 Biology, structure and mechanism of P-type ATPases Nat Rev Mol Cell Biol 2004