Reactome: A Curated Pathway Database

Ion transport by P-type ATPases (R-HSA-936837)

Species Homo sapiens


The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).

Locations in the PathwayBrowser
Additional Information
GO Biological Process ion transmembrane transport (0034220)
Literature References
pubMedId Title Journal Year
15071553 Biology, structure and mechanism of P-type ATPases Nat Rev Mol Cell Biol 2004