Reactome: A Curated Pathway Database

Ion transport by P-type ATPases

Stable Identifier
R-HSA-936837
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).

Literature References
PubMed ID Title Journal Year
15071553 Biology, structure and mechanism of P-type ATPases Nat Rev Mol Cell Biol 2004
Participants
Participant Of
Orthologous Events