The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).
|GO Biological Process||ion transmembrane transport (0034220)|
|15071553||Biology, structure and mechanism of P-type ATPases||Nat Rev Mol Cell Biol||2004|