Reactome: A Curated Pathway Database

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (R-HSA-975138) [Homo sapiens]


TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Additional Information
Compartment cytosol , endosome membrane , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000477
Inferred Entries
Orthologous events