TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
|22511786||Essential role for IKK? in production of type 1 interferons by plasmacytoid dendritic cells||J. Biol. Chem.||2012|
|18794297||The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation||J. Biol. Chem.||2008|