Reactome: A Curated Pathway Database

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975138
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database