There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

MyD88 dependent cascade initiated on endosome

Stable Identifier
R-HSA-975155
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Participants
Participant Of
Orthologous Events
Cross References
BioModels Database