Reactome: A Curated Pathway Database

MyD88 dependent cascade initiated on endosome (R-HSA-975155) [Homo sapiens]


Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Additional Information
Compartment cytosol , endosome membrane , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000477