Reactome: A Curated Pathway Database

MyD88 dependent cascade initiated on endosome (R-HSA-975155)

Species Homo sapiens

Summation

Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , endosome membrane , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000477