Reactome: A Curated Pathway Database

MyD88 dependent cascade initiated on endosome

Stable Identifier
R-HSA-975155
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database