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Amyloid fibrils have additional components (R-HSA-976734) [Homo sapiens]

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Summation

In addition to the main fibril peptide, mature amyloid fibrils have additional components. Serum amyloid P component (SAP) binds to all types of amyloid fibrils and is a universal constituent of amyloid deposits. SAP binding protects amyloid fibrils from proteolytic degradation (Tennent et al. 1995, Westermark 2005). SAP may function as a chaperone for amyloid formation (Coker et al. 2000). Glycosaminoglycans (GAGs) and proteoglycans are found associated with all types of amyloid deposits (Alexandrescu 2005). Of the different types of GAG heparan sulfate and dermatan sulfate are the most prominent in amyloid deposits (Hirschfield & Hawkins, 2003). GAGs have been implicated in the nucleation of fibrils, they can also stabilize mature fibrils against dissociation (Yamaguchi et al. 2003) and proteolytic degradation (Gupta-Bansal et al. 1995). Perlecan coimmunolocalizes with all types of amyloids (Snow & Wright 1989), accelerating fibril formation (Castillo et al. 1998), stabilizing them once formed (Castillo et al. 1997), and protecting them from proteolytic degradation (Gupta-Bansal et al. 1995). ApoE tightly binds to soluble ABeta peptide forming complexes that resist dissociation; it also binds to ABeta in its fibril form (Bales et al. 2002).

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Compartment extracellular region
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Diseases
Name Identifier Synonyms
Amyloidosis 9120
Literature References
pubMedId Title Journal Year
118839 Binding of serum amyloid P-component (SAP) by amyloid fibrils Clin Exp Immunol 1979
Amyloid P component. A critical review Amyloid 1997
20807650 Heparan sulfate proteoglycans in amyloidosis Prog Mol Biol Transl Sci 2010
2409350 Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study Lab Invest 1985
10583407 Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth Eur J Biochem 1999
 
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