Reactome: A Curated Pathway Database

APP(672-711) (R-HSA-976740) [Homo sapiens]

Reference Gene Product
Locations in the PathwayBrowser
Additional Information
External reference name APP
External reference id P05067
Synonyms Beta-amyloid protein 40, APP
Compartment extracellular region
Other Identifiers
 0001230601  11738008_s_at  11741216_x_at  11742210_a_at  11742211_x_at
 11742215_s_at  11746866_a_at  11750384_a_at  11751350_a_at  11752199_a_at
 11752200_x_at  11752481_a_at  11762804_x_at  1AAP  1AMB
 1AMC  1AML  1BA4  1BA6  1BJB
 1BJC  1BRC  1CA0  1HZ3  1IYT
 1MWP  1OWT  1QCM  1QWP  1QXC
 1QYT  1TAW  1TKN  1UO7  1UO8
 1UOA  1UOI  1X11  1Z0Q  1ZE7
 1ZE9  1ZJD  200602_at  211277_3p_x_at  211277_x_at
 214953_s_at  2BEG  2BOM  2BP4  2FJZ
 2FK1  2FK2  2FK3  2FKL  2FMA
 2G47  2IPU  2LFM  2LLM  2LMN
 2LMO  2LMP  2LMQ  2LNQ  2LOH
 2LP1  2LZ3  2LZ4  2M4J  2M9R
 2M9S  2MGT  2MJ1  2MPZ  2MVX
 2MXU  2OTK  2R0W  2WK3  2Y29
 2Y2A  2Y3J  2Y3K  2Y3L  351
 3AYU  3BAE  3BKJ  3DXC  3DXD
 3DXE  3GCI  3IFL  3IFN  3IFO
 3IFP  3JQ5  3JQL  3JTI  3KTM
 3L33  3L81  3MOQ  3MXC  3MXY
 3NYJ  3NYL  3OVJ  3OW9  3SV1
 3U0T  3UMH  3UMI  3UMK  41136_s_at
 4HIX  4JFN  4M1C  4MDR  4MVI
 4MVK  4MVL  4NGE  4OJF  4ONF
 4ONG  4PQD  4PWQ  4XXD  5AEF
 5CSZ  64309_f_at  A_24_P314159  A_33_P3296479  A_33_P3508822
 AAA35540  AAA51564  AAA51722  AAA51726  AAA51727
 AAA51768  AAA58727  AAA60163  AAB23646  AAB26263
 AAB26264  AAB26265  AAB59501  AAB59502  AAC13654
 AAC60601  AAH04369  AAH65529  AAQ14327  AAW82435
 AB066441  AF282245  AK295621  AK312326  AP001439
 AP001440  AP001441  AP001442  AP001443  APP
 APP-001  APP-002  APP-003  APP-004  APP-016
 APP-017  AY919674  BAA22264  BAB71958  BAG35248
 BAG58500  BC004369  BC065529  CAA30041  CAA30042
 CAA30050  CAA31830  CAA68374  CAB000157  CCDS13576
 CCDS13577  CCDS33523  CCDS46638  CCDS56212  CCDS56213
 CH471079  D87675  EAX09958  EAX09959  EAX09960
 EAX09961  EAX09963  EAX09965  ENSG00000142192  ENSP00000284981
 ENSP00000345463  ENSP00000346129  ENSP00000350578  ENSP00000351796  ENSP00000387483
 ENST00000346798  ENST00000348990  ENST00000354192  ENST00000357903  ENST00000358918
 ENST00000440126  EntrezGene:351  g4502166_3p_at  GE57419  HGNC:620
 HPA001462  Hs.177486.2.A1_3p_a_at  Hs.434980  ILMN_1653283  ILMN_1678152
 ILMN_2404063  ILMN_2404065  IPR002223  IPR008154  IPR008155
 IPR011178  IPR013803  IPR015849  IPR019543  IPR019744
 IPR019745  IPR020901  IPR024329  M15532  M15533
 M16765  M18734  M24546  M24547  M28373
 M29269  M29270  M33112  M34862  M34863
 M34864  M34865  M34866  M34867  M34868
 M34869  M34870  M34871  M34872  M34873
 M34874  M34875  M34876  M34877  M34878
 M34879  M35675  M37895  M37896  MIM:104760
 NM_000484  NM_001136016  NM_001136129  NM_001204301  NM_001204302
 NM_001204303  NM_201413  NM_201414  NP_000475  NP_001129488
 NP_001129601  NP_001191230  NP_001191231  NP_001191232  NP_958816
 NP_958817  OTTHUMP00000096095  OTTHUMP00000096096  OTTHUMP00000096097  OTTHUMP00000096098
 OTTHUMP00000272882  OTTHUMP00000274887  PF00014  PF02177  PF03494
 PF10515  PF12924  PF12925  PH_hs_0010546  PR00203
 PR00204  PR00759  R-HSA-109582  R-HSA-114608  R-HSA-1474244
 R-HSA-1606322  R-HSA-162582  R-HSA-166016  R-HSA-166054  R-HSA-166058
 R-HSA-166166  R-HSA-168138  R-HSA-168142  R-HSA-168164  R-HSA-168176
 R-HSA-168179  R-HSA-168181  R-HSA-168188  R-HSA-168249  R-HSA-168256
 R-HSA-168643  R-HSA-168898  R-HSA-168928  R-HSA-1810476  R-HSA-181438
 R-HSA-1834949  R-HSA-199991  R-HSA-199992  R-HSA-3000178  R-HSA-3134963
 R-HSA-372790  R-HSA-373076  R-HSA-375276  R-HSA-388396  R-HSA-392499
 R-HSA-416476  R-HSA-418594  R-HSA-421837  R-HSA-432720  R-HSA-444473
 R-HSA-445989  R-HSA-500792  R-HSA-5653656  R-HSA-622312  R-HSA-76002
 R-HSA-76005  R-HSA-844456  R-HSA-879415  R-HSA-881907  R-HSA-933542
 R-HSA-937061  R-HSA-975138  R-HSA-975155  R-HSA-975871  R-HSA-977225
 S45136  S60317  S60721  S61380  S61383
 SM00006  SM00131  uc002ylz.4  uc002yma.4  uc002ymb.4
 uc010glj.4  uc010glk.4  uc021whz.2  UPI000002A2F2  UPI000002A2F6
 UPI000002A2F7  UPI000002DB1C  UPI00001BE539  UPI00017A7091  X06981
 X06982  X06989  X13466  X13467  X13468
 X13469  X13470  X13471  X13472  X13473
 X13474  X13475  X13476  X13477  X13478
 X13479  X13487  X13488  Y00264  Y00264_at
Secondary Identifiers A4_HUMAN, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
Gene Names APP, A4, AD1
Chain signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
This entry is a component of:
hasMember
Reference Genes
Database Identifier
dbSNP Gene 351
CTD Gene 351
BioGPS Gene 351
NCBI Gene 351
ENSEMBL ENSG00000142192
KEGG Gene APP
Orphanet 15941
Reference Transcripts
Database Identifier
RefSeq NM_000484
Cross References
Database Identifier
RefSeq NP_000475, NP_001129601, NP_001191232, NP_958817, NP_001191231, NP_958816, NP_001129488, NP_001191230
ZINC_target P05067
DOCK Blaster 5CSZ, 4XXD, 5AEF, 4PQD, 4PWQ, 4ONF, 4ONG, 4NGE, 4OJF, 4MVK, 4MVL, 4MDR, 4MVI, 4JFN, 4M1C, 3UMK, 4HIX, 3UMH, 3UMI, 3SV1, 3U0T, 3OVJ, 3OW9, 3NYJ, 3NYL, 3MXC, 3MXY, 3L81, 3MOQ, 3KTM, 3L33, 3JQL, 3JTI, 3IFP, 3JQ5, 3IFN, 3IFO, 3GCI, 3IFL, 3DXD, 3DXE, 3BKJ, 3DXC, 3AYU, 3BAE, 2Y3K, 2Y3L, 2Y2A, 2Y3J, 2WK3, 2Y29, 2OTK, 2R0W, 2MVX, 2MXU, 2MJ1, 2MPZ, 2MGT, 2M9R, 2M9S, 2M4J, 2LZ3, 2LZ4, 2LOH, 2LP1, 2LNQ, 2LMP, 2LMQ, 2LMN, 2LMO, 2LFM, 2LLM, 2G47, 2IPU, 2FMA, 2FK3, 2FKL, 2FK1, 2FK2, 2BP4, 2FJZ, 2BEG, 2BOM, 1ZE9, 1ZJD, 1Z0Q, 1ZE7, 1UOI, 1X11, 1UO8, 1UOA, 1TKN, 1UO7, 1QYT, 1TAW, 1QWP, 1QXC, 1OWT, 1QCM, 1IYT, 1MWP, 1CA0, 1HZ3, 1BJC, 1BRC, 1BA6, 1BJB, 1BA4, 1AMC, 1AML, 1AAP, 1AMB
HMDB_protein HMDBP01991
PRO P05067
GeneCards P05067
UCSC human P05067
Protein Data Bank 5CSZ, 4XXD, 5AEF, 4PQD, 4PWQ, 4ONF, 4ONG, 4NGE, 4OJF, 4MVK, 4MVL, 4MDR, 4MVI, 4JFN, 4M1C, 3UMK, 4HIX, 3UMH, 3UMI, 3SV1, 3U0T, 3OVJ, 3OW9, 3NYJ, 3NYL, 3MXC, 3MXY, 3L81, 3MOQ, 3KTM, 3L33, 3JQL, 3JTI, 3IFP, 3JQ5, 3IFN, 3IFO, 3GCI, 3IFL, 3DXD, 3DXE, 3BKJ, 3DXC, 3AYU, 3BAE, 2Y3K, 2Y3L, 2Y2A, 2Y3J, 2WK3, 2Y29, 2OTK, 2R0W, 2MVX, 2MXU, 2MJ1, 2MPZ, 2MGT, 2M9R, 2M9S, 2M4J, 2LZ3, 2LZ4, 2LOH, 2LP1, 2LNQ, 2LMP, 2LMQ, 2LMN, 2LMO, 2LFM, 2LLM, 2G47, 2IPU, 2FMA, 2FK3, 2FKL, 2FK1, 2FK2, 2BP4, 2FJZ, 2BEG, 2BOM, 1ZE9, 1ZJD, 1Z0Q, 1ZE7, 1UOI, 1X11, 1UO8, 1UOA, 1TKN, 1UO7, 1QYT, 1TAW, 1QWP, 1QXC, 1OWT, 1QCM, 1IYT, 1MWP, 1CA0, 1HZ3, 1BJC, 1BRC, 1BA6, 1BJB, 1BA4, 1AMC, 1AML, 1AAP, 1AMB
Inferred Entries
Inferred to
Interactions
Confidence Score Interactor Accession Interactor Name Evidences
0.992 P05067 A4 104
0.728 O00213 APBB1 5
0.718 P61812 TGFB2 7
0.663 P10636 TAU 9
0.641 P01137 TGFB1 3
0.641 P04156 PRIO 3
0.633 Q9UQF2 JIP1 4
0.632 P49768 PSN1 6
0.625 P02647 APOA1 5
0.625 Q99714 HCD2 4
0.611 O75509 TNR21 3
0.589 P29353 SHC1 6
0.589 Q9NP59 S40A1 5
0.581 Q13625 ASPP2 3
0.581 O75955 FLOT1 5
0.564 P07196 NFL 2
0.564 Q99683 M3K5 2
0.564 P27797 CALR 2
0.558 P08138 TNR16 2
0.544 Q306T3 Q306T3 9ACTN 3
0.544 P15253 CALR RABIT 3
0.528 P46933 APBB1 RAT 2
0.524 P01100 FOS 3
0.524 Q02410 APBA1 3
0.524 P61457 PHS 2
0.508 P21359 NF1 3
0.508 Q92870 APBB2 2
0.499 P78352 DLG4 2
0.499 P30101 PDIA3 3
0.489 P56817-1 BACE1 2
0.482 O14879 IFIT3 2
0.463 P36544 ACHA7 2
0.462 P04578 ENV HV1H2 2