Reactome: A Curated Pathway Database

TNF (R-HSA-976821) [Homo sapiens]

Reference Gene Product
Locations in the PathwayBrowser
Other forms of this molecule
Additional Information
External reference name TNF
External reference id P01375
Synonyms TNF(77-233), TNF-alpha, Tumor necrosis factor, TNFA_HUMAN
Compartment extracellular region
Other Identifiers
 0002450619  11721577_at  1852_at  1A8M  1TNF
 207113_s_at  259_s_at  2AZ5  2E7A  2TUN
 2ZJC  2ZPX  3ALQ  3IT8  3L9J
 3WD5  4G3Y  4TSV  4TWT  5TSW
 7124  A_14_P110091  A_14_P125975  A_23_P376488  A_24_P50759
 AAA36758  AAA61198  AAA61200  AAC03542  AAD18091
 AAF71992  AAH28148  AAL47581  AAO21132  AB088112
 AB103618  AB202113  ADV31546  AF043342  AF098751
 AF129756  AHJ25918  AHJ25919  AHJ25920  AHJ25921
 AHJ25922  AHJ25923  AHJ25924  AHJ25925  AK314960
 AY066019  AY214167  BA000025  BAB63396  BAC54944
 BAE78639  BAF31279  BAG37464  BC028148  CAA25650
 CAA26669  CAA75070  CAA78745  CCDS4702  CH471081
 EAX03424  ENSG00000204490  ENSG00000206439  ENSG00000223952  ENSG00000228321
 ENSG00000228849  ENSG00000230108  ENSG00000232810  ENSP00000365290  ENSP00000372988
 ENSP00000389490  ENSP00000389492  ENSP00000392858  ENSP00000398698  ENSP00000410668
 ENST00000376122  ENST00000383496  ENST00000412275  ENST00000420425  ENST00000443707
 ENST00000448781  ENST00000449264  EntrezGene:7124  g10835154_3p_a_at  GE59636
 HGNC:11892  HPA064998  HQ201306  Hs.241570  ILMN_1728106
 IPR002959  IPR006052  IPR006053  IPR008983  IPR021184
 KF887965  KF887966  KF887967  KF887968  KF887969
 KF887970  KF887971  KF887972  M10988  M16441
 M26331  MIM:191160  NM_000594  NP_000585  OTTHUMP00000014621
 OTTHUMP00000029281  OTTHUMP00000029720  OTTHUMP00000037669  OTTHUMP00000193290  OTTHUMP00000193749
 OTTHUMP00000194120  PF00229  PH_hs_0012958  PR01234  PR01235
 Q5STB3  R-HSA-1266738  R-HSA-1280215  R-HSA-162582  R-HSA-168256
 R-HSA-381340  R-HSA-5357786  R-HSA-5357905  R-HSA-5357956  R-HSA-5626978
 R-HSA-5668541  R-HSA-73887  R-HSA-75893  SM00207  TNF
 TNF-001  uc003nui.5  UPI000000D745  X01394  X02910
 X02910_at  Y14768  Z15026
Secondary Identifiers TNFA_HUMAN, O43647, Q9P1Q2, Q9UIV3
Gene Names TNF, TNFA, TNFSF2
Chain chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
This entry is a component of:
hasComponent
Reference Genes
Database Identifier
dbSNP Gene 7124
CTD Gene 7124
BioGPS Gene 7124
NCBI Gene 7124
ENSEMBL ENSG00000223952
KEGG Gene TNF
Orphanet 16877
Reference Transcripts
Database Identifier
RefSeq NM_000594
Cross References
Database Identifier
RefSeq NP_000585
ZINC_target P01375
DOCK Blaster 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW, 3ALQ, 3IT8, 2TUN, 2ZJC, 2ZPX, 1A8M, 1TNF, 2AZ5, 2E7A, 3L9J
HMDB_protein HMDBP02070
PRO P01375
GeneCards P01375
UCSC human P01375
Protein Data Bank 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW, 3ALQ, 3IT8, 2TUN, 2ZJC, 2ZPX, 1A8M, 1TNF, 2AZ5, 2E7A, 3L9J
This entity regulates
Regulation type Name
NegativeRegulation
Interactions
Confidence Score Interactor Accession Interactor Name Evidence
0.926 P19438 TNR1A_HUMAN 12
0.788 Q13546 RIPK1_HUMAN 8
0.725 Q13490 BIRC2_HUMAN 4
0.643 Q12933 TRAF2_HUMAN 6
0.643 Q9BYM8 HOIL1_HUMAN 5
0.641 Q8UYL3 Q8UYL3_9POXV 3
0.609 P20333 TNR1B_HUMAN 2
0.564 Q9Y6K9 NEMO_HUMAN 2
0.527 Q9H0F6 SHRPN_HUMAN 2
0.527 Q15628 TRADD_HUMAN 4