Reactome: A Curated Pathway Database

TNF (R-HSA-976821)

Species Homo sapiens

Locations in the PathwayBrowser
Developmental Biology(Homo sapiens)
Signal Transduction(Homo sapiens)

Other forms of this molecule

Additional Information
External reference name TNF
External reference id P01375
Synonyms TNF(77-233), TNF-alpha, Tumor necrosis factor, TNFA_HUMAN
Compartment extracellular region
Other Identifiers 0002450619, 11721577_at, 1852_at, 1A8M, 1TNF, 207113_s_at, 259_s_at, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW, 7124, A_14_P110091, A_14_P125975, A_23_P376488, A_24_P50759, AAA36758, AAA61198, AAA61200, AAC03542, AAD18091, AAF71992, AAH28148, AAL47581, AAO21132, AB088112, AB103618, AB202113, ADV31546, AF043342, AF098751, AF129756, AHJ25918, AHJ25919, AHJ25920, AHJ25921, AHJ25922, AHJ25923, AHJ25924, AHJ25925, AK314960, AY066019, AY214167, BA000025, BAB63396, BAC54944, BAE78639, BAF31279, BAG37464, BC028148, CAA25650, CAA26669, CAA75070, CAA78745, CCDS4702, CH471081, EAX03424, ENSG00000204490, ENSG00000206439, ENSG00000223952, ENSG00000228321, ENSG00000228849, ENSG00000230108, ENSG00000232810, ENSP00000365290, ENSP00000372988, ENSP00000389490, ENSP00000389492, ENSP00000392858, ENSP00000398698, ENSP00000410668, ENST00000376122, ENST00000383496, ENST00000412275, ENST00000420425, ENST00000443707, ENST00000448781, ENST00000449264, EntrezGene:7124, g10835154_3p_a_at, GE59636, HGNC:11892, HPA064998, HQ201306, Hs.241570, ILMN_1728106, IPR002959, IPR006052, IPR006053, IPR008983, IPR021184, KF887965, KF887966, KF887967, KF887968, KF887969, KF887970, KF887971, KF887972, M10988, M16441, M26331, MIM:191160, MIM:607507, MIM:610424, MIM:611162, NM_000594, NP_000585, OTTHUMP00000014621, OTTHUMP00000029281, OTTHUMP00000029720, OTTHUMP00000037669, OTTHUMP00000193290, OTTHUMP00000193749, OTTHUMP00000194120, PF00229, PH_hs_0012958, PR01234, PR01235, Q5STB3, REACT_111045, REACT_111102, REACT_1432, REACT_1619, REACT_27161, REACT_355072, SM00207, TNF, TNF-001, uc003nui.4, UPI000000D745, X01394, X02910, X02910_at, Y14768, Z15026
Secondary Identifiers TNFA_HUMAN, O43647, Q9P1Q2, Q9UIV3
Gene Names TNF, TNFA, TNFSF2
Chain chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
This entry is a component of:
Reference Genes
Database Identifier
dbSNP Gene 7124
CTD Gene 7124
BioGPS Gene 7124
NCBI Gene 7124
ENSEMBL ENSG00000206439
KEGG Gene 7124
Orphanet 16877
Reference Transcripts
Database Identifier
RefSeq NM_000594
Cross References
Database Identifier
RefSeq NP_000585
ZINC_target P01375
DOCK Blaster 3L9J, 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
HMDB_protein HMDBP02070
PRO P01375
GeneCards P01375
UCSC human P01375
Protein Data Bank 3L9J, 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
This entity regulates
Regulation type Name