Reactome: A Curated Pathway Database

Polyubiquitination of substrate

Stable Identifier
R-HSA-983156
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol] E3:Ub:substrate [cytosol] ubiquitin-protein transferase activity (0004842)
Orthologous Events