Reactome: A Curated Pathway Database

Polyubiquitination of substrate (R-HSA-983156) [Homo sapiens]

Black Box Event

Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
16954532 A novel family of membrane-bound E3 ubiquitin ligases J Biochem 2006
12646216 U-box proteins as a new family of ubiquitin ligases Biochem Biophys Res Commun 2003
19489725 RING domain E3 ubiquitin ligases Annu Rev Biochem 2009
19874575 Mechanisms of ubiquitin transfer by the anaphase-promoting complex J Biol 2009