Polyubiquitination of substrate

Stable Identifier
R-HSA-983156
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Literature References
PubMed ID Title Journal Year
16954532 A novel family of membrane-bound E3 ubiquitin ligases

Ohmura-Hoshino, M, Goto, E, Matsuki, Y, Aoki, M, Mito, M, Uematsu, M, Hotta, H, Ishido, S

J Biochem 2006
12646216 U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S, Nakayama, KI

Biochem Biophys Res Commun 2003
19489725 RING domain E3 ubiquitin ligases

Deshaies, RJ, Joazeiro, CA

Annu Rev Biochem 2009
19874575 Mechanisms of ubiquitin transfer by the anaphase-promoting complex

Matyskiela, ME, Rodrigo-Brenni, MC, Morgan, DO

J Biol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created