Polyubiquitination of substrate

Stable Identifier
R-HSA-983156
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Literature References
PubMed ID Title Journal Year
16954532 A novel family of membrane-bound E3 ubiquitin ligases J Biochem 2006
12646216 U-box proteins as a new family of ubiquitin ligases Biochem Biophys Res Commun 2003
19489725 RING domain E3 ubiquitin ligases Annu Rev Biochem 2009
19874575 Mechanisms of ubiquitin transfer by the anaphase-promoting complex J Biol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
Physical Entity
Activity
Orthologous Events