Reactome: A Curated Pathway Database

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (R-HSA-983162)

Species Homo sapiens


Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

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Additional Information
Compartment cytosol
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Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
IFN gamma stimulated aminopeptidases aminopeptidase activity (0004177)
Inferred Entries
Orthologous events