Reactome: A Curated Pathway Database

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (R-HSA-983162) [Homo sapiens]

Black Box Event

Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
IFN gamma stimulated aminopeptidases aminopeptidase activity (0004177)  
Inferred Entries
Orthologous events