Reactome: A Curated Pathway Database

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Stable Identifier
R-HSA-983162
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aminopeptidase activity of IFN gamma stimulated aminopeptidases [cytosol] IFN gamma stimulated aminopeptidases [cytosol] aminopeptidase activity (0004177)
Orthologous Events