Class I MHC mediated antigen processing & presentation

Stable Identifier
R-HSA-983169
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface.

Literature References
PubMed ID Title Journal Year
17145306 Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

Loureiro, J, Ploegh, HL

Adv Immunol 2006
18926908 The quality control of MHC class I peptide loading

Wearsch, PA, Cresswell, P

Curr Opin Cell Biol 2008
8717519 Antigen processing and presentation by the class I major histocompatibility complex

York, IA, Rock, KL

Annu Rev Immunol 1996
18641646 The known unknowns of antigen processing and presentation

Vyas, JM, Van der Veen, AG, Ploegh, HL

Nat Rev Immunol 2008
12495737 Assembly and export of MHC class I peptide ligands

Antoniou, AN, Powis, SJ, Elliott, T

Curr Opin Immunol 2003
18243674 Molecular machinations of the MHC-I peptide loading complex

Purcell, AW, Elliott, T

Curr Opin Immunol 2008
17055423 The complex route to MHC class I-peptide complexes

Elliott, T, Neefjes, J

Cell 2006
Participants
Participant Of
Event Information
Orthologous Events
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