Reactome | Expression of peptide bound class I MHC on cell surface

Expression of peptide bound class I MHC on cell surface

Stable Identifier

R-HSA-983427

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, Golgi membrane

ReviewStatus

5/5

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Expression of peptide bound class I MHC on cell surface

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After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.

Literature References

PubMed ID	Title	Journal	Year
20605430	Passage through the Golgi Luini, A, Nakano, A	Curr Opin Cell Biol	2010
19193869	Mechanisms of transport through the Golgi complex Jackson, CL	J Cell Sci	2009
11163199	Selective export of MHC class I molecules from the ER after their dissociation from TAP Manley, H, Spiliotis, ET, Edidin, M, Zúñiga, MC, Osorio, M	Immunity	2000