Reactome: A Curated Pathway Database

Ion channel transport (R-HSA-983712) [Homo sapiens]


Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemical signal. Voltage-gated ion channels are activated by changes in electrical potential difference at the membrane (Purves, 2001; Kuhlbrandt, 2004).

Additional Information
GO Biological Process ion transmembrane transport (0034220)
Literature References
pubMedId Title Journal Year
Neuroscience (2nd ed.) 2001
15071553 Biology, structure and mechanism of P-type ATPases Nat Rev Mol Cell Biol 2004