Reactome: A Curated Pathway Database

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Stable Identifier
R-HSA-997272
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby hyper polarizing the cell which inhibits the release of neurotransmitters. The decrease in Ca2+ also inhibits neurotransmitter in two ways; first by preventing the fusion of synaptic vesicles containing the neurotransmitter with the plasma membrane and second by decreasing the Ca2+ dependent recruitment of synaptic vesicles to the plasma membrane. In particular GABA B receptors inhibit voltage gated Ca2+ channels via the activity of Gbeta/Ggamma subunits of G proteins.

Literature References
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