Reactome: A Curated Pathway Database

AGER binds rat ERK1/2

Stable Identifier
R-NUL-997411
Type
Reaction
Species
Homo sapiens
Compartment
Summation

A membrane-proximal cytoplasmic region of the advanced glycation end-products receptor (AGER) is responsible for binding to extracellular signal-regulated protein kinase-1 and -2 (ERK1/2 or MAPK3/1). This region is similar to the D-domain, an ERK docking site which is conserved in some ERK substrates (Ishihara et al. 2003).

Literature References
Participants
Orthologous Events