Reactome: A Curated Pathway Database

AGER binds rat ERK1/2 (R-NUL-997411) [Homo sapiens]


A membrane-proximal cytoplasmic region of the advanced glycation end-products receptor (AGER) is responsible for binding to extracellular signal-regulated protein kinase-1 and -2 (ERK1/2 or MAPK3/1). This region is similar to the D-domain, an ERK docking site which is conserved in some ERK substrates (Ishihara et al. 2003).

Additional Information
Compartment plasma membrane , cytosol
Literature References
pubMedId Title Journal Year
12935895 The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site FEBS Lett 2003