Activation of BAD and translocation to mitochondria

Stable Identifier
R-HSA-111447
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Pathway
Species
Homo sapiens
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5/5
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The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.
Literature References
PubMed ID Title Journal Year
15231831 BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.

Fannjiang, Y, Bellows, DS, Ranger, AM, Hardwick, JM, Ivanovska, I, Dawson, VL, Hong, SJ, Chen, YB, Seo, SY, Korsmeyer, SJ

J Biol Chem 2004
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Orthologous Events
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BioModels Database
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