Reactome | ABC-family proteins mediated transport

ABC-family proteins mediated transport

Stable Identifier

R-HSA-382556

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19234479	ABC transporters: the power to change Lewinson, O, Johnson, E, Rees, DC	Nat Rev Mol Cell Biol	2009
11435397	The human ATP-binding cassette (ABC) transporter superfamily Allikmets, R, Rzhetsky, A, Dean, M	Genome Res	2001
12045106	Mammalian ABC transporters in health and disease Elferink, RO, Borst, P	Annu Rev Biochem	2002