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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
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Tissue Distribution
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H2O [nucleoplasm]
Stable Identifier
R-ALL-113518
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Nuclear Envelope Breakdown (Bos taurus)
Depolymerization of the Nuclear Lamina (Bos taurus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)
H2O [nucleoplasm]
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Bos taurus)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Bos taurus)
PP2A mediated localization of RB1 protein in chromatin (Bos taurus)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
CDC25A dephosphorylates CCNA:CDK1 (Bos taurus)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Bos taurus)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
Myosin phosphatase dephosphorylates PLK1 (Bos taurus)
H2O [nucleoplasm]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
H2O [nucleoplasm]
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
H2O [nucleoplasm]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Bos taurus)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
H2O [nucleoplasm]
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
HDACs deacetylate histones (Bos taurus)
HDAC10 deacetylates histone (Bos taurus)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Bos taurus)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Bos taurus)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Bos taurus)
H2O [nucleoplasm]
PADI4 deiminates Histones (Bos taurus)
H2O [nucleoplasm]
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
PARG dePARylates PARP1,PARP2 (Bos taurus)
H2O [nucleoplasm]
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Termination of translesion DNA synthesis (Bos taurus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Bos taurus)
H2O [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
Initial resection of double-strand break ends (Bos taurus)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Bos taurus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
H2O [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
USP45 deubiquitinates ERCC1 (Bos taurus)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
H2O [nucleoplasm]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
H2O [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
MTA2-NuRD complex deacetylates TP53 (Bos taurus)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
Regulation of RUNX1 Expression and Activity (Bos taurus)
PTPN11 dephosphorylates RUNX1 (Bos taurus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Bos taurus)
PPM1D dephosphorylates RUNX2 (Bos taurus)
H2O [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
Regulation of IFNG signaling (Bos taurus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)
H2O [nucleoplasm]
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
H2O [nucleoplasm]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
dUTP + H2O => dUMP + pyrophosphate (Bos taurus)
H2O [nucleoplasm]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT16 hydrolyses IDP to IMP (Bos taurus)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)
H2O [nucleoplasm]
Metabolism of RNA (Bos taurus)
mRNA Editing (Bos taurus)
mRNA Editing: A to I Conversion (Bos taurus)
C6 deamination of adenosine (Bos taurus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Bos taurus)
C4 deamination of cytidine (Bos taurus)
H2O [nucleoplasm]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Metalloprotease DUBs (Bos taurus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Bos taurus)
H2O [nucleoplasm]
UCH proteinases (Bos taurus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)
H2O [nucleoplasm]
Ub-specific processing proteases (Bos taurus)
USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Bos taurus)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Bos taurus)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Bos taurus)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Bos taurus)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Bos taurus)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Bos taurus)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Bos taurus)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Bos taurus)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Bos taurus)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)
H2O [nucleoplasm]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
H2O [nucleoplasm]
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
STAT3 nuclear events downstream of ALK signaling (Bos taurus)
HDACs deacetylate p-STAT3 dimers (Bos taurus)
H2O [nucleoplasm]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
H2O [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerization of the Nuclear Lamina (Caenorhabditis elegans)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)
H2O [nucleoplasm]
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
CDC25A dephosphorylates CCNA:CDK1 (Caenorhabditis elegans)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Caenorhabditis elegans)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)
H2O [nucleoplasm]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)
H2O [nucleoplasm]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
H2O [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Double-Strand Break Repair (Caenorhabditis elegans)
Homology Directed Repair (Caenorhabditis elegans)
HDR through MMEJ (alt-NHEJ) (Caenorhabditis elegans)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)
H2O [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
H2O [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
H2O [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
MTA2-NuRD complex deacetylates TP53 (Caenorhabditis elegans)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)
H2O [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs in the nucleus (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)
H2O [nucleoplasm]
Nucleotide catabolism (Caenorhabditis elegans)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of RNA (Caenorhabditis elegans)
mRNA Editing (Caenorhabditis elegans)
mRNA Editing: A to I Conversion (Caenorhabditis elegans)
C6 deamination of adenosine (Caenorhabditis elegans)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
Metalloprotease DUBs (Caenorhabditis elegans)
MYSM1 deubiquitinates Histone H2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Ub-specific processing proteases (Caenorhabditis elegans)
USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Caenorhabditis elegans)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Caenorhabditis elegans)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
H2O [nucleoplasm]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN localization (Caenorhabditis elegans)
USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)
H2O [nucleoplasm]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK6/MAPK4 signaling (Caenorhabditis elegans)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Caenorhabditis elegans)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
STAT3 nuclear events downstream of ALK signaling (Caenorhabditis elegans)
HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)
H2O [nucleoplasm]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
H2O [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Prophase (Canis familiaris)
Nuclear Envelope Breakdown (Canis familiaris)
Depolymerization of the Nuclear Lamina (Canis familiaris)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)
H2O [nucleoplasm]
G1/S Transition (Canis familiaris)
Cyclin E associated events during G1/S transition (Canis familiaris)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Canis familiaris)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Canis familiaris)
PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
CDC25A dephosphorylates CCNA:CDK1 (Canis familiaris)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Canis familiaris)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
Myosin phosphatase dephosphorylates PLK1 (Canis familiaris)
H2O [nucleoplasm]
S Phase (Canis familiaris)
Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)
H2O [nucleoplasm]
Chromosome Maintenance (Canis familiaris)
Telomere Maintenance (Canis familiaris)
Extension of Telomeres (Canis familiaris)
Telomere C-strand (Lagging Strand) Synthesis (Canis familiaris)
Polymerase switching on the C-strand of the telomere (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Canis familiaris)
PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)
H2O [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Canis familiaris)
H2O [nucleoplasm]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
HDACs deacetylate histones (Canis familiaris)
HDAC10 deacetylates histone (Canis familiaris)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Canis familiaris)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Canis familiaris)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Canis familiaris)
H2O [nucleoplasm]
PADI4 deiminates Histones (Canis familiaris)
H2O [nucleoplasm]
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Canis familiaris)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
H2O [nucleoplasm]
DNA Damage Bypass (Canis familiaris)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Canis familiaris)
Termination of translesion DNA synthesis (Canis familiaris)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Canis familiaris)
H2O [nucleoplasm]
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
Initial resection of double-strand break ends (Canis familiaris)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Canis familiaris)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)
H2O [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
H2O [nucleoplasm]
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
H2O [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Acetylation (Canis familiaris)
MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Canis familiaris)
Regulation of RUNX1 Expression and Activity (Canis familiaris)
PTPN11 dephosphorylates RUNX1 (Canis familiaris)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Canis familiaris)
PPM1D dephosphorylates RUNX2 (Canis familiaris)
H2O [nucleoplasm]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon gamma signaling (Canis familiaris)
Regulation of IFNG signaling (Canis familiaris)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)
H2O [nucleoplasm]
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs in the nucleus (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)
H2O [nucleoplasm]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)
H2O [nucleoplasm]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT16 hydrolyses IDP to IMP (Canis familiaris)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)
H2O [nucleoplasm]
Metabolism of RNA (Canis familiaris)
mRNA Editing (Canis familiaris)
mRNA Editing: A to I Conversion (Canis familiaris)
C6 deamination of adenosine (Canis familiaris)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Canis familiaris)
C4 deamination of cytidine (Canis familiaris)
H2O [nucleoplasm]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Metalloprotease DUBs (Canis familiaris)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Canis familiaris)
H2O [nucleoplasm]
UCH proteinases (Canis familiaris)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)
H2O [nucleoplasm]
Ub-specific processing proteases (Canis familiaris)
USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Canis familiaris)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Canis familiaris)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Canis familiaris)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Canis familiaris)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Canis familiaris)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Canis familiaris)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Canis familiaris)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
H2O [nucleoplasm]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
H2O [nucleoplasm]
MAPK family signaling cascades (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
STAT3 nuclear events downstream of ALK signaling (Canis familiaris)
HDACs deacetylate p-STAT3 dimers (Canis familiaris)
H2O [nucleoplasm]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
H2O [nucleoplasm]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
Mitotic G1 phase and G1/S transition (Danio rerio)
G1 Phase (Danio rerio)
Cyclin D associated events in G1 (Danio rerio)
Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)
H2O [nucleoplasm]
G1/S Transition (Danio rerio)
E2F mediated regulation of DNA replication (Danio rerio)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Danio rerio)
PP2A mediated localization of RB1 protein in chromatin (Danio rerio)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
Cyclin A/B1/B2 associated events during G2/M transition (Danio rerio)
PP2A demethylation by PPME1 (Danio rerio)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Danio rerio)
Myosin phosphatase dephosphorylates PLK1 (Danio rerio)
H2O [nucleoplasm]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)
H2O [nucleoplasm]
Chromatin organization (Danio rerio)
Chromatin modifying enzymes (Danio rerio)
HDACs deacetylate histones (Danio rerio)
HDAC10 deacetylates histone (Danio rerio)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Danio rerio)
H2O [nucleoplasm]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Danio rerio)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
Processing of DNA double-strand break ends (Danio rerio)
PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
H2O [nucleoplasm]
Nucleotide Excision Repair (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
Formation of Incision Complex in GG-NER (Danio rerio)
USP45 deubiquitinates ERCC1 (Danio rerio)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
Formation of TC-NER Pre-Incision Complex (Danio rerio)
UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
H2O [nucleoplasm]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Activity through Acetylation (Danio rerio)
PI5P Regulates TP53 Acetylation (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
H2O [nucleoplasm]
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Interferon Signaling (Danio rerio)
Interferon gamma signaling (Danio rerio)
Regulation of IFNG signaling (Danio rerio)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)
H2O [nucleoplasm]
Signaling by Interleukins (Danio rerio)
Interleukin-17 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs in the nucleus (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
H2O [nucleoplasm]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
dUTP + H2O => dUMP + pyrophosphate (Danio rerio)
H2O [nucleoplasm]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT16 hydrolyses IDP to IMP (Danio rerio)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)
H2O [nucleoplasm]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Deubiquitination (Danio rerio)
Metalloprotease DUBs (Danio rerio)
MYSM1 deubiquitinates Histone H2A (Danio rerio)
H2O [nucleoplasm]
Ub-specific processing proteases (Danio rerio)
USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Danio rerio)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Danio rerio)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Danio rerio)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Danio rerio)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Danio rerio)
H2O [nucleoplasm]
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK6/MAPK4 signaling (Danio rerio)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Nuclear Events (kinase and transcription factor activation) (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Prophase (Dictyostelium discoideum)
Nuclear Envelope Breakdown (Dictyostelium discoideum)
Depolymerization of the Nuclear Lamina (Dictyostelium discoideum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
G1 Phase (Dictyostelium discoideum)
Cyclin D associated events in G1 (Dictyostelium discoideum)
Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)
H2O [nucleoplasm]
G1/S Transition (Dictyostelium discoideum)
E2F mediated regulation of DNA replication (Dictyostelium discoideum)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Dictyostelium discoideum)
PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Dictyostelium discoideum)
G2/M Transition (Dictyostelium discoideum)
Cyclin A/B1/B2 associated events during G2/M transition (Dictyostelium discoideum)
PP2A demethylation by PPME1 (Dictyostelium discoideum)
H2O [nucleoplasm]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Dictyostelium discoideum)
H2O [nucleoplasm]
Chromatin organization (Dictyostelium discoideum)
Chromatin modifying enzymes (Dictyostelium discoideum)
HDACs deacetylate histones (Dictyostelium discoideum)
HDAC10 deacetylates histone (Dictyostelium discoideum)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Dictyostelium discoideum)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Dictyostelium discoideum)
H2O [nucleoplasm]
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Dictyostelium discoideum)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Dictyostelium discoideum)
POLB-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Dictyostelium discoideum)
DNA Double Strand Break Response (Dictyostelium discoideum)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Dictyostelium discoideum)
PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)
H2O [nucleoplasm]
Nucleotide Excision Repair (Dictyostelium discoideum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Formation of TC-NER Pre-Incision Complex (Dictyostelium discoideum)
UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
H2O [nucleoplasm]
Developmental Biology (Dictyostelium discoideum)
MITF-M-regulated melanocyte development (Dictyostelium discoideum)
Transcriptional and post-translational regulation of MITF-M expression and activity (Dictyostelium discoideum)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
H2O [nucleoplasm]
Immune System (Dictyostelium discoideum)
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-17 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Innate Immune System (Dictyostelium discoideum)
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Metabolism (Dictyostelium discoideum)
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)
H2O [nucleoplasm]
Nucleotide catabolism (Dictyostelium discoideum)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)
H2O [nucleoplasm]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Deubiquitination (Dictyostelium discoideum)
Metalloprotease DUBs (Dictyostelium discoideum)
MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Ub-specific processing proteases (Dictyostelium discoideum)
USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Dictyostelium discoideum)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)
H2O [nucleoplasm]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN localization (Dictyostelium discoideum)
USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by ALK (Dictyostelium discoideum)
STAT3 nuclear events downstream of ALK signaling (Dictyostelium discoideum)
HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)
H2O [nucleoplasm]
Signaling by NTRKs (Dictyostelium discoideum)
Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
Nuclear Events (kinase and transcription factor activation) (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Prophase (Drosophila melanogaster)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Depolymerization of the Nuclear Lamina (Drosophila melanogaster)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)
H2O [nucleoplasm]
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
CDC25A dephosphorylates CCNA:CDK1 (Drosophila melanogaster)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Drosophila melanogaster)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)
H2O [nucleoplasm]
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
H2O [nucleoplasm]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
H2O [nucleoplasm]
Chromatin organization (Drosophila melanogaster)
Chromatin modifying enzymes (Drosophila melanogaster)
HDACs deacetylate histones (Drosophila melanogaster)
HDAC10 deacetylates histone (Drosophila melanogaster)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Drosophila melanogaster)
H2O [nucleoplasm]
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
POLB-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
H2O [nucleoplasm]
DNA Damage Bypass (Drosophila melanogaster)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Drosophila melanogaster)
Termination of translesion DNA synthesis (Drosophila melanogaster)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Drosophila melanogaster)
DNA Double Strand Break Response (Drosophila melanogaster)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)
H2O [nucleoplasm]
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)
H2O [nucleoplasm]
Nucleotide Excision Repair (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
H2O [nucleoplasm]
Developmental Biology (Drosophila melanogaster)
MITF-M-regulated melanocyte development (Drosophila melanogaster)
Transcriptional and post-translational regulation of MITF-M expression and activity (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
H2O [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Drosophila melanogaster)
Regulation of TP53 Degradation (Drosophila melanogaster)
USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates p14-ARF (Drosophila melanogaster)
HDAC4 deacetylates RUNX3 (Drosophila melanogaster)
H2O [nucleoplasm]
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Interferon gamma signaling (Drosophila melanogaster)
Regulation of IFNG signaling (Drosophila melanogaster)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)
H2O [nucleoplasm]
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs in the nucleus (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
H2O [nucleoplasm]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)
H2O [nucleoplasm]
Nucleotide catabolism (Drosophila melanogaster)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)
H2O [nucleoplasm]
Metabolism of RNA (Drosophila melanogaster)
mRNA Editing (Drosophila melanogaster)
mRNA Editing: A to I Conversion (Drosophila melanogaster)
C6 deamination of adenosine (Drosophila melanogaster)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)
H2O [nucleoplasm]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Metalloprotease DUBs (Drosophila melanogaster)
MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)
H2O [nucleoplasm]
UCH proteinases (Drosophila melanogaster)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Drosophila melanogaster)
H2O [nucleoplasm]
Ub-specific processing proteases (Drosophila melanogaster)
USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Drosophila melanogaster)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Drosophila melanogaster)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Drosophila melanogaster)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)
H2O [nucleoplasm]
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN localization (Drosophila melanogaster)
USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
STAT3 nuclear events downstream of ALK signaling (Drosophila melanogaster)
HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)
H2O [nucleoplasm]
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
H2O [nucleoplasm]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Prophase (Gallus gallus)
Nuclear Envelope Breakdown (Gallus gallus)
Depolymerization of the Nuclear Lamina (Gallus gallus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Gallus gallus)
G1/S Transition (Gallus gallus)
Cyclin E associated events during G1/S transition (Gallus gallus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
Cyclin A/B1/B2 associated events during G2/M transition (Gallus gallus)
CDC25A dephosphorylates CCNA:CDK1 (Gallus gallus)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Gallus gallus)
Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)
H2O [nucleoplasm]
S Phase (Gallus gallus)
Cyclin A:Cdk2-associated events at S phase entry (Gallus gallus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)
H2O [nucleoplasm]
Chromosome Maintenance (Gallus gallus)
Telomere Maintenance (Gallus gallus)
Extension of Telomeres (Gallus gallus)
Telomere C-strand (Lagging Strand) Synthesis (Gallus gallus)
Polymerase switching on the C-strand of the telomere (Gallus gallus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)
H2O [nucleoplasm]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to heat stress (Gallus gallus)
Regulation of HSF1-mediated heat shock response (Gallus gallus)
SIRT1 deacetylates HSF1 (Gallus gallus)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
ATP hydrolysis by HSP90 (Gallus gallus)
H2O [nucleoplasm]
Chromatin organization (Gallus gallus)
Chromatin modifying enzymes (Gallus gallus)
HDACs deacetylate histones (Gallus gallus)
HDAC10 deacetylates histone (Gallus gallus)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Gallus gallus)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Gallus gallus)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Gallus gallus)
H2O [nucleoplasm]
DNA Repair (Gallus gallus)
Base Excision Repair (Gallus gallus)
Resolution of Abasic Sites (AP sites) (Gallus gallus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Gallus gallus)
POLB-Dependent Long Patch Base Excision Repair (Gallus gallus)
PARG dePARylates PARP1,PARP2 (Gallus gallus)
H2O [nucleoplasm]
DNA Damage Bypass (Gallus gallus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Gallus gallus)
Termination of translesion DNA synthesis (Gallus gallus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Gallus gallus)
DNA Double Strand Break Response (Gallus gallus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Gallus gallus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)
H2O [nucleoplasm]
Homology Directed Repair (Gallus gallus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
Processing of DNA double-strand break ends (Gallus gallus)
Initial resection of double-strand break ends (Gallus gallus)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Gallus gallus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)
H2O [nucleoplasm]
Nucleotide Excision Repair (Gallus gallus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
Formation of TC-NER Pre-Incision Complex (Gallus gallus)
UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
H2O [nucleoplasm]
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
H2O [nucleoplasm]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX1 (Gallus gallus)
Regulation of RUNX1 Expression and Activity (Gallus gallus)
PTPN11 dephosphorylates RUNX1 (Gallus gallus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Gallus gallus)
PPM1D dephosphorylates RUNX2 (Gallus gallus)
H2O [nucleoplasm]
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
Regulation of IFNG signaling (Gallus gallus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)
H2O [nucleoplasm]
Signaling by Interleukins (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Metabolism (Gallus gallus)
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
dUTP + H2O => dUMP + pyrophosphate (Gallus gallus)
H2O [nucleoplasm]
Nucleotide catabolism (Gallus gallus)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Gallus gallus)
H2O [nucleoplasm]
Metabolism of RNA (Gallus gallus)
mRNA Editing (Gallus gallus)
mRNA Editing: A to I Conversion (Gallus gallus)
C6 deamination of adenosine (Gallus gallus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)
H2O [nucleoplasm]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Metalloprotease DUBs (Gallus gallus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Gallus gallus)
H2O [nucleoplasm]
UCH proteinases (Gallus gallus)
Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)
H2O [nucleoplasm]
Ub-specific processing proteases (Gallus gallus)
USP12, USP26 deubiquitinate AR (Gallus gallus)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Gallus gallus)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Gallus gallus)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Gallus gallus)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Gallus gallus)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Gallus gallus)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Gallus gallus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)
H2O [nucleoplasm]
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN localization (Gallus gallus)
USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)
H2O [nucleoplasm]
MAPK family signaling cascades (Gallus gallus)
MAPK6/MAPK4 signaling (Gallus gallus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
STAT3 nuclear events downstream of ALK signaling (Gallus gallus)
HDACs deacetylate p-STAT3 dimers (Gallus gallus)
H2O [nucleoplasm]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Nuclear Events (kinase and transcription factor activation) (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
H2O [nucleoplasm]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerization of the Nuclear Lamina (Homo sapiens)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
H2O [nucleoplasm]
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
CDC25A dephosphorylates CCNA:CDK1 (Homo sapiens)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Homo sapiens)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
H2O [nucleoplasm]
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
H2O [nucleoplasm]
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
H2O [nucleoplasm]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Homo sapiens)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
H2O [nucleoplasm]
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC10 deacetylates histone (Homo sapiens)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Homo sapiens)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Homo sapiens)
H2O [nucleoplasm]
PADI4 deiminates Histones (Homo sapiens)
H2O [nucleoplasm]
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARG dePARylates PARP1,PARP2 (Homo sapiens)
H2O [nucleoplasm]
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Homo sapiens)
H2O [nucleoplasm]
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
H2O [nucleoplasm]
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
H2O [nucleoplasm]
Processing of DNA double-strand break ends (Homo sapiens)
Initial resection of double-strand break ends (Homo sapiens)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)
H2O [nucleoplasm]
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
USP45 deubiquitinates ERCC1 (Homo sapiens)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
H2O [nucleoplasm]
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
H2O [nucleoplasm]
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Homo sapiens)
H2O [nucleoplasm]
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
TET1,2,3 and TDG demethylate DNA (Homo sapiens)
TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)
H2O [nucleoplasm]
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Homo sapiens)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Homo sapiens)
Regulation of RUNX1 Expression and Activity (Homo sapiens)
PTPN11 dephosphorylates RUNX1 (Homo sapiens)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Homo sapiens)
PPM1D dephosphorylates RUNX2 (Homo sapiens)
H2O [nucleoplasm]
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
HDAC4 deacetylates RUNX3 (Homo sapiens)
H2O [nucleoplasm]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)
H2O [nucleoplasm]
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs in the nucleus (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)
H2O [nucleoplasm]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)
H2O [nucleoplasm]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
NUDT16 hydrolyses IDP to IMP (Homo sapiens)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)
H2O [nucleoplasm]
Metabolism of RNA (Homo sapiens)
mRNA Editing (Homo sapiens)
mRNA Editing: A to I Conversion (Homo sapiens)
C6 deamination of adenosine (Homo sapiens)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Homo sapiens)
C4 deamination of cytidine (Homo sapiens)
H2O [nucleoplasm]
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)
H2O [nucleoplasm]
ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)
H2O [nucleoplasm]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Homo sapiens)
H2O [nucleoplasm]
UCH proteinases (Homo sapiens)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
H2O [nucleoplasm]
Ub-specific processing proteases (Homo sapiens)
USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Homo sapiens)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Homo sapiens)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Homo sapiens)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Homo sapiens)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Homo sapiens)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Homo sapiens)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Homo sapiens)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Homo sapiens)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Homo sapiens)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
H2O [nucleoplasm]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
PPM1E dephosphorylates CAMK4 (Homo sapiens)
H2O [nucleoplasm]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN localization (Homo sapiens)
USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)
H2O [nucleoplasm]
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
HDACs deacetylate p-STAT3 dimers (Homo sapiens)
H2O [nucleoplasm]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
H2O [nucleoplasm]
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
H2O [nucleoplasm]
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Prophase (Mus musculus)
Nuclear Envelope Breakdown (Mus musculus)
Depolymerization of the Nuclear Lamina (Mus musculus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)
H2O [nucleoplasm]
G1/S Transition (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Mus musculus)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Mus musculus)
PP2A mediated localization of RB1 protein in chromatin (Mus musculus)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
CDC25A dephosphorylates CCNA:CDK1 (Mus musculus)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Mus musculus)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Mus musculus)
Myosin phosphatase dephosphorylates PLK1 (Mus musculus)
H2O [nucleoplasm]
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)
H2O [nucleoplasm]
Chromosome Maintenance (Mus musculus)
Telomere Maintenance (Mus musculus)
Extension of Telomeres (Mus musculus)
Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
Polymerase switching on the C-strand of the telomere (Mus musculus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
H2O [nucleoplasm]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Mus musculus)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
ATP hydrolysis by HSP90 (Mus musculus)
H2O [nucleoplasm]
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
HDACs deacetylate histones (Mus musculus)
HDAC10 deacetylates histone (Mus musculus)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Mus musculus)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Mus musculus)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Mus musculus)
H2O [nucleoplasm]
PADI4 deiminates Histones (Mus musculus)
H2O [nucleoplasm]
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Mus musculus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
PARG dePARylates PARP1,PARP2 (Mus musculus)
H2O [nucleoplasm]
DNA Damage Bypass (Mus musculus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Mus musculus)
Termination of translesion DNA synthesis (Mus musculus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Mus musculus)
H2O [nucleoplasm]
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
Initial resection of double-strand break ends (Mus musculus)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Mus musculus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)
H2O [nucleoplasm]
Nucleotide Excision Repair (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
Formation of Incision Complex in GG-NER (Mus musculus)
USP45 deubiquitinates ERCC1 (Mus musculus)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
H2O [nucleoplasm]
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
H2O [nucleoplasm]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Acetylation (Mus musculus)
MTA2-NuRD complex deacetylates TP53 (Mus musculus)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Mus musculus)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Mus musculus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Mus musculus)
Regulation of RUNX1 Expression and Activity (Mus musculus)
PTPN11 dephosphorylates RUNX1 (Mus musculus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Mus musculus)
PPM1D dephosphorylates RUNX2 (Mus musculus)
H2O [nucleoplasm]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon gamma signaling (Mus musculus)
Regulation of IFNG signaling (Mus musculus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)
H2O [nucleoplasm]
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs in the nucleus (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)
H2O [nucleoplasm]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
dUTP + H2O => dUMP + pyrophosphate (Mus musculus)
H2O [nucleoplasm]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
Phosphate bond hydrolysis by NUDT proteins (Mus musculus)
NUDT16 hydrolyses IDP to IMP (Mus musculus)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Mus musculus)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)
H2O [nucleoplasm]
Metabolism of RNA (Mus musculus)
mRNA Editing (Mus musculus)
mRNA Editing: A to I Conversion (Mus musculus)
C6 deamination of adenosine (Mus musculus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Mus musculus)
C4 deamination of cytidine (Mus musculus)
H2O [nucleoplasm]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Metalloprotease DUBs (Mus musculus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Mus musculus)
H2O [nucleoplasm]
UCH proteinases (Mus musculus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)
H2O [nucleoplasm]
Ub-specific processing proteases (Mus musculus)
USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Mus musculus)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Mus musculus)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Mus musculus)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Mus musculus)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Mus musculus)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Mus musculus)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Mus musculus)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Mus musculus)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Mus musculus)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Mus musculus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
H2O [nucleoplasm]
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN localization (Mus musculus)
USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)
H2O [nucleoplasm]
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
STAT3 nuclear events downstream of ALK signaling (Mus musculus)
HDACs deacetylate p-STAT3 dimers (Mus musculus)
H2O [nucleoplasm]
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Nuclear Events (kinase and transcription factor activation) (Mus musculus)
ERK/MAPK targets (Mus musculus)
ERKs are inactivated (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
H2O [nucleoplasm]
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)
H2O [nucleoplasm]
Cell Cycle (Plasmodium falciparum)
Cell Cycle, Mitotic (Plasmodium falciparum)
M Phase (Plasmodium falciparum)
Mitotic Prophase (Plasmodium falciparum)
Nuclear Envelope Breakdown (Plasmodium falciparum)
Depolymerization of the Nuclear Lamina (Plasmodium falciparum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)
H2O [nucleoplasm]
Chromatin organization (Plasmodium falciparum)
Chromatin modifying enzymes (Plasmodium falciparum)
HDACs deacetylate histones (Plasmodium falciparum)
HDAC10 deacetylates histone (Plasmodium falciparum)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Plasmodium falciparum)
H2O [nucleoplasm]
DNA Repair (Plasmodium falciparum)
DNA Damage Bypass (Plasmodium falciparum)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Plasmodium falciparum)
Termination of translesion DNA synthesis (Plasmodium falciparum)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)
H2O [nucleoplasm]
Immune System (Plasmodium falciparum)
Cytokine Signaling in Immune system (Plasmodium falciparum)
Signaling by Interleukins (Plasmodium falciparum)
Interleukin-17 signaling (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Innate Immune System (Plasmodium falciparum)
Toll-like Receptor Cascades (Plasmodium falciparum)
Toll Like Receptor 10 (TLR10) Cascade (Plasmodium falciparum)
MyD88 cascade initiated on plasma membrane (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Plasmodium falciparum)
Toll Like Receptor TLR1:TLR2 Cascade (Plasmodium falciparum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Plasmodium falciparum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Plasmodium falciparum)
MyD88-independent TLR4 cascade (Plasmodium falciparum)
TRIF (TICAM1)-mediated TLR4 signaling (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Plasmodium falciparum)
MyD88 cascade initiated on plasma membrane (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Plasmodium falciparum)
MyD88 dependent cascade initiated on endosome (Plasmodium falciparum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Plasmodium falciparum)
MyD88 dependent cascade initiated on endosome (Plasmodium falciparum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Plasmodium falciparum)
MAP kinase activation (Plasmodium falciparum)
MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)
H2O [nucleoplasm]
Nucleotide catabolism (Plasmodium falciparum)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)
H2O [nucleoplasm]
Signal Transduction (Plasmodium falciparum)
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by NTRKs (Plasmodium falciparum)
Signaling by NTRK1 (TRKA) (Plasmodium falciparum)
Nuclear Events (kinase and transcription factor activation) (Plasmodium falciparum)
ERK/MAPK targets (Plasmodium falciparum)
ERKs are inactivated (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
H2O [nucleoplasm]
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
M Phase (Rattus norvegicus)
Mitotic Prophase (Rattus norvegicus)
Nuclear Envelope Breakdown (Rattus norvegicus)
Depolymerization of the Nuclear Lamina (Rattus norvegicus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1 Phase (Rattus norvegicus)
Cyclin D associated events in G1 (Rattus norvegicus)
Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)
H2O [nucleoplasm]
G1/S Transition (Rattus norvegicus)
Cyclin E associated events during G1/S transition (Rattus norvegicus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Rattus norvegicus)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Rattus norvegicus)
PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Rattus norvegicus)
G2/M Transition (Rattus norvegicus)
Cyclin A/B1/B2 associated events during G2/M transition (Rattus norvegicus)
CDC25A dephosphorylates CCNA:CDK1 (Rattus norvegicus)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Rattus norvegicus)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Rattus norvegicus)
Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)
H2O [nucleoplasm]
S Phase (Rattus norvegicus)
Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)
H2O [nucleoplasm]
Chromosome Maintenance (Rattus norvegicus)
Telomere Maintenance (Rattus norvegicus)
Extension of Telomeres (Rattus norvegicus)
Telomere C-strand (Lagging Strand) Synthesis (Rattus norvegicus)
Polymerase switching on the C-strand of the telomere (Rattus norvegicus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Rattus norvegicus)
Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Rattus norvegicus)
Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)
H2O [nucleoplasm]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Rattus norvegicus)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Rattus norvegicus)
ATP hydrolysis by HSP90 (Rattus norvegicus)
H2O [nucleoplasm]
Chromatin organization (Rattus norvegicus)
Chromatin modifying enzymes (Rattus norvegicus)
PADI4 deiminates Histones (Rattus norvegicus)
H2O [nucleoplasm]
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Rattus norvegicus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
PARG dePARylates PARP1,PARP2 (Rattus norvegicus)
H2O [nucleoplasm]
DNA Damage Bypass (Rattus norvegicus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Rattus norvegicus)
Termination of translesion DNA synthesis (Rattus norvegicus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)
H2O [nucleoplasm]
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
Processing of DNA double-strand break ends (Rattus norvegicus)
Initial resection of double-strand break ends (Rattus norvegicus)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Rattus norvegicus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)
H2O [nucleoplasm]
Nucleotide Excision Repair (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
Formation of Incision Complex in GG-NER (Rattus norvegicus)
USP45 deubiquitinates ERCC1 (Rattus norvegicus)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
H2O [nucleoplasm]
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
H2O [nucleoplasm]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Rattus norvegicus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Rattus norvegicus)
Regulation of RUNX1 Expression and Activity (Rattus norvegicus)
PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)
H2O [nucleoplasm]
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
Regulation of IFNG signaling (Rattus norvegicus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)
H2O [nucleoplasm]
Signaling by Interleukins (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs in the nucleus (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)
H2O [nucleoplasm]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)
H2O [nucleoplasm]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
Phosphate bond hydrolysis by NUDT proteins (Rattus norvegicus)
NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)
H2O [nucleoplasm]
Metabolism of RNA (Rattus norvegicus)
mRNA Editing (Rattus norvegicus)
mRNA Editing: A to I Conversion (Rattus norvegicus)
C6 deamination of adenosine (Rattus norvegicus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Rattus norvegicus)
C4 deamination of cytidine (Rattus norvegicus)
H2O [nucleoplasm]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Metalloprotease DUBs (Rattus norvegicus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Rattus norvegicus)
H2O [nucleoplasm]
UCH proteinases (Rattus norvegicus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Rattus norvegicus)
H2O [nucleoplasm]
Ub-specific processing proteases (Rattus norvegicus)
USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Rattus norvegicus)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Rattus norvegicus)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Rattus norvegicus)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Rattus norvegicus)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Rattus norvegicus)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Rattus norvegicus)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Rattus norvegicus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)
H2O [nucleoplasm]
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN localization (Rattus norvegicus)
USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
H2O [nucleoplasm]
MAPK family signaling cascades (Rattus norvegicus)
MAPK6/MAPK4 signaling (Rattus norvegicus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
STAT3 nuclear events downstream of ALK signaling (Rattus norvegicus)
HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)
H2O [nucleoplasm]
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Nuclear Events (kinase and transcription factor activation) (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERKs are inactivated (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
H2O [nucleoplasm]
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
H2O [nucleoplasm]
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
M Phase (Saccharomyces cerevisiae)
Mitotic Prophase (Saccharomyces cerevisiae)
Nuclear Envelope Breakdown (Saccharomyces cerevisiae)
Depolymerization of the Nuclear Lamina (Saccharomyces cerevisiae)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
G2/M Transition (Saccharomyces cerevisiae)
Cyclin A/B1/B2 associated events during G2/M transition (Saccharomyces cerevisiae)
PP2A demethylation by PPME1 (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to heat stress (Saccharomyces cerevisiae)
Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Chromatin organization (Saccharomyces cerevisiae)
Chromatin modifying enzymes (Saccharomyces cerevisiae)
HDACs deacetylate histones (Saccharomyces cerevisiae)
HDAC10 deacetylates histone (Saccharomyces cerevisiae)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Saccharomyces cerevisiae)
H2O [nucleoplasm]
DNA Repair (Saccharomyces cerevisiae)
DNA Damage Bypass (Saccharomyces cerevisiae)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Saccharomyces cerevisiae)
Termination of translesion DNA synthesis (Saccharomyces cerevisiae)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
DNA Double Strand Break Response (Saccharomyces cerevisiae)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Nucleotide Excision Repair (Saccharomyces cerevisiae)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Saccharomyces cerevisiae)
Formation of TC-NER Pre-Incision Complex (Saccharomyces cerevisiae)
UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Immune System (Saccharomyces cerevisiae)
Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
Signaling by Interleukins (Saccharomyces cerevisiae)
Interleukin-17 signaling (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Innate Immune System (Saccharomyces cerevisiae)
Toll-like Receptor Cascades (Saccharomyces cerevisiae)
Toll Like Receptor 10 (TLR10) Cascade (Saccharomyces cerevisiae)
MyD88 cascade initiated on plasma membrane (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Saccharomyces cerevisiae)
Toll Like Receptor TLR1:TLR2 Cascade (Saccharomyces cerevisiae)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Saccharomyces cerevisiae)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Saccharomyces cerevisiae)
MyD88-independent TLR4 cascade (Saccharomyces cerevisiae)
TRIF (TICAM1)-mediated TLR4 signaling (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Saccharomyces cerevisiae)
MyD88 cascade initiated on plasma membrane (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Saccharomyces cerevisiae)
MyD88 dependent cascade initiated on endosome (Saccharomyces cerevisiae)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Saccharomyces cerevisiae)
MyD88 dependent cascade initiated on endosome (Saccharomyces cerevisiae)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Saccharomyces cerevisiae)
MAP kinase activation (Saccharomyces cerevisiae)
MAPK targets/ Nuclear events mediated by MAP kinases (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Deubiquitination (Saccharomyces cerevisiae)
Ub-specific processing proteases (Saccharomyces cerevisiae)
USP17 deubiquitinates SUDS3 (Saccharomyces cerevisiae)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Saccharomyces cerevisiae)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
PTEN Regulation (Saccharomyces cerevisiae)
Regulation of PTEN localization (Saccharomyces cerevisiae)
USP7 deubiquitinates monoubiquitinated PTEN (Saccharomyces cerevisiae)
H2O [nucleoplasm]
MAPK family signaling cascades (Saccharomyces cerevisiae)
MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by NTRKs (Saccharomyces cerevisiae)
Signaling by NTRK1 (TRKA) (Saccharomyces cerevisiae)
Nuclear Events (kinase and transcription factor activation) (Saccharomyces cerevisiae)
ERK/MAPK targets (Saccharomyces cerevisiae)
ERKs are inactivated (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
H2O [nucleoplasm]
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
M Phase (Schizosaccharomyces pombe)
Mitotic Prophase (Schizosaccharomyces pombe)
Nuclear Envelope Breakdown (Schizosaccharomyces pombe)
Depolymerization of the Nuclear Lamina (Schizosaccharomyces pombe)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Schizosaccharomyces pombe)
G2/M Transition (Schizosaccharomyces pombe)
Cyclin A/B1/B2 associated events during G2/M transition (Schizosaccharomyces pombe)
PP2A demethylation by PPME1 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
S Phase (Schizosaccharomyces pombe)
Cyclin A:Cdk2-associated events at S phase entry (Schizosaccharomyces pombe)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to heat stress (Schizosaccharomyces pombe)
Regulation of HSF1-mediated heat shock response (Schizosaccharomyces pombe)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Chromatin organization (Schizosaccharomyces pombe)
Chromatin modifying enzymes (Schizosaccharomyces pombe)
HDACs deacetylate histones (Schizosaccharomyces pombe)
HDAC10 deacetylates histone (Schizosaccharomyces pombe)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Schizosaccharomyces pombe)
H2O [nucleoplasm]
DNA Repair (Schizosaccharomyces pombe)
DNA Damage Bypass (Schizosaccharomyces pombe)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Schizosaccharomyces pombe)
Termination of translesion DNA synthesis (Schizosaccharomyces pombe)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
DNA Double Strand Break Response (Schizosaccharomyces pombe)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Schizosaccharomyces pombe)
PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Homology Directed Repair (Schizosaccharomyces pombe)
HDR through MMEJ (alt-NHEJ) (Schizosaccharomyces pombe)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Nucleotide Excision Repair (Schizosaccharomyces pombe)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Schizosaccharomyces pombe)
Formation of TC-NER Pre-Incision Complex (Schizosaccharomyces pombe)
UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Immune System (Schizosaccharomyces pombe)
Cytokine Signaling in Immune system (Schizosaccharomyces pombe)
Signaling by Interleukins (Schizosaccharomyces pombe)
Interleukin-17 signaling (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Innate Immune System (Schizosaccharomyces pombe)
Toll-like Receptor Cascades (Schizosaccharomyces pombe)
Toll Like Receptor 10 (TLR10) Cascade (Schizosaccharomyces pombe)
MyD88 cascade initiated on plasma membrane (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Schizosaccharomyces pombe)
Toll Like Receptor TLR1:TLR2 Cascade (Schizosaccharomyces pombe)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Schizosaccharomyces pombe)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Schizosaccharomyces pombe)
MyD88-independent TLR4 cascade (Schizosaccharomyces pombe)
TRIF (TICAM1)-mediated TLR4 signaling (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Schizosaccharomyces pombe)
MyD88 cascade initiated on plasma membrane (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Schizosaccharomyces pombe)
MyD88 dependent cascade initiated on endosome (Schizosaccharomyces pombe)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Schizosaccharomyces pombe)
MyD88 dependent cascade initiated on endosome (Schizosaccharomyces pombe)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Schizosaccharomyces pombe)
MAP kinase activation (Schizosaccharomyces pombe)
MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Deubiquitination (Schizosaccharomyces pombe)
Ub-specific processing proteases (Schizosaccharomyces pombe)
USP12, USP26 deubiquitinate AR (Schizosaccharomyces pombe)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Schizosaccharomyces pombe)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Schizosaccharomyces pombe)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
PTEN Regulation (Schizosaccharomyces pombe)
Regulation of PTEN localization (Schizosaccharomyces pombe)
USP7 deubiquitinates monoubiquitinated PTEN (Schizosaccharomyces pombe)
H2O [nucleoplasm]
MAPK family signaling cascades (Schizosaccharomyces pombe)
MAPK6/MAPK4 signaling (Schizosaccharomyces pombe)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by NTRKs (Schizosaccharomyces pombe)
Signaling by NTRK1 (TRKA) (Schizosaccharomyces pombe)
Nuclear Events (kinase and transcription factor activation) (Schizosaccharomyces pombe)
ERK/MAPK targets (Schizosaccharomyces pombe)
ERKs are inactivated (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
H2O [nucleoplasm]
Cell Cycle (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
M Phase (Sus scrofa)
Mitotic Prophase (Sus scrofa)
Nuclear Envelope Breakdown (Sus scrofa)
Depolymerization of the Nuclear Lamina (Sus scrofa)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Sus scrofa)
G1 Phase (Sus scrofa)
Cyclin D associated events in G1 (Sus scrofa)
Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)
H2O [nucleoplasm]
G1/S Transition (Sus scrofa)
Cyclin E associated events during G1/S transition (Sus scrofa)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Sus scrofa)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Sus scrofa)
PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Sus scrofa)
G2/M Transition (Sus scrofa)
Cyclin A/B1/B2 associated events during G2/M transition (Sus scrofa)
CDC25A dephosphorylates CCNA:CDK1 (Sus scrofa)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Sus scrofa)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Sus scrofa)
Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)
H2O [nucleoplasm]
S Phase (Sus scrofa)
Cyclin A:Cdk2-associated events at S phase entry (Sus scrofa)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)
H2O [nucleoplasm]
Chromosome Maintenance (Sus scrofa)
Telomere Maintenance (Sus scrofa)
Extension of Telomeres (Sus scrofa)
Telomere C-strand (Lagging Strand) Synthesis (Sus scrofa)
Polymerase switching on the C-strand of the telomere (Sus scrofa)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Sus scrofa)
Formation of the Flap Intermediate on the C-strand (Sus scrofa)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Sus scrofa)
Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)
H2O [nucleoplasm]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to heat stress (Sus scrofa)
Regulation of HSF1-mediated heat shock response (Sus scrofa)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Sus scrofa)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Sus scrofa)
ATP hydrolysis by HSP90 (Sus scrofa)
H2O [nucleoplasm]
Chromatin organization (Sus scrofa)
Chromatin modifying enzymes (Sus scrofa)
HDACs deacetylate histones (Sus scrofa)
HDAC10 deacetylates histone (Sus scrofa)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Sus scrofa)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Sus scrofa)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Sus scrofa)
H2O [nucleoplasm]
PADI4 deiminates Histones (Sus scrofa)
H2O [nucleoplasm]
DNA Repair (Sus scrofa)
Base Excision Repair (Sus scrofa)
Resolution of Abasic Sites (AP sites) (Sus scrofa)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Sus scrofa)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
PARG dePARylates PARP1,PARP2 (Sus scrofa)
H2O [nucleoplasm]
DNA Damage Bypass (Sus scrofa)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Sus scrofa)
Termination of translesion DNA synthesis (Sus scrofa)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Sus scrofa)
DNA Double Strand Break Response (Sus scrofa)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Sus scrofa)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Sus scrofa)
H2O [nucleoplasm]
Homology Directed Repair (Sus scrofa)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
Processing of DNA double-strand break ends (Sus scrofa)
Initial resection of double-strand break ends (Sus scrofa)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Sus scrofa)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)
H2O [nucleoplasm]
Nucleotide Excision Repair (Sus scrofa)
Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
Formation of Incision Complex in GG-NER (Sus scrofa)
USP45 deubiquitinates ERCC1 (Sus scrofa)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
Formation of TC-NER Pre-Incision Complex (Sus scrofa)
UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)
H2O [nucleoplasm]
Developmental Biology (Sus scrofa)
MITF-M-regulated melanocyte development (Sus scrofa)
Transcriptional and post-translational regulation of MITF-M expression and activity (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
H2O [nucleoplasm]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Activity through Acetylation (Sus scrofa)
MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Sus scrofa)
Regulation of TP53 Degradation (Sus scrofa)
PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Sus scrofa)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Sus scrofa)
Regulation of RUNX1 Expression and Activity (Sus scrofa)
PTPN11 dephosphorylates RUNX1 (Sus scrofa)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Sus scrofa)
PPM1D dephosphorylates RUNX2 (Sus scrofa)
H2O [nucleoplasm]
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Interferon gamma signaling (Sus scrofa)
Regulation of IFNG signaling (Sus scrofa)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)
H2O [nucleoplasm]
Signaling by Interleukins (Sus scrofa)
Interleukin-17 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Phospholipid metabolism (Sus scrofa)
PI Metabolism (Sus scrofa)
Synthesis of PIPs in the nucleus (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)
H2O [nucleoplasm]
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)
H2O [nucleoplasm]
Nucleotide catabolism (Sus scrofa)
Purine catabolism (Sus scrofa)
Phosphate bond hydrolysis by NUDT proteins (Sus scrofa)
NUDT16 hydrolyses IDP to IMP (Sus scrofa)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)
H2O [nucleoplasm]
Metabolism of RNA (Sus scrofa)
mRNA Editing (Sus scrofa)
mRNA Editing: A to I Conversion (Sus scrofa)
C6 deamination of adenosine (Sus scrofa)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Sus scrofa)
C4 deamination of cytidine (Sus scrofa)
H2O [nucleoplasm]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
Metalloprotease DUBs (Sus scrofa)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Sus scrofa)
H2O [nucleoplasm]
UCH proteinases (Sus scrofa)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Sus scrofa)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)
H2O [nucleoplasm]
Ub-specific processing proteases (Sus scrofa)
USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Sus scrofa)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Sus scrofa)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Sus scrofa)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Sus scrofa)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Sus scrofa)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Sus scrofa)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Sus scrofa)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Sus scrofa)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Sus scrofa)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
H2O [nucleoplasm]
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
PTEN Regulation (Sus scrofa)
Regulation of PTEN localization (Sus scrofa)
USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)
H2O [nucleoplasm]
MAPK family signaling cascades (Sus scrofa)
MAPK6/MAPK4 signaling (Sus scrofa)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
STAT3 nuclear events downstream of ALK signaling (Sus scrofa)
HDACs deacetylate p-STAT3 dimers (Sus scrofa)
H2O [nucleoplasm]
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
Nuclear Events (kinase and transcription factor activation) (Sus scrofa)
ERK/MAPK targets (Sus scrofa)
ERKs are inactivated (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
H2O [nucleoplasm]
Signaling by TGFB family members (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
H2O [nucleoplasm]
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
M Phase (Xenopus tropicalis)
Mitotic Prophase (Xenopus tropicalis)
Nuclear Envelope Breakdown (Xenopus tropicalis)
Depolymerization of the Nuclear Lamina (Xenopus tropicalis)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Xenopus tropicalis)
G1 Phase (Xenopus tropicalis)
Cyclin D associated events in G1 (Xenopus tropicalis)
Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Xenopus tropicalis)
H2O [nucleoplasm]
G1/S Transition (Xenopus tropicalis)
Cyclin E associated events during G1/S transition (Xenopus tropicalis)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Xenopus tropicalis)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Xenopus tropicalis)
G2/M Transition (Xenopus tropicalis)
Cyclin A/B1/B2 associated events during G2/M transition (Xenopus tropicalis)
CDC25A dephosphorylates CCNA:CDK1 (Xenopus tropicalis)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Xenopus tropicalis)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Xenopus tropicalis)
Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)
H2O [nucleoplasm]
S Phase (Xenopus tropicalis)
Cyclin A:Cdk2-associated events at S phase entry (Xenopus tropicalis)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)
H2O [nucleoplasm]
Chromosome Maintenance (Xenopus tropicalis)
Telomere Maintenance (Xenopus tropicalis)
Extension of Telomeres (Xenopus tropicalis)
Telomere C-strand (Lagging Strand) Synthesis (Xenopus tropicalis)
Polymerase switching on the C-strand of the telomere (Xenopus tropicalis)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Xenopus tropicalis)
PP6-PPP6R3 dephosphorylates TERF2 (Xenopus tropicalis)
H2O [nucleoplasm]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to heat stress (Xenopus tropicalis)
Regulation of HSF1-mediated heat shock response (Xenopus tropicalis)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)
H2O [nucleoplasm]
DNA Repair (Xenopus tropicalis)
Base Excision Repair (Xenopus tropicalis)
Resolution of Abasic Sites (AP sites) (Xenopus tropicalis)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Xenopus tropicalis)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Xenopus tropicalis)
POLB-Dependent Long Patch Base Excision Repair (Xenopus tropicalis)
PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)
H2O [nucleoplasm]
DNA Damage Bypass (Xenopus tropicalis)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Xenopus tropicalis)
Termination of translesion DNA synthesis (Xenopus tropicalis)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Xenopus tropicalis)
Homology Directed Repair (Xenopus tropicalis)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
Processing of DNA double-strand break ends (Xenopus tropicalis)
PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)
H2O [nucleoplasm]
Nucleotide Excision Repair (Xenopus tropicalis)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
Formation of TC-NER Pre-Incision Complex (Xenopus tropicalis)
UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
H2O [nucleoplasm]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
Regulation of TP53 Activity (Xenopus tropicalis)
Regulation of TP53 Activity through Acetylation (Xenopus tropicalis)
MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Xenopus tropicalis)
Regulation of TP53 Degradation (Xenopus tropicalis)
PP2A-PP2R5C dephosphorylates MDM2 (Xenopus tropicalis)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Xenopus tropicalis)
Regulation of RUNX1 Expression and Activity (Xenopus tropicalis)
PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)
H2O [nucleoplasm]
Immune System (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
Signaling by Interleukins (Xenopus tropicalis)
Interleukin-17 signaling (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Innate Immune System (Xenopus tropicalis)
Toll-like Receptor Cascades (Xenopus tropicalis)
Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
MyD88-independent TLR4 cascade (Xenopus tropicalis)
TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Phospholipid metabolism (Xenopus tropicalis)
PI Metabolism (Xenopus tropicalis)
Synthesis of PIPs in the nucleus (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)
H2O [nucleoplasm]
Metabolism of nucleotides (Xenopus tropicalis)
Interconversion of nucleotide di- and triphosphates (Xenopus tropicalis)
dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)
H2O [nucleoplasm]
Nucleotide catabolism (Xenopus tropicalis)
Purine catabolism (Xenopus tropicalis)
Phosphate bond hydrolysis by NUDT proteins (Xenopus tropicalis)
NUDT16 hydrolyses IDP to IMP (Xenopus tropicalis)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Xenopus tropicalis)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)
H2O [nucleoplasm]
Metabolism of RNA (Xenopus tropicalis)
mRNA Editing (Xenopus tropicalis)
mRNA Editing: A to I Conversion (Xenopus tropicalis)
C6 deamination of adenosine (Xenopus tropicalis)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)
H2O [nucleoplasm]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Deubiquitination (Xenopus tropicalis)
Metalloprotease DUBs (Xenopus tropicalis)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)
H2O [nucleoplasm]
UCH proteinases (Xenopus tropicalis)
Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)
H2O [nucleoplasm]
Ub-specific processing proteases (Xenopus tropicalis)
USP10,USP24,USP42 deubiquitinate TP53 (Xenopus tropicalis)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Xenopus tropicalis)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Xenopus tropicalis)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Xenopus tropicalis)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Xenopus tropicalis)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Xenopus tropicalis)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Xenopus tropicalis)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Xenopus tropicalis)
H2O [nucleoplasm]
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK6/MAPK4 signaling (Xenopus tropicalis)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
STAT3 nuclear events downstream of ALK signaling (Xenopus tropicalis)
HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)
H2O [nucleoplasm]
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
Nuclear Events (kinase and transcription factor activation) (Xenopus tropicalis)
ERK/MAPK targets (Xenopus tropicalis)
ERKs are inactivated (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
H2O [nucleoplasm]
External Reference Information
External Reference
water [ChEBI:15377]
Participates
as an input of
CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Caenorhabditis elegans)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)
ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)
ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)
USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)
USP16,USP21 deubiquitinate Histone H2A (Caenorhabditis elegans)
USP16,USP21 deubiquitinate Histone H2A (Drosophila melanogaster)
USP16,USP21 deubiquitinate Histone H2A (Gallus gallus)
USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)
USP16,USP21 deubiquitinate Histone H2A (Danio rerio)
USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)
USP16,USP21 deubiquitinate Histone H2A (Bos taurus)
USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)
USP16,USP21 deubiquitinate Histone H2A (Rattus norvegicus)
USP16,USP21 deubiquitinate Histone H2A (Mus musculus)
USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)
USP3,SAGA deubiquitinate Histone H2A,H2B (Schizosaccharomyces pombe)
USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)
USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)
USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)
USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)
USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)
USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)
USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)
USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)
USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP24 deubiquitinates DDB2 (Gallus gallus)
USP24 deubiquitinates DDB2 (Xenopus tropicalis)
USP24 deubiquitinates DDB2 (Sus scrofa)
USP24 deubiquitinates DDB2 (Bos taurus)
USP24 deubiquitinates DDB2 (Rattus norvegicus)
USP24 deubiquitinates DDB2 (Mus musculus)
USP24 deubiquitinates DDB2 (Homo sapiens)
USP48 cleaves polyubiquitin (Gallus gallus)
USP48 cleaves polyubiquitin (Xenopus tropicalis)
USP48 cleaves polyubiquitin (Sus scrofa)
USP48 cleaves polyubiquitin (Bos taurus)
USP48 cleaves polyubiquitin (Canis familiaris)
USP48 cleaves polyubiquitin (Rattus norvegicus)
USP48 cleaves polyubiquitin (Mus musculus)
USP48 cleaves polyubiquitin (Homo sapiens)
USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)
USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)
USP21 deubiquitinates GATA3,IL33 (Xenopus tropicalis)
USP21 deubiquitinates GATA3,IL33 (Sus scrofa)
USP21 deubiquitinates GATA3,IL33 (Bos taurus)
USP21 deubiquitinates GATA3,IL33 (Canis familiaris)
USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)
USP21 deubiquitinates GATA3,IL33 (Mus musculus)
USP21 deubiquitinates GATA3,IL33 (Homo sapiens)
USP44 deubiquitinates CDC20 (Dictyostelium discoideum)
USP44 deubiquitinates CDC20 (Caenorhabditis elegans)
USP44 deubiquitinates CDC20 (Gallus gallus)
USP44 deubiquitinates CDC20 (Xenopus tropicalis)
USP44 deubiquitinates CDC20 (Danio rerio)
USP44 deubiquitinates CDC20 (Sus scrofa)
USP44 deubiquitinates CDC20 (Bos taurus)
USP44 deubiquitinates CDC20 (Canis familiaris)
USP44 deubiquitinates CDC20 (Rattus norvegicus)
USP44 deubiquitinates CDC20 (Mus musculus)
USP44 deubiquitinates CDC20 (Homo sapiens)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Schizosaccharomyces pombe)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
USP47 deubiquitinates POLB (Xenopus tropicalis)
USP47 deubiquitinates POLB (Sus scrofa)
USP47 deubiquitinates POLB (Bos taurus)
USP47 deubiquitinates POLB (Canis familiaris)
USP47 deubiquitinates POLB (Rattus norvegicus)
USP47 deubiquitinates POLB (Mus musculus)
USP47 deubiquitinates POLB (Homo sapiens)
USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)
USP10,USP24,USP42 deubiquitinate TP53 (Xenopus tropicalis)
USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)
USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)
USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)
USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)
USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)
USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)
USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)
USP49 deubiquitinates H2B (Dictyostelium discoideum)
USP49 deubiquitinates H2B (Gallus gallus)
USP49 deubiquitinates H2B (Xenopus tropicalis)
USP49 deubiquitinates H2B (Danio rerio)
USP49 deubiquitinates H2B (Sus scrofa)
USP49 deubiquitinates H2B (Bos taurus)
USP49 deubiquitinates H2B (Canis familiaris)
USP49 deubiquitinates H2B (Homo sapiens)
USP12, USP26 deubiquitinate AR (Schizosaccharomyces pombe)
USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)
USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)
USP12, USP26 deubiquitinate AR (Drosophila melanogaster)
USP12, USP26 deubiquitinate AR (Gallus gallus)
USP12, USP26 deubiquitinate AR (Xenopus tropicalis)
USP12, USP26 deubiquitinate AR (Danio rerio)
USP12, USP26 deubiquitinate AR (Sus scrofa)
USP12, USP26 deubiquitinate AR (Bos taurus)
USP12, USP26 deubiquitinate AR (Canis familiaris)
USP12, USP26 deubiquitinate AR (Rattus norvegicus)
USP12, USP26 deubiquitinate AR (Mus musculus)
USP12, USP26 deubiquitinate AR (Homo sapiens)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Saccharomyces cerevisiae)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Schizosaccharomyces pombe)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
USP28 deubiquitinates CLSPN and MYC (Saccharomyces cerevisiae)
USP28 deubiquitinates CLSPN and MYC (Schizosaccharomyces pombe)
USP28 deubiquitinates CLSPN and MYC (Gallus gallus)
USP28 deubiquitinates CLSPN and MYC (Sus scrofa)
USP28 deubiquitinates CLSPN and MYC (Bos taurus)
USP28 deubiquitinates CLSPN and MYC (Canis familiaris)
USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)
USP28 deubiquitinates CLSPN and MYC (Mus musculus)
USP28 deubiquitinates CLSPN and MYC (Homo sapiens)
USP17 deubiquitinates SUDS3 (Saccharomyces cerevisiae)
USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)
USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)
USP17 deubiquitinates SUDS3 (Drosophila melanogaster)
USP17 deubiquitinates SUDS3 (Danio rerio)
USP17 deubiquitinates SUDS3 (Sus scrofa)
USP17 deubiquitinates SUDS3 (Bos taurus)
USP17 deubiquitinates SUDS3 (Canis familiaris)
USP17 deubiquitinates SUDS3 (Rattus norvegicus)
USP17 deubiquitinates SUDS3 (Mus musculus)
USP17 deubiquitinates SUDS3 (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)
MYSM1 deubiquitinates Histone H2A (Caenorhabditis elegans)
MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)
MYSM1 deubiquitinates Histone H2A (Gallus gallus)
MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)
MYSM1 deubiquitinates Histone H2A (Danio rerio)
MYSM1 deubiquitinates Histone H2A (Sus scrofa)
MYSM1 deubiquitinates Histone H2A (Bos taurus)
MYSM1 deubiquitinates Histone H2A (Canis familiaris)
MYSM1 deubiquitinates Histone H2A (Rattus norvegicus)
MYSM1 deubiquitinates Histone H2A (Mus musculus)
MYSM1 deubiquitinates Histone H2A (Homo sapiens)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Sus scrofa)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)
Histone H2A is dubiquitinated by the PR-DUB complex (Drosophila melanogaster)
Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)
Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)
Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)
Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)
Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)
Histone H2A is dubiquitinated by the PR-DUB complex (Rattus norvegicus)
Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
PARG dePARylates PARP1,PARP2 (Gallus gallus)
PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)
PARG dePARylates PARP1,PARP2 (Sus scrofa)
PARG dePARylates PARP1,PARP2 (Bos taurus)
PARG dePARylates PARP1,PARP2 (Rattus norvegicus)
PARG dePARylates PARP1,PARP2 (Mus musculus)
PARG dePARylates PARP1,PARP2 (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)
HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)
HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)
HDACs deacetylate p-STAT3 dimers (Gallus gallus)
HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)
HDACs deacetylate p-STAT3 dimers (Sus scrofa)
HDACs deacetylate p-STAT3 dimers (Bos taurus)
HDACs deacetylate p-STAT3 dimers (Canis familiaris)
HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)
HDACs deacetylate p-STAT3 dimers (Mus musculus)
HDACs deacetylate p-STAT3 dimers (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)
HDAC1:2-containing complex deacetylate histones (Schizosaccharomyces pombe)
HDAC1:2-containing complex deacetylate histones (Dictyostelium discoideum)
HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)
HDAC1:2-containing complex deacetylate histones (Gallus gallus)
HDAC1:2-containing complex deacetylate histones (Sus scrofa)
HDAC1:2-containing complex deacetylate histones (Bos taurus)
HDAC1:2-containing complex deacetylate histones (Canis familiaris)
HDAC1:2-containing complex deacetylate histones (Mus musculus)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
HDAC10 deacetylates histone (Plasmodium falciparum)
HDAC10 deacetylates histone (Saccharomyces cerevisiae)
HDAC10 deacetylates histone (Schizosaccharomyces pombe)
HDAC10 deacetylates histone (Dictyostelium discoideum)
HDAC10 deacetylates histone (Drosophila melanogaster)
HDAC10 deacetylates histone (Gallus gallus)
HDAC10 deacetylates histone (Danio rerio)
HDAC10 deacetylates histone (Sus scrofa)
HDAC10 deacetylates histone (Bos taurus)
HDAC10 deacetylates histone (Canis familiaris)
HDAC10 deacetylates histone (Mus musculus)
HDAC10 deacetylates histone (Homo sapiens)
HDAC8 deacetylates histones (Plasmodium falciparum)
HDAC8 deacetylates histones (Saccharomyces cerevisiae)
HDAC8 deacetylates histones (Dictyostelium discoideum)
HDAC8 deacetylates histones (Gallus gallus)
HDAC8 deacetylates histones (Danio rerio)
HDAC8 deacetylates histones (Sus scrofa)
HDAC8 deacetylates histones (Bos taurus)
HDAC8 deacetylates histones (Canis familiaris)
HDAC8 deacetylates histones (Mus musculus)
HDAC8 deacetylates histones (Homo sapiens)
HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)
HDAC3 containing complexes deacetylate histone (Drosophila melanogaster)
HDAC3 containing complexes deacetylate histone (Gallus gallus)
HDAC3 containing complexes deacetylate histone (Sus scrofa)
HDAC3 containing complexes deacetylate histone (Bos taurus)
HDAC3 containing complexes deacetylate histone (Canis familiaris)
HDAC3 containing complexes deacetylate histone (Mus musculus)
HDAC3 containing complexes deacetylate histone (Homo sapiens)
PADI4 deiminates Histones (Sus scrofa)
PADI4 deiminates Histones (Bos taurus)
PADI4 deiminates Histones (Canis familiaris)
PADI4 deiminates Histones (Rattus norvegicus)
PADI4 deiminates Histones (Mus musculus)
PADI4 deiminates Histones (Homo sapiens)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Gallus gallus)
ATP hydrolysis by HSP90 (Sus scrofa)
ATP hydrolysis by HSP90 (Bos taurus)
ATP hydrolysis by HSP90 (Rattus norvegicus)
ATP hydrolysis by HSP90 (Mus musculus)
ATP hydrolysis by HSP90 (Homo sapiens)
SIRT1 deacetylates HSF1 (Gallus gallus)
SIRT1 deacetylates HSF1 (Sus scrofa)
SIRT1 deacetylates HSF1 (Bos taurus)
SIRT1 deacetylates HSF1 (Canis familiaris)
SIRT1 deacetylates HSF1 (Rattus norvegicus)
SIRT1 deacetylates HSF1 (Mus musculus)
SIRT1 deacetylates HSF1 (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Saccharomyces cerevisiae)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Schizosaccharomyces pombe)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)
Ppm1e dephosphorylates Camk4 (Rattus norvegicus)
PPM1E dephosphorylates CAMK4 (Homo sapiens)
PTPN11 dephosphorylates RUNX1 (Gallus gallus)
PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)
PTPN11 dephosphorylates RUNX1 (Sus scrofa)
PTPN11 dephosphorylates RUNX1 (Bos taurus)
PTPN11 dephosphorylates RUNX1 (Canis familiaris)
PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)
PTPN11 dephosphorylates RUNX1 (Mus musculus)
PTPN11 dephosphorylates RUNX1 (Homo sapiens)
HDAC4 deacetylates RUNX3 (Drosophila melanogaster)
HDAC4 deacetylates RUNX3 (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)
UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)
UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
USP45 deubiquitinates ERCC1 (Danio rerio)
USP45 deubiquitinates ERCC1 (Sus scrofa)
USP45 deubiquitinates ERCC1 (Bos taurus)
USP45 deubiquitinates ERCC1 (Rattus norvegicus)
USP45 deubiquitinates ERCC1 (Mus musculus)
USP45 deubiquitinates ERCC1 (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Caenorhabditis elegans)
MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)
MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
MTA2-NuRD complex deacetylates TP53 (Bos taurus)
MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
MTA2-NuRD complex deacetylates TP53 (Mus musculus)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Gallus gallus)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)
NUDT16 hydrolyses IDP to IMP (Xenopus tropicalis)
NUDT16 hydrolyses IDP to IMP (Danio rerio)
NUDT16 hydrolyses IDP to IMP (Sus scrofa)
NUDT16 hydrolyses IDP to IMP (Bos taurus)
NUDT16 hydrolyses IDP to IMP (Canis familiaris)
NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)
NUDT16 hydrolyses IDP to IMP (Mus musculus)
NUDT16 hydrolyses IDP to IMP (Homo sapiens)
NUDT16 hydrolyses dIDP to dIMP (Xenopus tropicalis)
NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)
NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)
NUDT16 hydrolyses dIDP to dIMP (Mus musculus)
NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)
dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)
dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)
dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)
dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)
dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)
dUTP + H2O => dUMP + pyrophosphate (Gallus gallus)
dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)
dUTP + H2O => dUMP + pyrophosphate (Danio rerio)
dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)
dUTP + H2O => dUMP + pyrophosphate (Bos taurus)
dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)
dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)
dUTP + H2O => dUMP + pyrophosphate (Mus musculus)
dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)
dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)
C4 deamination of cytidine (Sus scrofa)
C4 deamination of cytidine (Bos taurus)
C4 deamination of cytidine (Canis familiaris)
C4 deamination of cytidine (Rattus norvegicus)
C4 deamination of cytidine (Mus musculus)
C4 deamination of cytidine (Homo sapiens)
PP2A demethylation by PPME1 (Saccharomyces cerevisiae)
PP2A demethylation by PPME1 (Schizosaccharomyces pombe)
PP2A demethylation by PPME1 (Dictyostelium discoideum)
PP2A demethylation by PPME1 (Caenorhabditis elegans)
PP2A demethylation by PPME1 (Drosophila melanogaster)
PP2A demethylation by PPME1 (Xenopus tropicalis)
PP2A demethylation by PPME1 (Danio rerio)
PP2A demethylation by PPME1 (Sus scrofa)
PP2A demethylation by PPME1 (Bos taurus)
PP2A demethylation by PPME1 (Canis familiaris)
PP2A demethylation by PPME1 (Rattus norvegicus)
PP2A demethylation by PPME1 (Mus musculus)
PP2A demethylation by PPME1 (Homo sapiens)
Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)
Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)
Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)
Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)
Myosin phosphatase dephosphorylates PLK1 (Danio rerio)
Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)
Myosin phosphatase dephosphorylates PLK1 (Bos taurus)
Myosin phosphatase dephosphorylates PLK1 (Canis familiaris)
Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)
Myosin phosphatase dephosphorylates PLK1 (Mus musculus)
Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)
MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)
MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)
MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)
MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)
MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)
PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)
PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)
PPP5C dephosphorylates TP53BP1 (Sus scrofa)
PPP5C dephosphorylates TP53BP1 (Canis familiaris)
PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)
PPP5C dephosphorylates TP53BP1 (Mus musculus)
PPP5C dephosphorylates TP53BP1 (Homo sapiens)
PPP5C dephosphorylates TP53BP1 (Bos taurus)
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
USP2 deubiquitinates MDM2,MDM4 (Mus musculus)
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
USP7 deubiquitinates MDM2 (Sus scrofa)
USP7 deubiquitinates MDM2 (Canis familiaris)
USP7 deubiquitinates MDM2 (Rattus norvegicus)
USP7 deubiquitinates MDM2 (Mus musculus)
USP7 deubiquitinates MDM2 (Homo sapiens)
USP7 deubiquitinates MDM2 (Bos taurus)
PP2A-PP2R5C dephosphorylates MDM2 (Xenopus tropicalis)
PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)
PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)
PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)
PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)
PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)
USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)
PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)
PP2A mediated localization of RB1 protein in chromatin (Danio rerio)
PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)
PP2A mediated localization of RB1 protein in chromatin (Bos taurus)
PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)
PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)
PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)
PP2A mediated localization of RB1 protein in chromatin (Mus musculus)
PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)
PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)
PPM1D dephosphorylates RUNX2 (Gallus gallus)
PPM1D dephosphorylates RUNX2 (Sus scrofa)
PPM1D dephosphorylates RUNX2 (Bos taurus)
PPM1D dephosphorylates RUNX2 (Canis familiaris)
PPM1D dephosphorylates RUNX2 (Homo sapiens)
PPM1D dephosphorylates RUNX2 (Mus musculus)
USP7 deubiquitinates monoubiquitinated PTEN (Saccharomyces cerevisiae)
USP7 deubiquitinates monoubiquitinated PTEN (Schizosaccharomyces pombe)
USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)
USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)
USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)
USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)
USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)
USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
ERKs are inactivated by protein phosphatase 2A (Mus musculus)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)
Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)
Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)
Dephosphorylation of p130 (RBL2) by PP2A (Xenopus tropicalis)
Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)
Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)
Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)
Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)
Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)
Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)
Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)
Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)
Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)
Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)
Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)
Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)
Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)
Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Xenopus tropicalis)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)
PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)
PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)
PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)
CDC25A dephosphorylates CCNA:CDK1 (Caenorhabditis elegans)
CDC25A dephosphorylates CCNA:CDK1 (Drosophila melanogaster)
CDC25A dephosphorylates CCNA:CDK1 (Gallus gallus)
CDC25A dephosphorylates CCNA:CDK1 (Xenopus tropicalis)
CDC25A dephosphorylates CCNA:CDK1 (Sus scrofa)
CDC25A dephosphorylates CCNA:CDK1 (Bos taurus)
CDC25A dephosphorylates CCNA:CDK1 (Canis familiaris)
CDC25A dephosphorylates CCNA:CDK1 (Rattus norvegicus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Sus scrofa)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
PP6-PPP6R3 dephosphorylates TERF2 (Xenopus tropicalis)
PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)
CDC25A dephosphorylates CCNA:CDK1 (Homo sapiens)
CDC25A dephosphorylates CCNA:CDK1 (Mus musculus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
Initial resection of double-strand break ends (Mus musculus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)
D-loop dissociation and strand annealing (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
Initial resection of double-strand break ends (Homo sapiens)
Initial resection of double-strand break ends (Rattus norvegicus)
Initial resection of double-strand break ends (Canis familiaris)
Initial resection of double-strand break ends (Bos taurus)
Initial resection of double-strand break ends (Sus scrofa)
Initial resection of double-strand break ends (Gallus gallus)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)
PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)
PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)
PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
as an output of
TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)
Other forms of this molecule
H2O [cytoplasm]
H2O [lipid droplet]
H2O [early endosome]
H2O [multivesicular body lumen]
H2O [endoplasmic reticulum quality control compartment]
H2O [melanosome lumen]
H2O [secretory granule lumen]
H2O [Golgi lumen]
H2O [endocytic vesicle lumen]
H2O [phagocytic vesicle lumen]
H2O [endoplasmic reticulum lumen]
H2O [peroxisomal matrix]
H2O [lysosomal lumen]
H2O [mitochondrial intermembrane space]
H2O [mitochondrial matrix]
H2O [extracellular region]
H2O [cytosol]
Cross References
COMPOUND
C00001
PubChem Substance
8145132
HMDB Metabolite
HMDB0002111
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