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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
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COVID-19 Disease Pathways
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How do I search ?
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H2O [endoplasmic reticulum lumen]
Stable Identifier
R-ALL-113519
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum lumen
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
CES1,CES2 hydrolyze ASA- to ST (Bos taurus)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)
H2O [endoplasmic reticulum lumen]
COX reactions (Bos taurus)
PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Fatty acids (Bos taurus)
CYP2J2 oxidises ARA (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP4F12 18-hydroxylates ARA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Bos taurus)
CYP2S1 4-hydroxylates atRA (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)
H2O [endoplasmic reticulum lumen]
Vitamins (Bos taurus)
CYP26A1,B1 4-hydroxylate atRA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Bos taurus)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Bos taurus)
N-atom dealkylation of caffeine (Bos taurus)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Bos taurus)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Bos taurus)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Bos taurus)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Bos taurus)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Bos taurus)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Bos taurus)
FMO1:FAD N-oxidises TAM (Bos taurus)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Bos taurus)
Glutathione conjugation (Bos taurus)
ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)
H2O [endoplasmic reticulum lumen]
Methylation (Bos taurus)
CYP1A2 S-demethylates 6MMP (Bos taurus)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IPs in the ER lumen (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Bos taurus)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Bos taurus)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Bos taurus)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Bos taurus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Bos taurus)
PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Bos taurus)
Linoleic acid (LA) metabolism (Bos taurus)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Bos taurus)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Bos taurus)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
Nicotinamide salvaging (Bos taurus)
PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Bos taurus)
Peptide hormone metabolism (Bos taurus)
Metabolism of Angiotensinogen to Angiotensins (Bos taurus)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Bos taurus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Bos taurus)
Gamma-carboxylation of protein precursors (Bos taurus)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Bos taurus)
Attachment of GPI anchor to uPAR (Bos taurus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)
H2O [endoplasmic reticulum lumen]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
CES1 trimer.CES2 hydrolyse COCN to BEG (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Miscellaneous substrates (Caenorhabditis elegans)
CYP2U1 19-hydroxylates ARA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Caenorhabditis elegans)
FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Glutathione conjugation (Caenorhabditis elegans)
ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Caenorhabditis elegans)
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Caenorhabditis elegans)
Linoleic acid (LA) metabolism (Caenorhabditis elegans)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Caenorhabditis elegans)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Caenorhabditis elegans)
Peptide hormone metabolism (Caenorhabditis elegans)
Metabolism of Angiotensinogen to Angiotensins (Caenorhabditis elegans)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)
H2O [endoplasmic reticulum lumen]
COX reactions (Canis familiaris)
PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Fatty acids (Canis familiaris)
CYP2J2 oxidises ARA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Canis familiaris)
CYP2S1 4-hydroxylates atRA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Vitamins (Canis familiaris)
CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Canis familiaris)
CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Canis familiaris)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Canis familiaris)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Canis familiaris)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Canis familiaris)
FMO1:FAD N-oxidises TAM (Canis familiaris)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Canis familiaris)
Glutathione conjugation (Canis familiaris)
ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Canis familiaris)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Canis familiaris)
Linoleic acid (LA) metabolism (Canis familiaris)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Canis familiaris)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Nicotinate metabolism (Canis familiaris)
Nicotinamide salvaging (Canis familiaris)
PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Metabolism of Angiotensinogen to Angiotensins (Canis familiaris)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Canis familiaris)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Canis familiaris)
Gamma-carboxylation of protein precursors (Canis familiaris)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Canis familiaris)
Attachment of GPI anchor to uPAR (Canis familiaris)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Drug ADME (Danio rerio)
Aspirin ADME (Danio rerio)
CES1,CES2 hydrolyze ASA- to ST (Danio rerio)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)
H2O [endoplasmic reticulum lumen]
COX reactions (Danio rerio)
PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F3 20-hydroxylates LTB4 (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Fatty acids (Danio rerio)
CYP2J2 oxidises ARA (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP4F12 18-hydroxylates ARA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Danio rerio)
CYP2S1 4-hydroxylates atRA (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)
H2O [endoplasmic reticulum lumen]
Vitamins (Danio rerio)
CYP26A1,B1 4-hydroxylate atRA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Danio rerio)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Danio rerio)
N-atom dealkylation of caffeine (Danio rerio)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Danio rerio)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Danio rerio)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Danio rerio)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Danio rerio)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Danio rerio)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Danio rerio)
FMO1:FAD N-oxidises TAM (Danio rerio)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)
H2O [endoplasmic reticulum lumen]
Methylation (Danio rerio)
CYP1A2 S-demethylates 6MMP (Danio rerio)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IPs in the ER lumen (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Danio rerio)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Danio rerio)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)
PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Danio rerio)
Linoleic acid (LA) metabolism (Danio rerio)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Danio rerio)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Danio rerio)
Glycosphingolipid metabolism (Danio rerio)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Danio rerio)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Danio rerio)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
Nicotinamide salvaging (Danio rerio)
PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Danio rerio)
Peptide hormone metabolism (Danio rerio)
Metabolism of Angiotensinogen to Angiotensins (Danio rerio)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)
H2O [endoplasmic reticulum lumen]
Drug ADME (Dictyostelium discoideum)
Aspirin ADME (Dictyostelium discoideum)
CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Fatty acids (Dictyostelium discoideum)
CYP2J2 oxidises ARA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Dictyostelium discoideum)
CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Dictyostelium discoideum)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Dictyostelium discoideum)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glutathione conjugation (Dictyostelium discoideum)
ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IPs in the ER lumen (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Dictyostelium discoideum)
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Dictyostelium discoideum)
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Dictyostelium discoideum)
Linoleic acid (LA) metabolism (Dictyostelium discoideum)
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Dictyostelium discoideum)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Dictyostelium discoideum)
Peptide hormone metabolism (Dictyostelium discoideum)
Metabolism of Angiotensinogen to Angiotensins (Dictyostelium discoideum)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)
H2O [endoplasmic reticulum lumen]
Drug ADME (Drosophila melanogaster)
Aspirin ADME (Drosophila melanogaster)
CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase I - Functionalization of compounds (Drosophila melanogaster)
CES1 trimer.CES2 hydrolyse COCN to BEG (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Drosophila melanogaster)
Miscellaneous substrates (Drosophila melanogaster)
CYP2U1 19-hydroxylates ARA (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Drosophila melanogaster)
Glutathione conjugation (Drosophila melanogaster)
ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IPs in the ER lumen (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Drosophila melanogaster)
Fatty acid metabolism (Drosophila melanogaster)
Arachidonic acid metabolism (Drosophila melanogaster)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Drosophila melanogaster)
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Drosophila melanogaster)
Linoleic acid (LA) metabolism (Drosophila melanogaster)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Drosophila melanogaster)
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid metabolism (Drosophila melanogaster)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Drosophila melanogaster)
Peptide hormone metabolism (Drosophila melanogaster)
Metabolism of Angiotensinogen to Angiotensins (Drosophila melanogaster)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)
H2O [endoplasmic reticulum lumen]
Drug ADME (Gallus gallus)
Aspirin ADME (Gallus gallus)
CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)
H2O [endoplasmic reticulum lumen]
Metabolism (Gallus gallus)
Carbohydrate metabolism (Gallus gallus)
Glucose transport (Gallus gallus)
glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Gallus gallus)
Peptide hormone metabolism (Gallus gallus)
Metabolism of Angiotensinogen to Angiotensins (Gallus gallus)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of carbohydrate metabolism (Homo sapiens)
Glycogen storage diseases (Homo sapiens)
Glycogen storage disease type Ia (G6PC) (Homo sapiens)
Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Severe congenital neutropenia type 4 (G6PC3) (Homo sapiens)
Defective G6PC3 does not hydrolyze glucose 6-phosphate (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
N-glycan trimming of Spike (Homo sapiens)
H2O [endoplasmic reticulum lumen]
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
N-glycan glucose trimming of Spike (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)
H2O [endoplasmic reticulum lumen]
COX reactions (Homo sapiens)
PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
CYP4F3 20-hydroxylates LTB4 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Fatty acids (Homo sapiens)
CYP2J2 oxidises ARA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP4F12 18-hydroxylates ARA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Homo sapiens)
CYP2S1 4-hydroxylates atRA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Vitamins (Homo sapiens)
CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Homo sapiens)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Homo sapiens)
N-atom dealkylation of caffeine (Homo sapiens)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Homo sapiens)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Homo sapiens)
FMO1:FAD N-oxidises TAM (Homo sapiens)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Methylation (Homo sapiens)
CYP1A2 S-demethylates 6MMP (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IPs in the ER lumen (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Homo sapiens)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
PGD2 is dehydrated to PGJ2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)
H2O [endoplasmic reticulum lumen]
TXA2 is hydrolysed to TXB2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Homo sapiens)
Linoleic acid (LA) metabolism (Homo sapiens)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Homo sapiens)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
Gamma-carboxylation of protein precursors (Homo sapiens)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Attachment of GPI anchor to uPAR (Homo sapiens)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Drug ADME (Mus musculus)
Aspirin ADME (Mus musculus)
CES1,CES2 hydrolyze ASA- to ST (Mus musculus)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)
H2O [endoplasmic reticulum lumen]
COX reactions (Mus musculus)
PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Mus musculus)
Eicosanoids (Mus musculus)
CYP4F3 20-hydroxylates LTB4 (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Fatty acids (Mus musculus)
CYP2J2 oxidises ARA (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Mus musculus)
CYP2S1 4-hydroxylates atRA (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Mus musculus)
H2O [endoplasmic reticulum lumen]
Vitamins (Mus musculus)
CYP26A1,B1 4-hydroxylate atRA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Mus musculus)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Mus musculus)
N-atom dealkylation of caffeine (Mus musculus)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Mus musculus)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Mus musculus)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Mus musculus)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Mus musculus)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Mus musculus)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Mus musculus)
FMO1:FAD N-oxidises TAM (Mus musculus)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Mus musculus)
Glutathione conjugation (Mus musculus)
ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)
H2O [endoplasmic reticulum lumen]
Methylation (Mus musculus)
CYP1A2 S-demethylates 6MMP (Mus musculus)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Mus musculus)
Synthesis of IPs in the ER lumen (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Mus musculus)
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Mus musculus)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Mus musculus)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Arachidonic acid metabolism (Mus musculus)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Mus musculus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Mus musculus)
PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Mus musculus)
Linoleic acid (LA) metabolism (Mus musculus)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Mus musculus)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Mus musculus)
Glycosphingolipid metabolism (Mus musculus)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Mus musculus)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Nicotinate metabolism (Mus musculus)
Nicotinamide salvaging (Mus musculus)
PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Mus musculus)
Peptide hormone metabolism (Mus musculus)
Metabolism of Angiotensinogen to Angiotensins (Mus musculus)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Mus musculus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Mus musculus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Mus musculus)
Gamma-carboxylation of protein precursors (Mus musculus)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Mus musculus)
Attachment of GPI anchor to uPAR (Mus musculus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
Cellular response to chemical stress (Plasmodium falciparum)
Detoxification of Reactive Oxygen Species (Plasmodium falciparum)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Metabolism (Plasmodium falciparum)
Metabolism of lipids (Plasmodium falciparum)
Fatty acid metabolism (Plasmodium falciparum)
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Plasmodium falciparum)
Linoleic acid (LA) metabolism (Plasmodium falciparum)
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Plasmodium falciparum)
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
COX reactions (Rattus norvegicus)
PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Eicosanoids (Rattus norvegicus)
CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Fatty acids (Rattus norvegicus)
CYP2J2 oxidises ARA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Rattus norvegicus)
CYP2S1 4-hydroxylates atRA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Vitamins (Rattus norvegicus)
CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Rattus norvegicus)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Rattus norvegicus)
N-atom dealkylation of caffeine (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Rattus norvegicus)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Rattus norvegicus)
FMO1:FAD N-oxidises TAM (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Rattus norvegicus)
Glutathione conjugation (Rattus norvegicus)
ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Methylation (Rattus norvegicus)
CYP1A2 S-demethylates 6MMP (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IPs in the ER lumen (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Rattus norvegicus)
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Arachidonic acid metabolism (Rattus norvegicus)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Rattus norvegicus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)
PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Rattus norvegicus)
Linoleic acid (LA) metabolism (Rattus norvegicus)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Rattus norvegicus)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid metabolism (Rattus norvegicus)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Nicotinate metabolism (Rattus norvegicus)
Nicotinamide salvaging (Rattus norvegicus)
PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Rattus norvegicus)
Peptide hormone metabolism (Rattus norvegicus)
Metabolism of Angiotensinogen to Angiotensins (Rattus norvegicus)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Rattus norvegicus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Rattus norvegicus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Rattus norvegicus)
Gamma-carboxylation of protein precursors (Rattus norvegicus)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Rattus norvegicus)
Attachment of GPI anchor to uPAR (Rattus norvegicus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)
H2O [endoplasmic reticulum lumen]
Metabolism (Saccharomyces cerevisiae)
Biological oxidations (Saccharomyces cerevisiae)
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Glutathione conjugation (Saccharomyces cerevisiae)
ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Detoxification of Reactive Oxygen Species (Sus scrofa)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Drug ADME (Sus scrofa)
Aspirin ADME (Sus scrofa)
CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)
H2O [endoplasmic reticulum lumen]
COX reactions (Sus scrofa)
PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Eicosanoids (Sus scrofa)
CYP4F3 20-hydroxylates LTB4 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Fatty acids (Sus scrofa)
CYP2J2 oxidises ARA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP4A11 12-hydroxylates DDCX (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Sus scrofa)
CYP2S1 4-hydroxylates atRA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Vitamins (Sus scrofa)
CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Sus scrofa)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Sus scrofa)
N-atom dealkylation of caffeine (Sus scrofa)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Sus scrofa)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Sus scrofa)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Sus scrofa)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Sus scrofa)
FMO1:FAD N-oxidises TAM (Sus scrofa)
H2O [endoplasmic reticulum lumen]
FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)
H2O [endoplasmic reticulum lumen]
FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Phase II - Conjugation of compounds (Sus scrofa)
Glutathione conjugation (Sus scrofa)
ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Methylation (Sus scrofa)
CYP1A2 S-demethylates 6MMP (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IPs in the ER lumen (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)
H2O [endoplasmic reticulum lumen]
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)
H2O [endoplasmic reticulum lumen]
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Metabolism of carbohydrates (Sus scrofa)
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
G6PC hydrolyzes G6P to Glc and Pi (liver) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Metabolism of lipids (Sus scrofa)
Fatty acid metabolism (Sus scrofa)
Arachidonic acid metabolism (Sus scrofa)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Sus scrofa)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Sus scrofa)
PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism (Sus scrofa)
Linoleic acid (LA) metabolism (Sus scrofa)
Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
alpha-linolenic acid (ALA) metabolism (Sus scrofa)
Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Sphingolipid metabolism (Sus scrofa)
Glycosphingolipid metabolism (Sus scrofa)
Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Steryl sulfatase hydrolyses sulfate from steroid sulfates (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Nicotinate metabolism (Sus scrofa)
Nicotinamide salvaging (Sus scrofa)
PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Metabolism of proteins (Sus scrofa)
Peptide hormone metabolism (Sus scrofa)
Metabolism of Angiotensinogen to Angiotensins (Sus scrofa)
CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Post-translational protein modification (Sus scrofa)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Sus scrofa)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Sus scrofa)
Gamma-carboxylation of protein precursors (Sus scrofa)
GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Post-translational modification: synthesis of GPI-anchored proteins (Sus scrofa)
Attachment of GPI anchor to uPAR (Sus scrofa)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)
H2O [endoplasmic reticulum lumen]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Drug ADME (Xenopus tropicalis)
Aspirin ADME (Xenopus tropicalis)
CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CES2 hydrolyzes ASA- (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
COX reactions (Xenopus tropicalis)
PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Cytochrome P450 - arranged by substrate type (Xenopus tropicalis)
Eicosanoids (Xenopus tropicalis)
CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Fatty acids (Xenopus tropicalis)
CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Miscellaneous substrates (Xenopus tropicalis)
CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2W1 oxidises INDOL (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP4F11 16-hydroxylates 3OH-PALM (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Vitamins (Xenopus tropicalis)
CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Xenobiotics (Xenopus tropicalis)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Xenopus tropicalis)
N-atom dealkylation of caffeine (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
N-hydroxylation of 4-aminobiphenyl (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2C19 5-hydroxylates omeprazole (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2E1 reactions (Xenopus tropicalis)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Benzene is hydroxylated to phenol (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP3A4 can N-demethylate loperamide (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A13 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
Ethylene is oxidized to Ethylene oxide by CYP1A1 (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
O-atom dealkylation of dextromethorphan (Xenopus tropicalis)
H2O [endoplasmic reticulum lumen]
FMO oxidises nucleophiles (Xenopus tropicalis)