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What is Reactome ?
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Privacy Notice
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Digital Preservation
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H2O [mitochondrial matrix]
Stable Identifier
R-ALL-113521
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Bos taurus)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
H2O [mitochondrial matrix]
NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)
H2O [mitochondrial matrix]
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)
H2O [mitochondrial matrix]
Mitochondrial unfolded protein response (UPRmt) (Bos taurus)
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Bos taurus)
H2O [mitochondrial matrix]
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)
H2O [mitochondrial matrix]
Extracellular matrix organization (Bos taurus)
Degradation of the extracellular matrix (Bos taurus)
Collagen degradation (Bos taurus)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)
H2O [mitochondrial matrix]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
CS acetylates OA to citrate (Bos taurus)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Bos taurus)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Bos taurus)
ATPase synthesizes ATP (Bos taurus)
H2O [mitochondrial matrix]
Pyruvate metabolism (Bos taurus)
Regulation of pyruvate metabolism (Bos taurus)
Regulation of pyruvate dehydrogenase (PDH) complex (Bos taurus)
PDP1,2 dephosphorylate p-lipo-PDH (Bos taurus)
H2O [mitochondrial matrix]
SIRT4 cleaves lipoyl from DLAT (Bos taurus)
H2O [mitochondrial matrix]
Respiratory electron transport (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H2O [mitochondrial matrix]
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Endogenous sterols (Bos taurus)
CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)
H2O [mitochondrial matrix]
CYP11B1 oxidises 11DCORT (Bos taurus)
H2O [mitochondrial matrix]
CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Bos taurus)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates CHOL (Bos taurus)
H2O [mitochondrial matrix]
Vitamins (Bos taurus)
CYP24A1 24-hydroxylates CTL (Bos taurus)
H2O [mitochondrial matrix]
Ethanol oxidation (Bos taurus)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)
H2O [mitochondrial matrix]
Phase II - Conjugation of compounds (Bos taurus)
Glucuronidation (Bos taurus)
ABHD10 hydrolyses MPAG (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Bos taurus)
Branched-chain amino acid catabolism (Bos taurus)
ECHS1 hydrates methacrylyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
PPM1K dephosphorylates p-BCKDH (Bos taurus)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)
H2O [mitochondrial matrix]
Choline catabolism (Bos taurus)
ALDH7A1 oxidises BETALD to BET (Bos taurus)
H2O [mitochondrial matrix]
DMGDH:FAD oxidatively demethylates DMGLY to SARC (Bos taurus)
H2O [mitochondrial matrix]
SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Bos taurus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)
H2O [mitochondrial matrix]
Lysine catabolism (Bos taurus)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Bos taurus)
H2O [mitochondrial matrix]
Proline catabolism (Bos taurus)
ALDH4A1 oxidises L-GluSS to Glu (Bos taurus)
H2O [mitochondrial matrix]
PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
Sulfide oxidation to sulfate (Bos taurus)
Persulfide sulfur is dioxygenated (Bos taurus)
H2O [mitochondrial matrix]
Sulfite is oxidized to sulfate (Bos taurus)
H2O [mitochondrial matrix]
Urea cycle (Bos taurus)
arginine + H2O => ornithine + urea [ARG2] (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Mitochondrial Fatty Acid Beta-Oxidation (Bos taurus)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Bos taurus)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Bos taurus)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Bos taurus)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Bos taurus)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Bos taurus)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Bos taurus)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Bos taurus)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Bos taurus)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Bos taurus)
H2O [mitochondrial matrix]
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
CYP27A1 27-hydroxylates CHOL (Bos taurus)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)
H2O [mitochondrial matrix]
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of steroid hormones (Bos taurus)
Glucocorticoid biosynthesis (Bos taurus)
CYP11B1 oxidises 11DCORT (Bos taurus)
H2O [mitochondrial matrix]
Mineralocorticoid biosynthesis (Bos taurus)
CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Bos taurus)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)
H2O [mitochondrial matrix]
Pregnenolone biosynthesis (Bos taurus)
CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)
H2O [mitochondrial matrix]
Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)
H2O [mitochondrial matrix]
Oxidation of cholesterol to 22beta-hydroxycholesterol (Bos taurus)
H2O [mitochondrial matrix]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodeling of CL (Bos taurus)
MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)
H2O [mitochondrial matrix]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)
H2O [mitochondrial matrix]
PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)
H2O [mitochondrial matrix]
Synthesis of PA (Bos taurus)
ACP6 hydrolyses MYS-LPA (Bos taurus)
H2O [mitochondrial matrix]
Synthesis of PE (Bos taurus)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)
H2O [mitochondrial matrix]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
H2O [mitochondrial matrix]
Pyrimidine catabolism (Bos taurus)
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
COX10 transforms heme to heme O (Bos taurus)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Ubiquinol biosynthesis (Bos taurus)
COQ6 hydroxylates DHB (Bos taurus)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Metabolism of folate and pterines (Bos taurus)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
H2O [mitochondrial matrix]
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)
H2O [mitochondrial matrix]
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Bos taurus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)
H2O [mitochondrial matrix]
Metabolism of proteins (Bos taurus)
Mitochondrial protein degradation (Bos taurus)
AFG3L2 degrades mitochondrial inner membrane proteins (Bos taurus)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Bos taurus)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Bos taurus)
H2O [mitochondrial matrix]
CLPXP degrades mitochondrial matrix proteins (Bos taurus)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Bos taurus)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Bos taurus)
H2O [mitochondrial matrix]
Translation (Bos taurus)
tRNA Aminoacylation (Bos taurus)
Mitochondrial tRNA aminoacylation (Bos taurus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)
H2O [mitochondrial matrix]
Muscle contraction (Bos taurus)
Smooth Muscle Contraction (Bos taurus)
ALDH2 transforms GTN to NO (Bos taurus)
H2O [mitochondrial matrix]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
GABA synthesis, release, reuptake and degradation (Bos taurus)
Degradation of GABA (Bos taurus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Bos taurus)
glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)
H2O [mitochondrial matrix]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Regulation of Apoptosis (Bos taurus)
OMA1 hydrolyses OPA1 (Bos taurus)
H2O [mitochondrial matrix]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
Mitochondrial ABC transporters (Bos taurus)
ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Extracellular matrix organization (Caenorhabditis elegans)
Degradation of the extracellular matrix (Caenorhabditis elegans)
Collagen degradation (Caenorhabditis elegans)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
CS acetylates OA to citrate (Caenorhabditis elegans)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Caenorhabditis elegans)
ATPase synthesizes ATP (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate dehydrogenase (PDH) complex (Caenorhabditis elegans)
PDP1,2 dephosphorylate p-lipo-PDH (Caenorhabditis elegans)
H2O [mitochondrial matrix]
SIRT4 cleaves lipoyl from DLAT (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Ethanol oxidation (Caenorhabditis elegans)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Branched-chain amino acid catabolism (Caenorhabditis elegans)
ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Choline catabolism (Caenorhabditis elegans)
ALDH7A1 oxidises BETALD to BET (Caenorhabditis elegans)
H2O [mitochondrial matrix]
DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Caenorhabditis elegans)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Lysine catabolism (Caenorhabditis elegans)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Proline catabolism (Caenorhabditis elegans)
PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Sulfide oxidation to sulfate (Caenorhabditis elegans)
Persulfide sulfur is dioxygenated (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Sulfite is oxidized to sulfate (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Urea cycle (Caenorhabditis elegans)
arginine + H2O => ornithine + urea [ARG2] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Mitochondrial Fatty Acid Beta-Oxidation (Caenorhabditis elegans)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Caenorhabditis elegans)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Caenorhabditis elegans)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Caenorhabditis elegans)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Caenorhabditis elegans)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Caenorhabditis elegans)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Caenorhabditis elegans)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Caenorhabditis elegans)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Caenorhabditis elegans)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PA (Caenorhabditis elegans)
ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Synthesis of PE (Caenorhabditis elegans)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
COX10 transforms heme to heme O (Caenorhabditis elegans)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Ubiquinol biosynthesis (Caenorhabditis elegans)
COQ6 hydroxylates DHB (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Metabolism of folate and pterines (Caenorhabditis elegans)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Metabolism of proteins (Caenorhabditis elegans)
Mitochondrial protein degradation (Caenorhabditis elegans)
AFG3L2 degrades mitochondrial inner membrane proteins (Caenorhabditis elegans)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Caenorhabditis elegans)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Caenorhabditis elegans)
H2O [mitochondrial matrix]
CLPXP degrades mitochondrial matrix proteins (Caenorhabditis elegans)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Caenorhabditis elegans)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Translation (Caenorhabditis elegans)
tRNA Aminoacylation (Caenorhabditis elegans)
Mitochondrial tRNA aminoacylation (Caenorhabditis elegans)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Muscle contraction (Caenorhabditis elegans)
Smooth Muscle Contraction (Caenorhabditis elegans)
ALDH2 transforms GTN to NO (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
GABA synthesis, release, reuptake and degradation (Caenorhabditis elegans)
Degradation of GABA (Caenorhabditis elegans)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Caenorhabditis elegans)
glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Canis familiaris)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [mitochondrial matrix]
NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)
H2O [mitochondrial matrix]
Mitochondrial unfolded protein response (UPRmt) (Canis familiaris)
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Canis familiaris)
H2O [mitochondrial matrix]
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
Collagen degradation (Canis familiaris)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
CS acetylates OA to citrate (Canis familiaris)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Canis familiaris)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Canis familiaris)
ATPase synthesizes ATP (Canis familiaris)
H2O [mitochondrial matrix]
Pyruvate metabolism (Canis familiaris)
Regulation of pyruvate metabolism (Canis familiaris)
Regulation of pyruvate dehydrogenase (PDH) complex (Canis familiaris)
PDP1,2 dephosphorylate p-lipo-PDH (Canis familiaris)
H2O [mitochondrial matrix]
SIRT4 cleaves lipoyl from DLAT (Canis familiaris)
H2O [mitochondrial matrix]
Respiratory electron transport (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H2O [mitochondrial matrix]
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Endogenous sterols (Canis familiaris)
CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B1 oxidises 11DCORT (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates CHOL (Canis familiaris)
H2O [mitochondrial matrix]
Vitamins (Canis familiaris)
CYP24A1 24-hydroxylates CTL (Canis familiaris)
H2O [mitochondrial matrix]
Ethanol oxidation (Canis familiaris)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)
H2O [mitochondrial matrix]
Phase II - Conjugation of compounds (Canis familiaris)
Glucuronidation (Canis familiaris)
ABHD10 hydrolyses MPAG (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Canis familiaris)
Branched-chain amino acid catabolism (Canis familiaris)
ECHS1 hydrates methacrylyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
PPM1K dephosphorylates p-BCKDH (Canis familiaris)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)
H2O [mitochondrial matrix]
Choline catabolism (Canis familiaris)
ALDH7A1 oxidises BETALD to BET (Canis familiaris)
H2O [mitochondrial matrix]
DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)
H2O [mitochondrial matrix]
SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Canis familiaris)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)
H2O [mitochondrial matrix]
Lysine catabolism (Canis familiaris)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)
H2O [mitochondrial matrix]
Proline catabolism (Canis familiaris)
ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)
H2O [mitochondrial matrix]
PRODH2 oxidises HPRO to 1PYR-5COOH (Canis familiaris)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
Sulfide oxidation to sulfate (Canis familiaris)
Persulfide sulfur is dioxygenated (Canis familiaris)
H2O [mitochondrial matrix]
Sulfite is oxidized to sulfate (Canis familiaris)
H2O [mitochondrial matrix]
Urea cycle (Canis familiaris)
arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Fatty acyl-CoA biosynthesis (Canis familiaris)
RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Mitochondrial Fatty Acid Beta-Oxidation (Canis familiaris)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Canis familiaris)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Canis familiaris)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Canis familiaris)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Canis familiaris)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Canis familiaris)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Canis familiaris)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Canis familiaris)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Canis familiaris)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)
H2O [mitochondrial matrix]
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
CYP27A1 27-hydroxylates CHOL (Canis familiaris)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)
H2O [mitochondrial matrix]
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of steroid hormones (Canis familiaris)
Glucocorticoid biosynthesis (Canis familiaris)
CYP11B1 oxidises 11DCORT (Canis familiaris)
H2O [mitochondrial matrix]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)
H2O [mitochondrial matrix]
Pregnenolone biosynthesis (Canis familiaris)
CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)
H2O [mitochondrial matrix]
Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)
H2O [mitochondrial matrix]
Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)
H2O [mitochondrial matrix]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodeling of CL (Canis familiaris)
MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)
H2O [mitochondrial matrix]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)
H2O [mitochondrial matrix]
PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)
H2O [mitochondrial matrix]
Synthesis of PA (Canis familiaris)
ACP6 hydrolyses MYS-LPA (Canis familiaris)
H2O [mitochondrial matrix]
Synthesis of PE (Canis familiaris)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)
H2O [mitochondrial matrix]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
H2O [mitochondrial matrix]
Pyrimidine catabolism (Canis familiaris)
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
COX10 transforms heme to heme O (Canis familiaris)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Ubiquinol biosynthesis (Canis familiaris)
COQ6 hydroxylates DHB (Canis familiaris)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Metabolism of folate and pterines (Canis familiaris)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
H2O [mitochondrial matrix]
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)
H2O [mitochondrial matrix]
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Canis familiaris)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)
H2O [mitochondrial matrix]
Metabolism of proteins (Canis familiaris)
Mitochondrial protein degradation (Canis familiaris)
AFG3L2 degrades mitochondrial inner membrane proteins (Canis familiaris)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Canis familiaris)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Canis familiaris)
H2O [mitochondrial matrix]
CLPXP degrades mitochondrial matrix proteins (Canis familiaris)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Canis familiaris)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Canis familiaris)
H2O [mitochondrial matrix]
Translation (Canis familiaris)
tRNA Aminoacylation (Canis familiaris)
Mitochondrial tRNA aminoacylation (Canis familiaris)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)
H2O [mitochondrial matrix]
Muscle contraction (Canis familiaris)
Smooth Muscle Contraction (Canis familiaris)
ALDH2 transforms GTN to NO (Canis familiaris)
H2O [mitochondrial matrix]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
GABA synthesis, release, reuptake and degradation (Canis familiaris)
Degradation of GABA (Canis familiaris)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Canis familiaris)
glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)
H2O [mitochondrial matrix]
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Regulation of Apoptosis (Canis familiaris)
OMA1 hydrolyses OPA1 (Canis familiaris)
H2O [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
Mitochondrial ABC transporters (Canis familiaris)
ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Danio rerio)
NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)
H2O [mitochondrial matrix]
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)
H2O [mitochondrial matrix]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Danio rerio)
POLB-Dependent Long Patch Base Excision Repair (Danio rerio)
ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)
H2O [mitochondrial matrix]
Extracellular matrix organization (Danio rerio)
Degradation of the extracellular matrix (Danio rerio)
Collagen degradation (Danio rerio)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)
H2O [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
CS acetylates OA to citrate (Danio rerio)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Danio rerio)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Danio rerio)
ATPase synthesizes ATP (Danio rerio)
H2O [mitochondrial matrix]
Pyruvate metabolism (Danio rerio)
Regulation of pyruvate metabolism (Danio rerio)
Regulation of pyruvate dehydrogenase (PDH) complex (Danio rerio)
SIRT4 cleaves lipoyl from DLAT (Danio rerio)
H2O [mitochondrial matrix]
Respiratory electron transport (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H2O [mitochondrial matrix]
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
Cytochrome P450 - arranged by substrate type (Danio rerio)
Endogenous sterols (Danio rerio)
CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)
H2O [mitochondrial matrix]
Vitamins (Danio rerio)
CYP24A1 24-hydroxylates CTL (Danio rerio)
H2O [mitochondrial matrix]
Ethanol oxidation (Danio rerio)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Danio rerio)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Danio rerio)
Branched-chain amino acid catabolism (Danio rerio)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)
H2O [mitochondrial matrix]
Choline catabolism (Danio rerio)
ALDH7A1 oxidises BETALD to BET (Danio rerio)
H2O [mitochondrial matrix]
SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Danio rerio)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)
H2O [mitochondrial matrix]
Lysine catabolism (Danio rerio)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)
H2O [mitochondrial matrix]
Proline catabolism (Danio rerio)
ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
Sulfide oxidation to sulfate (Danio rerio)
Persulfide sulfur is dioxygenated (Danio rerio)
H2O [mitochondrial matrix]
Urea cycle (Danio rerio)
arginine + H2O => ornithine + urea [ARG2] (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Mitochondrial Fatty Acid Beta-Oxidation (Danio rerio)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Danio rerio)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Danio rerio)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Danio rerio)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of steroids (Danio rerio)
Metabolism of steroid hormones (Danio rerio)
Pregnenolone biosynthesis (Danio rerio)
CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)
H2O [mitochondrial matrix]
Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)
H2O [mitochondrial matrix]
Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)
H2O [mitochondrial matrix]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Acyl chain remodeling of CL (Danio rerio)
MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)
H2O [mitochondrial matrix]
Synthesis of PA (Danio rerio)
ACP6 hydrolyses MYS-LPA (Danio rerio)
H2O [mitochondrial matrix]
Synthesis of PE (Danio rerio)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
Ubiquinol biosynthesis (Danio rerio)
COQ6 hydroxylates DHB (Danio rerio)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)
H2O [mitochondrial matrix]
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Danio rerio)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)
H2O [mitochondrial matrix]
Metabolism of proteins (Danio rerio)
Mitochondrial protein degradation (Danio rerio)
AFG3L2 degrades mitochondrial inner membrane proteins (Danio rerio)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Danio rerio)
H2O [mitochondrial matrix]
Translation (Danio rerio)
tRNA Aminoacylation (Danio rerio)
Mitochondrial tRNA aminoacylation (Danio rerio)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)
H2O [mitochondrial matrix]
Muscle contraction (Danio rerio)
Smooth Muscle Contraction (Danio rerio)
ALDH2 transforms GTN to NO (Danio rerio)
H2O [mitochondrial matrix]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter release cycle (Danio rerio)
Glutamate Neurotransmitter Release Cycle (Danio rerio)
glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)
H2O [mitochondrial matrix]
Programmed Cell Death (Danio rerio)
Apoptosis (Danio rerio)
Regulation of Apoptosis (Danio rerio)
OMA1 hydrolyses OPA1 (Danio rerio)
H2O [mitochondrial matrix]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
Mitochondrial ABC transporters (Danio rerio)
ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)
H2O [mitochondrial matrix]
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
CS acetylates OA to citrate (Dictyostelium discoideum)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Ethanol oxidation (Dictyostelium discoideum)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Branched-chain amino acid catabolism (Dictyostelium discoideum)
ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Choline catabolism (Dictyostelium discoideum)
ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Dictyostelium discoideum)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Lysine catabolism (Dictyostelium discoideum)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Proline catabolism (Dictyostelium discoideum)
PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
Sulfide oxidation to sulfate (Dictyostelium discoideum)
Sulfite is oxidized to sulfate (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Urea cycle (Dictyostelium discoideum)
arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of lipids (Dictyostelium discoideum)
Fatty acid metabolism (Dictyostelium discoideum)
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Mitochondrial Fatty Acid Beta-Oxidation (Dictyostelium discoideum)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Dictyostelium discoideum)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Dictyostelium discoideum)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Dictyostelium discoideum)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Dictyostelium discoideum)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Dictyostelium discoideum)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Dictyostelium discoideum)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Synthesis of PA (Dictyostelium discoideum)
ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
COX10 transforms heme to heme O (Dictyostelium discoideum)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Ubiquinol biosynthesis (Dictyostelium discoideum)
COQ6 hydroxylates DHB (Dictyostelium discoideum)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Metabolism of folate and pterines (Dictyostelium discoideum)
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)
H2O [mitochondrial matrix]
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Dictyostelium discoideum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Metabolism of proteins (Dictyostelium discoideum)
Mitochondrial protein degradation (Dictyostelium discoideum)
AFG3L2 degrades mitochondrial inner membrane proteins (Dictyostelium discoideum)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Dictyostelium discoideum)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Dictyostelium discoideum)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Translation (Dictyostelium discoideum)
tRNA Aminoacylation (Dictyostelium discoideum)
Mitochondrial tRNA aminoacylation (Dictyostelium discoideum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Muscle contraction (Dictyostelium discoideum)
Smooth Muscle Contraction (Dictyostelium discoideum)
ALDH2 transforms GTN to NO (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Programmed Cell Death (Dictyostelium discoideum)
Apoptosis (Dictyostelium discoideum)
Regulation of Apoptosis (Dictyostelium discoideum)
OMA1 hydrolyses OPA1 (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
Mitochondrial ABC transporters (Dictyostelium discoideum)
ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)
H2O [mitochondrial matrix]
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)
H2O [mitochondrial matrix]
Extracellular matrix organization (Drosophila melanogaster)
Degradation of the extracellular matrix (Drosophila melanogaster)
Collagen degradation (Drosophila melanogaster)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Citric acid cycle (TCA cycle) (Drosophila melanogaster)
CS acetylates OA to citrate (Drosophila melanogaster)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Drosophila melanogaster)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Drosophila melanogaster)
ATPase synthesizes ATP (Drosophila melanogaster)
H2O [mitochondrial matrix]
Pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
PDP1,2 dephosphorylate p-lipo-PDH (Drosophila melanogaster)
H2O [mitochondrial matrix]
SIRT4 cleaves lipoyl from DLAT (Drosophila melanogaster)
H2O [mitochondrial matrix]
Respiratory electron transport (Drosophila melanogaster)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H2O [mitochondrial matrix]
Biological oxidations (Drosophila melanogaster)
Phase I - Functionalization of compounds (Drosophila melanogaster)
Ethanol oxidation (Drosophila melanogaster)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Branched-chain amino acid catabolism (Drosophila melanogaster)
ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)
H2O [mitochondrial matrix]
Choline catabolism (Drosophila melanogaster)
ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)
H2O [mitochondrial matrix]
SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Drosophila melanogaster)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Lysine catabolism (Drosophila melanogaster)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)
H2O [mitochondrial matrix]
Proline catabolism (Drosophila melanogaster)
PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Sulfide oxidation to sulfate (Drosophila melanogaster)
Persulfide sulfur is dioxygenated (Drosophila melanogaster)
H2O [mitochondrial matrix]
Sulfite is oxidized to sulfate (Drosophila melanogaster)
H2O [mitochondrial matrix]
Urea cycle (Drosophila melanogaster)
arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of lipids (Drosophila melanogaster)
Fatty acid metabolism (Drosophila melanogaster)
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Mitochondrial Fatty Acid Beta-Oxidation (Drosophila melanogaster)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Drosophila melanogaster)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Drosophila melanogaster)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Drosophila melanogaster)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Drosophila melanogaster)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Drosophila melanogaster)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Drosophila melanogaster)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Drosophila melanogaster)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Drosophila melanogaster)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Synthesis of PE (Drosophila melanogaster)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
Phosphate bond hydrolysis by NUDT proteins (Drosophila melanogaster)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
COX10 transforms heme to heme O (Drosophila melanogaster)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Ubiquinol biosynthesis (Drosophila melanogaster)
COQ6 hydroxylates DHB (Drosophila melanogaster)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Metabolism of folate and pterines (Drosophila melanogaster)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
H2O [mitochondrial matrix]
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Drosophila melanogaster)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)
H2O [mitochondrial matrix]
Metabolism of proteins (Drosophila melanogaster)
Mitochondrial protein degradation (Drosophila melanogaster)
AFG3L2 degrades mitochondrial inner membrane proteins (Drosophila melanogaster)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Drosophila melanogaster)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Drosophila melanogaster)
H2O [mitochondrial matrix]
CLPXP degrades mitochondrial matrix proteins (Drosophila melanogaster)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Drosophila melanogaster)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Drosophila melanogaster)
H2O [mitochondrial matrix]
Translation (Drosophila melanogaster)
tRNA Aminoacylation (Drosophila melanogaster)
Mitochondrial tRNA aminoacylation (Drosophila melanogaster)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Muscle contraction (Drosophila melanogaster)
Smooth Muscle Contraction (Drosophila melanogaster)
ALDH2 transforms GTN to NO (Drosophila melanogaster)
H2O [mitochondrial matrix]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
Degradation of GABA (Drosophila melanogaster)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Drosophila melanogaster)
glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)
H2O [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
Mitochondrial ABC transporters (Drosophila melanogaster)
ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Gallus gallus)
NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)
H2O [mitochondrial matrix]
Mitochondrial unfolded protein response (UPRmt) (Gallus gallus)
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Gallus gallus)
H2O [mitochondrial matrix]
DNA Repair (Gallus gallus)
Base Excision Repair (Gallus gallus)
Resolution of Abasic Sites (AP sites) (Gallus gallus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Gallus gallus)
POLB-Dependent Long Patch Base Excision Repair (Gallus gallus)
ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)
H2O [mitochondrial matrix]
Extracellular matrix organization (Gallus gallus)
Degradation of the extracellular matrix (Gallus gallus)
Collagen degradation (Gallus gallus)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)
H2O [mitochondrial matrix]
Metabolism (Gallus gallus)
Amino acid metabolism (Gallus gallus)
Arginine metabolism (Gallus gallus)
arginine + H2O => ornithine + urea (Gallus gallus)
H2O [mitochondrial matrix]
The tricarboxylic acid cycle (Gallus gallus)
acetyl-CoA + H2O + oxaloacetate => citrate + CoA (Gallus gallus)
H2O [mitochondrial matrix]
fumarate + H2O <=> malate (Gallus gallus)
H2O [mitochondrial matrix]
malate <=> fumarate + H2O (Gallus gallus)
H2O [mitochondrial matrix]
Metabolism of proteins (Gallus gallus)
Mitochondrial protein degradation (Gallus gallus)
AFG3L2 degrades mitochondrial inner membrane proteins (Gallus gallus)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Gallus gallus)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Gallus gallus)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Gallus gallus)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Gallus gallus)
H2O [mitochondrial matrix]
Translation (Gallus gallus)
tRNA Aminoacylation (Gallus gallus)
Mitochondrial tRNA aminoacylation (Gallus gallus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Gallus gallus)
H2O [mitochondrial matrix]
Muscle contraction (Gallus gallus)
Smooth Muscle Contraction (Gallus gallus)
ALDH2 transforms GTN to NO (Gallus gallus)
H2O [mitochondrial matrix]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter release cycle (Gallus gallus)
GABA synthesis, release, reuptake and degradation (Gallus gallus)
Degradation of GABA (Gallus gallus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Gallus gallus)
glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)
H2O [mitochondrial matrix]
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Regulation of Apoptosis (Gallus gallus)
OMA1 hydrolyses OPA1 (Gallus gallus)
H2O [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
Mitochondrial ABC transporters (Gallus gallus)
ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)
H2O [mitochondrial matrix]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H2O [mitochondrial matrix]
Detoxification of Reactive Oxygen Species (Homo sapiens)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
H2O [mitochondrial matrix]
NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)
H2O [mitochondrial matrix]
PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)
H2O [mitochondrial matrix]
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)
H2O [mitochondrial matrix]
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Homo sapiens)
H2O [mitochondrial matrix]
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)
H2O [mitochondrial matrix]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of branched-chain amino acid catabolism (Homo sapiens)
3-hydroxyisobutyryl-CoA hydrolase deficiency (Homo sapiens)
HIBCH mutants don't synthesize beta-hydroxyisobutyrate (Homo sapiens)
H2O [mitochondrial matrix]
3-methylglutaconic aciduria (Homo sapiens)
AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Maple Syrup Urine Disease (Homo sapiens)
H139Hfs13* PPM1K causes a mild variant of MSUD (Homo sapiens)
H139Hfs13* PPM1K does not dephosphorylate BCKDH (Homo sapiens)
H2O [mitochondrial matrix]
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 (Homo sapiens)
ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)
H2O [mitochondrial matrix]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
CS acetylates OA to citrate (Homo sapiens)
H2O [mitochondrial matrix]
FH tetramer hydrates fumarate to L-malate (Homo sapiens)
H2O [mitochondrial matrix]
Formation of ATP by chemiosmotic coupling (Homo sapiens)
ATPase synthesizes ATP (Homo sapiens)
H2O [mitochondrial matrix]
Pyruvate metabolism (Homo sapiens)
Mitochondrial H2O2 decarboxylates PYR to acetate (Homo sapiens)
H2O [mitochondrial matrix]
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
GS-MCA spontaneously hydrolyzes (Homo sapiens)
H2O [mitochondrial matrix]
PDP1,2 dephosphorylate p-lipo-PDH (Homo sapiens)
H2O [mitochondrial matrix]
SIRT4 cleaves lipoyl from DLAT (Homo sapiens)
H2O [mitochondrial matrix]
Respiratory electron transport (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H2O [mitochondrial matrix]
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B1 oxidises 11DCORT (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates CHOL (Homo sapiens)
H2O [mitochondrial matrix]
Vitamins (Homo sapiens)
CYP24A1 24-hydroxylates CTL (Homo sapiens)
H2O [mitochondrial matrix]
Ethanol oxidation (Homo sapiens)
ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)
H2O [mitochondrial matrix]
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)
H2O [mitochondrial matrix]
Phase II - Conjugation of compounds (Homo sapiens)
Glucuronidation (Homo sapiens)
ABHD10 hydrolyses MPAG (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
ECHS1 hydrates methacrylyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
PPM1K dephosphorylates p-BCKDH (Homo sapiens)
H2O [mitochondrial matrix]
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)
H2O [mitochondrial matrix]
beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Homo sapiens)
H2O [mitochondrial matrix]
tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Choline catabolism (Homo sapiens)
ALDH7A1 oxidises BETALD to BET (Homo sapiens)
H2O [mitochondrial matrix]
DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)
H2O [mitochondrial matrix]
SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)
H2O [mitochondrial matrix]
Glutamate and glutamine metabolism (Homo sapiens)
L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)
H2O [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)
H2O [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)
H2O [mitochondrial matrix]
glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)
H2O [mitochondrial matrix]
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)
H2O [mitochondrial matrix]
Lysine catabolism (Homo sapiens)
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)
H2O [mitochondrial matrix]
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Homo sapiens)
H2O [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)
H2O [mitochondrial matrix]
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)
H2O [mitochondrial matrix]
Proline catabolism (Homo sapiens)
1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)
H2O [mitochondrial matrix]
ALDH4A1 oxidises L-GluSS to Glu (Homo sapiens)
H2O [mitochondrial matrix]
PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)
H2O [mitochondrial matrix]
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
Sulfide oxidation to sulfate (Homo sapiens)
Persulfide sulfur is dioxygenated (Homo sapiens)
H2O [mitochondrial matrix]
Sulfite is oxidized to sulfate (Homo sapiens)
H2O [mitochondrial matrix]
Tryptophan catabolism (Homo sapiens)
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)
H2O [mitochondrial matrix]
Urea cycle (Homo sapiens)
arginine + H2O => ornithine + urea [ARG2] (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Homo sapiens)
Beta oxidation of butanoyl-CoA to acetyl-CoA (Homo sapiens)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Homo sapiens)
trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Homo sapiens)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Homo sapiens)
2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Homo sapiens)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Homo sapiens)
trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (Homo sapiens)
trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)
H2O [mitochondrial matrix]
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (Homo sapiens)
Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)
H2O [mitochondrial matrix]
Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Homo sapiens)
H2O [mitochondrial matrix]
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Homo sapiens)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
CYP27A1 27-hydroxylates CHOL (Homo sapiens)
H2O [mitochondrial matrix]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)
H2O [mitochondrial matrix]
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)
H2O [mitochondrial matrix]
5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)
H2O [mitochondrial matrix]
CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of steroid hormones (Homo sapiens)
Glucocorticoid biosynthesis (Homo sapiens)
CYP11B1 oxidises 11DCORT (Homo sapiens)
H2O [mitochondrial matrix]
Mineralocorticoid biosynthesis (Homo sapiens)
CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)
H2O [mitochondrial matrix]
CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)
H2O [mitochondrial matrix]
Pregnenolone biosynthesis (Homo sapiens)
CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)
H2O [mitochondrial matrix]
Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)
H2O [mitochondrial matrix]
Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)
H2O [mitochondrial matrix]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodeling of CL (Homo sapiens)
CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)
H2O [mitochondrial matrix]
MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)
H2O [mitochondrial matrix]
Acyl chain remodelling of PG (Homo sapiens)
PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Homo sapiens)
H2O [mitochondrial matrix]
PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)
H2O [mitochondrial matrix]
Synthesis of PA (Homo sapiens)
ACP6 hydrolyses MYS-LPA (Homo sapiens)
H2O [mitochondrial matrix]
Synthesis of PE (Homo sapiens)
PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)
H2O [mitochondrial matrix]
Synthesis of PG (Homo sapiens)
PTPMT1 dephosphorylates PGP to PG (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)
H2O [mitochondrial matrix]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
H2O [mitochondrial matrix]
Pyrimidine catabolism (Homo sapiens)
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
COX10 transforms heme to heme O (Homo sapiens)
H2O [mitochondrial matrix]
COX15 transforms heme O to heme A (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Ubiquinol biosynthesis (Homo sapiens)
COQ6 hydroxylates DHB (Homo sapiens)
H2O [mitochondrial matrix]
COQ7:COQ9 octamer hydroxylates DMQ10H2 (Homo sapiens)
H2O [mitochondrial matrix]
Unknown dehydrogenase oxidizes 4-HBz (Homo sapiens)
H2O [mitochondrial matrix]
Unknown enzyme hydroxylates DMPhOH (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
H2O [mitochondrial matrix]
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)
H2O [mitochondrial matrix]
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)
H2O [mitochondrial matrix]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
NUDT8 hydrolyzes CoA-SH to PPANT (Homo sapiens)
H2O [mitochondrial matrix]
Pyrophosphate hydrolysis (Homo sapiens)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)
H2O [mitochondrial matrix]
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)
H2O [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of RNA (Homo sapiens)
Mitochondrial RNA degradation (Homo sapiens)
REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides (Homo sapiens)
H2O [mitochondrial matrix]
SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides (Homo sapiens)
H2O [mitochondrial matrix]
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
AFG3L2 degrades mitochondrial inner membrane proteins (Homo sapiens)
H2O [mitochondrial matrix]
AFG3L2 degrades mitochondrial matrix proteins (Homo sapiens)
H2O [mitochondrial matrix]
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Homo sapiens)
H2O [mitochondrial matrix]
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial inner membrane proteins (Homo sapiens)
H2O [mitochondrial matrix]
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
H2O [mitochondrial matrix]
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)
H2O [mitochondrial matrix]
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ALDH2 transforms GTN to NO (Homo sapiens)
H2O [mitochondrial matrix]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Degradation of GABA (Homo sapiens)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)
H2O [mitochondrial matrix]
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)
H2O [mitochondrial matrix]
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Regulation of Apoptosis (Homo sapiens)
OMA1 hydrolyses OPA1 (Homo sapiens)
H2O [mitochondrial matrix]
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)
H2O [mitochondrial matrix]
MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)
H2O [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
Mitochondrial ABC transporters (Homo sapiens)