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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
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Developer's Zone
Graph Database
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Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
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Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
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PPi [nucleoplasm]
Stable Identifier
R-ALL-113541
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
pyrophosphate, diphosphoric acid, pyrophosphoric acid, diphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
PCNA-Dependent Long Patch Base Excision Repair (Bos taurus)
POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
POLB-mediated DNA strand displacement synthesis (Bos taurus)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Bos taurus)
Resynthesis of excised residue by POLB (Bos taurus)
PPi [nucleoplasm]
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Translesion Synthesis by POLH (Bos taurus)
Elongation by POLH (Bos taurus)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Bos taurus)
PPi [nucleoplasm]
Translesion synthesis by POLI (Bos taurus)
POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Bos taurus)
PPi [nucleoplasm]
Translesion synthesis by POLK (Bos taurus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Bos taurus)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Bos taurus)
POLZ extends translesion synthesis (Bos taurus)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
HDR through Homologous Recombination (HRR) (Bos taurus)
D-loop extension by DNA polymerases (Bos taurus)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Bos taurus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Bos taurus)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Bos taurus)
Translesion synthesis across unhooked ICL by POLN (Bos taurus)
PPi [nucleoplasm]
Mismatch Repair (Bos taurus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
PPi [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Bos taurus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
Active RNA Pol II complex transcribes lesion-containing DNA template (Bos taurus)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
PPi [nucleoplasm]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Bos taurus)
PPi [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX2 (Bos taurus)
PPM1D dephosphorylates RUNX2 (Bos taurus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Bos taurus)
RNA Polymerase II Promoter Escape (Bos taurus)
Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Bos taurus)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Bos taurus)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Bos taurus)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Bos taurus)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)
PPi [nucleoplasm]
Metabolism (Bos taurus)
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
dUTP + H2O => dUMP + pyrophosphate (Bos taurus)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
PPi [nucleoplasm]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Sialic acid metabolism (Bos taurus)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Bos taurus)
PPi [nucleoplasm]
Protein ubiquitination (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)
PPi [nucleoplasm]
SUMOylation (Bos taurus)
Processing and activation of SUMO (Bos taurus)
SUMO is conjugated to E1 (UBA2:SAE1) (Bos taurus)
Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)
PPi [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
Base Excision Repair (Caenorhabditis elegans)
Resolution of Abasic Sites (AP sites) (Caenorhabditis elegans)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Caenorhabditis elegans)
PCNA-Dependent Long Patch Base Excision Repair (Caenorhabditis elegans)
POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
PPi [nucleoplasm]
DNA Damage Bypass (Caenorhabditis elegans)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
Translesion Synthesis by POLH (Caenorhabditis elegans)
Elongation by POLH (Caenorhabditis elegans)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)
PPi [nucleoplasm]
Translesion synthesis by POLI (Caenorhabditis elegans)
POLI incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
PPi [nucleoplasm]
Translesion synthesis by POLK (Caenorhabditis elegans)
POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
PPi [nucleoplasm]
Mismatch Repair (Caenorhabditis elegans)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
PPi [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Gap-filling DNA repair synthesis and ligation in GG-NER (Caenorhabditis elegans)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
PPi [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Caenorhabditis elegans)
PPi [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase II Promoter Escape (Caenorhabditis elegans)
Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Caenorhabditis elegans)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Caenorhabditis elegans)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)
PPi [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Nicotinate metabolism (Caenorhabditis elegans)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
PPi [nucleoplasm]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Protein ubiquitination (Caenorhabditis elegans)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)
PPi [nucleoplasm]
SUMOylation (Caenorhabditis elegans)
Processing and activation of SUMO (Caenorhabditis elegans)
SUMO is conjugated to E1 (UBA2:SAE1) (Caenorhabditis elegans)
Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)
PPi [nucleoplasm]
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Canis familiaris)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Canis familiaris)
PCNA-Dependent Long Patch Base Excision Repair (Canis familiaris)
POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Canis familiaris)
POLB-mediated DNA strand displacement synthesis (Canis familiaris)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Canis familiaris)
Resynthesis of excised residue by POLB (Canis familiaris)
PPi [nucleoplasm]
DNA Damage Bypass (Canis familiaris)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Canis familiaris)
Translesion Synthesis by POLH (Canis familiaris)
Elongation by POLH (Canis familiaris)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Canis familiaris)
PPi [nucleoplasm]
Translesion synthesis by POLI (Canis familiaris)
POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Canis familiaris)
PPi [nucleoplasm]
Translesion synthesis by POLK (Canis familiaris)
POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Canis familiaris)
POLZ extends translesion synthesis (Canis familiaris)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
HDR through Homologous Recombination (HRR) (Canis familiaris)
D-loop extension by DNA polymerases (Canis familiaris)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Canis familiaris)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Canis familiaris)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Canis familiaris)
Translesion synthesis across unhooked ICL by POLN (Canis familiaris)
PPi [nucleoplasm]
Mismatch Repair (Canis familiaris)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Canis familiaris)
DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Canis familiaris)
DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)
PPi [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in GG-NER (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
PPi [nucleoplasm]
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Canis familiaris)
PPi [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX2 (Canis familiaris)
PPM1D dephosphorylates RUNX2 (Canis familiaris)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Canis familiaris)
RNA Polymerase II Promoter Escape (Canis familiaris)
Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Canis familiaris)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Canis familiaris)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Canis familiaris)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Canis familiaris)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)
PPi [nucleoplasm]
Metabolism (Canis familiaris)
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Nicotinate metabolism (Canis familiaris)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
PPi [nucleoplasm]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
Sialic acid metabolism (Canis familiaris)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)
PPi [nucleoplasm]
Protein ubiquitination (Canis familiaris)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Canis familiaris)
UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)
PPi [nucleoplasm]
SUMOylation (Canis familiaris)
Processing and activation of SUMO (Canis familiaris)
SUMO is conjugated to E1 (UBA2:SAE1) (Canis familiaris)
Conjugation of SUMO1 to UBA2:SAE1 (Canis familiaris)
PPi [nucleoplasm]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Danio rerio)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Danio rerio)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Danio rerio)
POLB-mediated DNA strand displacement synthesis (Danio rerio)
PPi [nucleoplasm]
DNA Damage Bypass (Danio rerio)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Danio rerio)
Translesion Synthesis by POLH (Danio rerio)
Elongation by POLH (Danio rerio)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Danio rerio)
PPi [nucleoplasm]
Translesion synthesis by POLI (Danio rerio)
POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)
PPi [nucleoplasm]
Developmental Biology (Danio rerio)
MITF-M-regulated melanocyte development (Danio rerio)
Transcriptional and post-translational regulation of MITF-M expression and activity (Danio rerio)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Danio rerio)
PPi [nucleoplasm]
Metabolism (Danio rerio)
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
dUTP + H2O => dUMP + pyrophosphate (Danio rerio)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
PPi [nucleoplasm]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)
PPi [nucleoplasm]
Protein ubiquitination (Danio rerio)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Danio rerio)
UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)
PPi [nucleoplasm]
SUMOylation (Danio rerio)
Processing and activation of SUMO (Danio rerio)
SUMO is conjugated to E1 (UBA2:SAE1) (Danio rerio)
Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)
PPi [nucleoplasm]
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Dictyostelium discoideum)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Dictyostelium discoideum)
PCNA-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
POLD,POLE-mediated DNA strand displacement synthesis (Dictyostelium discoideum)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Dictyostelium discoideum)
Resynthesis of excised residue by POLB (Dictyostelium discoideum)
PPi [nucleoplasm]
DNA Damage Bypass (Dictyostelium discoideum)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Dictyostelium discoideum)
Translesion synthesis by POLK (Dictyostelium discoideum)
POLK incorporates dNMP opposite to damaged DNA base (Dictyostelium discoideum)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Dictyostelium discoideum)
Nonhomologous End-Joining (NHEJ) (Dictyostelium discoideum)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)
PPi [nucleoplasm]
Mismatch Repair (Dictyostelium discoideum)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Dictyostelium discoideum)
DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Dictyostelium discoideum)
DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)
PPi [nucleoplasm]
Nucleotide Excision Repair (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
Gap-filling DNA repair synthesis and ligation in GG-NER (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Dictyostelium discoideum)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Formation of TC-NER Pre-Incision Complex (Dictyostelium discoideum)
Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)
PPi [nucleoplasm]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Dictyostelium discoideum)
RNA Polymerase II Promoter Escape (Dictyostelium discoideum)
Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Dictyostelium discoideum)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Dictyostelium discoideum)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)
PPi [nucleoplasm]
Metabolism (Dictyostelium discoideum)
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Nicotinate metabolism (Dictyostelium discoideum)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
PPi [nucleoplasm]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Protein ubiquitination (Dictyostelium discoideum)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Dictyostelium discoideum)
UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)
PPi [nucleoplasm]
SUMOylation (Dictyostelium discoideum)
Processing and activation of SUMO (Dictyostelium discoideum)
SUMO is conjugated to E1 (UBA2:SAE1) (Dictyostelium discoideum)
Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)
PPi [nucleoplasm]
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
PCNA-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
PPi [nucleoplasm]
DNA Damage Bypass (Drosophila melanogaster)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Drosophila melanogaster)
Translesion Synthesis by POLH (Drosophila melanogaster)
Elongation by POLH (Drosophila melanogaster)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)
PPi [nucleoplasm]
Translesion synthesis by POLI (Drosophila melanogaster)
POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)
PPi [nucleoplasm]
Translesion synthesis by POLK (Drosophila melanogaster)
POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Drosophila melanogaster)
POLZ extends translesion synthesis (Drosophila melanogaster)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)
PPi [nucleoplasm]
Mismatch Repair (Drosophila melanogaster)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Drosophila melanogaster)
DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Drosophila melanogaster)
DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)
PPi [nucleoplasm]
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in GG-NER (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
PPi [nucleoplasm]
Developmental Biology (Drosophila melanogaster)
MITF-M-regulated melanocyte development (Drosophila melanogaster)
Transcriptional and post-translational regulation of MITF-M expression and activity (Drosophila melanogaster)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Drosophila melanogaster)
PPi [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Drosophila melanogaster)
RNA Polymerase II Promoter Escape (Drosophila melanogaster)
Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Drosophila melanogaster)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Drosophila melanogaster)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)
PPi [nucleoplasm]
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Nicotinate metabolism (Drosophila melanogaster)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
PPi [nucleoplasm]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Protein ubiquitination (Drosophila melanogaster)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Drosophila melanogaster)
UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)
PPi [nucleoplasm]
DNA Repair (Gallus gallus)
DNA Damage Bypass (Gallus gallus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Gallus gallus)
Translesion Synthesis by POLH (Gallus gallus)
Elongation by POLH (Gallus gallus)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Gallus gallus)
PPi [nucleoplasm]
Translesion synthesis by POLI (Gallus gallus)
POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Gallus gallus)
PPi [nucleoplasm]
Translesion synthesis by POLK (Gallus gallus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Gallus gallus)
POLZ extends translesion synthesis (Gallus gallus)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Gallus gallus)
Homology Directed Repair (Gallus gallus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
HDR through Homologous Recombination (HRR) (Gallus gallus)
D-loop extension by DNA polymerases (Gallus gallus)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Gallus gallus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Gallus gallus)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)
PPi [nucleoplasm]
Mismatch Repair (Gallus gallus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Gallus gallus)
DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Gallus gallus)
DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)
PPi [nucleoplasm]
Nucleotide Excision Repair (Gallus gallus)
Global Genome Nucleotide Excision Repair (GG-NER) (Gallus gallus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Gallus gallus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
Formation of TC-NER Pre-Incision Complex (Gallus gallus)
Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Gallus gallus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)
PPi [nucleoplasm]
DNA replication and repair (Gallus gallus)
Telomere maintenance (Gallus gallus)
Assembly of telomerase and telomere extension (Gallus gallus)
Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)
PPi [nucleoplasm]
Elongation and translocation of the telomeric chromosome end (Gallus gallus)
PPi [nucleoplasm]
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Gallus gallus)
PPi [nucleoplasm]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX2 (Gallus gallus)
PPM1D dephosphorylates RUNX2 (Gallus gallus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Gallus gallus)
RNA Polymerase II Promoter Escape (Gallus gallus)
Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Gallus gallus)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Gallus gallus)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Gallus gallus)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Gallus gallus)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)
PPi [nucleoplasm]
Metabolism (Gallus gallus)
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
dUTP + H2O => dUMP + pyrophosphate (Gallus gallus)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Nicotinate metabolism (Gallus gallus)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Gallus gallus)
PPi [nucleoplasm]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
Sialic acid metabolism (Gallus gallus)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)
PPi [nucleoplasm]
Protein ubiquitination (Gallus gallus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Gallus gallus)
UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)
PPi [nucleoplasm]
SUMOylation (Gallus gallus)
Processing and activation of SUMO (Gallus gallus)
SUMO is conjugated to E1 (UBA2:SAE1) (Gallus gallus)
Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)
PPi [nucleoplasm]
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
POLB-mediated DNA strand displacement synthesis (Homo sapiens)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Resynthesis of excised residue by POLB (Homo sapiens)
PPi [nucleoplasm]
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
PPi [nucleoplasm]
Translesion Synthesis by POLH (Homo sapiens)
Elongation by POLH (Homo sapiens)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Homo sapiens)
PPi [nucleoplasm]
Translesion synthesis by POLI (Homo sapiens)
POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Homo sapiens)
PPi [nucleoplasm]
Translesion synthesis by POLK (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Homo sapiens)
POLZ extends translesion synthesis (Homo sapiens)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
PPi [nucleoplasm]
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)
PPi [nucleoplasm]
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
PPi [nucleoplasm]
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Homo sapiens)
PPi [nucleoplasm]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
HIV Transcription Initiation (Homo sapiens)
Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)
PPi [nucleoplasm]
RNA Polymerase II HIV Promoter Escape (Homo sapiens)
Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)
PPi [nucleoplasm]
Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)
PPi [nucleoplasm]
Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)
PPi [nucleoplasm]
Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)
PPi [nucleoplasm]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
PPM1D dephosphorylates RUNX2 (Homo sapiens)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Homo sapiens)
RNA Polymerase II Promoter Escape (Homo sapiens)
Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Homo sapiens)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Homo sapiens)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Homo sapiens)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Homo sapiens)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)
PPi [nucleoplasm]
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
PPi [nucleoplasm]
Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)
PPi [nucleoplasm]
tRNA ligase complex ligates tRNA exons (Homo sapiens)
PPi [nucleoplasm]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)
PPi [nucleoplasm]
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)
PPi [nucleoplasm]
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)
Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)
PPi [nucleoplasm]
Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)
PPi [nucleoplasm]
Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)
PPi [nucleoplasm]
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Mus musculus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
PCNA-Dependent Long Patch Base Excision Repair (Mus musculus)
POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
POLB-mediated DNA strand displacement synthesis (Mus musculus)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Mus musculus)
Resynthesis of excised residue by POLB (Mus musculus)
PPi [nucleoplasm]
DNA Damage Bypass (Mus musculus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Mus musculus)
Translesion Synthesis by POLH (Mus musculus)
Elongation by POLH (Mus musculus)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Mus musculus)
PPi [nucleoplasm]
Translesion synthesis by POLI (Mus musculus)
POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Mus musculus)
PPi [nucleoplasm]
Translesion synthesis by POLK (Mus musculus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Mus musculus)
POLZ extends translesion synthesis (Mus musculus)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
HDR through Homologous Recombination (HRR) (Mus musculus)
D-loop extension by DNA polymerases (Mus musculus)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Mus musculus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Mus musculus)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Mus musculus)
Translesion synthesis across unhooked ICL by POLN (Mus musculus)
PPi [nucleoplasm]
Mismatch Repair (Mus musculus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Mus musculus)
DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Mus musculus)
DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)
PPi [nucleoplasm]
Nucleotide Excision Repair (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
PPi [nucleoplasm]
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Mus musculus)
PPi [nucleoplasm]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
PPM1D dephosphorylates RUNX2 (Mus musculus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Mus musculus)
RNA Polymerase II Promoter Escape (Mus musculus)
Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Mus musculus)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Mus musculus)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Mus musculus)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Mus musculus)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)
PPi [nucleoplasm]
Metabolism (Mus musculus)
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
dUTP + H2O => dUMP + pyrophosphate (Mus musculus)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Nicotinate metabolism (Mus musculus)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
PPi [nucleoplasm]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
Sialic acid metabolism (Mus musculus)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)
PPi [nucleoplasm]
Protein ubiquitination (Mus musculus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Mus musculus)
UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)
PPi [nucleoplasm]
SUMOylation (Mus musculus)
Processing and activation of SUMO (Mus musculus)
SUMO is conjugated to E1 (UBA2:SAE1) (Mus musculus)
Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)
PPi [nucleoplasm]
DNA Repair (Plasmodium falciparum)
Base Excision Repair (Plasmodium falciparum)
Resolution of Abasic Sites (AP sites) (Plasmodium falciparum)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Plasmodium falciparum)
PCNA-Dependent Long Patch Base Excision Repair (Plasmodium falciparum)
POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)
PPi [nucleoplasm]
DNA Damage Bypass (Plasmodium falciparum)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Plasmodium falciparum)
Translesion Synthesis by POLH (Plasmodium falciparum)
Elongation by POLH (Plasmodium falciparum)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)
PPi [nucleoplasm]
Translesion synthesis by POLI (Plasmodium falciparum)
POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)
PPi [nucleoplasm]
Translesion synthesis by POLK (Plasmodium falciparum)
POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Plasmodium falciparum)
POLZ extends translesion synthesis (Plasmodium falciparum)
PPi [nucleoplasm]
Mismatch Repair (Plasmodium falciparum)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Plasmodium falciparum)
DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Plasmodium falciparum)
DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)
PPi [nucleoplasm]
Nucleotide Excision Repair (Plasmodium falciparum)
Global Genome Nucleotide Excision Repair (GG-NER) (Plasmodium falciparum)
Gap-filling DNA repair synthesis and ligation in GG-NER (Plasmodium falciparum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Plasmodium falciparum)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Plasmodium falciparum)
Formation of TC-NER Pre-Incision Complex (Plasmodium falciparum)
Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Plasmodium falciparum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Plasmodium falciparum)
PPi [nucleoplasm]
Gene expression (Transcription) (Plasmodium falciparum)
RNA Polymerase II Transcription (Plasmodium falciparum)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Plasmodium falciparum)
RNA Polymerase II Promoter Escape (Plasmodium falciparum)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)
PPi [nucleoplasm]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)
PPi [nucleoplasm]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Protein ubiquitination (Plasmodium falciparum)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Plasmodium falciparum)
UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)
PPi [nucleoplasm]
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Rattus norvegicus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
PCNA-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Rattus norvegicus)
Resynthesis of excised residue by POLB (Rattus norvegicus)
PPi [nucleoplasm]
DNA Damage Bypass (Rattus norvegicus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Rattus norvegicus)
Translesion Synthesis by POLH (Rattus norvegicus)
Elongation by POLH (Rattus norvegicus)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)
PPi [nucleoplasm]
Translesion synthesis by POLI (Rattus norvegicus)
POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)
PPi [nucleoplasm]
Translesion synthesis by POLK (Rattus norvegicus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Rattus norvegicus)
POLZ extends translesion synthesis (Rattus norvegicus)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
HDR through Homologous Recombination (HRR) (Rattus norvegicus)
D-loop extension by DNA polymerases (Rattus norvegicus)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Rattus norvegicus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Rattus norvegicus)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Rattus norvegicus)
Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
PPi [nucleoplasm]
Mismatch Repair (Rattus norvegicus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Rattus norvegicus)
DNA ligase I ligates single stranded nick in double stranded DNA (Rattus norvegicus)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Rattus norvegicus)
DNA ligase I ligates single stranded nick in double stranded DNA (Rattus norvegicus)
PPi [nucleoplasm]
Nucleotide Excision Repair (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
PPi [nucleoplasm]
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Rattus norvegicus)
PPi [nucleoplasm]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Rattus norvegicus)
RNA Polymerase II Promoter Escape (Rattus norvegicus)
Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Rattus norvegicus)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Rattus norvegicus)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Rattus norvegicus)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)
PPi [nucleoplasm]
Metabolism (Rattus norvegicus)
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Nicotinate metabolism (Rattus norvegicus)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
PPi [nucleoplasm]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
Sialic acid metabolism (Rattus norvegicus)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)
PPi [nucleoplasm]
Protein ubiquitination (Rattus norvegicus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Rattus norvegicus)
UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)
PPi [nucleoplasm]
SUMOylation (Rattus norvegicus)
Processing and activation of SUMO (Rattus norvegicus)
SUMO is conjugated to E1 (UBA2:SAE1) (Rattus norvegicus)
Conjugation of SUMO1 to UBA2:SAE1 (Rattus norvegicus)
PPi [nucleoplasm]
DNA Repair (Saccharomyces cerevisiae)
DNA Damage Bypass (Saccharomyces cerevisiae)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Saccharomyces cerevisiae)
Translesion Synthesis by POLH (Saccharomyces cerevisiae)
Elongation by POLH (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Translesion synthesis by POLI (Saccharomyces cerevisiae)
POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Translesion synthesis by POLK (Saccharomyces cerevisiae)
POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Saccharomyces cerevisiae)
POLZ extends translesion synthesis (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Mismatch Repair (Saccharomyces cerevisiae)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Saccharomyces cerevisiae)
DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Saccharomyces cerevisiae)
DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Nucleotide Excision Repair (Saccharomyces cerevisiae)
Global Genome Nucleotide Excision Repair (GG-NER) (Saccharomyces cerevisiae)
Gap-filling DNA repair synthesis and ligation in GG-NER (Saccharomyces cerevisiae)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Saccharomyces cerevisiae)
Formation of TC-NER Pre-Incision Complex (Saccharomyces cerevisiae)
Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Saccharomyces cerevisiae)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Saccharomyces cerevisiae)
RNA Polymerase II Promoter Escape (Saccharomyces cerevisiae)
Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Saccharomyces cerevisiae)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Nicotinate metabolism (Saccharomyces cerevisiae)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Protein ubiquitination (Saccharomyces cerevisiae)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the nucleoplasm (Saccharomyces cerevisiae)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Saccharomyces cerevisiae)
PPi [nucleoplasm]
SUMOylation (Saccharomyces cerevisiae)
Processing and activation of SUMO (Saccharomyces cerevisiae)
SUMO is conjugated to E1 (UBA2:SAE1) (Saccharomyces cerevisiae)
Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)
PPi [nucleoplasm]
DNA Repair (Schizosaccharomyces pombe)
Base Excision Repair (Schizosaccharomyces pombe)
Resolution of Abasic Sites (AP sites) (Schizosaccharomyces pombe)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Schizosaccharomyces pombe)
PCNA-Dependent Long Patch Base Excision Repair (Schizosaccharomyces pombe)
POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)
PPi [nucleoplasm]
DNA Damage Bypass (Schizosaccharomyces pombe)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Schizosaccharomyces pombe)
Translesion Synthesis by POLH (Schizosaccharomyces pombe)
Elongation by POLH (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Translesion synthesis by POLI (Schizosaccharomyces pombe)
POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Translesion synthesis by POLK (Schizosaccharomyces pombe)
POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Schizosaccharomyces pombe)
POLZ extends translesion synthesis (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Mismatch Repair (Schizosaccharomyces pombe)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Schizosaccharomyces pombe)
DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Schizosaccharomyces pombe)
DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Nucleotide Excision Repair (Schizosaccharomyces pombe)
Global Genome Nucleotide Excision Repair (GG-NER) (Schizosaccharomyces pombe)
Gap-filling DNA repair synthesis and ligation in GG-NER (Schizosaccharomyces pombe)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Schizosaccharomyces pombe)
Formation of TC-NER Pre-Incision Complex (Schizosaccharomyces pombe)
Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Schizosaccharomyces pombe)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Schizosaccharomyces pombe)
RNA Polymerase II Promoter Escape (Schizosaccharomyces pombe)
Addition of Nucleotides 5 through 9 on the growing Transcript (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Schizosaccharomyces pombe)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Nicotinate metabolism (Schizosaccharomyces pombe)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Protein ubiquitination (Schizosaccharomyces pombe)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Schizosaccharomyces pombe)
UBA1 adenylates ubiquitin in the nucleoplasm (Schizosaccharomyces pombe)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Schizosaccharomyces pombe)
PPi [nucleoplasm]
SUMOylation (Schizosaccharomyces pombe)
Processing and activation of SUMO (Schizosaccharomyces pombe)
SUMO is conjugated to E1 (UBA2:SAE1) (Schizosaccharomyces pombe)
Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)
PPi [nucleoplasm]
DNA Repair (Sus scrofa)
Base Excision Repair (Sus scrofa)
Resolution of Abasic Sites (AP sites) (Sus scrofa)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Sus scrofa)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
PCNA-Dependent Long Patch Base Excision Repair (Sus scrofa)
POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
POLB-mediated DNA strand displacement synthesis (Sus scrofa)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Sus scrofa)
Resynthesis of excised residue by POLB (Sus scrofa)
PPi [nucleoplasm]
DNA Damage Bypass (Sus scrofa)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Sus scrofa)
Translesion Synthesis by POLH (Sus scrofa)
Elongation by POLH (Sus scrofa)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Sus scrofa)
PPi [nucleoplasm]
Translesion synthesis by POLI (Sus scrofa)
POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Sus scrofa)
PPi [nucleoplasm]
Translesion synthesis by POLK (Sus scrofa)
POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Sus scrofa)
POLZ extends translesion synthesis (Sus scrofa)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
HDR through Homologous Recombination (HRR) (Sus scrofa)
D-loop extension by DNA polymerases (Sus scrofa)
PPi [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Sus scrofa)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)
PPi [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Sus scrofa)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)
PPi [nucleoplasm]
Fanconi Anemia Pathway (Sus scrofa)
Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
PPi [nucleoplasm]
Mismatch Repair (Sus scrofa)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Sus scrofa)
DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)
PPi [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Sus scrofa)
DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)
PPi [nucleoplasm]
Nucleotide Excision Repair (Sus scrofa)
Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
Gap-filling DNA repair synthesis and ligation in GG-NER (Sus scrofa)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
Formation of TC-NER Pre-Incision Complex (Sus scrofa)
Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
PPi [nucleoplasm]
Developmental Biology (Sus scrofa)
MITF-M-regulated melanocyte development (Sus scrofa)
Transcriptional and post-translational regulation of MITF-M expression and activity (Sus scrofa)
p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Sus scrofa)
PPi [nucleoplasm]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional regulation by RUNX2 (Sus scrofa)
PPM1D dephosphorylates RUNX2 (Sus scrofa)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Sus scrofa)
RNA Polymerase II Promoter Escape (Sus scrofa)
Addition of Nucleotides 5 through 9 on the growing Transcript (Sus scrofa)
PPi [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Sus scrofa)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Sus scrofa)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Sus scrofa)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Sus scrofa)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)
PPi [nucleoplasm]
Metabolism (Sus scrofa)
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)
PPi [nucleoplasm]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Nicotinate metabolism (Sus scrofa)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
PPi [nucleoplasm]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
Sialic acid metabolism (Sus scrofa)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)
PPi [nucleoplasm]
Protein ubiquitination (Sus scrofa)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Sus scrofa)
UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)
PPi [nucleoplasm]
SUMOylation (Sus scrofa)
Processing and activation of SUMO (Sus scrofa)
SUMO is conjugated to E1 (UBA2:SAE1) (Sus scrofa)
Conjugation of SUMO1 to UBA2:SAE1 (Sus scrofa)
PPi [nucleoplasm]
DNA Repair (Xenopus tropicalis)
Base Excision Repair (Xenopus tropicalis)
Resolution of Abasic Sites (AP sites) (Xenopus tropicalis)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Xenopus tropicalis)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)
PPi [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Xenopus tropicalis)
PCNA-Dependent Long Patch Base Excision Repair (Xenopus tropicalis)
POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)
PPi [nucleoplasm]
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)
PPi [nucleoplasm]
POLB-Dependent Long Patch Base Excision Repair (Xenopus tropicalis)
POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)
PPi [nucleoplasm]
Resolution of AP sites via the single-nucleotide replacement pathway (Xenopus tropicalis)
Resynthesis of excised residue by POLB (Xenopus tropicalis)
PPi [nucleoplasm]
DNA Damage Bypass (Xenopus tropicalis)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Xenopus tropicalis)
Translesion Synthesis by POLH (Xenopus tropicalis)
Elongation by POLH (Xenopus tropicalis)
PPi [nucleoplasm]
Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)
PPi [nucleoplasm]
Translesion synthesis by POLI (Xenopus tropicalis)
POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
PPi [nucleoplasm]
POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)
PPi [nucleoplasm]
Translesion synthesis by POLK (Xenopus tropicalis)
POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)
PPi [nucleoplasm]
POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
PPi [nucleoplasm]
Translesion synthesis by REV1 (Xenopus tropicalis)
POLZ extends translesion synthesis (Xenopus tropicalis)
PPi [nucleoplasm]
DNA Double-Strand Break Repair (Xenopus tropicalis)
Nonhomologous End-Joining (NHEJ) (Xenopus tropicalis)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)
PPi [nucleoplasm]
Nucleotide Excision Repair (Xenopus tropicalis)
Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
Gap-filling DNA repair synthesis and ligation in GG-NER (Xenopus tropicalis)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)
PPi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
Formation of TC-NER Pre-Incision Complex (Xenopus tropicalis)
Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)
PPi [nucleoplasm]
Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
PPi [nucleoplasm]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Xenopus tropicalis)
RNA Polymerase II Promoter Escape (Xenopus tropicalis)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)
PPi [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Xenopus tropicalis)
PPi [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)
PPi [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)
PPi [nucleoplasm]
Unwinding DNA for the nascent transcript (Xenopus tropicalis)
PPi [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)
PPi [nucleoplasm]
RNA Polymerase II Transcription Initiation (Xenopus tropicalis)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Xenopus tropicalis)
PPi [nucleoplasm]
Metabolism (Xenopus tropicalis)
Metabolism of nucleotides (Xenopus tropicalis)
Interconversion of nucleotide di- and triphosphates (Xenopus tropicalis)
dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)
PPi [nucleoplasm]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
Sialic acid metabolism (Xenopus tropicalis)
CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Xenopus tropicalis)
PPi [nucleoplasm]
Protein ubiquitination (Xenopus tropicalis)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Xenopus tropicalis)
UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)
PPi [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)
PPi [nucleoplasm]
SUMOylation (Xenopus tropicalis)
Processing and activation of SUMO (Xenopus tropicalis)
SUMO is conjugated to E1 (UBA2:SAE1) (Xenopus tropicalis)
Conjugation of SUMO1 to UBA2:SAE1 (Xenopus tropicalis)
PPi [nucleoplasm]
External Reference Information
External Reference
diphosphate(3-) [ChEBI:33019]
Participates
as an output of
Elongation and translocation of the telomeric chromosome end (Gallus gallus)
Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)
tRNA ligase complex ligates tRNA exons (Homo sapiens)
TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Saccharomyces cerevisiae)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Schizosaccharomyces pombe)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)
UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)
UBA1 adenylates ubiquitin in the nucleoplasm (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the nucleoplasm (Schizosaccharomyces pombe)
UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)
UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)
UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)
UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)
UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)
UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)
UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)
UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)
UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)
UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)
UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)
POLZ elongates POLI-incorporated dNMP (Saccharomyces cerevisiae)
POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)
POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)
POLZ elongates POLI-incorporated dNMP (Gallus gallus)
POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)
POLZ elongates POLI-incorporated dNMP (Sus scrofa)
POLZ elongates POLI-incorporated dNMP (Bos taurus)
POLZ elongates POLI-incorporated dNMP (Canis familiaris)
POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)
POLZ elongates POLI-incorporated dNMP (Mus musculus)
POLZ elongates POLI-incorporated dNMP (Homo sapiens)
POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)
POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
POLI incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)
POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)
POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)
POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)
POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)
POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)
POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLZ extends translesion synthesis (Plasmodium falciparum)
POLZ extends translesion synthesis (Saccharomyces cerevisiae)
POLZ extends translesion synthesis (Schizosaccharomyces pombe)
POLZ extends translesion synthesis (Drosophila melanogaster)
POLZ extends translesion synthesis (Gallus gallus)
POLZ extends translesion synthesis (Xenopus tropicalis)
POLZ extends translesion synthesis (Sus scrofa)
POLZ extends translesion synthesis (Bos taurus)
POLZ extends translesion synthesis (Canis familiaris)
POLZ extends translesion synthesis (Rattus norvegicus)
POLZ extends translesion synthesis (Mus musculus)
POLZ extends translesion synthesis (Homo sapiens)
Elongation by POLH (Plasmodium falciparum)
Elongation by POLH (Saccharomyces cerevisiae)
Elongation by POLH (Schizosaccharomyces pombe)
Elongation by POLH (Caenorhabditis elegans)
Elongation by POLH (Drosophila melanogaster)
Elongation by POLH (Gallus gallus)
Elongation by POLH (Xenopus tropicalis)
Elongation by POLH (Danio rerio)
Elongation by POLH (Sus scrofa)
Elongation by POLH (Bos taurus)
Elongation by POLH (Canis familiaris)
Elongation by POLH (Rattus norvegicus)
Elongation by POLH (Mus musculus)
Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)
Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)
Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)
Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)
Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)
Insertion of correct bases opposite the lesion by POLH (Gallus gallus)
Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)
Insertion of correct bases opposite the lesion by POLH (Danio rerio)
Insertion of correct bases opposite the lesion by POLH (Sus scrofa)
Insertion of correct bases opposite the lesion by POLH (Bos taurus)
Insertion of correct bases opposite the lesion by POLH (Canis familiaris)
Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)
Insertion of correct bases opposite the lesion by POLH (Mus musculus)
Insertion of correct bases opposite the lesion by POLH (Homo sapiens)
Elongation by POLH (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)
POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)
POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)
POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)
POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)
POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)
POLK and POLZ cooperate in elongation of mispaired primer termini (Bos taurus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)
POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)
POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
POLK incorporates dNMP opposite to damaged DNA base (Dictyostelium discoideum)
POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)
POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)
POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)
POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)
POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)
POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
Resynthesis of excised residue by POLB (Dictyostelium discoideum)
Resynthesis of excised residue by POLB (Xenopus tropicalis)
Resynthesis of excised residue by POLB (Sus scrofa)
Resynthesis of excised residue by POLB (Bos taurus)
Resynthesis of excised residue by POLB (Canis familiaris)
Resynthesis of excised residue by POLB (Rattus norvegicus)
Resynthesis of excised residue by POLB (Mus musculus)
Resynthesis of excised residue by POLB (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)
POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)
POLD,POLE-mediated DNA strand displacement synthesis (Dictyostelium discoideum)
POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)
POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)
POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)
POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)
POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)