Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
O2.- [cytosol]
Stable Identifier
R-ALL-1222424
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
SO2.-, superoxide
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
O2.- [cytosol]
Metabolism (Bos taurus)
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
O2.- [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
O2.- [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
O2.- [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
O2.- [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
O2.- [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
O2.- [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
O2.- [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
O2.- [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
O2.- [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
NOX2 generates superoxide from oxygen (Gallus gallus)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)
O2.- [cytosol]
Metabolism (Gallus gallus)
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
O2.- [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
BIL scavenges O2.- (Homo sapiens)
O2.- [cytosol]
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
O2.- [cytosol]
Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)
O2.- [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
O2.- [cytosol]
SodC reduces superoxide to H2O2 (Homo sapiens)
O2.- [cytosol]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
Semiquinone reacts with oxygen (Homo sapiens)
O2.- [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)
O2.- [cytosol]
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)
O2.- [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
O2.- [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
NOX2 generates superoxide from oxygen (Mus musculus)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Mus musculus)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)
O2.- [cytosol]
Metabolism (Mus musculus)
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
eNOS activation (Mus musculus)
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
O2.- [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of nitric oxide: NOS3 activation and regulation (Plasmodium falciparum)
eNOS activation (Plasmodium falciparum)
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
O2.- [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)
O2.- [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
O2.- [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
NOX4, NOX5 reduce O2 to O2.- (Saccharomyces cerevisiae)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
O2.- [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
eNOS activation (Saccharomyces cerevisiae)
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
O2.- [cytosol]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
O2.- [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
O2.- [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Detoxification of Reactive Oxygen Species (Sus scrofa)
NOX2 generates superoxide from oxygen (Sus scrofa)
O2.- [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)
O2.- [cytosol]
Metabolism (Sus scrofa)
Metabolism of nitric oxide: NOS3 activation and regulation (Sus scrofa)
eNOS activation (Sus scrofa)
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
O2.- [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
O2.- [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)
O2.- [cytosol]
External Reference Information
External Reference
superoxide [ChEBI:18421]
Participates
as an input of
BIL scavenges O2.- (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
SodC reduces superoxide to H2O2 (Homo sapiens)
Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)
as an output of
NOX4, NOX5 reduce O2 to O2.- (Saccharomyces cerevisiae)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
Semiquinone reacts with oxygen (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
NOX2 generates superoxide from oxygen (Mus musculus)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 generates superoxide from oxygen (Sus scrofa)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)
NOX4, NOX5 reduce O2 to O2.- (Mus musculus)
NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)
NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)
Other forms of this molecule
O2.- [phagolysosome]
O2- [cytoplasm]
O2.- [phagocytic vesicle lumen]
O2- [mitochondrial intermembrane space]
O2.- [extracellular region]
O2.- [mitochondrial matrix]
Cross References
COMPOUND
C00704
HMDB Metabolite
HMDB0002168
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text