Reactome | Zn2+ [extracellular region]

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Zn2+ [extracellular region]

Stable Identifier

R-ALL-158417

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

Zn++, zinc(2+), Zinc ion, Zn(II)

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Cellular responses to external stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Detoxification of Reactive Oxygen Species (Bos taurus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)
      - SOD3 tetramer [extracellular region] (Bos taurus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Bos taurus)
      - SOD3 tetramer [extracellular region] (Bos taurus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]

Hemostasis (Bos taurus)

- Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
  - Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)
      - Zn2+ [extracellular region]

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Growth hormone receptor signaling (Bos taurus)
    - JAK2 phosphorylation (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Bos taurus)
    - JAK2 phosphorylation (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Bos taurus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Bos taurus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Bos taurus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Bos taurus)
  - Antimicrobial peptides (Bos taurus)
    - Metal sequestration by antimicrobial proteins (Bos taurus)
      - S100A7 or S100A7A binds Zn2+ (Bos taurus)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)
      - Zn2+ [extracellular region]

Metabolism (Bos taurus)

- Integration of energy metabolism (Bos taurus)
  - Regulation of insulin secretion (Bos taurus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
      - Zn2+ [extracellular region]

Metabolism of proteins (Bos taurus)

- Surfactant metabolism (Bos taurus)
  - CECRI deaminates Ade-Rib to Ino (Bos taurus)
    - CECR1:Zn2+ dimer [extracellular region] (Bos taurus)
      - CECR1:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]

Signal Transduction (Bos taurus)

- Death Receptor Signalling (Bos taurus)
  - TNF signaling (Bos taurus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Bos taurus)
      - ADAM17 [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (q) signalling events (Bos taurus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Bos taurus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Zinc is an agonist of GPR39 (Bos taurus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Bos taurus)

- Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
  - Plasma lipoprotein assembly (Bos taurus)
    - HDL assembly (Bos taurus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)
        
        BMP1-3:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Bos taurus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
    - Metal ion SLC transporters (Bos taurus)
      - Zinc transporters (Bos taurus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Bos taurus)
        
        ZnT1 mediates the efflux of zinc from the cell (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Bos taurus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Bos taurus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Caenorhabditis elegans)
      - SOD3 tetramer [extracellular region] (Caenorhabditis elegans)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Caenorhabditis elegans)
      - SOD3 tetramer [extracellular region] (Caenorhabditis elegans)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Signal Transduction (Caenorhabditis elegans)

- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (q) signalling events (Caenorhabditis elegans)
      - The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Transport of small molecules (Caenorhabditis elegans)

- SLC-mediated transmembrane transport (Caenorhabditis elegans)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
    - Metal ion SLC transporters (Caenorhabditis elegans)
      - Zinc transporters (Caenorhabditis elegans)
        
        Zinc efflux and compartmentalization by the SLC30 family (Caenorhabditis elegans)
        
        ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Caenorhabditis elegans)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Detoxification of Reactive Oxygen Species (Canis familiaris)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)
      - SOD3 tetramer [extracellular region] (Canis familiaris)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Canis familiaris)
      - SOD3 tetramer [extracellular region] (Canis familiaris)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]

Hemostasis (Canis familiaris)

- Formation of Fibrin Clot (Clotting Cascade) (Canis familiaris)
  - Intrinsic Pathway of Fibrin Clot Formation (Canis familiaris)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)
      - Zn2+ [extracellular region]

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Growth hormone receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PRLR activation (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
- Innate Immune System (Canis familiaris)
  - Antimicrobial peptides (Canis familiaris)
    - Metal sequestration by antimicrobial proteins (Canis familiaris)
      - S100A8:S100A9 binds Zn2+ (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)
      - Zn2+ [extracellular region]

Metabolism (Canis familiaris)

- Integration of energy metabolism (Canis familiaris)
  - Regulation of insulin secretion (Canis familiaris)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)
      - Zn2+ [extracellular region]

Metabolism of proteins (Canis familiaris)

- Surfactant metabolism (Canis familiaris)
  - CECRI deaminates Ade-Rib to Ino (Canis familiaris)
    - CECR1:Zn2+ dimer [extracellular region] (Canis familiaris)
      - CECR1:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]

Signal Transduction (Canis familiaris)

- Death Receptor Signalling (Canis familiaris)
  - TNF signaling (Canis familiaris)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Canis familiaris)
      - ADAM17 [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Canis familiaris)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Zinc is an agonist of GPR39 (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]

Transport of small molecules (Canis familiaris)

- SLC-mediated transmembrane transport (Canis familiaris)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
    - Metal ion SLC transporters (Canis familiaris)
      - Zinc transporters (Canis familiaris)
        
        Zinc efflux and compartmentalization by the SLC30 family (Canis familiaris)
        
        ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Canis familiaris)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Canis familiaris)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Detoxification of Reactive Oxygen Species (Danio rerio)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)
      - SOD3 tetramer [extracellular region] (Danio rerio)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Danio rerio)
      - SOD3 tetramer [extracellular region] (Danio rerio)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]

Hemostasis (Danio rerio)

- Dissolution of Fibrin Clot (Danio rerio)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)
    - Zn2+ [extracellular region]

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Growth hormone receptor signaling (Danio rerio)
    - JAK2 phosphorylation (Danio rerio)
      - Activated cytokine-like hormone receptors [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Danio rerio)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Danio rerio)
    - JAK2 phosphorylation (Danio rerio)
      - Activated cytokine-like hormone receptors [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Danio rerio)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR activation (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Danio rerio)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Danio rerio)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Danio rerio)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
- Innate Immune System (Danio rerio)
  - Antimicrobial peptides (Danio rerio)
    - Metal sequestration by antimicrobial proteins (Danio rerio)
      - S100A7 or S100A7A binds Zn2+ (Danio rerio)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Danio rerio)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)
      - Zn2+ [extracellular region]

Metabolism (Danio rerio)

- Integration of energy metabolism (Danio rerio)
  - Regulation of insulin secretion (Danio rerio)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Danio rerio)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)
    - CA6:Zinc [extracellular region] (Danio rerio)
      - Zn2+ [extracellular region]

Metabolism of proteins (Danio rerio)

- Surfactant metabolism (Danio rerio)
  - CECRI deaminates Ade-Rib to Ino (Danio rerio)
    - CECR1:Zn2+ dimer [extracellular region] (Danio rerio)
      - CECR1:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]

Signal Transduction (Danio rerio)

- Death Receptor Signalling (Danio rerio)
  - TNF signaling (Danio rerio)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Danio rerio)
      - ADAM17 [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Danio rerio)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Danio rerio)
    - Class A/1 (Rhodopsin-like receptors) (Danio rerio)
      - Zinc is an agonist of GPR39 (Danio rerio)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]

Transport of small molecules (Danio rerio)

- Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
  - Plasma lipoprotein assembly (Danio rerio)
    - HDL assembly (Danio rerio)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)
        
        BMP1-3:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Danio rerio)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
    - Metal ion SLC transporters (Danio rerio)
      - Zinc transporters (Danio rerio)
        
        Zinc efflux and compartmentalization by the SLC30 family (Danio rerio)
        
        ZnT1 mediates the efflux of zinc from the cell (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Danio rerio)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Danio rerio)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)
      - SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Dictyostelium discoideum)
      - SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Metabolism of proteins (Dictyostelium discoideum)

- Surfactant metabolism (Dictyostelium discoideum)
  - CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)
    - CECR1:Zn2+ dimer [extracellular region] (Dictyostelium discoideum)
      - CECR1:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Transport of small molecules (Dictyostelium discoideum)

- SLC-mediated transmembrane transport (Dictyostelium discoideum)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
    - Metal ion SLC transporters (Dictyostelium discoideum)
      - Zinc transporters (Dictyostelium discoideum)
        
        Zinc efflux and compartmentalization by the SLC30 family (Dictyostelium discoideum)
        
        ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Dictyostelium discoideum)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Drosophila melanogaster)
      - SOD3 tetramer [extracellular region] (Drosophila melanogaster)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Drosophila melanogaster)
      - SOD3 tetramer [extracellular region] (Drosophila melanogaster)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - Antimicrobial peptides (Drosophila melanogaster)
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Drosophila melanogaster)
      - Zn2+ [extracellular region]

Metabolism (Drosophila melanogaster)

- Integration of energy metabolism (Drosophila melanogaster)
  - Regulation of insulin secretion (Drosophila melanogaster)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Drosophila melanogaster)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Drosophila melanogaster)
    - CA6:Zinc [extracellular region] (Drosophila melanogaster)
      - Zn2+ [extracellular region]

Metabolism of proteins (Drosophila melanogaster)

- Surfactant metabolism (Drosophila melanogaster)
  - CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)
    - CECR1:Zn2+ dimer [extracellular region] (Drosophila melanogaster)
      - CECR1:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (q) signalling events (Drosophila melanogaster)
      - The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Transport of small molecules (Drosophila melanogaster)

- SLC-mediated transmembrane transport (Drosophila melanogaster)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
    - Metal ion SLC transporters (Drosophila melanogaster)
      - Zinc transporters (Drosophila melanogaster)
        
        Zinc efflux and compartmentalization by the SLC30 family (Drosophila melanogaster)
        
        ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Drosophila melanogaster)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Detoxification of Reactive Oxygen Species (Gallus gallus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)
      - SOD3 tetramer [extracellular region] (Gallus gallus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Gallus gallus)
      - SOD3 tetramer [extracellular region] (Gallus gallus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]

Hemostasis (Gallus gallus)

- Dissolution of Fibrin Clot (Gallus gallus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Gallus gallus)
  - Intrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)
      - Zn2+ [extracellular region]

Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Antimicrobial peptides (Gallus gallus)
    - Metal sequestration by antimicrobial proteins (Gallus gallus)
      - S100A8:S100A9 binds Zn2+ (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Gallus gallus)
      - Zn2+ [extracellular region]

Metabolism (Gallus gallus)

- Integration of energy metabolism (Gallus gallus)
  - Regulation of insulin secretion (Gallus gallus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Gallus gallus)
      - Zn2+ [extracellular region]

Metabolism of proteins (Gallus gallus)

- Surfactant metabolism (Gallus gallus)
  - CECRI deaminates Ade-Rib to Ino (Gallus gallus)
    - CECR1:Zn2+ dimer [extracellular region] (Gallus gallus)
      - CECR1:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Gallus gallus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Zinc is an agonist of GPR39 (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Gallus gallus)

- SLC-mediated transmembrane transport (Gallus gallus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
    - Metal ion SLC transporters (Gallus gallus)
      - Zinc transporters (Gallus gallus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Gallus gallus)
        
        ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Gallus gallus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Gallus gallus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Detoxification of Reactive Oxygen Species (Homo sapiens)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)
      - SOD3 tetramer [extracellular region] (Homo sapiens)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Homo sapiens)
      - SOD3 tetramer [extracellular region] (Homo sapiens)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]

Disease (Homo sapiens)

- Disorders of transmembrane transporters (Homo sapiens)
  - SLC transporter disorders (Homo sapiens)
    - Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (Homo sapiens)
      - Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        Zn2+ [extracellular region]
- Infectious disease (Homo sapiens)
  - Uptake and actions of bacterial toxins (Homo sapiens)
    - Neurotoxicity of clostridium toxins (Homo sapiens)
      - Toxicity of botulinum toxin type A (BoNT/A) (Homo sapiens)
        
        BoNT/A HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/A:NTNHA:HA (Homo sapiens)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/A:NTNHA:HA [extracellular region] (Clostridium botulinum)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type B (BoNT/B) (Homo sapiens)
        
        BoNT/B HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/B:NTNHA:HA (Homo sapiens)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/B:NTNHA:HA [extracellular region] (Clostridium botulinum)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type C (BoNT/C) (Homo sapiens)
        
        BoNT/C HC:LC binds GT1b on the target cell surface (Homo sapiens)
        
        BoNT/C HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/C LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type D (BoNT/D) (Homo sapiens)
        
        BoNT/D HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)
        
        BoNT/D HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/D LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type E (BoNT/E) (Homo sapiens)
        
        BoNT/E HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/E:NTNHA (Homo sapiens)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/E:NTNHA [extracellular region] (Clostridium botulinum)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type F (BoNT/F) (Homo sapiens)
        
        BoNT/F HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/F HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/F LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type G (BoNT/G) (Homo sapiens)
        
        BoNT/G HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/G HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/G LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of tetanus toxin (TeNT) (Homo sapiens)
        
        TeNT HC:LC binds target cell-surface gangliosides (Homo sapiens)
        
        TeNT HC:LC dimer [extracellular region] (Clostridium tetani)
        
        TeNT LC:Zn2+ disulfide bonded [extracellular region] (Clostridium tetani)
        
        Zn2+ [extracellular region]
    - Uptake and function of anthrax toxins (Homo sapiens)
      - EF and LF bind to PA63:ANTXR1 oligomer (Homo sapiens)
        
        LF [extracellular region] (Bacillus anthracis)
        
        Zn2+ [extracellular region]
      - EF and LF bind to PA63:ANTXR2 oligomer (Homo sapiens)
        
        LF [extracellular region] (Bacillus anthracis)
        
        Zn2+ [extracellular region]

Hemostasis (Homo sapiens)

- Dissolution of Fibrin Clot (Homo sapiens)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
  - Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)
      - Zn2+ [extracellular region]

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Innate Immune System (Homo sapiens)
  - Antimicrobial peptides (Homo sapiens)
    - DCD forms oligomeric complex (Homo sapiens)
      - Zn2+ [extracellular region]
      - DCD hexamer:Zn(2+):anionic phospholipids [extracellular region] (Homo sapiens)
        
        DCD dimer:Zn(2+):anionic phospholipids: [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Metal sequestration by antimicrobial proteins (Homo sapiens)
      - S100A7 or S100A7A binds Zn2+ (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)
      - Zn2+ [extracellular region]

Metabolism (Homo sapiens)

- Integration of energy metabolism (Homo sapiens)
  - Regulation of insulin secretion (Homo sapiens)
    - Exocytosis of Insulin (Homo sapiens)
      - Zn2+ [extracellular region]
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Homo sapiens)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)
    - CA6:Zinc [extracellular region] (Homo sapiens)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)
    - CA6:Zinc [extracellular region] (Homo sapiens)
      - Zn2+ [extracellular region]

Metabolism of proteins (Homo sapiens)

- Surfactant metabolism (Homo sapiens)
  - CECRI deaminates Ade-Rib to Ino (Homo sapiens)
    - CECR1:Zn2+ dimer [extracellular region] (Homo sapiens)
      - CECR1:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]

Signal Transduction (Homo sapiens)

- Death Receptor Signalling (Homo sapiens)
  - TNF signaling (Homo sapiens)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
      - ADAM17 [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Zinc is an agonist of GPR39 (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB4 (Homo sapiens)
    - Nuclear signaling by ERBB4 (Homo sapiens)
      - Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)
        
        ADAM17 [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]

Transport of small molecules (Homo sapiens)

- Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
  - Plasma lipoprotein assembly (Homo sapiens)
    - HDL assembly (Homo sapiens)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)
        
        BMP1-3:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        hZIP10 mediates zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        hZIP5 mediates zinc uptake by cells (Homo sapiens)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Detoxification of Reactive Oxygen Species (Mus musculus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)
      - SOD3 tetramer [extracellular region] (Mus musculus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Mus musculus)
      - SOD3 tetramer [extracellular region] (Mus musculus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]

Hemostasis (Mus musculus)

- Dissolution of Fibrin Clot (Mus musculus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
  - Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)
      - Zn2+ [extracellular region]

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Growth hormone receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Mus musculus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Mus musculus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Mus musculus)
  - Antimicrobial peptides (Mus musculus)
    - Metal sequestration by antimicrobial proteins (Mus musculus)
      - S100A8:S100A9 binds Zn2+ (Mus musculus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)
      - Zn2+ [extracellular region]

Metabolism (Mus musculus)

- Integration of energy metabolism (Mus musculus)
  - Regulation of insulin secretion (Mus musculus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Mus musculus)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)
    - CA6:Zinc [extracellular region] (Mus musculus)
      - Zn2+ [extracellular region]

Signal Transduction (Mus musculus)

- Death Receptor Signalling (Mus musculus)
  - TNF signaling (Mus musculus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Mus musculus)
      - ADAM17 [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Zinc is an agonist of GPR39 (Mus musculus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Mus musculus)

- Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
  - Plasma lipoprotein assembly (Mus musculus)
    - HDL assembly (Mus musculus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)
        
        BMP1-3:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Mus musculus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
    - Metal ion SLC transporters (Mus musculus)
      - Zinc transporters (Mus musculus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Mus musculus)
        
        ZnT1 mediates the efflux of zinc from the cell (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Mus musculus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Mus musculus)
        
        Zn2+ [extracellular region]

Metabolism (Plasmodium falciparum)

- Reversible hydration of carbon dioxide (Plasmodium falciparum)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Plasmodium falciparum)
    - CA6:Zinc [extracellular region] (Plasmodium falciparum)
      - Zn2+ [extracellular region]

Transport of small molecules (Plasmodium falciparum)

- SLC-mediated transmembrane transport (Plasmodium falciparum)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
    - Metal ion SLC transporters (Plasmodium falciparum)
      - Zinc transporters (Plasmodium falciparum)
        
        Zinc influx into cells by the SLC39 gene family (Plasmodium falciparum)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Detoxification of Reactive Oxygen Species (Rattus norvegicus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)
      - SOD3 tetramer [extracellular region] (Rattus norvegicus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Rattus norvegicus)
      - SOD3 tetramer [extracellular region] (Rattus norvegicus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Hemostasis (Rattus norvegicus)

- Dissolution of Fibrin Clot (Rattus norvegicus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Rattus norvegicus)
  - Intrinsic Pathway of Fibrin Clot Formation (Rattus norvegicus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)
      - Zn2+ [extracellular region]

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Growth hormone receptor signaling (Rattus norvegicus)
    - JAK2 phosphorylation (Rattus norvegicus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Rattus norvegicus)
    - JAK2 phosphorylation (Rattus norvegicus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Rattus norvegicus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Rattus norvegicus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Rattus norvegicus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Rattus norvegicus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Rattus norvegicus)
  - Antimicrobial peptides (Rattus norvegicus)
    - Metal sequestration by antimicrobial proteins (Rattus norvegicus)
      - S100A8:S100A9 binds Zn2+ (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Rattus norvegicus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)
      - Zn2+ [extracellular region]

Metabolism (Rattus norvegicus)

- Integration of energy metabolism (Rattus norvegicus)
  - Regulation of insulin secretion (Rattus norvegicus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Rattus norvegicus)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)
    - CA6:Zinc [extracellular region] (Rattus norvegicus)
      - Zn2+ [extracellular region]

Signal Transduction (Rattus norvegicus)

- Death Receptor Signalling (Rattus norvegicus)
  - TNF signaling (Rattus norvegicus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Rattus norvegicus)
      - ADAM17 [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (q) signalling events (Rattus norvegicus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Rattus norvegicus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Rattus norvegicus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Zinc is an agonist of GPR39 (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Rattus norvegicus)

- Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
  - Plasma lipoprotein assembly (Rattus norvegicus)
    - HDL assembly (Rattus norvegicus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)
        
        BMP1-3:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Rattus norvegicus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
    - Metal ion SLC transporters (Rattus norvegicus)
      - Zinc transporters (Rattus norvegicus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Rattus norvegicus)
        
        ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Rattus norvegicus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)
      - SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Saccharomyces cerevisiae)
      - SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]

Transport of small molecules (Saccharomyces cerevisiae)

- SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
    - Metal ion SLC transporters (Saccharomyces cerevisiae)
      - Zinc transporters (Saccharomyces cerevisiae)
        
        Zinc efflux and compartmentalization by the SLC30 family (Saccharomyces cerevisiae)
        
        ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Saccharomyces cerevisiae)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)
      - SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Schizosaccharomyces pombe)
      - SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]

Transport of small molecules (Schizosaccharomyces pombe)

- SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
    - Metal ion SLC transporters (Schizosaccharomyces pombe)
      - Zinc transporters (Schizosaccharomyces pombe)
        
        Zinc efflux and compartmentalization by the SLC30 family (Schizosaccharomyces pombe)
        
        ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Detoxification of Reactive Oxygen Species (Sus scrofa)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)
      - SOD3 tetramer [extracellular region] (Sus scrofa)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Sus scrofa)
      - SOD3 tetramer [extracellular region] (Sus scrofa)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Hemostasis (Sus scrofa)

- Formation of Fibrin Clot (Clotting Cascade) (Sus scrofa)
  - Intrinsic Pathway of Fibrin Clot Formation (Sus scrofa)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)
      - Zn2+ [extracellular region]

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Antimicrobial peptides (Sus scrofa)
    - Metal sequestration by antimicrobial proteins (Sus scrofa)
      - S100A7 or S100A7A binds Zn2+ (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)
      - Zn2+ [extracellular region]

Metabolism (Sus scrofa)

- Reversible hydration of carbon dioxide (Sus scrofa)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)
    - CA6:Zinc [extracellular region] (Sus scrofa)
      - Zn2+ [extracellular region]

Metabolism of proteins (Sus scrofa)

- Surfactant metabolism (Sus scrofa)
  - CECRI deaminates Ade-Rib to Ino (Sus scrofa)
    - CECR1:Zn2+ dimer [extracellular region] (Sus scrofa)
      - CECR1:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Transport of small molecules (Sus scrofa)

- SLC-mediated transmembrane transport (Sus scrofa)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
    - Metal ion SLC transporters (Sus scrofa)
      - Zinc transporters (Sus scrofa)
        
        Zinc efflux and compartmentalization by the SLC30 family (Sus scrofa)
        
        ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Sus scrofa)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Sus scrofa)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)
      - SOD3 tetramer [extracellular region] (Xenopus tropicalis)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Xenopus tropicalis)
      - SOD3 tetramer [extracellular region] (Xenopus tropicalis)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]

Hemostasis (Xenopus tropicalis)

- Dissolution of Fibrin Clot (Xenopus tropicalis)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)
    - Zn2+ [extracellular region]

Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Growth hormone receptor signaling (Xenopus tropicalis)
    - JAK2 phosphorylation (Xenopus tropicalis)
      - Activated cytokine-like hormone receptors [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Xenopus tropicalis)
    - JAK2 phosphorylation (Xenopus tropicalis)
      - Activated cytokine-like hormone receptors [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - PRLR activation (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
- Innate Immune System (Xenopus tropicalis)
  - Antimicrobial peptides (Xenopus tropicalis)
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Xenopus tropicalis)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)
      - Zn2+ [extracellular region]

Metabolism (Xenopus tropicalis)

- Reversible hydration of carbon dioxide (Xenopus tropicalis)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Xenopus tropicalis)
    - CA6:Zinc [extracellular region] (Xenopus tropicalis)
      - Zn2+ [extracellular region]

Metabolism of proteins (Xenopus tropicalis)

- Surfactant metabolism (Xenopus tropicalis)
  - CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)
    - CECR1:Zn2+ dimer [extracellular region] (Xenopus tropicalis)
      - CECR1:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]

Signal Transduction (Xenopus tropicalis)

- Death Receptor Signalling (Xenopus tropicalis)
  - TNF signaling (Xenopus tropicalis)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Xenopus tropicalis)
      - ADAM17 [plasma membrane] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G alpha (q) signalling events (Xenopus tropicalis)
      - The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]

Transport of small molecules (Xenopus tropicalis)

- Plasma lipoprotein assembly, remodeling, and clearance (Xenopus tropicalis)
  - Plasma lipoprotein assembly (Xenopus tropicalis)
    - HDL assembly (Xenopus tropicalis)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Xenopus tropicalis)
        
        BMP1-3:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Xenopus tropicalis)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
    - Metal ion SLC transporters (Xenopus tropicalis)
      - Zinc transporters (Xenopus tropicalis)
        
        Zinc efflux and compartmentalization by the SLC30 family (Xenopus tropicalis)
        
        ZnT1 mediates the efflux of zinc from the cell (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Xenopus tropicalis)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Xenopus tropicalis)
        
        Zn2+ [extracellular region]

External Reference Information

External Reference

zinc(2+) [ChEBI:29105]

Participant Of

hasMember

Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region]
Ligands of GPCRs that activate Gs [extracellular region]

hasComponent

ADAM17 [plasma membrane]
ADAM17 [plasma membrane]
ADAM17 [plasma membrane]
ADAM17 [plasma membrane]
ADAM17 [plasma membrane]
Adam17 [plasma membrane]
ADAM17 [plasma membrane]
ADAM17 [plasma membrane]
BMP1-3:Zn2+ [extracellular region]
BMP1-3:Zn2+ [extracellular region]
BMP1-3:Zn2+ [extracellular region]
BMP1-3:Zn2+ [extracellular region]
BMP1-3:Zn2+ [extracellular region]
BMP1-3:Zn2+ [extracellular region]
BoNT/A LC:Zn2+ disulfide bonded [extracellular region]
BoNT/B LC:Zn2+ disulfide bonded [extracellular region]
BoNT/C LC:Zn2+ disulfide bonded [extracellular region]
BoNT/D LC:Zn2+ disulfide bonded [extracellular region]
BoNT/E LC:Zn2+ disulfide bonded [extracellular region]
BoNT/F LC:Zn2+ disulfide bonded [extracellular region]
BoNT/G LC:Zn2+ disulfide bonded [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CA6:Zinc [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
CECR1:Zn2+ [extracellular region]
DCD dimer:Zn(2+):anionic phospholipids: [extracellular region]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
GPR39:Zn2+ [plasma membrane]
Insulin:Zinc:Calcium [extracellular region]
LF [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
Placental lactogen [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
SOD3:Cu2+:Zn2+ [extracellular region]
TeNT LC:Zn2+ disulfide bonded [extracellular region]

input

DCD forms oligomeric complex
Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol
hZIP10 mediates zinc influx into cells
hZIP5 mediates zinc uptake by cells
mZIP5 mediates zinc uptake by cells
rZip10 mediates zinc influx into cells
S100A7 or S100A7A binds Zn2+
S100A7 or S100A7A binds Zn2+
S100A7 or S100A7A binds Zn2+
S100A7 or S100A7A binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
S100A8:S100A9 binds Zn2+
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
Zinc is an agonist of GPR39