Reactome | Zn2+ [extracellular region]

About
Content
Docs
Tools
Community
Download

About
Content
Docs
Tools
Community
Download

Search ...

Zn2+ [extracellular region]

Stable Identifier

R-ALL-158417

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

Zn++, zinc(2+), Zinc ion, Zn(II)

Icon

Locations in the PathwayBrowser

for Species:

Expand all

Cellular responses to external stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Detoxification of Reactive Oxygen Species (Bos taurus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)
      - SOD3 tetramer [extracellular region] (Bos taurus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Bos taurus)
      - SOD3 tetramer [extracellular region] (Bos taurus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]

Hemostasis (Bos taurus)

- Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
  - Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)
      - Zn2+ [extracellular region]

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Growth hormone receptor signaling (Bos taurus)
    - JAK2 phosphorylation (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Bos taurus)
    - JAK2 phosphorylation (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Bos taurus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Bos taurus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Bos taurus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Bos taurus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Bos taurus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Bos taurus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Bos taurus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Bos taurus)
        
        Prolactin receptor ligands [extracellular region] (Bos taurus)
        
        Placental lactogen [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Bos taurus)
  - Antimicrobial peptides (Bos taurus)
    - Metal sequestration by antimicrobial proteins (Bos taurus)
      - S100A7 or S100A7A binds Zn2+ (Bos taurus)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)
      - Zn2+ [extracellular region]

Metabolism (Bos taurus)

- Integration of energy metabolism (Bos taurus)
  - Regulation of insulin secretion (Bos taurus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
      - Zn2+ [extracellular region]

Metabolism of proteins (Bos taurus)

- Surfactant metabolism (Bos taurus)
  - CECRI deaminates Ade-Rib to Ino (Bos taurus)
    - CECR1:Zn2+ dimer [extracellular region] (Bos taurus)
      - CECR1:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]

Signal Transduction (Bos taurus)

- Death Receptor Signalling (Bos taurus)
  - TNF signaling (Bos taurus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Bos taurus)
      - ADAM17 [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Bos taurus)
    - Regulated proteolysis of p75NTR (Bos taurus)
      - alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (q) signalling events (Bos taurus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Bos taurus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Zinc is an agonist of GPR39 (Bos taurus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Bos taurus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Bos taurus)

- Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
  - Plasma lipoprotein assembly (Bos taurus)
    - HDL assembly (Bos taurus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)
        
        BMP1-3:Zn2+ [extracellular region] (Bos taurus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Bos taurus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
    - Metal ion SLC transporters (Bos taurus)
      - Zinc transporters (Bos taurus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Bos taurus)
        
        ZnT1 mediates the efflux of zinc from the cell (Bos taurus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Bos taurus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Bos taurus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Caenorhabditis elegans)
      - SOD3 tetramer [extracellular region] (Caenorhabditis elegans)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Caenorhabditis elegans)
      - SOD3 tetramer [extracellular region] (Caenorhabditis elegans)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Metabolism (Caenorhabditis elegans)

- Reversible hydration of carbon dioxide (Caenorhabditis elegans)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Caenorhabditis elegans)
    - CA6:Zinc [extracellular region] (Caenorhabditis elegans)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Caenorhabditis elegans)
    - CA6:Zinc [extracellular region] (Caenorhabditis elegans)
      - Zn2+ [extracellular region]

Signal Transduction (Caenorhabditis elegans)

- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (q) signalling events (Caenorhabditis elegans)
      - The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Transport of small molecules (Caenorhabditis elegans)

- SLC-mediated transmembrane transport (Caenorhabditis elegans)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
    - Metal ion SLC transporters (Caenorhabditis elegans)
      - Zinc transporters (Caenorhabditis elegans)
        
        Zinc efflux and compartmentalization by the SLC30 family (Caenorhabditis elegans)
        
        ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Caenorhabditis elegans)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Detoxification of Reactive Oxygen Species (Canis familiaris)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)
      - SOD3 tetramer [extracellular region] (Canis familiaris)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Canis familiaris)
      - SOD3 tetramer [extracellular region] (Canis familiaris)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Growth hormone receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PRLR activation (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Prolactin receptor ligands [extracellular region] (Canis familiaris)
        
        Placental lactogen [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
- Innate Immune System (Canis familiaris)
  - Antimicrobial peptides (Canis familiaris)
    - Metal sequestration by antimicrobial proteins (Canis familiaris)
      - S100A8:S100A9 binds Zn2+ (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)
      - Zn2+ [extracellular region]

Metabolism (Canis familiaris)

- Integration of energy metabolism (Canis familiaris)
  - Regulation of insulin secretion (Canis familiaris)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)
      - Zn2+ [extracellular region]

Metabolism of proteins (Canis familiaris)

- Surfactant metabolism (Canis familiaris)
  - CECRI deaminates Ade-Rib to Ino (Canis familiaris)
    - CECR1:Zn2+ dimer [extracellular region] (Canis familiaris)
      - CECR1:Zn2+ [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]

Signal Transduction (Canis familiaris)

- Death Receptor Signalling (Canis familiaris)
  - TNF signaling (Canis familiaris)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Canis familiaris)
      - ADAM17 [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Canis familiaris)
    - Regulated proteolysis of p75NTR (Canis familiaris)
      - alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Canis familiaris)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Zinc is an agonist of GPR39 (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Canis familiaris)
        
        Zn2+ [extracellular region]

Transport of small molecules (Canis familiaris)

- SLC-mediated transmembrane transport (Canis familiaris)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
    - Metal ion SLC transporters (Canis familiaris)
      - Zinc transporters (Canis familiaris)
        
        Zinc efflux and compartmentalization by the SLC30 family (Canis familiaris)
        
        ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Canis familiaris)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Canis familiaris)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Detoxification of Reactive Oxygen Species (Danio rerio)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)
      - SOD3 tetramer [extracellular region] (Danio rerio)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Danio rerio)
      - SOD3 tetramer [extracellular region] (Danio rerio)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]

Hemostasis (Danio rerio)

- Dissolution of Fibrin Clot (Danio rerio)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Danio rerio)
  - Intrinsic Pathway of Fibrin Clot Formation (Danio rerio)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Danio rerio)
      - Zn2+ [extracellular region]

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Growth hormone receptor signaling (Danio rerio)
    - JAK2 phosphorylation (Danio rerio)
      - Activated cytokine-like hormone receptors [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Danio rerio)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Danio rerio)
    - JAK2 phosphorylation (Danio rerio)
      - Activated cytokine-like hormone receptors [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Danio rerio)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR activation (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Danio rerio)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Danio rerio)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Danio rerio)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Danio rerio)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Danio rerio)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Danio rerio)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Danio rerio)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Danio rerio)
        
        Prolactin receptor ligands [extracellular region] (Danio rerio)
        
        Placental lactogen [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
- Innate Immune System (Danio rerio)
  - Antimicrobial peptides (Danio rerio)
    - Metal sequestration by antimicrobial proteins (Danio rerio)
      - S100A7 or S100A7A binds Zn2+ (Danio rerio)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Danio rerio)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)
      - Zn2+ [extracellular region]

Metabolism (Danio rerio)

- Integration of energy metabolism (Danio rerio)
  - Regulation of insulin secretion (Danio rerio)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Danio rerio)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)
    - CA6:Zinc [extracellular region] (Danio rerio)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Danio rerio)
    - CA6:Zinc [extracellular region] (Danio rerio)
      - Zn2+ [extracellular region]

Metabolism of proteins (Danio rerio)

- Surfactant metabolism (Danio rerio)
  - CECRI deaminates Ade-Rib to Ino (Danio rerio)
    - CECR1:Zn2+ dimer [extracellular region] (Danio rerio)
      - CECR1:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]

Signal Transduction (Danio rerio)

- Death Receptor Signalling (Danio rerio)
  - TNF signaling (Danio rerio)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Danio rerio)
      - ADAM17 [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Danio rerio)
    - Regulated proteolysis of p75NTR (Danio rerio)
      - alpha-secretase cleaves the p75NTR extracellular domain (Danio rerio)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Danio rerio)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Danio rerio)
    - Class A/1 (Rhodopsin-like receptors) (Danio rerio)
      - Zinc is an agonist of GPR39 (Danio rerio)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Danio rerio)
        
        Zn2+ [extracellular region]

Transport of small molecules (Danio rerio)

- Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
  - Plasma lipoprotein assembly (Danio rerio)
    - HDL assembly (Danio rerio)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)
        
        BMP1-3:Zn2+ [extracellular region] (Danio rerio)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Danio rerio)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
    - Metal ion SLC transporters (Danio rerio)
      - Zinc transporters (Danio rerio)
        
        Zinc efflux and compartmentalization by the SLC30 family (Danio rerio)
        
        ZnT1 mediates the efflux of zinc from the cell (Danio rerio)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Danio rerio)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Danio rerio)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)
      - SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Dictyostelium discoideum)
      - SOD3 tetramer [extracellular region] (Dictyostelium discoideum)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Metabolism of proteins (Dictyostelium discoideum)

- Surfactant metabolism (Dictyostelium discoideum)
  - CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)
    - CECR1:Zn2+ dimer [extracellular region] (Dictyostelium discoideum)
      - CECR1:Zn2+ [extracellular region] (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Transport of small molecules (Dictyostelium discoideum)

- SLC-mediated transmembrane transport (Dictyostelium discoideum)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
    - Metal ion SLC transporters (Dictyostelium discoideum)
      - Zinc transporters (Dictyostelium discoideum)
        
        Zinc efflux and compartmentalization by the SLC30 family (Dictyostelium discoideum)
        
        ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Dictyostelium discoideum)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Drosophila melanogaster)
      - SOD3 tetramer [extracellular region] (Drosophila melanogaster)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Drosophila melanogaster)
      - SOD3 tetramer [extracellular region] (Drosophila melanogaster)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - Antimicrobial peptides (Drosophila melanogaster)
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Drosophila melanogaster)
      - Zn2+ [extracellular region]

Metabolism (Drosophila melanogaster)

- Integration of energy metabolism (Drosophila melanogaster)
  - Regulation of insulin secretion (Drosophila melanogaster)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Drosophila melanogaster)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Drosophila melanogaster)
    - CA6:Zinc [extracellular region] (Drosophila melanogaster)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Drosophila melanogaster)
    - CA6:Zinc [extracellular region] (Drosophila melanogaster)
      - Zn2+ [extracellular region]

Metabolism of proteins (Drosophila melanogaster)

- Surfactant metabolism (Drosophila melanogaster)
  - CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)
    - CECR1:Zn2+ dimer [extracellular region] (Drosophila melanogaster)
      - CECR1:Zn2+ [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (q) signalling events (Drosophila melanogaster)
      - The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Transport of small molecules (Drosophila melanogaster)

- SLC-mediated transmembrane transport (Drosophila melanogaster)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
    - Metal ion SLC transporters (Drosophila melanogaster)
      - Zinc transporters (Drosophila melanogaster)
        
        Zinc efflux and compartmentalization by the SLC30 family (Drosophila melanogaster)
        
        ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Drosophila melanogaster)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Drosophila melanogaster)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Detoxification of Reactive Oxygen Species (Gallus gallus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)
      - SOD3 tetramer [extracellular region] (Gallus gallus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Gallus gallus)
      - SOD3 tetramer [extracellular region] (Gallus gallus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]

Hemostasis (Gallus gallus)

- Dissolution of Fibrin Clot (Gallus gallus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Gallus gallus)
  - Intrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)
      - Zn2+ [extracellular region]

Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Antimicrobial peptides (Gallus gallus)
    - Metal sequestration by antimicrobial proteins (Gallus gallus)
      - S100A7 or S100A7A binds Zn2+ (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)
      - Zn2+ [extracellular region]

Metabolism (Gallus gallus)

- Integration of energy metabolism (Gallus gallus)
  - Regulation of insulin secretion (Gallus gallus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Gallus gallus)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Gallus gallus)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Gallus gallus)
    - CA6:Zinc [extracellular region] (Gallus gallus)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Gallus gallus)
    - CA6:Zinc [extracellular region] (Gallus gallus)
      - Zn2+ [extracellular region]

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Gallus gallus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Zinc is an agonist of GPR39 (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Gallus gallus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Gallus gallus)

- SLC-mediated transmembrane transport (Gallus gallus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
    - Metal ion SLC transporters (Gallus gallus)
      - Zinc transporters (Gallus gallus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Gallus gallus)
        
        ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Gallus gallus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Gallus gallus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Detoxification of Reactive Oxygen Species (Homo sapiens)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)
      - SOD3 tetramer [extracellular region] (Homo sapiens)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Homo sapiens)
      - SOD3 tetramer [extracellular region] (Homo sapiens)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]

Disease (Homo sapiens)

- Disorders of transmembrane transporters (Homo sapiens)
  - SLC transporter disorders (Homo sapiens)
    - Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (Homo sapiens)
      - Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        Zn2+ [extracellular region]
- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - Uptake and actions of bacterial toxins (Homo sapiens)
    - Neurotoxicity of clostridium toxins (Homo sapiens)
      - Toxicity of botulinum toxin type A (BoNT/A) (Homo sapiens)
        
        BoNT/A HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/A:NTNHA:HA (Homo sapiens)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/A:NTNHA:HA [extracellular region] (Clostridium botulinum)
        
        BoNT/A HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/A LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type B (BoNT/B) (Homo sapiens)
        
        BoNT/B HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/B:NTNHA:HA (Homo sapiens)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/B:NTNHA:HA [extracellular region] (Clostridium botulinum)
        
        BoNT/B HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/B LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type C (BoNT/C) (Homo sapiens)
        
        BoNT/C HC:LC binds GT1b on the target cell surface (Homo sapiens)
        
        BoNT/C HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/C LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type D (BoNT/D) (Homo sapiens)
        
        BoNT/D HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)
        
        BoNT/D HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/D LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type E (BoNT/E) (Homo sapiens)
        
        BoNT/E HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        Transcytosis and dissociation of BoNT/E:NTNHA (Homo sapiens)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
        
        BoNT/E:NTNHA [extracellular region] (Clostridium botulinum)
        
        BoNT/E HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/E LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type F (BoNT/F) (Homo sapiens)
        
        BoNT/F HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/F HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/F LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of botulinum toxin type G (BoNT/G) (Homo sapiens)
        
        BoNT/G HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)
        
        BoNT/G HC:LC dimer [extracellular region] (Clostridium botulinum)
        
        BoNT/G LC:Zn2+ disulfide bonded [extracellular region] (Clostridium botulinum)
        
        Zn2+ [extracellular region]
      - Toxicity of tetanus toxin (TeNT) (Homo sapiens)
        
        TeNT HC:LC binds target cell-surface gangliosides (Homo sapiens)
        
        TeNT HC:LC dimer [extracellular region] (Clostridium tetani)
        
        TeNT LC:Zn2+ disulfide bonded [extracellular region] (Clostridium tetani)
        
        Zn2+ [extracellular region]
    - Uptake and function of anthrax toxins (Homo sapiens)
      - EF and LF bind to PA63:ANTXR1 oligomer (Homo sapiens)
        
        LF [extracellular region] (Bacillus anthracis)
        
        Zn2+ [extracellular region]
      - EF and LF bind to PA63:ANTXR2 oligomer (Homo sapiens)
        
        LF [extracellular region] (Bacillus anthracis)
        
        Zn2+ [extracellular region]

Hemostasis (Homo sapiens)

- Dissolution of Fibrin Clot (Homo sapiens)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
  - Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)
      - Zn2+ [extracellular region]

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Placental lactogen [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Innate Immune System (Homo sapiens)
  - Antimicrobial peptides (Homo sapiens)
    - DCD forms oligomeric complex (Homo sapiens)
      - Zn2+ [extracellular region]
      - DCD hexamer:Zn(2+):anionic phospholipids [extracellular region] (Homo sapiens)
        
        DCD dimer:Zn(2+):anionic phospholipids: [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - Metal sequestration by antimicrobial proteins (Homo sapiens)
      - S100A7 or S100A7A binds Zn2+ (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)
      - Zn2+ [extracellular region]

Metabolism (Homo sapiens)

- Integration of energy metabolism (Homo sapiens)
  - Regulation of insulin secretion (Homo sapiens)
    - Exocytosis of Insulin (Homo sapiens)
      - Zn2+ [extracellular region]
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Homo sapiens)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)
    - CA6:Zinc [extracellular region] (Homo sapiens)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)
    - CA6:Zinc [extracellular region] (Homo sapiens)
      - Zn2+ [extracellular region]

Metabolism of proteins (Homo sapiens)

- Surfactant metabolism (Homo sapiens)
  - CECRI deaminates Ade-Rib to Ino (Homo sapiens)
    - CECR1:Zn2+ dimer [extracellular region] (Homo sapiens)
      - CECR1:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]

Signal Transduction (Homo sapiens)

- Death Receptor Signalling (Homo sapiens)
  - TNF signaling (Homo sapiens)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
      - ADAM17 [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Regulated proteolysis of p75NTR (Homo sapiens)
      - alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Zinc is an agonist of GPR39 (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB4 (Homo sapiens)
    - Nuclear signaling by ERBB4 (Homo sapiens)
      - Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)
        
        ADAM17 [plasma membrane] (Homo sapiens)
        
        Zn2+ [extracellular region]

Transport of small molecules (Homo sapiens)

- Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
  - Plasma lipoprotein assembly (Homo sapiens)
    - HDL assembly (Homo sapiens)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)
        
        BMP1-3:Zn2+ [extracellular region] (Homo sapiens)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        hZIP10 mediates zinc influx into cells (Homo sapiens)
        
        Zn2+ [extracellular region]
        
        hZIP5 mediates zinc uptake by cells (Homo sapiens)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Detoxification of Reactive Oxygen Species (Mus musculus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)
      - SOD3 tetramer [extracellular region] (Mus musculus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Mus musculus)
      - SOD3 tetramer [extracellular region] (Mus musculus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]

Hemostasis (Mus musculus)

- Dissolution of Fibrin Clot (Mus musculus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)
    - Zn2+ [extracellular region]
- Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
  - Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)
      - Zn2+ [extracellular region]

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Growth hormone receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Mus musculus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Mus musculus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Mus musculus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Mus musculus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Mus musculus)
        
        Prolactin receptor ligands [extracellular region] (Mus musculus)
        
        Placental lactogen [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Mus musculus)
  - Antimicrobial peptides (Mus musculus)
    - Metal sequestration by antimicrobial proteins (Mus musculus)
      - S100A8:S100A9 binds Zn2+ (Mus musculus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)
      - Zn2+ [extracellular region]

Metabolism (Mus musculus)

- Integration of energy metabolism (Mus musculus)
  - Regulation of insulin secretion (Mus musculus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Mus musculus)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)
    - CA6:Zinc [extracellular region] (Mus musculus)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)
    - CA6:Zinc [extracellular region] (Mus musculus)
      - Zn2+ [extracellular region]

Signal Transduction (Mus musculus)

- Death Receptor Signalling (Mus musculus)
  - TNF signaling (Mus musculus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Mus musculus)
      - ADAM17 [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Mus musculus)
    - Regulated proteolysis of p75NTR (Mus musculus)
      - alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
      - The Ligand:GPCR:Gq complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Zinc is an agonist of GPR39 (Mus musculus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Mus musculus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Mus musculus)

- Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
  - Plasma lipoprotein assembly (Mus musculus)
    - HDL assembly (Mus musculus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)
        
        BMP1-3:Zn2+ [extracellular region] (Mus musculus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Mus musculus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
    - Metal ion SLC transporters (Mus musculus)
      - Zinc transporters (Mus musculus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Mus musculus)
        
        ZnT1 mediates the efflux of zinc from the cell (Mus musculus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Mus musculus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Mus musculus)
        
        Zn2+ [extracellular region]

Metabolism (Plasmodium falciparum)

- Reversible hydration of carbon dioxide (Plasmodium falciparum)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Plasmodium falciparum)
    - CA6:Zinc [extracellular region] (Plasmodium falciparum)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Plasmodium falciparum)
    - CA6:Zinc [extracellular region] (Plasmodium falciparum)
      - Zn2+ [extracellular region]

Transport of small molecules (Plasmodium falciparum)

- SLC-mediated transmembrane transport (Plasmodium falciparum)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
    - Metal ion SLC transporters (Plasmodium falciparum)
      - Zinc transporters (Plasmodium falciparum)
        
        Zinc influx into cells by the SLC39 gene family (Plasmodium falciparum)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Detoxification of Reactive Oxygen Species (Rattus norvegicus)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)
      - SOD3 tetramer [extracellular region] (Rattus norvegicus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Rattus norvegicus)
      - SOD3 tetramer [extracellular region] (Rattus norvegicus)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Hemostasis (Rattus norvegicus)

- Dissolution of Fibrin Clot (Rattus norvegicus)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)
    - Zn2+ [extracellular region]

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Growth hormone receptor signaling (Rattus norvegicus)
    - JAK2 phosphorylation (Rattus norvegicus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Rattus norvegicus)
    - JAK2 phosphorylation (Rattus norvegicus)
      - Activated cytokine-like hormone receptors [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR activation (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR binds SCF beta-TrCP complex (Rattus norvegicus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor is internalized (Rattus norvegicus)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Rattus norvegicus)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - SH2B binds JAK2 (Rattus norvegicus)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Rattus norvegicus)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Rattus norvegicus)
        
        Prolactin receptor ligands [extracellular region] (Rattus norvegicus)
        
        Placental lactogen [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- Innate Immune System (Rattus norvegicus)
  - Antimicrobial peptides (Rattus norvegicus)
    - Metal sequestration by antimicrobial proteins (Rattus norvegicus)
      - S100A8:S100A9 binds Zn2+ (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)
      - Zn2+ [extracellular region]

Metabolism (Rattus norvegicus)

- Integration of energy metabolism (Rattus norvegicus)
  - Regulation of insulin secretion (Rattus norvegicus)
    - KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)
      - Zn2+ [extracellular region]
- Reversible hydration of carbon dioxide (Rattus norvegicus)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)
    - CA6:Zinc [extracellular region] (Rattus norvegicus)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)
    - CA6:Zinc [extracellular region] (Rattus norvegicus)
      - Zn2+ [extracellular region]

Signal Transduction (Rattus norvegicus)

- Death Receptor Signalling (Rattus norvegicus)
  - TNF signaling (Rattus norvegicus)
    - TNF-alpha is cleaved by ADAM17 (TACE) (Rattus norvegicus)
      - ADAM17 [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
  - p75 NTR receptor-mediated signalling (Rattus norvegicus)
    - Regulated proteolysis of p75NTR (Rattus norvegicus)
      - alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)
        
        p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (q) signalling events (Rattus norvegicus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Zinc is an agonist of GPR39 (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        GPR39:Zn2+ [plasma membrane] (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Transport of small molecules (Rattus norvegicus)

- Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
  - Plasma lipoprotein assembly (Rattus norvegicus)
    - HDL assembly (Rattus norvegicus)
      - BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)
        
        BMP1-3:Zn2+ [extracellular region] (Rattus norvegicus)
        
        Zn2+ [extracellular region]
- SLC-mediated transmembrane transport (Rattus norvegicus)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
    - Metal ion SLC transporters (Rattus norvegicus)
      - Zinc transporters (Rattus norvegicus)
        
        Zinc efflux and compartmentalization by the SLC30 family (Rattus norvegicus)
        
        ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Rattus norvegicus)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Rattus norvegicus)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)
      - SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Saccharomyces cerevisiae)
      - SOD3 tetramer [extracellular region] (Saccharomyces cerevisiae)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]

Transport of small molecules (Saccharomyces cerevisiae)

- SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
    - Metal ion SLC transporters (Saccharomyces cerevisiae)
      - Zinc transporters (Saccharomyces cerevisiae)
        
        Zinc efflux and compartmentalization by the SLC30 family (Saccharomyces cerevisiae)
        
        ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)
      - SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Schizosaccharomyces pombe)
      - SOD3 tetramer [extracellular region] (Schizosaccharomyces pombe)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]

Transport of small molecules (Schizosaccharomyces pombe)

- SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
    - Metal ion SLC transporters (Schizosaccharomyces pombe)
      - Zinc transporters (Schizosaccharomyces pombe)
        
        Zinc efflux and compartmentalization by the SLC30 family (Schizosaccharomyces pombe)
        
        ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Detoxification of Reactive Oxygen Species (Sus scrofa)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)
      - SOD3 tetramer [extracellular region] (Sus scrofa)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Sus scrofa)
      - SOD3 tetramer [extracellular region] (Sus scrofa)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Hemostasis (Sus scrofa)

- Formation of Fibrin Clot (Clotting Cascade) (Sus scrofa)
  - Intrinsic Pathway of Fibrin Clot Formation (Sus scrofa)
    - kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)
      - Zn2+ [extracellular region]

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Antimicrobial peptides (Sus scrofa)
    - Metal sequestration by antimicrobial proteins (Sus scrofa)
      - S100A7 or S100A7A binds Zn2+ (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
      - S100A8:S100A9 binds Zn2+ (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)
      - Zn2+ [extracellular region]

Metabolism (Sus scrofa)

- Reversible hydration of carbon dioxide (Sus scrofa)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)
    - CA6:Zinc [extracellular region] (Sus scrofa)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)
    - CA6:Zinc [extracellular region] (Sus scrofa)
      - Zn2+ [extracellular region]

Metabolism of proteins (Sus scrofa)

- Surfactant metabolism (Sus scrofa)
  - CECRI deaminates Ade-Rib to Ino (Sus scrofa)
    - CECR1:Zn2+ dimer [extracellular region] (Sus scrofa)
      - CECR1:Zn2+ [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Sus scrofa)
        
        Zn2+ [extracellular region]

Transport of small molecules (Sus scrofa)

- SLC-mediated transmembrane transport (Sus scrofa)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
    - Metal ion SLC transporters (Sus scrofa)
      - Zinc transporters (Sus scrofa)
        
        Zinc efflux and compartmentalization by the SLC30 family (Sus scrofa)
        
        ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        Zinc influx into cells by the SLC39 gene family (Sus scrofa)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)
        
        Zn2+ [extracellular region]
        
        ZIP8 mediates zinc influx into cells (Sus scrofa)
        
        Zn2+ [extracellular region]

Cellular responses to external stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
    - SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)
      - SOD3 tetramer [extracellular region] (Xenopus tropicalis)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - Secretion of SOD3 (Xenopus tropicalis)
      - SOD3 tetramer [extracellular region] (Xenopus tropicalis)
        
        SOD3:Cu2+:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]

Hemostasis (Xenopus tropicalis)

- Dissolution of Fibrin Clot (Xenopus tropicalis)
  - plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)
    - Zn2+ [extracellular region]

Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Growth hormone receptor signaling (Xenopus tropicalis)
    - JAK2 phosphorylation (Xenopus tropicalis)
      - Activated cytokine-like hormone receptors [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
  - Prolactin receptor signaling (Xenopus tropicalis)
    - JAK2 phosphorylation (Xenopus tropicalis)
      - Activated cytokine-like hormone receptors [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Xenopus tropicalis)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - PRLR activation (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - PRLR is phosphorylated at Ser-349 (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - Prolactin receptor ligands bind the prolactin receptor (Xenopus tropicalis)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Xenopus tropicalis)
        
        Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
      - Prolactin receptor ligands [extracellular region] (Xenopus tropicalis)
        
        Placental lactogen [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
- Innate Immune System (Xenopus tropicalis)
  - Antimicrobial peptides (Xenopus tropicalis)
    - Metal sequestration by antimicrobial proteins (Xenopus tropicalis)
      - S100A7 or S100A7A binds Zn2+ (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
        
        S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]
    - PGLYRP2 hydrolyzes bacterial peptidoglycan (Xenopus tropicalis)
      - Zn2+ [extracellular region]
    - PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)
      - Zn2+ [extracellular region]

Metabolism (Xenopus tropicalis)

- Reversible hydration of carbon dioxide (Xenopus tropicalis)
  - Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Xenopus tropicalis)
    - CA6:Zinc [extracellular region] (Xenopus tropicalis)
      - Zn2+ [extracellular region]
  - Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Xenopus tropicalis)
    - CA6:Zinc [extracellular region] (Xenopus tropicalis)
      - Zn2+ [extracellular region]

Metabolism of proteins (Xenopus tropicalis)

- Surfactant metabolism (Xenopus tropicalis)
  - CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)
    - CECR1:Zn2+ dimer [extracellular region] (Xenopus tropicalis)
      - CECR1:Zn2+ [extracellular region] (Xenopus tropicalis)
        
        Zn2+ [extracellular region]