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About
What is Reactome ?
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Table of Contents
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Unmethylated CpG DNA [endosome membrane]
Stable Identifier
R-ALL-167913
Type
OtherEntity
Compartment
endosome membrane
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Bos taurus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Bos taurus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
activated TLR9:PI3K class III [cytosol] (Bos taurus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
activated TLR9:PI3K class III [cytosol] (Bos taurus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Bos taurus)
Unmethylated CpG DNA [endosome membrane]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR21 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TLR21homodimer binds to DNA (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TLR7 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Rattus norvegicus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Rattus norvegicus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
activated TLR9:PI3K class III [cytosol] (Rattus norvegicus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
activated TLR9:PI3K class III [cytosol] (Rattus norvegicus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
Unmethylated CpG DNA [endosome membrane]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Sus scrofa)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes [cytosol] (Sus scrofa)
activated TLR9:PI3K class III [cytosol] (Sus scrofa)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes [cytosol] (Sus scrofa)
activated TLR9:PI3K class III [cytosol] (Sus scrofa)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
Unmethylated CpG DNA [endosome membrane]
Participates
as an input of
Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)
Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)
Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)
Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)
Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)
as a component of
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Bos taurus)
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Bos taurus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Bos taurus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Sus scrofa)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Rattus norvegicus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
disease by infectious agent
DOID:0050117
infectious disease
Cross References
ChEBI
61120
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