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PI(3,4,5)P3 [plasma membrane]
Stable Identifier
R-ALL-179838
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP3, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, Phosphatidylinositol-3,4,5-trisphosphate
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14451
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Bos taurus)
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Costimulation by the CD28 family (Caenorhabditis elegans)
CD28 co-stimulation (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
GAB1 signalosome (Caenorhabditis elegans)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Caenorhabditis elegans)
Activated FGFR1 binds PLCG1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
PI-3K cascade:FGFR2 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Caenorhabditis elegans)
Activated FGFR2 binds PLCG1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
PI-3K cascade:FGFR3 (Caenorhabditis elegans)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Caenorhabditis elegans)
Activated FGFR3 binds PLCG1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Caenorhabditis elegans)
Activated FGFR4 binds PLCG1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
PI3K/AKT activation (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Canis familiaris)
Translocation of Vav1 to CD28 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through BTK (Canis familiaris)
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Canis familiaris)
Activated FGFR1 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Canis familiaris)
Activated FGFR2 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Canis familiaris)
Activated FGFR3 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Canis familiaris)
Activated FGFR4 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
Activation of AKT2 (Canis familiaris)
AKT2 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Phosphorylation and activation of VAV1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
Activation of AKT2 (Canis familiaris)
AKT2 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Canis familiaris)
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Costimulation by the CD28 family (Danio rerio)
CD28 co-stimulation (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Danio rerio)
DAP12 interactions (Danio rerio)
DAP12 signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated MAPK activation (Danio rerio)
Phosphorylation and activation of VAV (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Danio rerio)
Phosphorylation of PIP2 to PIP3 by PI3K (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Danio rerio)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Danio rerio)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G-protein beta:gamma signalling (Danio rerio)
G beta:gamma signalling through BTK (Danio rerio)
G beta-gamma complex and PIP3 recruit BTK to membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Danio rerio)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Danio rerio)
Activated FGFR1 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
PI-3K cascade:FGFR2 (Danio rerio)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Danio rerio)
Activated FGFR2 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
PI-3K cascade:FGFR3 (Danio rerio)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Danio rerio)
Activated FGFR3 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
PI-3K cascade:FGFR4 (Danio rerio)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Danio rerio)
Activated FGFR4 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
Activation of AKT2 (Danio rerio)
AKT2 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Danio rerio)
MET activates PI3K/AKT signaling (Danio rerio)
MET bound PI3K generates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
Activation of AKT2 (Danio rerio)
AKT2 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Danio rerio)
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate WASPs and WAVEs (Danio rerio)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
GPVI-mediated activation cascade (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Costimulation by the CD28 family (Dictyostelium discoideum)
CD28 co-stimulation (Dictyostelium discoideum)
CD28 dependent PI3K/Akt signaling (Dictyostelium discoideum)
PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Dictyostelium discoideum)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Dictyostelium discoideum)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G-protein beta:gamma signalling (Dictyostelium discoideum)
G beta:gamma signalling through PI3Kgamma (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor signalling cascade (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
AKT2 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Dictyostelium discoideum)
IGF1R signaling cascade (Dictyostelium discoideum)
IRS-related events triggered by IGF1R (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
AKT2 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Costimulation by the CD28 family (Drosophila melanogaster)
CD28 co-stimulation (Drosophila melanogaster)
CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)
PIP3 recruits AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Drosophila melanogaster)
Activated FGFR1 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Drosophila melanogaster)
Activated FGFR2 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Drosophila melanogaster)
Activated FGFR3 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Drosophila melanogaster)
Activated FGFR4 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
AKT2 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
PI3K/AKT activation (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Drosophila melanogaster)
Synthesis of PIP3 from PIP2 by PI3K (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
AKT2 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Phosphorylation and activation of VAV (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Gallus gallus)
Activated FGFR4 binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate WASPs and WAVEs (Gallus gallus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN Loss of Function in Cancer (Homo sapiens)
PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 KD Mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 in disease (Homo sapiens)
Signaling by FGFR3 fusions in cancer (Homo sapiens)
Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 point mutants in cancer (Homo sapiens)
Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR3A (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through BTK (Homo sapiens)
G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Homo sapiens)
Activated FGFR3 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
AKT2 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Homo sapiens)
MET activates PI3K/AKT signaling (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Homo sapiens)
Phosphorylation and activation of VAV1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
AKT2 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Phosphorylation and activation of VAV (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through BTK (Mus musculus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
GAB1 signalosome (Mus musculus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Mus musculus)
PI3K events in ERBB4 signaling (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Mus musculus)
Activated FGFR1 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Mus musculus)
Activated FGFR2 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Mus musculus)
Activated FGFR3 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Mus musculus)
Activated FGFR4 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
AKT2 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Mus musculus)
MET activates PI3K/AKT signaling (Mus musculus)
MET bound PI3K generates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
AKT2 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Mus musculus)
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate WASPs and WAVEs (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
GPVI-mediated activation cascade (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
Costimulation by the CD28 family (Plasmodium falciparum)
CD28 co-stimulation (Plasmodium falciparum)
CD28 dependent PI3K/Akt signaling (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Plasmodium falciparum)
Metabolism of lipids (Plasmodium falciparum)
Phospholipid metabolism (Plasmodium falciparum)
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Plasmodium falciparum)
Intracellular signaling by second messengers (Plasmodium falciparum)
PIP3 activates AKT signaling (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by Insulin receptor (Plasmodium falciparum)
Insulin receptor signalling cascade (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
Activation of AKT2 (Plasmodium falciparum)
PDPK1 binds PIP3 (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Plasmodium falciparum)
IGF1R signaling cascade (Plasmodium falciparum)
IRS-related events triggered by IGF1R (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
Activation of AKT2 (Plasmodium falciparum)
PDPK1 binds PIP3 (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Plasmodium falciparum)
VEGFA-VEGFR2 Pathway (Plasmodium falciparum)
VEGFR2 mediated vascular permeability (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Rattus norvegicus)
Translocation of Vav1 to CD28 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)