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PI(4,5)P2
Stable Identifier
R-ALL-179856
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP2, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, Phosphatidylinositol-4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
Locations in the PathwayBrowser for Species:
Homo sapiens
Arabidopsis thaliana
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Oryza sativa
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Taeniopygia guttata
Xenopus tropicalis
Expand all
Hemostasis (Arabidopsis thaliana)
Platelet activation, signaling and aggregation (Arabidopsis thaliana)
GPVI-mediated activation cascade (Arabidopsis thaliana)
PLC gamma 2-mediated PIP2 hydrolysis (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Immune System (Arabidopsis thaliana)
Adaptive Immune System (Arabidopsis thaliana)
TCR signaling (Arabidopsis thaliana)
Generation of second messenger molecules (Arabidopsis thaliana)
PLC-gamma1 hydrolyses PIP2 (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Arabidopsis thaliana)
C-type lectin receptors (CLRs) (Arabidopsis thaliana)
CLEC7A (Dectin-1) signaling (Arabidopsis thaliana)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Metabolism (Arabidopsis thaliana)
Inositol phosphate metabolism (Arabidopsis thaliana)
Synthesis of IP3 and IP4 in the cytosol (Arabidopsis thaliana)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Arabidopsis thaliana)
Regulation of insulin secretion (Arabidopsis thaliana)
Acetylcholine regulates insulin secretion (Arabidopsis thaliana)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Arabidopsis thaliana)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Arabidopsis thaliana)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Arabidopsis thaliana)
Phospholipid metabolism (Arabidopsis thaliana)
PI Metabolism (Arabidopsis thaliana)
Synthesis of PIPs at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Arabidopsis thaliana)
Intracellular signaling by second messengers (Arabidopsis thaliana)
PIP3 activates AKT signaling (Arabidopsis thaliana)
Negative regulation of the PI3K/AKT network (Arabidopsis thaliana)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Arabidopsis thaliana)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Arabidopsis thaliana)
GPCR downstream signalling (Arabidopsis thaliana)
G alpha (q) signalling events (Arabidopsis thaliana)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Arabidopsis thaliana)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Gastrin-CREB signalling pathway via PKC and MAPK (Arabidopsis thaliana)
G alpha (q) signalling events (Arabidopsis thaliana)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Arabidopsis thaliana)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Opioid Signalling (Arabidopsis thaliana)
G-protein mediated events (Arabidopsis thaliana)
PLC beta mediated events (Arabidopsis thaliana)
PIP2 hydrolysis (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Arabidopsis thaliana)
Membrane Trafficking (Arabidopsis thaliana)
Clathrin-mediated endocytosis (Arabidopsis thaliana)
AAK1 phosphorylates AP-2 mu subunit at T156 (Arabidopsis thaliana)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Arabidopsis thaliana)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
CDC42 and PIP2 bind WASL, activating it (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Bos taurus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Bos taurus)
Recycling pathway of L1 (Bos taurus)
L1 trans-homophilic interaction (Bos taurus)
L1 trans-homodimer [plasma membrane] (Bos taurus)
pL1:Ezrin [plasma membrane] (Bos taurus)
ERM:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Bos taurus)
ERM:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Bos taurus)
L1 trans-homodimer [plasma membrane] (Bos taurus)
pL1:Ezrin [plasma membrane] (Bos taurus)
ERM:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Bos taurus)
L1 trans-homodimer [plasma membrane] (Bos taurus)
pL1:Ezrin [plasma membrane] (Bos taurus)
ERM:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Bos taurus)
DCC mediated attractive signaling (Bos taurus)
Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Netrin:DCC:Nck:Cdc42-GTP:Active N-WASP:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Bos taurus)
Ezrin:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
pEzrin:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Ezrin:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Bos taurus)
Non-integrin membrane-ECM interactions (Bos taurus)
Syndecan interactions (Bos taurus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Bos taurus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Bos taurus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family kinases (Bos taurus)
VAV family:PIP2 [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin alphaIIb beta3 signaling (Bos taurus)
Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pFADK1 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of FADK1 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
Crk bound to p130Cas:FADK1 [plasma membrane] (Bos taurus)
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of p130Cas by SRC-FADK1 complex (Bos taurus)
FADK1 bound p130Cas complex [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of p130Cas to FADK1 (Bos taurus)
FADK1 bound p130Cas complex [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signalosomes assemble at the activated BCR (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-7 signaling (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Bos taurus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Attachment of preexisting mother filament and initiation of branching (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of WASP/N-WASP (Bos taurus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll-Like Receptors Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MAL(TIRAP) binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
MAL:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
PIPs [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
PIPs [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Integrin alphaIIb beta3 signaling (Bos taurus)
Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Bos taurus)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pFADK1 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of FADK1 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
Crk bound to p130Cas:FADK1 [plasma membrane] (Bos taurus)
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of p130Cas by SRC-FADK1 complex (Bos taurus)
FADK1 bound p130Cas complex [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of p130Cas to FADK1 (Bos taurus)
FADK1 bound p130Cas complex [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
G alpha (q) signalling events (Bos taurus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Bos taurus)
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Bos taurus)
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Bos taurus)
PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signalling by NGF (Bos taurus)
NGF signalling via TRKA from the plasma membrane (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Bos taurus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Attachment of preexisting mother filament and initiation of branching (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of WASP/N-WASP (Bos taurus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
FCHo proteins bind nascent clathrin-coated pit (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Caenorhabditis elegans)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
L1 trans-homophilic interaction (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Caenorhabditis elegans)
DCC interaction with Ezrin (Caenorhabditis elegans)
DCC:Ezrin complex [plasma membrane] (Caenorhabditis elegans)
pEzrin:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pEzrin:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
Ezrin:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pEzrin:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Ezrin:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Caenorhabditis elegans)
Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
Syndecan interactions (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)
VAV family:PIP2 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin alphaIIb beta3 signaling (Caenorhabditis elegans)
Activated integrin alphaIIb beta3 binds SHC1 (Caenorhabditis elegans)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Caenorhabditis elegans)
PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Integrin alphaIIb beta3 signaling (Caenorhabditis elegans)
Activated integrin alphaIIb beta3 binds SHC1 (Caenorhabditis elegans)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Caenorhabditis elegans)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
PI-3K cascade:FGFR2 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
PI-3K cascade:FGFR3 (Caenorhabditis elegans)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
WNT mediated activation of DVL (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Canis familiaris)
Recycling pathway of L1 (Canis familiaris)
L1 trans-homophilic interaction (Canis familiaris)
L1 trans-homodimer [plasma membrane] (Canis familiaris)
pL1:Ezrin [plasma membrane] (Canis familiaris)
ERM:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Canis familiaris)
ERM:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Canis familiaris)
L1 trans-homodimer [plasma membrane] (Canis familiaris)
pL1:Ezrin [plasma membrane] (Canis familiaris)
ERM:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Canis familiaris)
L1 trans-homodimer [plasma membrane] (Canis familiaris)
pL1:Ezrin [plasma membrane] (Canis familiaris)
ERM:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Canis familiaris)
DCC interaction with Ezrin (Canis familiaris)
DCC:Ezrin complex [plasma membrane] (Canis familiaris)
pEzrin:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
pEzrin:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin:DCC:Nck:Cdc42-GTP:Active N-WASP:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Canis familiaris)
Ezrin:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
pEzrin:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Ezrin:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Canis familiaris)
Non-integrin membrane-ECM interactions (Canis familiaris)
Syndecan interactions (Canis familiaris)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family kinases (Canis familiaris)
VAV family:PIP2 [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin alphaIIb beta3 signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pFADK1 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of FADK1 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
Crk bound to p130Cas:FADK1 [plasma membrane] (Canis familiaris)
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of p130Cas by SRC-FADK1 complex (Canis familiaris)
FADK1 bound p130Cas complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of p130Cas to FADK1 (Canis familiaris)
FADK1 bound p130Cas complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signalosomes assemble at the activated BCR (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-7 signaling (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Attachment of preexisting mother filament and initiation of branching (Canis familiaris)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Canis familiaris)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Canis familiaris)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of WASP/N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll-Like Receptors Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MAL(TIRAP) binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAL:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Integrin alphaIIb beta3 signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of FADK1 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SOS bound to Grb2:pFADK1 [plasma membrane] (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-FADK1 (Canis familiaris)
GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pFADK1 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:p(Y427)-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of FADK1 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
Crk bound to p130Cas:FADK1 [plasma membrane] (Canis familiaris)
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of p130Cas by SRC-FADK1 complex (Canis familiaris)
FADK1 bound p130Cas complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of p130Cas to FADK1 (Canis familiaris)
FADK1 bound p130Cas complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Gastrin-CREB signalling pathway via PKC and MAPK (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
