Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PI(4,5)P2 [plasma membrane]
Stable Identifier
R-ALL-179856
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP2, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, Phosphatidylinositol-4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Bos taurus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
L1 trans-homophilic interaction (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Caenorhabditis elegans)
DCC interaction with Ezrin (Caenorhabditis elegans)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Caenorhabditis elegans)
Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
Syndecan interactions (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
VAV family:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Caenorhabditis elegans)
PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Acetylcholine regulates insulin secretion (Caenorhabditis elegans)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Caenorhabditis elegans)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Caenorhabditis elegans)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Caenorhabditis elegans)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Caenorhabditis elegans)
PLC beta-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
PI-3K cascade:FGFR2 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
PI-3K cascade:FGFR3 (Caenorhabditis elegans)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
PLC beta-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
WNT mediated activation of DVL (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Canis familiaris)
DCC interaction with Ezrin (Canis familiaris)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Canis familiaris)
EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Canis familiaris)
Non-integrin membrane-ECM interactions (Canis familiaris)
Syndecan interactions (Canis familiaris)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
VAV family:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Canis familiaris)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Canis familiaris)
WNT mediated activation of DVL (Canis familiaris)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FCHo proteins bind nascent clathrin-coated pit (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
CDC42 and PIP2 bind WASL, activating it (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Danio rerio)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Danio rerio)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Danio rerio)
Recycling pathway of L1 (Danio rerio)
L1 trans-homophilic interaction (Danio rerio)
L1 trans-homodimer [plasma membrane] (Danio rerio)
pL1:Ezrin [plasma membrane] (Danio rerio)
ERM:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Danio rerio)
ERM:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Danio rerio)
L1 trans-homodimer [plasma membrane] (Danio rerio)
pL1:Ezrin [plasma membrane] (Danio rerio)
ERM:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Danio rerio)
L1 trans-homodimer [plasma membrane] (Danio rerio)
pL1:Ezrin [plasma membrane] (Danio rerio)
ERM:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Danio rerio)
DCC interaction with Ezrin (Danio rerio)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Danio rerio)
EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Danio rerio)
Non-integrin membrane-ECM interactions (Danio rerio)
Syndecan interactions (Danio rerio)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Danio rerio)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Danio rerio)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Danio rerio)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Danio rerio)
Interaction of SOS with GRB2 bound to FADK1 (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Danio rerio)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Danio rerio)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Danio rerio)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Danio rerio)
Crk binding to p130cas (Danio rerio)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Danio rerio)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Danio rerio)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Costimulation by the CD28 family (Danio rerio)
CD28 co-stimulation (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Danio rerio)
DAP12 interactions (Danio rerio)
DAP12 signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated Ca+2 mobilization (Danio rerio)
Hydrolysis of PIP2 by PLCG (Danio rerio)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Danio rerio)
Phosphorylation of PIP2 to PIP3 by PI3K (Danio rerio)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Danio rerio)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Acetylcholine regulates insulin secretion (Danio rerio)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Danio rerio)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Danio rerio)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Danio rerio)
Regulated Necrosis (Danio rerio)
RIPK1-mediated regulated necrosis (Danio rerio)
MLKL binds PIPs (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Danio rerio)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Danio rerio)
Interaction of SOS with GRB2 bound to FADK1 (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Danio rerio)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)