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PI(4,5)P2 [plasma membrane]
Stable Identifier
R-ALL-179856
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP2, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, Phosphatidylinositol-4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
Icon
Locations in the PathwayBrowser for interactor UniProt:O60749
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Caenorhabditis elegans)
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Caenorhabditis elegans)
PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Acetylcholine regulates insulin secretion (Caenorhabditis elegans)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Caenorhabditis elegans)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Caenorhabditis elegans)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Caenorhabditis elegans)
PLC beta-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
PI-3K cascade:FGFR2 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
PI-3K cascade:FGFR3 (Caenorhabditis elegans)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
PLC beta-mediated PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
WNT mediated activation of DVL (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Canis familiaris)
WNT mediated activation of DVL (Canis familiaris)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
CDC42 and PIP2 bind WASL, activating it (Danio rerio)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Costimulation by the CD28 family (Danio rerio)
CD28 co-stimulation (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Danio rerio)
DAP12 interactions (Danio rerio)
DAP12 signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated Ca+2 mobilization (Danio rerio)
Hydrolysis of PIP2 by PLCG (Danio rerio)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Danio rerio)
Phosphorylation of PIP2 to PIP3 by PI3K (Danio rerio)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Role of phospholipids in phagocytosis (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Acetylcholine regulates insulin secretion (Danio rerio)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Danio rerio)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Danio rerio)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Danio rerio)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Danio rerio)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
PLC beta mediated events (Danio rerio)
PIP2 hydrolysis (Danio rerio)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Danio rerio)
G beta:gamma signalling through PI3Kgamma (Danio rerio)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Danio rerio)
PLC beta-mediated PIP2 hydrolysis (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR downregulation (Danio rerio)
EGFR binds EPS15, EPN1, EPS15L1 (Danio rerio)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
PI-3K cascade:FGFR2 (Danio rerio)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
PI-3K cascade:FGFR3 (Danio rerio)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
PI-3K cascade:FGFR4 (Danio rerio)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Danio rerio)
MET activates PI3K/AKT signaling (Danio rerio)
MET bound PI3K generates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
Ca2+ pathway (Danio rerio)
PLC beta-mediated PIP2 hydrolysis (Danio rerio)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Danio rerio)
WNT mediated activation of DVL (Danio rerio)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Clathrin-mediated endocytosis (Danio rerio)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
GPVI-mediated activation cascade (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Acetylcholine regulates insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
PIP2 hydrolysis (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Dictyostelium discoideum)
G beta:gamma signalling through PI3Kgamma (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
Clathrin-mediated endocytosis (Dictyostelium discoideum)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Drosophila melanogaster)
Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
PI3K/AKT activation (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Drosophila melanogaster)
Synthesis of PIP3 from PIP2 by PI3K (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Drosophila melanogaster)
WNT mediated activation of DVL (Drosophila melanogaster)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
CDC42 and PIP2 bind WASL, activating it (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Gallus gallus)
Translocation of Ezrin to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Acetylcholine regulates insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Gallus gallus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Gallus gallus)
WNT mediated activation of DVL (Gallus gallus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
CDC42 and PIP2 bind WASL, activating it (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of second messengers in netrin-1 signaling (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 KD Mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 in disease (Homo sapiens)
Signaling by FGFR3 fusions in cancer (Homo sapiens)
Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 point mutants in cancer (Homo sapiens)
Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 binds inhibiting VAV (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Homo sapiens)
MET activates PI3K/AKT signaling (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VEGFR2 mediated cell proliferation (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
CDC42 and PIP2 bind WASL, activating it (Mus musculus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Mus musculus)
DCC mediated attractive signaling (Mus musculus)
Recruitment and activation of N-WASP by Cdc42 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Role of phospholipids in phagocytosis (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism (Mus musculus)
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Acetylcholine regulates insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Mus musculus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
G-protein mediated events (Mus musculus)
PLC beta mediated events (Mus musculus)