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PI(4,5)P2 [plasma membrane]
Stable Identifier
R-ALL-179856
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP2, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, Phosphatidylinositol-4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
Locations in the PathwayBrowser for interactor UniProt:P63000
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
CDC42 and PIP2 bind WASL, activating it (Bos taurus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Bos taurus)
DCC mediated attractive signaling (Bos taurus)
Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Caenorhabditis elegans)
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Caenorhabditis elegans)
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
WNT mediated activation of DVL (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Acetylcholine regulates insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Canis familiaris)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Canis familiaris)
WNT mediated activation of DVL (Canis familiaris)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
CDC42 and PIP2 bind WASL, activating it (Danio rerio)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
GPVI-mediated activation cascade (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Dictyostelium discoideum)
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
CLEC7A (Dectin-1) signaling (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Acetylcholine regulates insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
PIP2 hydrolysis (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Dictyostelium discoideum)
G beta:gamma signalling through PI3Kgamma (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
Clathrin-mediated endocytosis (Dictyostelium discoideum)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Drosophila melanogaster)
Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
PI3K/AKT activation (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Drosophila melanogaster)
WNT mediated activation of DVL (Drosophila melanogaster)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
CDC42 and PIP2 bind WASL, activating it (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Gallus gallus)
Translocation of Ezrin to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Acetylcholine regulates insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Gallus gallus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Gallus gallus)
WNT mediated activation of DVL (Gallus gallus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
CDC42 and PIP2 bind WASL, activating it (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of second messengers in netrin-1 signaling (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 KD Mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 binds inhibiting VAV (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Homo sapiens)
MET activates PI3K/AKT signaling (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VEGFR2 mediated cell proliferation (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
CDC42 and PIP2 bind WASL, activating it (Mus musculus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Mus musculus)
Translocation of Ezrin to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Role of phospholipids in phagocytosis (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism (Mus musculus)
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Acetylcholine regulates insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Mus musculus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
G-protein mediated events (Mus musculus)
PLC beta mediated events (Mus musculus)
PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through PI3Kgamma (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Mus musculus)
PI3K events in ERBB4 signaling (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Mus musculus)
MET activates PI3K/AKT signaling (Mus musculus)
MET bound PI3K generates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
Ca2+ pathway (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Mus musculus)
WNT mediated activation of DVL (Mus musculus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
GPVI-mediated activation cascade (Plasmodium falciparum)
PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
TCR signaling (Plasmodium falciparum)
Generation of second messenger molecules (Plasmodium falciparum)
PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Plasmodium falciparum)
C-type lectin receptors (CLRs) (Plasmodium falciparum)
CLEC7A (Dectin-1) signaling (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Metabolism (Plasmodium falciparum)
Inositol phosphate metabolism (Plasmodium falciparum)
Synthesis of IP3 and IP4 in the cytosol (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Plasmodium falciparum)
Phospholipid metabolism (Plasmodium falciparum)
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Plasmodium falciparum)
Intracellular signaling by second messengers (Plasmodium falciparum)
PIP3 activates AKT signaling (Plasmodium falciparum)
Negative regulation of the PI3K/AKT network (Plasmodium falciparum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Plasmodium falciparum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Plasmodium falciparum)
Membrane Trafficking (Plasmodium falciparum)
Clathrin-mediated endocytosis (Plasmodium falciparum)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Rattus norvegicus)
Translocation of Ezrin to plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Translocation of RIAM to plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Metabolism (Rattus norvegicus)
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Acetylcholine regulates insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Translocation of RIAM to plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein mediated events (Rattus norvegicus)
PLC beta mediated events (Rattus norvegicus)
PIP2 hydrolysis (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Rattus norvegicus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Rattus norvegicus)
PI3K events in ERBB2 signaling (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Rattus norvegicus)
PI3K events in ERBB4 signaling (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
PI-3K cascade:FGFR2 (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
PI-3K cascade:FGFR3 (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
PI-3K cascade:FGFR4 (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Rattus norvegicus)
MET activates PI3K/AKT signaling (Rattus norvegicus)
MET bound PI3K generates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
WNT mediated activation of DVL (Rattus norvegicus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
GPVI-mediated activation cascade (Saccharomyces cerevisiae)
PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
TCR signaling (Saccharomyces cerevisiae)
Downstream TCR signaling (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Saccharomyces cerevisiae)
PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Saccharomyces cerevisiae)
C-type lectin receptors (CLRs) (Saccharomyces cerevisiae)
CLEC7A (Dectin-1) signaling (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Metabolism (Saccharomyces cerevisiae)
Inositol phosphate metabolism (Saccharomyces cerevisiae)
Synthesis of IP3 and IP4 in the cytosol (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Saccharomyces cerevisiae)
Regulation of insulin secretion (Saccharomyces cerevisiae)
Acetylcholine regulates insulin secretion (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Saccharomyces cerevisiae)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Saccharomyces cerevisiae)
Phospholipid metabolism (Saccharomyces cerevisiae)
PI Metabolism (Saccharomyces cerevisiae)
Synthesis of PIPs at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Saccharomyces cerevisiae)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Saccharomyces cerevisiae)
GPCR downstream signalling (Saccharomyces cerevisiae)
G alpha (i) signalling events (Saccharomyces cerevisiae)
Opioid Signalling (Saccharomyces cerevisiae)
G-protein mediated events (Saccharomyces cerevisiae)
PLC beta mediated events (Saccharomyces cerevisiae)
PIP2 hydrolysis (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Saccharomyces cerevisiae)
Membrane Trafficking (Saccharomyces cerevisiae)
Clathrin-mediated endocytosis (Saccharomyces cerevisiae)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)
PI(4,5)P2 [plasma membrane]
Hemostasis (Schizosaccharomyces pombe)
Platelet activation, signaling and aggregation (Schizosaccharomyces pombe)
GPVI-mediated activation cascade (Schizosaccharomyces pombe)
PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
TCR signaling (Schizosaccharomyces pombe)
Downstream TCR signaling (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Schizosaccharomyces pombe)
PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Schizosaccharomyces pombe)
C-type lectin receptors (CLRs) (Schizosaccharomyces pombe)
CLEC7A (Dectin-1) signaling (Schizosaccharomyces pombe)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Metabolism (Schizosaccharomyces pombe)
Inositol phosphate metabolism (Schizosaccharomyces pombe)
Synthesis of IP3 and IP4 in the cytosol (Schizosaccharomyces pombe)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Schizosaccharomyces pombe)
Regulation of insulin secretion (Schizosaccharomyces pombe)
Acetylcholine regulates insulin secretion (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Schizosaccharomyces pombe)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Schizosaccharomyces pombe)
Phospholipid metabolism (Schizosaccharomyces pombe)
PI Metabolism (Schizosaccharomyces pombe)
Synthesis of PIPs at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Schizosaccharomyces pombe)
GPCR downstream signalling (Schizosaccharomyces pombe)
G alpha (i) signalling events (Schizosaccharomyces pombe)
Opioid Signalling (Schizosaccharomyces pombe)
G-protein mediated events (Schizosaccharomyces pombe)
PLC beta mediated events (Schizosaccharomyces pombe)
PIP2 hydrolysis (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Schizosaccharomyces pombe)
Membrane Trafficking (Schizosaccharomyces pombe)
Clathrin-mediated endocytosis (Schizosaccharomyces pombe)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
EPH-Ephrin signaling (Sus scrofa)
EPHB-mediated forward signaling (Sus scrofa)
CDC42 and PIP2 bind WASL, activating it (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Sus scrofa)
Translocation of Ezrin to plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
Translocation of RIAM to plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Costimulation by the CD28 family (Sus scrofa)
CD28 co-stimulation (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Role of phospholipids in phagocytosis (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Metabolism (Sus scrofa)
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP3 and IP4 in the cytosol (Sus scrofa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Sus scrofa)
Regulation of insulin secretion (Sus scrofa)
Acetylcholine regulates insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Sus scrofa)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Sus scrofa)
Phospholipid metabolism (Sus scrofa)
PI Metabolism (Sus scrofa)
Synthesis of PIPs at the plasma membrane (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
Translocation of RIAM to plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Sus scrofa)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Sus scrofa)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
G-protein mediated events (Sus scrofa)
PLC beta mediated events (Sus scrofa)
PIP2 hydrolysis (Sus scrofa)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Sus scrofa)
G beta:gamma signalling through PI3Kgamma (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Sus scrofa)
PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Sus scrofa)
EGFR downregulation (Sus scrofa)
EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Sus scrofa)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Sus scrofa)
PI3K events in ERBB2 signaling (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Sus scrofa)
PI3K events in ERBB4 signaling (Sus scrofa)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Downstream signaling of activated FGFR1 (Sus scrofa)
PI-3K cascade:FGFR1 (Sus scrofa)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Sus scrofa)
Downstream signaling of activated FGFR2 (Sus scrofa)
PI-3K cascade:FGFR2 (Sus scrofa)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Sus scrofa)
Downstream signaling of activated FGFR3 (Sus scrofa)
PI-3K cascade:FGFR3 (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Sus scrofa)
Downstream signaling of activated FGFR4 (Sus scrofa)
PI-3K cascade:FGFR4 (Sus scrofa)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Sus scrofa)
MET activates PI3K/AKT signaling (Sus scrofa)
MET bound PI3K generates PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
PI3K/AKT activation (Sus scrofa)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Sus scrofa)
Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
Ca2+ pathway (Sus scrofa)
PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Sus scrofa)
WNT mediated activation of DVL (Sus scrofa)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Sus scrofa)
Membrane Trafficking (Sus scrofa)
Clathrin-mediated endocytosis (Sus scrofa)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
Netrin-1 signaling (Xenopus tropicalis)
Translocation of Ezrin to plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
GPVI-mediated activation cascade (Xenopus tropicalis)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Xenopus tropicalis)
Integrin signaling (Xenopus tropicalis)
Translocation of RIAM to plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Costimulation by the CD28 family (Xenopus tropicalis)
CD28 co-stimulation (Xenopus tropicalis)
CD28 dependent PI3K/Akt signaling (Xenopus tropicalis)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
TCR signaling (Xenopus tropicalis)
Downstream TCR signaling (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Xenopus tropicalis)
PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Xenopus tropicalis)
C-type lectin receptors (CLRs) (Xenopus tropicalis)
CLEC7A (Dectin-1) signaling (Xenopus tropicalis)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Xenopus tropicalis)
Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Xenopus tropicalis)
Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Metabolism (Xenopus tropicalis)
Inositol phosphate metabolism (Xenopus tropicalis)
Synthesis of IP3 and IP4 in the cytosol (Xenopus tropicalis)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Xenopus tropicalis)
Phospholipid metabolism (Xenopus tropicalis)
PI Metabolism (Xenopus tropicalis)
Synthesis of PIPs at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Xenopus tropicalis)
Integrin signaling (Xenopus tropicalis)
Translocation of RIAM to plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Xenopus tropicalis)
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Xenopus tropicalis)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Xenopus tropicalis)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Opioid Signalling (Xenopus tropicalis)
G-protein mediated events (Xenopus tropicalis)
PLC beta mediated events (Xenopus tropicalis)
PIP2 hydrolysis (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Xenopus tropicalis)
G beta:gamma signalling through PI3Kgamma (Xenopus tropicalis)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Xenopus tropicalis)
PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Xenopus tropicalis)
GAB1 signalosome (Xenopus tropicalis)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Xenopus tropicalis)
PI3K events in ERBB2 signaling (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Xenopus tropicalis)
PI3K events in ERBB4 signaling (Xenopus tropicalis)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Xenopus tropicalis)
Signaling by FGFR1 (Xenopus tropicalis)
Downstream signaling of activated FGFR1 (Xenopus tropicalis)
PI-3K cascade:FGFR1 (Xenopus tropicalis)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Xenopus tropicalis)
Downstream signaling of activated FGFR2 (Xenopus tropicalis)
PI-3K cascade:FGFR2 (Xenopus tropicalis)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Xenopus tropicalis)
Downstream signaling of activated FGFR3 (Xenopus tropicalis)
PI-3K cascade:FGFR3 (Xenopus tropicalis)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Xenopus tropicalis)
Downstream signaling of activated FGFR4 (Xenopus tropicalis)
PI-3K cascade:FGFR4 (Xenopus tropicalis)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor signalling cascade (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Xenopus tropicalis)
MET activates PI3K/AKT signaling (Xenopus tropicalis)
MET bound PI3K generates PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
PI3K/AKT activation (Xenopus tropicalis)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Xenopus tropicalis)
Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Xenopus tropicalis)
IGF1R signaling cascade (Xenopus tropicalis)
IRS-related events triggered by IGF1R (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Xenopus tropicalis)
Beta-catenin independent WNT signaling (Xenopus tropicalis)
Ca2+ pathway (Xenopus tropicalis)
PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Xenopus tropicalis)
Membrane Trafficking (Xenopus tropicalis)
Clathrin-mediated endocytosis (Xenopus tropicalis)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)
PI(4,5)P2 [plasma membrane]
External Reference Information
External Reference
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456]
Participates
as a component of
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Gallus gallus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Schizosaccharomyces pombe)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Sus scrofa)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
Vav1:PIP2 [cytosol] (Mus musculus)
VAV family:PIP2 [plasma membrane] (Rattus norvegicus)
VAV family:PIP2 [plasma membrane] (Mus musculus)
VAV family:PIP2 [plasma membrane] (Sus scrofa)
VAV family:PIP2 [plasma membrane] (Drosophila melanogaster)
VAV family:PIP2 [plasma membrane] (Bos taurus)
VAV family:PIP2 [plasma membrane] (Caenorhabditis elegans)
VAV family:PIP2 [plasma membrane] (Canis familiaris)
VAV family:PIP2 [plasma membrane] (Xenopus tropicalis)
VAV family:PIP2 [plasma membrane] (Homo sapiens)
Sdc4:PI(4,5)P2 [plasma membrane] (Danio rerio)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Danio rerio)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Sus scrofa)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Mus musculus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Bos taurus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Gallus gallus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
EZR:PIP2 [plasma membrane] (Danio rerio)
EZR:PIP2 [plasma membrane] (Sus scrofa)
EZR:PIP2 [plasma membrane] (Rattus norvegicus)
EZR:PIP2 [plasma membrane] (Mus musculus)
EZR:PIP2 [plasma membrane] (Gallus gallus)
EZR:PIP2 [plasma membrane] (Canis familiaris)
EZR:PIP2 [plasma membrane] (Bos taurus)
EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
EZR:PIP2 [plasma membrane] (Xenopus tropicalis)
EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
EZR:PIP2 [plasma membrane] (Homo sapiens)
p-T567-EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
p-T567-EZR:PIP2 [plasma membrane] (Gallus gallus)
p-T567-EZR:PIP2 [plasma membrane] (Xenopus tropicalis)
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
p-T567-EZR:PIP2 [plasma membrane] (Sus scrofa)
p-T567-EZR:PIP2 [plasma membrane] (Bos taurus)
p-T567-EZR:PIP2 [plasma membrane] (Mus musculus)
p-T567-EZR:PIP2 [plasma membrane] (Rattus norvegicus)
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
p-T567-EZR:PIP2 [plasma membrane] (Homo sapiens)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Sus scrofa)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Xenopus tropicalis)
ERM:PIP2 [plasma membrane] (Mus musculus)
ERM:PIP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
Cdc42-GTP:Wasp/N-Wasp [cytosol] (Mus musculus)
PI(4,5)P2:WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Sus scrofa)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Danio rerio)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Mus musculus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP2 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP2 [plasma membrane] (Bos taurus)
PDPK1:PIP2 [plasma membrane] (Plasmodium falciparum)
PDPK1:PIP2 [plasma membrane] (Canis familiaris)
PDPK1:PIP2 [plasma membrane] (Sus scrofa)
PDPK1:PIP2 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP2 [plasma membrane] (Xenopus tropicalis)
PDPK1:PIP2 [plasma membrane] (Gallus gallus)
PDPK1:PIP2 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP2 [plasma membrane] (Danio rerio)
PDPK1:PIP2 [plasma membrane] (Mus musculus)
PDPK1:PIP2 [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP2 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
TIRAP:PI(4,5)P2 [plasma membrane] (Sus scrofa)
TIRAP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
TIRAP:PI(4,5)P2 [plasma membrane] (Xenopus tropicalis)
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
TIRAP:PI(4,5)P2 [plasma membrane] (Mus musculus)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Mus musculus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Xenopus tropicalis)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Bos taurus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Dictyostelium discoideum)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Schizosaccharomyces pombe)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Gallus gallus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Sus scrofa)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Saccharomyces cerevisiae)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Canis familiaris)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Drosophila melanogaster)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Rattus norvegicus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Dictyostelium discoideum)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Saccharomyces cerevisiae)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Mus musculus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Sus scrofa)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Xenopus tropicalis)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Rattus norvegicus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Danio rerio)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Plasmodium falciparum)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Gallus gallus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Schizosaccharomyces pombe)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
Vinculin bound to PIP2 [plasma membrane] (Sus scrofa)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Xenopus tropicalis)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
as an input of
Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Mus musculus)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Bos taurus)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate (Mus musculus)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PIP2 inhibits Vav1 (Mus musculus)
PIP2 binds inhibiting VAV (Homo sapiens)
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
Translocation of RIAM to plasma membrane (Gallus gallus)
Translocation of RIAM to plasma membrane (Xenopus tropicalis)
Translocation of RIAM to plasma membrane (Danio rerio)
Translocation of RIAM to plasma membrane (Sus scrofa)
Translocation of RIAM to plasma membrane (Bos taurus)
Translocation of RIAM to plasma membrane (Canis familiaris)
Translocation of RIAM to plasma membrane (Rattus norvegicus)
Translocation of RIAM to plasma membrane (Mus musculus)
Translocation of RIAM to plasma membrane (Homo sapiens)
Syndecan-4 binds PI(4,5)P2 (Danio rerio)
Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
AKT1 E17K mutant binds PIP2 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PIP2 hydrolysis (Rattus norvegicus)
PIP2 hydrolysis (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
Translocation of Ezrin to plasma membrane (Gallus gallus)
Translocation of Ezrin to plasma membrane (Xenopus tropicalis)
Translocation of Ezrin to plasma membrane (Danio rerio)
Translocation of Ezrin to plasma membrane (Sus scrofa)
Translocation of Ezrin to plasma membrane (Bos taurus)
Translocation of Ezrin to plasma membrane (Canis familiaris)
Translocation of Ezrin to plasma membrane (Rattus norvegicus)
Translocation of Ezrin to plasma membrane (Mus musculus)
Translocation of Ezrin to plasma membrane (Homo sapiens)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)
CDC42 and PIP2 bind WASL, activating it (Gallus gallus)
CDC42 and PIP2 bind WASL, activating it (Danio rerio)
CDC42 and PIP2 bind WASL, activating it (Sus scrofa)
CDC42 and PIP2 bind WASL, activating it (Bos taurus)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
CDC42 and PIP2 bind WASL, activating it (Mus musculus)
CDC42 and PIP2 bind WASL, activating it (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
Activated Ntrk2 activates PI3K signaling (Mus musculus)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
Activated Ntrk3 stimulates PI3K activity (Mus musculus)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Xenopus tropicalis)
MET bound PI3K generates PIP3 (Sus scrofa)
MET bound PI3K generates PIP3 (Bos taurus)
MET bound PI3K generates PIP3 (Canis familiaris)
MET bound PI3K generates PIP3 (Rattus norvegicus)
MET bound PI3K generates PIP3 (Mus musculus)
MET bound PI3K generates PIP3 (Homo sapiens)
MET bound PI3K generates PIP3 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)
EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)
EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Mus musculus)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)
TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
PDPK1 binds PIP2 (Plasmodium falciparum)
PDPK1 binds PIP2 (Saccharomyces cerevisiae)
PDPK1 binds PIP2 (Schizosaccharomyces pombe)
PDPK1 binds PIP2 (Dictyostelium discoideum)
PDPK1 binds PIP2 (Caenorhabditis elegans)
PDPK1 binds PIP2 (Drosophila melanogaster)
PDPK1 binds PIP2 (Gallus gallus)
PDPK1 binds PIP2 (Xenopus tropicalis)
PDPK1 binds PIP2 (Danio rerio)
PDPK1 binds PIP2 (Sus scrofa)
PDPK1 binds PIP2 (Bos taurus)
PDPK1 binds PIP2 (Canis familiaris)
PDPK1 binds PIP2 (Rattus norvegicus)
PDPK1 binds PIP2 (Mus musculus)
PDPK1 binds PIP2 (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Bos taurus)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PIP2 hydrolysis (Saccharomyces cerevisiae)
PIP2 hydrolysis (Schizosaccharomyces pombe)
PIP2 hydrolysis (Dictyostelium discoideum)
PIP2 hydrolysis (Caenorhabditis elegans)
PIP2 hydrolysis (Drosophila melanogaster)
PIP2 hydrolysis (Gallus gallus)
PIP2 hydrolysis (Xenopus tropicalis)
PIP2 hydrolysis (Sus scrofa)
PIP2 hydrolysis (Bos taurus)
PIP2 hydrolysis (Canis familiaris)
PIP2 hydrolysis (Rattus norvegicus)
PIP2 hydrolysis (Mus musculus)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)
Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)
Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)
Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)
Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
Translocation of PLC-gamma1 to PIP2 (Sus scrofa)
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
Active Plcg1 hydrolyses PIP2 (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)
PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)
PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)
PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)
as an output of
PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Danio rerio)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)
PTEN dephosphorylates PIP3 (Sus scrofa)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PTEN dephosphorylates PIP3 (Mus musculus)
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PTEN dephosphorylates PIP3 (Homo sapiens)
as a member of
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
Other forms of this molecule
PI(4,5)P2 [early endosome membrane]
PI(4,5)P2 [cytoplasmic vesicle membrane]
PI(4,5)P2 [nucleoplasm]
PI(4,5)P2 [Golgi membrane]
PI(4,5)P2 [endoplasmic reticulum membrane]
Cross References
COMPOUND
C04637
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