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About
What is Reactome ?
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Table of Contents
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Go!
Btn [cytosol]
Stable Identifier
R-ALL-199207
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
D-Biotin, biotin, Vitamin H, Coenzyme R
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Biotin transport and metabolism (Bos taurus)
HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Bos taurus)
Btn [cytosol]
HLCS biotinylates ACACB (Bos taurus)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Bos taurus)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)
Btn [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Biotin transport and metabolism (Caenorhabditis elegans)
HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
Btn [cytosol]
HLCS biotinylates ACACB (Caenorhabditis elegans)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Caenorhabditis elegans)
Btn [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of vitamins, nucleosides, and related molecules (Caenorhabditis elegans)
SLC5A6 transports vitamins from extracellular region to cytosol (Caenorhabditis elegans)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Biotin transport and metabolism (Canis familiaris)
HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
Btn [cytosol]
HLCS biotinylates ACACB (Canis familiaris)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Canis familiaris)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)
Btn [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of vitamins, nucleosides, and related molecules (Canis familiaris)
SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Danio rerio)
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Biotin transport and metabolism (Danio rerio)
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Danio rerio)
Btn [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of vitamins, nucleosides, and related molecules (Danio rerio)
SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Biotin transport and metabolism (Dictyostelium discoideum)
HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)
Btn [cytosol]
HLCS biotinylates ACACB (Dictyostelium discoideum)
Btn [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Biotin transport and metabolism (Drosophila melanogaster)
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Drosophila melanogaster)
Btn [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of vitamins, nucleosides, and related molecules (Drosophila melanogaster)
SLC5A6 transports vitamins from extracellular region to cytosol (Drosophila melanogaster)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Biotin transport and metabolism (Gallus gallus)
HLCS biotinylates 6x(PCCA:PCCB) (Gallus gallus)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Gallus gallus)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Gallus gallus)
Btn [cytosol]
HLCS biotinylates ACACB (Gallus gallus)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Gallus gallus)
Btn [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of vitamins, nucleosides, and related molecules (Gallus gallus)
SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in biotin (Btn) metabolism (Homo sapiens)
Defective HLCS causes multiple carboxylase deficiency (Homo sapiens)
Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)
Btn [cytosol]
Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)
Btn [cytosol]
Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)
Btn [cytosol]
Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)
Btn [cytosol]
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
Btn [cytosol]
HLCS biotinylates ACACB (Homo sapiens)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Homo sapiens)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)
Btn [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Biotin transport and metabolism (Mus musculus)
HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Mus musculus)
Btn [cytosol]
HLCS biotinylates ACACB (Mus musculus)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Mus musculus)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Mus musculus)
Btn [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of vitamins, nucleosides, and related molecules (Mus musculus)
SLC5A6 transports vitamins from extracellular region to cytosol (Mus musculus)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Biotin transport and metabolism (Rattus norvegicus)
HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)
Btn [cytosol]
HLCS biotinylates ACACB (Rattus norvegicus)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Rattus norvegicus)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)
Btn [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of vitamins, nucleosides, and related molecules (Rattus norvegicus)
SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Biotin transport and metabolism (Saccharomyces cerevisiae)
HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)
Btn [cytosol]
HLCS biotinylates ACACB (Saccharomyces cerevisiae)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)
Btn [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Biotin transport and metabolism (Schizosaccharomyces pombe)
HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)
Btn [cytosol]
HLCS biotinylates ACACB (Schizosaccharomyces pombe)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)
Btn [cytosol]
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Biotin transport and metabolism (Sus scrofa)
HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Sus scrofa)
Btn [cytosol]
HLCS biotinylates ACACB (Sus scrofa)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Sus scrofa)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)
Btn [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of vitamins, nucleosides, and related molecules (Sus scrofa)
SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Biotin transport and metabolism (Xenopus tropicalis)
HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)
Btn [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)
Btn [cytosol]
HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)
Btn [cytosol]
HLCS biotinylates ACACB (Xenopus tropicalis)
Btn [cytosol]
HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)
Btn [cytosol]
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Xenopus tropicalis)
Btn [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of vitamins, nucleosides, and related molecules (Xenopus tropicalis)
SLC5A6 transports vitamins from extracellular region to cytosol (Xenopus tropicalis)
vitamins transported by SMVT [cytosol]
Btn [cytosol]
External Reference Information
External Reference
biotin [ChEBI:15956]
Participant Of
input
Defective HLCS does not biotinylate 6x(PCCA:PCCB)
Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2
Defective HLCS does not biotinylate ACACA:Mn2+
Defective HLCS does not biotinylate PC:Mn2+
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACA:Mn2+
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates ACACB
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
HLCS biotinylates PC:Mn2+
hasMember
vitamins transported by SMVT [cytosol]
output
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
Other forms of this molecule
Btn [extracellular region]
Btn [mitochondrial matrix]
Cross References
COMPOUND
C00120
PubChem Substance
8143739
HMDB Metabolite
HMDB0000030
ZINC
000035024346
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