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Our Logo
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PI(3,4)P2 [plasma membrane]
Stable Identifier
R-ALL-202247
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphates, 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14451
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
PI(3,4)P2 [plasma membrane]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PI(3,4)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
PI(3,4)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)
PI(3,4)P2 [plasma membrane]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(3,4)P2 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Danio rerio)
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Danio rerio)
PI(3,4)P2 [plasma membrane]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Danio rerio)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Clathrin-mediated endocytosis (Danio rerio)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
PI(3,4)P2 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 [plasma membrane]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(3,4)P2 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
PI(3,4)P2 [plasma membrane]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Gallus gallus)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Gallus gallus)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
PI(3,4)P2 [plasma membrane]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
PIPs transport between plasma and early endosome membranes (Homo sapiens)
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(3,4)P2 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)
PI(3,4)P2 [plasma membrane]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
PI(3,4)P2 [plasma membrane]
Metabolism (Plasmodium falciparum)
Metabolism of lipids (Plasmodium falciparum)
Phospholipid metabolism (Plasmodium falciparum)
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 [plasma membrane]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
PI(3,4)P2 [plasma membrane]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Phospholipid metabolism (Saccharomyces cerevisiae)
PI Metabolism (Saccharomyces cerevisiae)
Synthesis of PIPs at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 [plasma membrane]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Phospholipid metabolism (Schizosaccharomyces pombe)
PI Metabolism (Schizosaccharomyces pombe)
Synthesis of PIPs at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Schizosaccharomyces pombe)
Membrane Trafficking (Schizosaccharomyces pombe)
Clathrin-mediated endocytosis (Schizosaccharomyces pombe)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Schizosaccharomyces pombe)
PI(3,4)P2 [plasma membrane]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)
PI(3,4)P2 [plasma membrane]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Phospholipid metabolism (Sus scrofa)
PI Metabolism (Sus scrofa)
Synthesis of PIPs at the plasma membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Sus scrofa)
Membrane Trafficking (Sus scrofa)
Clathrin-mediated endocytosis (Sus scrofa)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
PI(3,4)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
PI(3,4)P2 [plasma membrane]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
TCR signaling (Xenopus tropicalis)
Downstream TCR signaling (Xenopus tropicalis)
Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
Innate Immune System (Xenopus tropicalis)
Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Phospholipid metabolism (Xenopus tropicalis)
PI Metabolism (Xenopus tropicalis)
Synthesis of PIPs at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
Vesicle-mediated transport (Xenopus tropicalis)
Membrane Trafficking (Xenopus tropicalis)
Clathrin-mediated endocytosis (Xenopus tropicalis)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
PI(3,4)P2 [plasma membrane]
External Reference Information
External Reference
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [ChEBI:16152]
Participant Of
hasComponent
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
Actin filament bound Myosin-X [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
PTPN13:PLEKHA1,2:PIP2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
SH3PXD2A:PI(3,4)P2 [plasma membrane]
input
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Extension of pseudopodia by myosin-X in a PI3K dependent manner
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
PTPN13:PLEKHA1,2 bind PI(3,4)P2
output
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PI(3,4)P2
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
hasMember
PIP3, PI(3,4)P2 [plasma membrane]
This entity regulates
Positively
F- and N- BAR domain proteins bind the clathrin-coated pit
Other forms of this molecule
PI(3,4)P2 [Golgi membrane]
PI(3,4)P2 [early endosome membrane]
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![PI(3,4)P2 [plasma membrane] icon](/icon/R-ICO-013853.svg){kind=icon}
