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Ca2+ [secretory granule lumen]
Stable Identifier
R-ALL-216801
Type
Chemical Compound [SimpleEntity]
Compartment
secretory granule lumen
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism of proteins (Bos taurus)
Peptide hormone metabolism (Bos taurus)
Insulin processing (Bos taurus)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Bos taurus)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Bos taurus)
Corticotropin cleavage from POMC (Bos taurus)
PC1:calcium cofactor [secretory granule lumen] (Bos taurus)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Bos taurus)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Bos taurus)
PC1:calcium cofactor [secretory granule lumen] (Bos taurus)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Insulin processing (Canis familiaris)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Canis familiaris)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Canis familiaris)
Corticotropin cleavage from POMC (Canis familiaris)
PC1:calcium cofactor [secretory granule lumen] (Canis familiaris)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Canis familiaris)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)
PC1:calcium cofactor [secretory granule lumen] (Canis familiaris)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Danio rerio)
Peptide hormone metabolism (Danio rerio)
Insulin processing (Danio rerio)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Danio rerio)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Danio rerio)
Corticotropin cleavage from POMC (Danio rerio)
PC1:calcium cofactor [secretory granule lumen] (Danio rerio)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Danio rerio)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)
PC1:calcium cofactor [secretory granule lumen] (Danio rerio)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Gallus gallus)
Peptide hormone metabolism (Gallus gallus)
Insulin processing (Gallus gallus)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Gallus gallus)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Gallus gallus)
Corticotropin cleavage from POMC (Gallus gallus)
PC1:calcium cofactor [secretory granule lumen] (Gallus gallus)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Gallus gallus)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)
PC1:calcium cofactor [secretory granule lumen] (Gallus gallus)
Ca2+ [secretory granule lumen]
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Insulin processing (Homo sapiens)
Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)
6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Insulin secretory granule docks at the plasma membrane (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Insulin secretory granule translocates across the cortical actin network (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Insulin secretory granule translocates to cell cortex (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)
6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Homo sapiens)
Corticotropin cleavage from POMC (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Mus musculus)
Peptide hormone metabolism (Mus musculus)
Insulin processing (Mus musculus)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Mus musculus)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Mus musculus)
Corticotropin cleavage from POMC (Mus musculus)
PC1:calcium cofactor [secretory granule lumen] (Mus musculus)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Mus musculus)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)
PC1:calcium cofactor [secretory granule lumen] (Mus musculus)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Rattus norvegicus)
Peptide hormone metabolism (Rattus norvegicus)
Insulin processing (Rattus norvegicus)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Rattus norvegicus)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Rattus norvegicus)
Corticotropin cleavage from POMC (Rattus norvegicus)
PC1:calcium cofactor [secretory granule lumen] (Rattus norvegicus)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Rattus norvegicus)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)
PC1:calcium cofactor [secretory granule lumen] (Rattus norvegicus)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Sus scrofa)
Peptide hormone metabolism (Sus scrofa)
Insulin processing (Sus scrofa)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Sus scrofa)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Sus scrofa)
Ca2+ [secretory granule lumen]
Peptide hormone biosynthesis (Sus scrofa)
Corticotropin cleavage from POMC (Sus scrofa)
PC1:calcium cofactor [secretory granule lumen] (Sus scrofa)
Ca2+ [secretory granule lumen]
Synthesis, secretion, and deacylation of Ghrelin (Sus scrofa)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)
PC1:calcium cofactor [secretory granule lumen] (Sus scrofa)
Ca2+ [secretory granule lumen]
Metabolism of proteins (Xenopus tropicalis)
Peptide hormone metabolism (Xenopus tropicalis)
Insulin processing (Xenopus tropicalis)
Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Xenopus tropicalis)
Ca2+ [secretory granule lumen]
External Reference Information
External Reference
calcium(2+) [ChEBI:29108]
Participates
as a component of
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
Proinsulin-Zinc-Calcium complex [secretory granule lumen] (Mus musculus)
Pcsk1:Ca2+ [secretory granule lumen] (Rattus norvegicus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Canis familiaris)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Mus musculus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Bos taurus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Danio rerio)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Xenopus tropicalis)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Sus scrofa)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Rattus norvegicus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Gallus gallus)
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)
Insulin:Zinc:Calcium [secretory granule lumen] (Mus musculus)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Canis familiaris)
PC1:calcium cofactor [secretory granule lumen] (Bos taurus)
PC1:calcium cofactor [secretory granule lumen] (Rattus norvegicus)
PC1:calcium cofactor [secretory granule lumen] (Gallus gallus)
PC1:calcium cofactor [secretory granule lumen] (Danio rerio)
PC1:calcium cofactor [secretory granule lumen] (Sus scrofa)
PC1:calcium cofactor [secretory granule lumen] (Mus musculus)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
Ca2+ [platelet dense granule lumen]
Ca2+ [endosome membrane]
Ca2+ [sarcoplasmic reticulum lumen]
Ca2+ [mitochondrial intermembrane space]
Ca2+ [lysosomal lumen]
Ca2+ [endocytic vesicle lumen]
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
Ca2+ [Golgi lumen]
Ca2+ [platelet dense tubular network lumen]
Ca2+ [platelet dense tubular network membrane]
Ca2+ [plasma membrane]
Ca2+ [nuclear envelope]
Ca2+ [nucleoplasm]
Ca2+ [mitochondrial matrix]
Ca2+ [mitochondrial inner membrane]
Ca2+ [endoplasmic reticulum membrane]
Ca2+ [cytosol]
Ca2+ [extracellular region]
Ca2+ [endoplasmic reticulum lumen]
Cross References
COMPOUND
C00076
PubChem Substance
8145461
HMDB Metabolite
HMDB0000464
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