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Mn2+ [extracellular region]
Stable Identifier
R-ALL-266099
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Manganese, manganese(2+), Mn(II)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Fibronectin matrix formation (Bos taurus)
FN1 aggregation (Bos taurus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Metal sequestration by antimicrobial proteins (Bos taurus)
S100A8:S100A9 binds Mn2+ (Bos taurus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
Metabolism (Bos taurus)
Metabolism of carbohydrates (Bos taurus)
Blood group systems biosynthesis (Bos taurus)
ABO blood group biosynthesis (Bos taurus)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)
sABO-A:Mn2+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)
sABO-B:Mn2+ [extracellular region] (Bos taurus)
Mn2+ [extracellular region]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)
Mn2+ [extracellular region]
Extracellular matrix organization (Caenorhabditis elegans)
Fibronectin matrix formation (Caenorhabditis elegans)
FN1 aggregation (Caenorhabditis elegans)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Cell surface interactions at the vascular wall (Caenorhabditis elegans)
Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)
Mn2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Fibronectin matrix formation (Canis familiaris)
FN1 aggregation (Canis familiaris)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Metal sequestration by antimicrobial proteins (Canis familiaris)
S100A8:S100A9 binds Mn2+ (Canis familiaris)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
Metabolism (Canis familiaris)
Metabolism of carbohydrates (Canis familiaris)
Blood group systems biosynthesis (Canis familiaris)
ABO blood group biosynthesis (Canis familiaris)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)
sABO-A:Mn2+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)
sABO-B:Mn2+ [extracellular region] (Canis familiaris)
Mn2+ [extracellular region]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)
Mn2+ [extracellular region]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Metal sequestration by antimicrobial proteins (Danio rerio)
S100A8:S100A9 binds Mn2+ (Danio rerio)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
Metabolism (Danio rerio)
Metabolism of carbohydrates (Danio rerio)
Blood group systems biosynthesis (Danio rerio)
ABO blood group biosynthesis (Danio rerio)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)
sABO-A:Mn2+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)
sABO-B:Mn2+ [extracellular region] (Danio rerio)
Mn2+ [extracellular region]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)
Mn2+ [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)
Mn2+ [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)
Mn2+ [extracellular region]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Metal sequestration by antimicrobial proteins (Gallus gallus)
S100A8:S100A9 binds Mn2+ (Gallus gallus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Gallus gallus)
Mn2+ [extracellular region]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Extracellular matrix organization (Homo sapiens)
Fibronectin matrix formation (Homo sapiens)
FN1 aggregation (Homo sapiens)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
Mn2+ [extracellular region]
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Metal sequestration by antimicrobial proteins (Homo sapiens)
S100A8:S100A9 binds Mn2+ (Homo sapiens)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Homo sapiens)
Mn2+ [extracellular region]
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Blood group systems biosynthesis (Homo sapiens)
ABO blood group biosynthesis (Homo sapiens)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)
sABO-A:Mn2+ [extracellular region] (Homo sapiens)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)
sABO-B:Mn2+ [extracellular region] (Homo sapiens)
Mn2+ [extracellular region]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)
Mn2+ [extracellular region]
Extracellular matrix organization (Mus musculus)
Fibronectin matrix formation (Mus musculus)
FN1 aggregation (Mus musculus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Mus musculus)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Mus musculus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Mus musculus)
Mn2+ [extracellular region]
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Integrin alpha5beta1 binds FN1 dimer (Mus musculus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Mus musculus)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Metal sequestration by antimicrobial proteins (Mus musculus)
S100A8:S100A9 binds Mn2+ (Mus musculus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Mus musculus)
Mn2+ [extracellular region]
Metabolism (Mus musculus)
Metabolism of carbohydrates (Mus musculus)
Blood group systems biosynthesis (Mus musculus)
ABO blood group biosynthesis (Mus musculus)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)
sABO-A:Mn2+ [extracellular region] (Mus musculus)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)
sABO-B:Mn2+ [extracellular region] (Mus musculus)
Mn2+ [extracellular region]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Metal ion SLC transporters (Mus musculus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)
Mn2+ [extracellular region]
Extracellular matrix organization (Rattus norvegicus)
Fibronectin matrix formation (Rattus norvegicus)
FN1 aggregation (Rattus norvegicus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
Mn2+ [extracellular region]
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
Metal sequestration by antimicrobial proteins (Rattus norvegicus)
S100A8:S100A9 binds Mn2+ (Rattus norvegicus)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Rattus norvegicus)
Mn2+ [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of carbohydrates (Rattus norvegicus)
Blood group systems biosynthesis (Rattus norvegicus)
ABO blood group biosynthesis (Rattus norvegicus)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)
sABO-A:Mn2+ [extracellular region] (Rattus norvegicus)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)
sABO-B:Mn2+ [extracellular region] (Rattus norvegicus)
Mn2+ [extracellular region]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Metal ion SLC transporters (Rattus norvegicus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)
Mn2+ [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
Metal ion SLC transporters (Saccharomyces cerevisiae)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)
Mn2+ [extracellular region]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
Metal ion SLC transporters (Schizosaccharomyces pombe)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)
Mn2+ [extracellular region]
Extracellular matrix organization (Sus scrofa)
Fibronectin matrix formation (Sus scrofa)
FN1 aggregation (Sus scrofa)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Sus scrofa)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Sus scrofa)
Mn2+ [extracellular region]
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Sus scrofa)
Mn2+ [extracellular region]
Platelet activation, signaling and aggregation (Sus scrofa)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
Autophosphorylation of PTK2 at Y397 (Sus scrofa)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Sus scrofa)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Antimicrobial peptides (Sus scrofa)
Metal sequestration by antimicrobial proteins (Sus scrofa)
S100A8:S100A9 binds Mn2+ (Sus scrofa)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Sus scrofa)
Mn2+ [extracellular region]
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
Autophosphorylation of PTK2 at Y397 (Sus scrofa)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Autophosphorylation of SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Release of CSK from SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK activation by SRC (Sus scrofa)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
MAP2K and MAPK activation (Sus scrofa)
Dissociation of RAS:RAF complex (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mn2+ [extracellular region]
Extracellular matrix organization (Xenopus tropicalis)
Fibronectin matrix formation (Xenopus tropicalis)
FN1 aggregation (Xenopus tropicalis)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Xenopus tropicalis)
Mn2+ [extracellular region]
Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Xenopus tropicalis)
Mn2+ [extracellular region]
Hemostasis (Xenopus tropicalis)
Cell surface interactions at the vascular wall (Xenopus tropicalis)
Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)
Mn2+ [extracellular region]
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Xenopus tropicalis)
Mn2+ [extracellular region]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Antimicrobial peptides (Xenopus tropicalis)
Metal sequestration by antimicrobial proteins (Xenopus tropicalis)
S100A8:S100A9 binds Mn2+ (Xenopus tropicalis)
Mn2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Xenopus tropicalis)
Mn2+ [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of carbohydrates (Xenopus tropicalis)
Blood group systems biosynthesis (Xenopus tropicalis)
ABO blood group biosynthesis (Xenopus tropicalis)
sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)
sABO-A:Mn2+ [extracellular region] (Xenopus tropicalis)
Mn2+ [extracellular region]
sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)
sABO-B:Mn2+ [extracellular region] (Xenopus tropicalis)
Mn2+ [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Metal ion SLC transporters (Xenopus tropicalis)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)
Mn2+ [extracellular region]
External Reference Information
External Reference
manganese(2+) [ChEBI:29035]
Participates
as a component of
sABO-B:Mn2+ [extracellular region] (Bos taurus)
sABO-B:Mn2+ [extracellular region] (Xenopus tropicalis)
sABO-B:Mn2+ [extracellular region] (Danio rerio)
sABO-B:Mn2+ [extracellular region] (Canis familiaris)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis familiaris)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Xenopus tropicalis)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Caenorhabditis elegans)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Mus musculus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Sus scrofa)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Canis familiaris)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Homo sapiens)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Xenopus tropicalis)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Rattus norvegicus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Sus scrofa)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Bos taurus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Danio rerio)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Mus musculus)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Gallus gallus)
sABO-A:Mn2+ [extracellular region] (Homo sapiens)
sABO-A:Mn2+ [extracellular region] (Bos taurus)
sABO-A:Mn2+ [extracellular region] (Rattus norvegicus)
sABO-A:Mn2+ [extracellular region] (Canis familiaris)
sABO-A:Mn2+ [extracellular region] (Mus musculus)
sABO-A:Mn2+ [extracellular region] (Xenopus tropicalis)
sABO-A:Mn2+ [extracellular region] (Danio rerio)
sABO-B:Mn2+ [extracellular region] (Homo sapiens)
sABO-B:Mn2+ [extracellular region] (Rattus norvegicus)
sABO-B:Mn2+ [extracellular region] (Mus musculus)
as an input of
Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
Integrin alpha5beta1 binds FN1 dimer (Mus musculus)
Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)
Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)
Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
S100A8:S100A9 binds Mn2+ (Canis familiaris)
S100A8:S100A9 binds Mn2+ (Homo sapiens)
S100A8:S100A9 binds Mn2+ (Mus musculus)
S100A8:S100A9 binds Mn2+ (Rattus norvegicus)
S100A8:S100A9 binds Mn2+ (Bos taurus)
S100A8:S100A9 binds Mn2+ (Sus scrofa)
S100A8:S100A9 binds Mn2+ (Danio rerio)
S100A8:S100A9 binds Mn2+ (Xenopus tropicalis)
S100A8:S100A9 binds Mn2+ (Gallus gallus)
as an output of
SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)
SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)
as a member of
Integrin binding divalent cations [extracellular region]
Other forms of this molecule
Mn2+ [nucleoplasm]
Mn2+ [endoplasmic reticulum lumen]
Mn2+ [Golgi lumen]
Mn2+ [lysosomal lumen]
Mn2+ [phagocytic vesicle lumen]
Mn2+ [mitochondrial matrix]
Mn2+ [Golgi membrane]
Mn2+ [endoplasmic reticulum membrane]
Mn2+ [cytosol]
Cross References
AraCyc
MN+2
CAS
16397-91-4
,
7439-96-5
ChEBI
29035
COMPOUND
C00034
PubChem Compound
27854
HMDB Metabolite
HMDB0001333
KEGG Gene
C19610
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