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ATP
Stable Identifier
R-ALL-29358
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
Adenosine 5'-triphosphate
Locations in the PathwayBrowser for Species:
Homo sapiens
Arabidopsis thaliana
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Oryza sativa
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Taeniopygia guttata
Xenopus tropicalis
Expand all
Cell Cycle (Arabidopsis thaliana)
Cell Cycle Checkpoints (Arabidopsis thaliana)
G1/S DNA Damage Checkpoints (Arabidopsis thaliana)
p53-Dependent G1/S DNA damage checkpoint (Arabidopsis thaliana)
p53-Dependent G1 DNA Damage Response (Arabidopsis thaliana)
Stabilization of p53 (Arabidopsis thaliana)
Autodegradation of the E3 ubiquitin ligase COP1 (Arabidopsis thaliana)
Phosphorylation of COP1 at Ser-387 by ATM (Arabidopsis thaliana)
ATP [nucleoplasm]
G2/M Checkpoints (Arabidopsis thaliana)
G2/M DNA damage checkpoint (Arabidopsis thaliana)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Arabidopsis thaliana)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Arabidopsis thaliana)
ATP [nucleoplasm]
G2/M DNA replication checkpoint (Arabidopsis thaliana)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Arabidopsis thaliana)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Arabidopsis thaliana)
M Phase (Arabidopsis thaliana)
Mitotic Prophase (Arabidopsis thaliana)
Condensation of Prophase Chromosomes (Arabidopsis thaliana)
CDK1 phosphorylates condensin II subunit NCAPD3 (Arabidopsis thaliana)
ATP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Arabidopsis thaliana)
ATP [nucleoplasm]
Nuclear Envelope Breakdown (Arabidopsis thaliana)
Depolymerisation of the Nuclear Lamina (Arabidopsis thaliana)
CDK1 phosphorylates LPIN (Arabidopsis thaliana)
ATP [nucleoplasm]
Mitotic G1-G1/S phases (Arabidopsis thaliana)
G1/S Transition (Arabidopsis thaliana)
Cyclin E associated events during G1/S transition (Arabidopsis thaliana)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 (Arabidopsis thaliana)
ATP [nucleoplasm]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Arabidopsis thaliana)
Cyclin E:Cdk2-mediated phosphorylation of Rb (Arabidopsis thaliana)
ATP [nucleoplasm]
Mitotic G2-G2/M phases (Arabidopsis thaliana)
G2 Phase (Arabidopsis thaliana)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Arabidopsis thaliana)
ATP [nucleoplasm]
G2/M Transition (Arabidopsis thaliana)
Cyclin A/B1/B2 associated events during G2/M transition (Arabidopsis thaliana)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Arabidopsis thaliana)
ATP [nucleoplasm]
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Arabidopsis thaliana)
ATP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Arabidopsis thaliana)
ATP [nucleoplasm]
Regulation of DNA replication (Arabidopsis thaliana)
Removal of licensing factors from origins (Arabidopsis thaliana)
CDK-mediated phosphorylation and removal of Cdc6 (Arabidopsis thaliana)
Cdc6 protein is phosphorylated by CDK (Arabidopsis thaliana)
ATP [nucleoplasm]
Orc1 removal from chromatin (Arabidopsis thaliana)
Orc1 is phosphorylated by cyclin A/CDK2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Regulation of mitotic cell cycle (Arabidopsis thaliana)
APC/C-mediated degradation of cell cycle proteins (Arabidopsis thaliana)
Regulation of APC/C activators between G1/S and early anaphase (Arabidopsis thaliana)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Arabidopsis thaliana)
ATP [nucleoplasm]
S Phase (Arabidopsis thaliana)
Cyclin A:Cdk2-associated events at S phase entry (Arabidopsis thaliana)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Arabidopsis thaliana)
ATP [nucleoplasm]
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Synthesis of DNA (Arabidopsis thaliana)
DNA replication initiation (Arabidopsis thaliana)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Arabidopsis thaliana)
Lagging Strand Synthesis (Arabidopsis thaliana)
Polymerase switching (Arabidopsis thaliana)
Loading of PCNA - Sliding Clamp Formation (Arabidopsis thaliana)
ATP [nucleoplasm]
Leading Strand Synthesis (Arabidopsis thaliana)
Polymerase switching (Arabidopsis thaliana)
Loading of PCNA - Sliding Clamp Formation (Arabidopsis thaliana)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Arabidopsis thaliana)
CDK-mediated phosphorylation and removal of Cdc6 (Arabidopsis thaliana)
Cdc6 protein is phosphorylated by CDK (Arabidopsis thaliana)
ATP [nucleoplasm]
Orc1 removal from chromatin (Arabidopsis thaliana)
Orc1 is phosphorylated by cyclin A/CDK2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Chromosome Maintenance (Arabidopsis thaliana)
Telomere Maintenance (Arabidopsis thaliana)
Extension of Telomeres (Arabidopsis thaliana)
Telomere C-strand (Lagging Strand) Synthesis (Arabidopsis thaliana)
Polymerase switching on the C-strand of the telomere (Arabidopsis thaliana)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Arabidopsis thaliana)
ATP [nucleoplasm]
Telomere C-strand synthesis initiation (Arabidopsis thaliana)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Cellular responses to external stimuli (Arabidopsis thaliana)
Cellular responses to stress (Arabidopsis thaliana)
Cellular Senescence (Arabidopsis thaliana)
DNA Damage/Telomere Stress Induced Senescence (Arabidopsis thaliana)
MRN activates ATM (Arabidopsis thaliana)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Arabidopsis thaliana)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Arabidopsis thaliana)
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Cellular response to heat stress (Arabidopsis thaliana)
HSF1-dependent transactivation (Arabidopsis thaliana)
Phosphorylation of HSF1 at Ser230 induces transactivation (Arabidopsis thaliana)
ATP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Arabidopsis thaliana)
ATP [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Arabidopsis thaliana)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Arabidopsis thaliana)
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
DNA Repair (Arabidopsis thaliana)
DNA Damage Bypass (Arabidopsis thaliana)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Arabidopsis thaliana)
Translesion Synthesis by POLH (Arabidopsis thaliana)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Arabidopsis thaliana)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Arabidopsis thaliana)
DNA Double Strand Break Response (Arabidopsis thaliana)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Arabidopsis thaliana)
ATM phosphorylates EYA1-4 (Arabidopsis thaliana)
ATP [nucleoplasm]
ATM phosphorylates HERC2 (Arabidopsis thaliana)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ATM phosphorylates NBN (Arabidopsis thaliana)
ATP [nucleoplasm]
ATM phosphorylates WHSC1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Arabidopsis thaliana)
ATP [nucleoplasm]
WICH phosphorylates H2AFX on Y142 (Arabidopsis thaliana)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Arabidopsis thaliana)
MRN activates ATM (Arabidopsis thaliana)
ATP [nucleoplasm]
Homology Directed Repair (Arabidopsis thaliana)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) (Arabidopsis thaliana)
Processing of DNA double-strand break ends (Arabidopsis thaliana)
ATM phosphorylates RBBP8 (Arabidopsis thaliana)
ATP [nucleoplasm]
CDK2 phosphorylates RBBP8 (Arabidopsis thaliana)
ATP [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Arabidopsis thaliana)
PRKDC phosphorylates DCLRE1C at DNA DSBs (Arabidopsis thaliana)
ATP [nucleoplasm]
Mismatch Repair (Arabidopsis thaliana)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Arabidopsis thaliana)
DNA ligase I ligates single stranded nick in double stranded DNA (Arabidopsis thaliana)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Arabidopsis thaliana)
DNA ligase I ligates single stranded nick in double stranded DNA (Arabidopsis thaliana)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Arabidopsis thaliana)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Arabidopsis thaliana)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Arabidopsis thaliana)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Arabidopsis thaliana)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Arabidopsis thaliana)
MSH2:MSH6:ATP [nucleoplasm] (Arabidopsis thaliana)
ATP [nucleoplasm]
Nucleotide Excision Repair (Arabidopsis thaliana)
Global Genome Nucleotide Excision Repair (GG-NER) (Arabidopsis thaliana)
Formation of Incision Complex in GG-NER (Arabidopsis thaliana)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Arabidopsis thaliana)
ATP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Arabidopsis thaliana)
Dual incision in TC-NER (Arabidopsis thaliana)
RNA Pol II backtracking in TC-NER (Arabidopsis thaliana)
ATP [nucleoplasm]
DNA Replication (Arabidopsis thaliana)
Regulation of DNA replication (Arabidopsis thaliana)
Removal of licensing factors from origins (Arabidopsis thaliana)
CDK-mediated phosphorylation and removal of Cdc6 (Arabidopsis thaliana)
Cdc6 protein is phosphorylated by CDK (Arabidopsis thaliana)
ATP [nucleoplasm]
Orc1 removal from chromatin (Arabidopsis thaliana)
Orc1 is phosphorylated by cyclin A/CDK2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Synthesis of DNA (Arabidopsis thaliana)
DNA replication initiation (Arabidopsis thaliana)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Arabidopsis thaliana)
Lagging Strand Synthesis (Arabidopsis thaliana)
Polymerase switching (Arabidopsis thaliana)
Loading of PCNA - Sliding Clamp Formation (Arabidopsis thaliana)
ATP [nucleoplasm]
Leading Strand Synthesis (Arabidopsis thaliana)
Polymerase switching (Arabidopsis thaliana)
Loading of PCNA - Sliding Clamp Formation (Arabidopsis thaliana)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Arabidopsis thaliana)
CDK-mediated phosphorylation and removal of Cdc6 (Arabidopsis thaliana)
Cdc6 protein is phosphorylated by CDK (Arabidopsis thaliana)
ATP [nucleoplasm]
Orc1 removal from chromatin (Arabidopsis thaliana)
Orc1 is phosphorylated by cyclin A/CDK2 (Arabidopsis thaliana)
ATP [nucleoplasm]
Developmental Biology (Arabidopsis thaliana)
Axon guidance (Arabidopsis thaliana)
NCAM signaling for neurite out-growth (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
Gene expression (Transcription) (Arabidopsis thaliana)
RNA Polymerase II Transcription (Arabidopsis thaliana)
Generic Transcription Pathway (Arabidopsis thaliana)
Transcriptional Regulation by TP53 (Arabidopsis thaliana)
TP53 Regulates Transcription of Cell Death Genes (Arabidopsis thaliana)
TP53 Regulates Transcription of Caspase Activators and Caspases (Arabidopsis thaliana)
ATM phosphorylates PIDD1 (Arabidopsis thaliana)
ATP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Arabidopsis thaliana)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Arabidopsis thaliana)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Arabidopsis thaliana)
RNA Polymerase II Promoter Escape (Arabidopsis thaliana)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Promoter Opening: First Transition (Arabidopsis thaliana)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation (Arabidopsis thaliana)
NTP Binds Active Site of RNA Polymerase II (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II initiation complex [nucleoplasm] (Arabidopsis thaliana)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Arabidopsis thaliana)
Pol II initiation complex [nucleoplasm] (Arabidopsis thaliana)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Arabidopsis thaliana)
NTP [nucleoplasm]
ATP [nucleoplasm]
Immune System (Arabidopsis thaliana)
Cytokine Signaling in Immune system (Arabidopsis thaliana)
Signaling by Interleukins (Arabidopsis thaliana)
Interleukin-17 signaling (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Innate Immune System (Arabidopsis thaliana)
Toll-Like Receptors Cascades (Arabidopsis thaliana)
Toll Like Receptor 10 (TLR10) Cascade (Arabidopsis thaliana)
MyD88 cascade initiated on plasma membrane (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Arabidopsis thaliana)
Toll Like Receptor TLR1:TLR2 Cascade (Arabidopsis thaliana)
MyD88:Mal cascade initiated on plasma membrane (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Arabidopsis thaliana)
MyD88:Mal cascade initiated on plasma membrane (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Arabidopsis thaliana)
Activated TLR4 signalling (Arabidopsis thaliana)
MyD88-independent TLR4 cascade (Arabidopsis thaliana)
TRIF(TICAM1)-mediated TLR4 signaling (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
MyD88:Mal cascade initiated on plasma membrane (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Arabidopsis thaliana)
MyD88 cascade initiated on plasma membrane (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Arabidopsis thaliana)
MyD88 dependent cascade initiated on endosome (Arabidopsis thaliana)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Arabidopsis thaliana)
MyD88 dependent cascade initiated on endosome (Arabidopsis thaliana)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Arabidopsis thaliana)
MAP kinase activation in TLR cascade (Arabidopsis thaliana)
MAPK targets/ Nuclear events mediated by MAP kinases (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Metabolism (Arabidopsis thaliana)
Inositol phosphate metabolism (Arabidopsis thaliana)
Synthesis of IPs in the nucleus (Arabidopsis thaliana)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Arabidopsis thaliana)
ATP [nucleoplasm]
Metabolism of amino acids and derivatives (Arabidopsis thaliana)
Amino acid synthesis and interconversion (transamination) (Arabidopsis thaliana)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Arabidopsis thaliana)
ATP [nucleoplasm]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Arabidopsis thaliana)
ATP [nucleoplasm]
Metabolism of carbohydrates (Arabidopsis thaliana)
Glucose metabolism (Arabidopsis thaliana)
Glycolysis (Arabidopsis thaliana)
phosphoenolpyruvate + ADP => pyruvate + ATP (Arabidopsis thaliana)
ATP [nucleoplasm]
Metabolism of nucleotides (Arabidopsis thaliana)
Interconversion of nucleotide di- and triphosphates (Arabidopsis thaliana)
AK6 phosphorylates (d)NMPs to (d)NDPs (Arabidopsis thaliana)
ATP [nucleoplasm]
Metabolism of proteins (Arabidopsis thaliana)
Post-translational protein modification (Arabidopsis thaliana)
SUMOylation (Arabidopsis thaliana)
Processing and activation of SUMO (Arabidopsis thaliana)
SUMO is conjugated to E1 (UBA2:SAE1) (Arabidopsis thaliana)
Conjugation of SUMO1 to UBA2:SAE1 (Arabidopsis thaliana)
ATP [nucleoplasm]
Neuronal System (Arabidopsis thaliana)
Transmission across Chemical Synapses (Arabidopsis thaliana)
Neurotransmitter receptors and postsynaptic signal transmission (Arabidopsis thaliana)
Activation of NMDA receptor and postsynaptic events (Arabidopsis thaliana)
Post NMDA receptor activation events (Arabidopsis thaliana)
CREB phosphorylation through the activation of Ras (Arabidopsis thaliana)
RSK activation (Arabidopsis thaliana)
Phosphorylation by PDK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
Signal Transduction (Arabidopsis thaliana)
Signaling by GPCR (Arabidopsis thaliana)
Gastrin-CREB signalling pathway via PKC and MAPK (Arabidopsis thaliana)
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Arabidopsis thaliana)
Signalling by NGF (Arabidopsis thaliana)
NGF signalling via TRKA from the plasma membrane (Arabidopsis thaliana)
Nuclear Events (kinase and transcription factor activation) (Arabidopsis thaliana)
ERK/MAPK targets (Arabidopsis thaliana)
ERK1/2 phosphorylates MSK1 (Arabidopsis thaliana)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Arabidopsis thaliana)
ATP [nucleoplasm]
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
ATM phosphorylates MDM2 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
Autodegradation of the E3 ubiquitin ligase COP1 (Bos taurus)
Phosphorylation of COP1 at Ser-387 by ATM (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of MDM4 by ATM (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of MDM4 by CHEK2 (Bos taurus)
ATP [nucleoplasm]
p53-Independent G1/S DNA damage checkpoint (Bos taurus)
p53-Independent DNA Damage Response (Bos taurus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)
ATP [nucleoplasm]
G2/M Checkpoints (Bos taurus)
Activation of ATR in response to replication stress (Bos taurus)
Activation of claspin (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Bos taurus)
ATP [nucleoplasm]
Recruitment and activation of Chk1 (Bos taurus)
ATP [nucleoplasm]
G2/M DNA damage checkpoint (Bos taurus)
ATR phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CHEK1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Bos taurus)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)
ATP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ATP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
ATP [nucleoplasm]
Recruitment and activation of Chk1 (Bos taurus)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
G2/M DNA replication checkpoint (Bos taurus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)
ATP [nucleoplasm]
Condensation of Prophase Chromosomes (Bos taurus)
CDK1 phosphorylates PHF8 (Bos taurus)
ATP [nucleoplasm]
CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)
ATP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Bos taurus)
ATP [nucleoplasm]
MASTL Facilitates Mitotic Progression (Bos taurus)
MASTL (GWL) phosphorylates ARPP19 (Bos taurus)
ATP [nucleoplasm]
MASTL phosphorylates ENSA (Bos taurus)
ATP [nucleoplasm]
Nuclear Envelope Breakdown (Bos taurus)
Clearance of Nuclear Envelope Membranes from Chromatin (Bos taurus)
VRK1/VRK2 phosphorylate BANF1 (Bos taurus)
ATP [nucleoplasm]
Depolymerisation of the Nuclear Lamina (Bos taurus)
CDK1 phosphorylates LPIN (Bos taurus)
ATP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)
ATP [nucleoplasm]
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)
ATP [nucleoplasm]
M/G1 Transition (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
ATP [nucleoplasm]
Mitotic G1-G1/S phases (Bos taurus)
G0 and Early G1 (Bos taurus)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)
ATP [nucleoplasm]
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)
ATP [nucleoplasm]
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)
ATP [nucleoplasm]
Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes (Bos taurus)
ATP [nucleoplasm]
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)
ATP [nucleoplasm]
G1/S Transition (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
ATP [nucleoplasm]
Cyclin E associated events during G1/S transition (Bos taurus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Bos taurus)
Cyclin E:Cdk2-mediated phosphorylation of Rb (Bos taurus)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
ATP [nucleoplasm]
Mitotic G2-G2/M phases (Bos taurus)
G2 Phase (Bos taurus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)
ATP [nucleoplasm]
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)
ATP [nucleoplasm]
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Bos taurus)
ATP [nucleoplasm]
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)
ATP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
ATP [nucleoplasm]
Polo-like kinase mediated events (Bos taurus)
PLK1 phosphorylates FOXM1 (Bos taurus)
ATP [nucleoplasm]
Regulation of DNA replication (Bos taurus)
Removal of licensing factors from origins (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ATP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ATP [nucleoplasm]
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Emi1 (Bos taurus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)
ATP [nucleoplasm]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
ATP [nucleoplasm]
Synthesis of DNA (Bos taurus)
DNA replication initiation (Bos taurus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Bos taurus)
Lagging Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ATP [nucleoplasm]
Leading Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ATP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ATP [nucleoplasm]
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
ATP [nucleoplasm]
Telomere C-strand synthesis initiation (Bos taurus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
MRN activates ATM (Bos taurus)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Bos taurus)
ATP [nucleoplasm]
Oncogene Induced Senescence (Bos taurus)
MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)
ATP [nucleoplasm]
Oxidative Stress Induced Senescence (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
ATP [nucleoplasm]
Cellular response to heat stress (Bos taurus)
HSF1-dependent transactivation (Bos taurus)
Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)
ATP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
Hikeshi:HSP70s:ATP [nucleoplasm] (Bos taurus)
HSP70s:ATP [nucleoplasm] (Bos taurus)
HSPA1A:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)
Hikeshi:HSP70s:ATP [nucleoplasm] (Bos taurus)
HSP70s:ATP [nucleoplasm] (Bos taurus)
HSPA1A:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
DNA Repair (Bos taurus)
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Translesion Synthesis by POLH (Bos taurus)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
ATM phosphorylates EYA1-4 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates HERC2 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates NBN (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates WHSC1 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)
ATP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates BRCA1 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)
ATP [nucleoplasm]
WICH phosphorylates H2AFX on Y142 (Bos taurus)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Bos taurus)
MRN activates ATM (Bos taurus)
ATP [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) (Bos taurus)
HDR through Homologous Recombination (HRR) (Bos taurus)
Homologous DNA Pairing and Strand Exchange (Bos taurus)
Presynaptic phase of homologous DNA pairing and strand exchange (Bos taurus)
CHEK1 phosphorylates BRCA2 (Bos taurus)
ATP [nucleoplasm]
CHEK1 phosphorylates RAD51 (Bos taurus)
ATP [nucleoplasm]
HDR through Single Strand Annealing (SSA) (Bos taurus)
ABL1 phosphorylates RAD52 (Bos taurus)
ATP [nucleoplasm]
Processing of DNA double-strand break ends (Bos taurus)
ATM phosphorylates RBBP8 (Bos taurus)
ATP [nucleoplasm]
ATR phosphorylates RPA2 (Bos taurus)
ATP [nucleoplasm]
Activation of CHEK1 at resected DNA DSBs (Bos taurus)
ATP [nucleoplasm]
CDK2 phosphorylates RBBP8 (Bos taurus)
ATP [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Bos taurus)
Activated ATM phosphorylates DCLRE1C (Bos taurus)
ATP [nucleoplasm]
DNA-PKcs autophosphorylates (Bos taurus)
ATP [nucleoplasm]
PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)
ATP [nucleoplasm]
Fanconi Anemia Pathway (Bos taurus)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)
ATP [nucleoplasm]
Mismatch Repair (Bos taurus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
ATP [nucleoplasm]
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
ATP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
RNA Pol II backtracking in TC-NER (Bos taurus)
ATP [nucleoplasm]
DNA Replication (Bos taurus)
M/G1 Transition (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
ATP [nucleoplasm]
Regulation of DNA replication (Bos taurus)
Removal of licensing factors from origins (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ATP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ATP [nucleoplasm]
Synthesis of DNA (Bos taurus)
DNA replication initiation (Bos taurus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Bos taurus)
Lagging Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ATP [nucleoplasm]
Leading Strand Synthesis (Bos taurus)
Polymerase switching (Bos taurus)
Loading of PCNA - Sliding Clamp Formation (Bos taurus)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
ATP [nucleoplasm]
Orc1 removal from chromatin (Bos taurus)
Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
ATP [nucleoplasm]
Developmental Biology (Bos taurus)
Axon guidance (Bos taurus)
NCAM signaling for neurite out-growth (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
Myogenesis (Bos taurus)
CDO in myogenesis (Bos taurus)
Phosphorylation of MEF2 proteins by p38 (Bos taurus)
ATP [nucleoplasm]
Regulation of beta-cell development (Bos taurus)
Regulation of gene expression in beta cells (Bos taurus)
AKT-mediated inactivation of FOXO1A (Bos taurus)
AKT phosphorylates FOXO1A (Bos taurus)
ATP [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase I Transcription (Bos taurus)
RNA Polymerase I Chain Elongation (Bos taurus)
Elongation of pre-rRNA transcript (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase I Promoter Clearance (Bos taurus)
RNA Polymerase I Promoter Opening (Bos taurus)
Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)
ATP [nucleoplasm]
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by E2F6 (Bos taurus)
CHEK1 phosphorylates E2F6 (Bos taurus)
ATP [nucleoplasm]
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
AKT phosphorylates KAT6A (Bos taurus)
ATP [nucleoplasm]
PI5P Regulates TP53 Acetylation (Bos taurus)
MAP2K6 phosphorylates PIP4K2B (Bos taurus)
ATP [nucleoplasm]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ATP [nucleoplasm]
Regulation of TP53 Activity through Association with Co-factors (Bos taurus)
AKT phosphorylates PHF20 (Bos taurus)
ATP [nucleoplasm]
Regulation of TP53 Activity through Methylation (Bos taurus)
ATM phosphorylates TTC5 (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates TTC5 (Bos taurus)
ATP [nucleoplasm]
Regulation of TP53 Activity through Phosphorylation (Bos taurus)
AMPK phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates DYRK2 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
ATR phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
AURKA phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
AURKB phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CDK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CDK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CHEK1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CK2:FACT phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
DYRK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
HIPK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
NUAK1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
PLK3 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)
ATP [nucleoplasm]
TAF1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
TP53RK phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates MDM2 (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of MDM4 by ATM (Bos taurus)
ATP [nucleoplasm]
Phosphorylation of MDM4 by CHEK2 (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)
PLK3 phosphorylates CDC25C (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of Cell Death Genes (Bos taurus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Bos taurus)
ATM phosphorylates PIDD1 (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Bos taurus)
ATM phosphorylates ZNF420 (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Bos taurus)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)
ATP [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
ATP [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Bos taurus)
HIPK2 phosphorylates RUNX1 (Bos taurus)
ATP [nucleoplasm]
HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)
ATP [nucleoplasm]
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
ABL1 phosphorylates YAP1 (Bos taurus)
ATP [nucleoplasm]
Regulation of RUNX1 Expression and Activity (Bos taurus)
SRC phosphorylates RUNX1 (Bos taurus)
ATP [nucleoplasm]
Transcriptional regulation by RUNX2 (Bos taurus)
CDK1 phosphorylates RUNX2 (Bos taurus)
ATP [nucleoplasm]
CDK4 phosphorylates RUNX2 (Bos taurus)
ATP [nucleoplasm]
RNA Polymerase II Pre-transcription Events (Bos taurus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Abortive termination of elongation after arrest (Bos taurus)
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Resumption of elongation after recovery from pausing (Bos taurus)
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
TFIIS-mediated recovery of elongation from arrest (Bos taurus)
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Elongation (Bos taurus)
Addition of nucleotides leads to transcript elongation (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Formation of the Early Elongation Complex (Bos taurus)
Formation of DSIF:NELF:early elongation complex (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II elongation complex moves on the template as transcript elongates (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Elongation complex prior to separation [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Processive elongation complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Separation of elongating transcript from template (Bos taurus)
Elongation complex prior to separation [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Bos taurus)
RNA Polymerase II Promoter Escape (Bos taurus)
Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Promoter Opening: First Transition (Bos taurus)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation (Bos taurus)
NTP Binds Active Site of RNA Polymerase II (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II initiation complex [nucleoplasm] (Bos taurus)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)
Pol II initiation complex [nucleoplasm] (Bos taurus)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Termination (Bos taurus)
Cleavage of Growing Transcript in the Termination Region (Bos taurus)
Cleavage of mRNA at the 3'-end (Bos taurus)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Bos taurus)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
ATP [nucleoplasm]
Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
ATP [nucleoplasm]
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
ATP [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CD209 (DC-SIGN) signaling (Bos taurus)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)
ATP [nucleoplasm]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
Toll-Like Receptors Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:Mal cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:Mal cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
Activated TLR4 signalling (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
MyD88:Mal cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation in TLR cascade (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IPs in the nucleus (Bos taurus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
Metabolism of amino acids and derivatives (Bos taurus)
Amino acid synthesis and interconversion (transamination) (Bos taurus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)
ATP [nucleoplasm]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)
ATP [nucleoplasm]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Glycolysis (Bos taurus)
phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)
ATP [nucleoplasm]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ATP [nucleoplasm]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
ATP [nucleoplasm]
Metabolism of RNA (Bos taurus)
Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
Transport of Mature Transcript to Cytoplasm (Bos taurus)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Bos taurus)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
mRNA 3'-end processing (Bos taurus)
Cleavage of mRNA at the 3'-end (Bos taurus)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
mRNA polyadenylation (Bos taurus)
ATP [nucleoplasm]
3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
DDX39B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
HuR (ELAVL1) binds and stabilizes mRNA (Bos taurus)
PKCalpha phosphorylates HuR (Bos taurus)
ATP [nucleoplasm]
PKCdelta phosphorylates HuR (Bos taurus)
ATP [nucleoplasm]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Protein ubiquitination (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)
ATP [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)
ATP [nucleoplasm]
SUMOylation (Bos taurus)
Processing and activation of SUMO (Bos taurus)
SUMO is conjugated to E1 (UBA2:SAE1) (Bos taurus)
Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)
ATP [nucleoplasm]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptor and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
CREB phosphorylation through the activation of Adenylate Cyclase (Bos taurus)
Phosphorylation of CREB by PKA (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation through the activation of CaMKII (Bos taurus)
Phosphorylation of CREB by CaMKII (Bos taurus)
ATP [nucleoplasm]
CREB phosphorylation through the activation of Ras (Bos taurus)
Phosphorylation of CREB by ribosomal protein S6 kinase (Bos taurus)
ATP [nucleoplasm]
RSK activation (Bos taurus)
Phosphorylation by PDK1 (Bos taurus)
ATP [nucleoplasm]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
AKT phosphorylates targets in the nucleus (Bos taurus)
AKT can phosphorylate NR4A1 (NUR77) (Bos taurus)
ATP [nucleoplasm]
AKT can phosphorylate RSK (Bos taurus)
ATP [nucleoplasm]
AKT can phosphorylate forkhead box transcription factors (Bos taurus)
ATP [nucleoplasm]
AKT phosphorylates CREB1 (Bos taurus)
ATP [nucleoplasm]
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
CDK1 phosphorylates MAPK6 (Bos taurus)
ATP [nucleoplasm]
PKA phosphorylates MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
p-S MAPK6 phosphorylates NCOA3 (Bos taurus)
ATP [nucleoplasm]
p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
p-S182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
ATP [nucleoplasm]
Signaling by GPCR (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates Proteins Involved in RNA Processing (Bos taurus)
PTK6 phosphorylates KHDRBS1 (Bos taurus)
ATP [nucleoplasm]
PTK6 phosphorylates KHDRBS2 (Bos taurus)
ATP [nucleoplasm]
PTK6 phosphorylates KHDRBS3 (Bos taurus)
ATP [nucleoplasm]
PTK6 phosphorylates SFPQ (Bos taurus)
ATP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signalling by NGF (Bos taurus)
NGF signalling via TRKA from the plasma membrane (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
CREB phosphorylation (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates ATF1 (Bos taurus)
ATP [nucleoplasm]
MSK1 activates CREB (Bos taurus)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2 phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Bos taurus)
ATP [nucleoplasm]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate PKNs (Bos taurus)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Bos taurus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)
ATP [nucleoplasm]
Signaling by TGF-beta family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
ATP [nucleoplasm]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
NLK phosphorylates TCF/LEF (Bos taurus)
ATP [nucleoplasm]
TCF dependent signaling in response to WNT (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
AKT phosphorylates CBY1 (Bos taurus)
ATP [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle Checkpoints (Caenorhabditis elegans)
G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
p53-Independent G1/S DNA damage checkpoint (Caenorhabditis elegans)
p53-Independent DNA Damage Response (Caenorhabditis elegans)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)
ATP [nucleoplasm]
G2/M Checkpoints (Caenorhabditis elegans)
G2/M DNA damage checkpoint (Caenorhabditis elegans)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Condensation of Prophase Chromosomes (Caenorhabditis elegans)
CDK1 phosphorylates PHF8 (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)
ATP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)
ATP [nucleoplasm]
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerisation of the Nuclear Lamina (Caenorhabditis elegans)
CDK1 phosphorylates LPIN (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)
ATP [nucleoplasm]
Mitotic G1-G1/S phases (Caenorhabditis elegans)
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Caenorhabditis elegans)
ATP [nucleoplasm]
Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes (Caenorhabditis elegans)
ATP [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)
ATP [nucleoplasm]
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Polo-like kinase mediated events (Caenorhabditis elegans)
PLK1 phosphorylates FOXM1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of mitotic cell cycle (Caenorhabditis elegans)
APC/C-mediated degradation of cell cycle proteins (Caenorhabditis elegans)
Regulation of APC/C activators between G1/S and early anaphase (Caenorhabditis elegans)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Caenorhabditis elegans)
ATP [nucleoplasm]
S Phase (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
DNA replication initiation (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Chromosome Maintenance (Caenorhabditis elegans)
Telomere Maintenance (Caenorhabditis elegans)
Extension of Telomeres (Caenorhabditis elegans)
Telomere C-strand (Lagging Strand) Synthesis (Caenorhabditis elegans)
Polymerase switching on the C-strand of the telomere (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Caenorhabditis elegans)
ATP [nucleoplasm]
Telomere C-strand synthesis initiation (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
DNA Damage/Telomere Stress Induced Senescence (Caenorhabditis elegans)
MRN activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Caenorhabditis elegans)
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Caenorhabditis elegans)
ATP [nucleoplasm]
Cellular response to heat stress (Caenorhabditis elegans)
HSF1-dependent transactivation (Caenorhabditis elegans)
Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
Hikeshi:HSP70s:ATP [nucleoplasm] (Caenorhabditis elegans)
HSP70s:ATP [nucleoplasm] (Caenorhabditis elegans)
HSPA1A:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Damage Bypass (Caenorhabditis elegans)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
Translesion Synthesis by POLH (Caenorhabditis elegans)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Caenorhabditis elegans)
DNA Double Strand Break Response (Caenorhabditis elegans)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Caenorhabditis elegans)
ATM phosphorylates EYA1-4 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates NBN (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Caenorhabditis elegans)
ATP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Caenorhabditis elegans)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Caenorhabditis elegans)
MRN activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
Mismatch Repair (Caenorhabditis elegans)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Formation of Incision Complex in GG-NER (Caenorhabditis elegans)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Replication (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
DNA replication initiation (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
NCAM signaling for neurite out-growth (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
Myogenesis (Caenorhabditis elegans)
CDO in myogenesis (Caenorhabditis elegans)
Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of beta-cell development (Caenorhabditis elegans)
Regulation of gene expression in beta cells (Caenorhabditis elegans)
AKT-mediated inactivation of FOXO1A (Caenorhabditis elegans)
AKT phosphorylates FOXO1A (Caenorhabditis elegans)
ATP [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
AKT phosphorylates KAT6A (Caenorhabditis elegans)
ATP [nucleoplasm]
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)
ATP [nucleoplasm]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of TP53 Activity through Methylation (Caenorhabditis elegans)
ATM phosphorylates TTC5 (Caenorhabditis elegans)
ATP [nucleoplasm]
CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of TP53 Activity through Phosphorylation (Caenorhabditis elegans)
ATM phosphorylates DYRK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Caenorhabditis elegans)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase II Promoter Escape (Caenorhabditis elegans)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation (Caenorhabditis elegans)
NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II initiation complex [nucleoplasm] (Caenorhabditis elegans)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)
Pol II initiation complex [nucleoplasm] (Caenorhabditis elegans)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Termination (Caenorhabditis elegans)
Cleavage of Growing Transcript in the Termination Region (Caenorhabditis elegans)
Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
ATP [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Toll-Like Receptors Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:Mal cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:Mal cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
Activated TLR4 signalling (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF(TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
MyD88:Mal cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation in TLR cascade (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
