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What is Reactome ?
News
Team
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Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
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Table of Contents
DOIs
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ORCID Integration Project
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ATP [nucleoplasm]
Stable Identifier
R-ALL-29358
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
Adenosine 5'-triphosphate, ATP(4-)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
G2/M Checkpoints (Bos taurus)
G2/M DNA damage checkpoint (Bos taurus)
p-T68-CHEK2 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Condensation of Prophase Chromosomes (Bos taurus)
PLK1 hyperphosphorylates Condensin II complex (Bos taurus)
ATP [nucleoplasm]
MASTL Facilitates Mitotic Progression (Bos taurus)
MASTL (GWL) phosphorylates ARPP19 (Bos taurus)
ATP [nucleoplasm]
MASTL phosphorylates ENSA (Bos taurus)
ATP [nucleoplasm]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)
ATP [nucleoplasm]
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)
ATP [nucleoplasm]
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
MRN activates ATM (Bos taurus)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Bos taurus)
ATP [nucleoplasm]
Oxidative Stress Induced Senescence (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
DBC1 is phosphorylated by ATM/ART (Bos taurus)
ATP [nucleoplasm]
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
Hikeshi:HSP70s:ATP [nucleoplasm] (Bos taurus)
HSP70s:ATP [nucleoplasm] (Bos taurus)
HSPA12B:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA13:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA14:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA1A:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA1L:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA4:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA4L:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA7:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
HSPA9:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
DNA Repair (Bos taurus)
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Translesion Synthesis by POLH (Bos taurus)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
ATM phosphorylates EYA1-4 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates HERC2 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates NBN (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates WHSC1 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)
ATP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Bos taurus)
ATP [nucleoplasm]
WICH phosphorylates H2AFX on Y142 (Bos taurus)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Bos taurus)
MRN activates ATM (Bos taurus)
ATP [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
HDR through Single Strand Annealing (SSA) (Bos taurus)
ABL1 phosphorylates RAD52 (Bos taurus)
ATP [nucleoplasm]
Processing of DNA double-strand break ends (Bos taurus)
ATM phosphorylates RBBP8 (Bos taurus)
ATP [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Bos taurus)
DNA-PKcs autophosphorylates (Bos taurus)
ATP [nucleoplasm]
PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)
ATP [nucleoplasm]
Mismatch Repair (Bos taurus)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Bos taurus)
DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Bos taurus)
MSH2:MSH6:ATP [nucleoplasm] (Bos taurus)
ATP [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
PI5P Regulates TP53 Acetylation (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ATP [nucleoplasm]
Regulation of TP53 Activity through Phosphorylation (Bos taurus)
AMPK phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates DYRK2 (Bos taurus)
ATP [nucleoplasm]
ATM phosphorylates TP53 at S15 (Bos taurus)
ATP [nucleoplasm]
CDK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
CHEK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
DYRK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
HIPK2 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
MAPKAPK5 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
NUAK1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
PLK3 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)
ATP [nucleoplasm]
TAF1 phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
TP53RK phosphorylates TP53 (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of Cell Death Genes (Bos taurus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Bos taurus)
ATM phosphorylates PIDD1 (Bos taurus)
ATP [nucleoplasm]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Bos taurus)
ATM phosphorylates ZNF420 (Bos taurus)
ATP [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
ABL1 phosphorylates YAP1 (Bos taurus)
ATP [nucleoplasm]
Transcriptional regulation by RUNX2 (Bos taurus)
CDK4 phosphorylates RUNX2 (Bos taurus)
ATP [nucleoplasm]
RNA Polymerase II Transcription Elongation (Bos taurus)
Formation of the Early Elongation Complex (Bos taurus)
Formation of DSIF:NELF:early elongation complex (Bos taurus)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Bos taurus)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
ATP [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Innate Immune System (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
Activation of the AP-1 family of transcription factors (Bos taurus)
Activated JNKs phosphorylate c-JUN (Bos taurus)
ATP [nucleoplasm]
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
ATP [nucleoplasm]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IPs in the nucleus (Bos taurus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
ATP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
ATP [nucleoplasm]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Glycolysis (Bos taurus)
phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)
ATP [nucleoplasm]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
ATP [nucleoplasm]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
ATP [nucleoplasm]
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
HuR (ELAVL1) binds and stabilizes mRNA (Bos taurus)
PKCdelta phosphorylates HuR (Bos taurus)
ATP [nucleoplasm]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ATP [nucleoplasm]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
CaMK IV-mediated phosphorylation of CREB (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ATP [nucleoplasm]
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)
ATP [nucleoplasm]
p-S182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
ATP [nucleoplasm]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
CaMK IV-mediated phosphorylation of CREB (Bos taurus)
CAMK4 autophosphorylates (Bos taurus)
ATP [nucleoplasm]
CaMKK autophosphorylates in the nucleus (Bos taurus)
ATP [nucleoplasm]
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
Signaling by NOTCH (Bos taurus)
Pre-NOTCH Expression and Processing (Bos taurus)
Pre-NOTCH Transcription and Translation (Bos taurus)
PRKCI phosphorylates ELF3 (Bos taurus)
ATP [nucleoplasm]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates Proteins Involved in RNA Processing (Bos taurus)
PTK6 phosphorylates KHDRBS1 (Bos taurus)
ATP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERK1/2/5 activate RSK1/2/3 (Bos taurus)
ATP [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle Checkpoints (Caenorhabditis elegans)
G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
p53-Dependent G1/S DNA damage checkpoint (Caenorhabditis elegans)
p53-Dependent G1 DNA Damage Response (Caenorhabditis elegans)
Stabilization of p53 (Caenorhabditis elegans)
Autodegradation of the E3 ubiquitin ligase COP1 (Caenorhabditis elegans)
Phosphorylation of COP1 at Ser-387 by ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
p53-Independent G1/S DNA damage checkpoint (Caenorhabditis elegans)
p53-Independent DNA Damage Response (Caenorhabditis elegans)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)
ATP [nucleoplasm]
G2/M Checkpoints (Caenorhabditis elegans)
Activation of ATR in response to replication stress (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)
ATP [nucleoplasm]
G2/M DNA damage checkpoint (Caenorhabditis elegans)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Condensation of Prophase Chromosomes (Caenorhabditis elegans)
CDK1 phosphorylates PHF8 (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)
ATP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)
ATP [nucleoplasm]
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerisation of the Nuclear Lamina (Caenorhabditis elegans)
CDK1 phosphorylates LPIN (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)
ATP [nucleoplasm]
Mitotic Telophase/Cytokinesis (Caenorhabditis elegans)
Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)
ATP [nucleoplasm]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G0 and Early G1 (Caenorhabditis elegans)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)
ATP [nucleoplasm]
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Caenorhabditis elegans)
ATP [nucleoplasm]
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)
ATP [nucleoplasm]
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Caenorhabditis elegans)
Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ATP [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2 Phase (Caenorhabditis elegans)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Caenorhabditis elegans)
ATP [nucleoplasm]
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)
ATP [nucleoplasm]
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)
ATP [nucleoplasm]
Polo-like kinase mediated events (Caenorhabditis elegans)
Inactivation of Myt1 kinase (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of mitotic cell cycle (Caenorhabditis elegans)
APC/C-mediated degradation of cell cycle proteins (Caenorhabditis elegans)
Regulation of APC/C activators between G1/S and early anaphase (Caenorhabditis elegans)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Caenorhabditis elegans)
ATP [nucleoplasm]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Caenorhabditis elegans)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
ATP [nucleoplasm]
Synthesis of DNA (Caenorhabditis elegans)
DNA replication initiation (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
ATP [nucleoplasm]
Orc1 removal from chromatin (Caenorhabditis elegans)
Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
DNA Damage/Telomere Stress Induced Senescence (Caenorhabditis elegans)
MRN activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Caenorhabditis elegans)
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Caenorhabditis elegans)
ATP [nucleoplasm]
Cellular response to heat stress (Caenorhabditis elegans)
HSF1-dependent transactivation (Caenorhabditis elegans)
Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
DBC1 is phosphorylated by ATM/ART (Caenorhabditis elegans)
ATP [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Caenorhabditis elegans)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Caenorhabditis elegans)
HSP90:ATP:PTGES3:FKBP52:NR3C1:SH [nucleoplasm] (Caenorhabditis elegans)
HSP90:ATP:PTGES3:FKBP52:NR3C1 [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Damage Bypass (Caenorhabditis elegans)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
Translesion Synthesis by POLH (Caenorhabditis elegans)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Caenorhabditis elegans)
DNA Double Strand Break Response (Caenorhabditis elegans)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Caenorhabditis elegans)
ATM phosphorylates EYA1-4 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates HERC2 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates NBN (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates TP53BP1 at DNA DSBs (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates WHSC1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Caenorhabditis elegans)
ATP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Caenorhabditis elegans)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Caenorhabditis elegans)
MRN activates ATM (Caenorhabditis elegans)
ATP [nucleoplasm]
Homology Directed Repair (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) (Caenorhabditis elegans)
Homologous DNA Pairing and Strand Exchange (Caenorhabditis elegans)
Presynaptic phase of homologous DNA pairing and strand exchange (Caenorhabditis elegans)
CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)
ATP [nucleoplasm]
Processing of DNA double-strand break ends (Caenorhabditis elegans)
ATM phosphorylates RBBP8 (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK2 phosphorylates RBBP8 (Caenorhabditis elegans)
ATP [nucleoplasm]
Mismatch Repair (Caenorhabditis elegans)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Caenorhabditis elegans)
DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Caenorhabditis elegans)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Caenorhabditis elegans)
MSH2:MSH6:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Formation of Incision Complex in GG-NER (Caenorhabditis elegans)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
ATP [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
ATP [nucleoplasm]
DNA Replication (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
DNA replication initiation (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Caenorhabditis elegans)
Lagging Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Leading Strand Synthesis (Caenorhabditis elegans)
Polymerase switching (Caenorhabditis elegans)
Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
ATP [nucleoplasm]
Orc1 removal from chromatin (Caenorhabditis elegans)
Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
Myogenesis (Caenorhabditis elegans)
Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)
ATP [nucleoplasm]
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
NCAM signaling for neurite out-growth (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of beta-cell development (Caenorhabditis elegans)
Regulation of gene expression in beta cells (Caenorhabditis elegans)
AKT-mediated inactivation of FOXO1A (Caenorhabditis elegans)
AKT phosphorylates FOXO1A (Caenorhabditis elegans)
ATP [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase I Transcription (Caenorhabditis elegans)
RNA Polymerase I Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase I Promoter Escape (Caenorhabditis elegans)
Elongation of pre-rRNA transcript (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of localization of FOXO transcription factors (Caenorhabditis elegans)
AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional Regulation by E2F6 (Caenorhabditis elegans)
CHEK1 phosphorylates E2F6 (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)
ATP [nucleoplasm]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of TP53 Activity through Methylation (Caenorhabditis elegans)
ATM phosphorylates TTC5 (Caenorhabditis elegans)
ATP [nucleoplasm]
CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)
ATP [nucleoplasm]
Regulation of TP53 Activity through Phosphorylation (Caenorhabditis elegans)
ATM phosphorylates DYRK2 (Caenorhabditis elegans)
ATP [nucleoplasm]
TP53 Regulates Transcription of Cell Death Genes (Caenorhabditis elegans)
TP53 Regulates Transcription of Caspase Activators and Caspases (Caenorhabditis elegans)
ATM phosphorylates PIDD1 (Caenorhabditis elegans)
ATP [nucleoplasm]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Caenorhabditis elegans)
ATM phosphorylates ZNF420 (Caenorhabditis elegans)
ATP [nucleoplasm]
TP53 Regulates Transcription of DNA Repair Genes (Caenorhabditis elegans)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional regulation by RUNX1 (Caenorhabditis elegans)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Caenorhabditis elegans)
HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)
ATP [nucleoplasm]
HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)
ATP [nucleoplasm]
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Caenorhabditis elegans)
ABL1 phosphorylates YAP1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CDK4 phosphorylates RUNX2 (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Pol II CTD phosphorylation and interaction with CE (Caenorhabditis elegans)
Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Polymerase II Pre-transcription Events (Caenorhabditis elegans)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Abortive termination of elongation after arrest (Caenorhabditis elegans)
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Resumption of elongation after recovery from pausing (Caenorhabditis elegans)
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Elongation (Caenorhabditis elegans)
Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Elongation complex prior to separation [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Separation of elongating transcript from template (Caenorhabditis elegans)
Elongation complex prior to separation [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase II Promoter Escape (Caenorhabditis elegans)
Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Unwinding DNA for the nascent transcript (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA Polymerase II Transcription Initiation (Caenorhabditis elegans)
NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Pol II initiation complex [nucleoplasm] (Caenorhabditis elegans)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)
Pol II initiation complex [nucleoplasm] (Caenorhabditis elegans)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
NTP [nucleoplasm]
ATP [nucleoplasm]
RNA Polymerase II Transcription Termination (Caenorhabditis elegans)
Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
ATP [nucleoplasm]
Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)
ATP [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
FLT3 Signaling (Caenorhabditis elegans)
AKT phosphorylates FOXO3 downstream of FLT3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated MAPK activation (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF(TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
ATP [nucleoplasm]
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IPs in the nucleus (Caenorhabditis elegans)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Glycolysis (Caenorhabditis elegans)
phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs in the nucleus (Caenorhabditis elegans)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Nicotinate metabolism (Caenorhabditis elegans)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of RNA (Caenorhabditis elegans)
Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
Transport of Mature Transcript to Cytoplasm (Caenorhabditis elegans)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Caenorhabditis elegans)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
mRNA 3'-end processing (Caenorhabditis elegans)
Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
mRNA polyadenylation (Caenorhabditis elegans)
ATP [nucleoplasm]
3' end cleaved, ligated exon containing complex [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Caenorhabditis elegans)
TREX (DDX39B:ATP) [nucleoplasm] (Caenorhabditis elegans)
DDX39B:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Protein ubiquitination (Caenorhabditis elegans)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)
ATP [nucleoplasm]
Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
SUMOylation (Caenorhabditis elegans)
Processing and activation of SUMO (Caenorhabditis elegans)
SUMO is conjugated to E1 (UBA2:SAE1) (Caenorhabditis elegans)
Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)
ATP [nucleoplasm]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Post NMDA receptor activation events (Caenorhabditis elegans)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Caenorhabditis elegans)
Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)
ATP [nucleoplasm]
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
PIP3 activates AKT signaling (Caenorhabditis elegans)
AKT phosphorylates targets in the nucleus (Caenorhabditis elegans)
AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)
ATP [nucleoplasm]
AKT can phosphorylate RSK (Caenorhabditis elegans)
ATP [nucleoplasm]
AKT phosphorylates CREB1 (Caenorhabditis elegans)
ATP [nucleoplasm]
AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)
ATP [nucleoplasm]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK6/MAPK4 signaling (Caenorhabditis elegans)
CDK1 phosphorylates MAPK6 (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
ATP [nucleoplasm]
G alpha (q) signalling events (Caenorhabditis elegans)
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by NOTCH (Caenorhabditis elegans)
Pre-NOTCH Expression and Processing (Caenorhabditis elegans)
Pre-NOTCH Transcription and Translation (Caenorhabditis elegans)
PRKCI phosphorylates ELF3 (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates Proteins Involved in RNA Processing (Caenorhabditis elegans)
PTK6 phosphorylates SFPQ (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
ESTG binds the ESR:chaperone complex (Caenorhabditis elegans)
ESRs:chaperone complex [nucleoplasm] (Caenorhabditis elegans)
HSP90 dimer:ATP [nucleoplasm] (Caenorhabditis elegans)
HSP90:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
ESTG:ESRs:chaperone complex [nucleoplasm] (Caenorhabditis elegans)
ESRs:chaperone complex [nucleoplasm] (Caenorhabditis elegans)
HSP90 dimer:ATP [nucleoplasm] (Caenorhabditis elegans)
HSP90:ATP [nucleoplasm] (Caenorhabditis elegans)
ATP [nucleoplasm]
Estrogen-dependent gene expression (Caenorhabditis elegans)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
ATP [nucleoplasm]
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Caenorhabditis elegans)
AKT phosphorylates CREB1 (Caenorhabditis elegans)
ATP [nucleoplasm]
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
CREB phosphorylation (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates ATF1 (Caenorhabditis elegans)
ATP [nucleoplasm]
MSK1 activates CREB (Caenorhabditis elegans)
ATP [nucleoplasm]
RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK/MAPK targets (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
ATP [nucleoplasm]
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
ATP [nucleoplasm]
NGF-stimulated transcription (Caenorhabditis elegans)
SGK phosphorylates CREB1 (Caenorhabditis elegans)
ATP [nucleoplasm]
SGK phosphorylates SRF (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases activate PKNs (Caenorhabditis elegans)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Caenorhabditis elegans)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
ATP [nucleoplasm]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
NLK phosphorylates TCF/LEF (Caenorhabditis elegans)
ATP [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
ATM phosphorylates MDM2 (Canis familiaris)
ATP [nucleoplasm]
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Phosphorylation of COP1 at Ser-387 by ATM (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of MDM4 by ATM (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
ATP [nucleoplasm]
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Canis familiaris)
ATP [nucleoplasm]
G2/M Checkpoints (Canis familiaris)
Activation of ATR in response to replication stress (Canis familiaris)
Activation of claspin (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)
ATP [nucleoplasm]
Recruitment and activation of Chk1 (Canis familiaris)
ATP [nucleoplasm]
G2/M DNA damage checkpoint (Canis familiaris)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Canis familiaris)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Canis familiaris)
ATP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
ATP [nucleoplasm]
Recruitment and activation of Chk1 (Canis familiaris)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Canis familiaris)
ATP [nucleoplasm]
G2/M DNA replication checkpoint (Canis familiaris)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
ATP [nucleoplasm]
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Metaphase/Anaphase Transition (Canis familiaris)
Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)
ATP [nucleoplasm]
Mitotic Prophase (Canis familiaris)
CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)
ATP [nucleoplasm]
Condensation of Prophase Chromosomes (Canis familiaris)
CDK1 phosphorylates PHF8 (Canis familiaris)
ATP [nucleoplasm]
CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)
ATP [nucleoplasm]
PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)
ATP [nucleoplasm]
MASTL Facilitates Mitotic Progression (Canis familiaris)
MASTL (GWL) phosphorylates ARPP19 (Canis familiaris)
ATP [nucleoplasm]
MASTL phosphorylates ENSA (Canis familiaris)
ATP [nucleoplasm]
Nuclear Envelope Breakdown (Canis familiaris)
Depolymerisation of the Nuclear Lamina (Canis familiaris)
CDK1 phosphorylates LPIN (Canis familiaris)
ATP [nucleoplasm]
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)
ATP [nucleoplasm]
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)
ATP [nucleoplasm]
VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)
ATP [nucleoplasm]
Mitotic Telophase/Cytokinesis (Canis familiaris)
Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)
ATP [nucleoplasm]
Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)
ATP [nucleoplasm]
Mitotic G1 phase and G1/S transition (Canis familiaris)
G0 and Early G1 (Canis familiaris)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)
ATP [nucleoplasm]
G1/S Transition (Canis familiaris)
Activation of the pre-replicative complex (Canis familiaris)
Mcm2-7 is phosphorylated by DDK (Canis familiaris)
ATP [nucleoplasm]
Cyclin E associated events during G1/S transition (Canis familiaris)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Canis familiaris)
Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Canis familiaris)
ATP [nucleoplasm]
Mitotic G2-G2/M phases (Canis familiaris)
G2 Phase (Canis familiaris)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)
ATP [nucleoplasm]
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)
ATP [nucleoplasm]
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)
ATP [nucleoplasm]
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)
ATP [nucleoplasm]
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
ATP [nucleoplasm]
Polo-like kinase mediated events (Canis familiaris)
Inactivation of Myt1 kinase (Canis familiaris)
ATP [nucleoplasm]
Inactivation of Wee1 kinase (Canis familiaris)
ATP [nucleoplasm]
PLK1 phosphorylates FOXM1 (Canis familiaris)
ATP [nucleoplasm]
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
Regulation of APC/C activators between G1/S and early anaphase (Canis familiaris)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Emi1 (Canis familiaris)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)
ATP [nucleoplasm]
S Phase (Canis familiaris)
Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)
ATP [nucleoplasm]
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)
ATP [nucleoplasm]
SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Canis familiaris)
ATP [nucleoplasm]
Synthesis of DNA (Canis familiaris)
DNA replication initiation (Canis familiaris)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)
NTP [nucleoplasm]
ATP [nucleoplasm]
DNA strand elongation (Canis familiaris)
Lagging Strand Synthesis (Canis familiaris)
Polymerase switching (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation (Canis familiaris)
ATP [nucleoplasm]
Leading Strand Synthesis (Canis familiaris)
Polymerase switching (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation (Canis familiaris)
ATP [nucleoplasm]
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cdc6 protein is phosphorylated by CDK (Canis familiaris)
ATP [nucleoplasm]
Orc1 removal from chromatin (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
ATP [nucleoplasm]
Chromosome Maintenance (Canis familiaris)
Telomere Maintenance (Canis familiaris)
Extension of Telomeres (Canis familiaris)
Telomere C-strand (Lagging Strand) Synthesis (Canis familiaris)
Polymerase switching on the C-strand of the telomere (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
ATP [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
ATP [nucleoplasm]
Telomere C-strand synthesis initiation (Canis familiaris)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)
NTP [nucleoplasm]
ATP [nucleoplasm]
Telomere Extension By Telomerase (Canis familiaris)
CDK2:CCNA phosphorylates TERF2 (Canis familiaris)
ATP [nucleoplasm]
Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)
ATP [nucleoplasm]
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
DNA Damage/Telomere Stress Induced Senescence (Canis familiaris)
MRN activates ATM (Canis familiaris)
ATP [nucleoplasm]
MRN bound to shortened telomeres activates ATM (Canis familiaris)
ATP [nucleoplasm]
Oncogene Induced Senescence (Canis familiaris)
MAPKs phosphorylate ETS1 and ETS2 (Canis familiaris)
ATP [nucleoplasm]
Oxidative Stress Induced Senescence (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Canis familiaris)
ATP [nucleoplasm]
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Canis familiaris)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Canis familiaris)
ATP [nucleoplasm]
Active p38 MAPK phosphorylates MAPKAPK5 (Canis familiaris)
ATP [nucleoplasm]
c-FOS activation by phospho ERK1/2 (Canis familiaris)
ATP [nucleoplasm]
p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)
ATP [nucleoplasm]
Senescence-Associated Secretory Phenotype (SASP) (Canis familiaris)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
ATP [nucleoplasm]
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
ATP [nucleoplasm]
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)
ATP [nucleoplasm]
Cellular response to heat stress (Canis familiaris)
HSF1-dependent transactivation (Canis familiaris)
Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)
ATP [nucleoplasm]
Regulation of HSF1-mediated heat shock response (Canis familiaris)
DBC1 is phosphorylated by ATM/ART (Canis familiaris)
ATP [nucleoplasm]
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
Hikeshi:HSP70s:ATP [nucleoplasm] (Canis familiaris)
HSP70s:ATP [nucleoplasm] (Canis familiaris)
HSPA12A:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA12B:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA13:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA14:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA1A:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA1L:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA2:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA4L:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA5:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA8:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)
Hikeshi:HSP70s:ATP [nucleoplasm] (Canis familiaris)
HSP70s:ATP [nucleoplasm] (Canis familiaris)
HSPA12A:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA12B:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA13:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA14:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA1A:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA1L:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA2:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA4L:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA5:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSPA8:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Canis familiaris)
ATP hydrolysis by HSP90 (Canis familiaris)
HSP90 complexes [nucleoplasm] (Canis familiaris)
HSP90:ATP:PTGES3:FKBP52:NR3C1:SH [nucleoplasm] (Canis familiaris)
HSP90:ATP:PTGES3:FKBP52:NR3C1 [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
HSP90:ATP:PTGES3:FKBP52:NR3C1:SH [nucleoplasm] (Canis familiaris)
HSP90:ATP:PTGES3:FKBP52:NR3C1 [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
HSP90:ATP:PTGES3:FKBP52:SHR:SH [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
DNA Repair (Canis familiaris)
DNA Damage Bypass (Canis familiaris)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Canis familiaris)
Translesion Synthesis by POLH (Canis familiaris)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)
ATP [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
ATM phosphorylates EYA1-4 (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates HERC2 (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates MDC1 (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates NBN (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates WHSC1 (Canis familiaris)
ATP [nucleoplasm]
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)
ATP [nucleoplasm]
Activated ATM phosphorylates ABL1 (Canis familiaris)
ATP [nucleoplasm]
CHEK2 phosphorylates BRCA1 (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
ATP [nucleoplasm]
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
ATP [nucleoplasm]
WICH phosphorylates H2AFX on Y142 (Canis familiaris)
ATP [nucleoplasm]
p-T68-CHEK2 autophosphorylates (Canis familiaris)
ATP [nucleoplasm]
Sensing of DNA Double Strand Breaks (Canis familiaris)
MRN activates ATM (Canis familiaris)
ATP [nucleoplasm]
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
HDR through Homologous Recombination (HRR) (Canis familiaris)
Homologous DNA Pairing and Strand Exchange (Canis familiaris)
Presynaptic phase of homologous DNA pairing and strand exchange (Canis familiaris)
CHEK1 phosphorylates BRCA2 (Canis familiaris)
ATP [nucleoplasm]
CHEK1 phosphorylates RAD51 (Canis familiaris)
ATP [nucleoplasm]
HDR through Single Strand Annealing (SSA) (Canis familiaris)
ABL1 phosphorylates RAD52 (Canis familiaris)
ATP [nucleoplasm]
Processing of DNA double-strand break ends (Canis familiaris)
ATM phosphorylates RBBP8 (Canis familiaris)
ATP [nucleoplasm]
ATR phosphorylates RPA2 (Canis familiaris)
ATP [nucleoplasm]
Activation of CHEK1 at resected DNA DSBs (Canis familiaris)
ATP [nucleoplasm]
CDK2 phosphorylates RBBP8 (Canis familiaris)
ATP [nucleoplasm]
Nonhomologous End-Joining (NHEJ) (Canis familiaris)
Activated ATM phosphorylates DCLRE1C (Canis familiaris)
ATP [nucleoplasm]
DNA-PKcs autophosphorylates (Canis familiaris)
ATP [nucleoplasm]
PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)
ATP [nucleoplasm]
Fanconi Anemia Pathway (Canis familiaris)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)
ATP [nucleoplasm]
Mismatch Repair (Canis familiaris)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Canis familiaris)
DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)
ATP [nucleoplasm]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Canis familiaris)
DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)
ATP [nucleoplasm]
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Canis familiaris)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] (Canis familiaris)
MSH2:MSH6:ATP [nucleoplasm] (Canis familiaris)
ATP [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
Formation of Incision Complex in GG-NER (Canis familiaris)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
ATP [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)