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NADP+ [cytosol]
Stable Identifier
R-ALL-29366
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
NADP, NADP(+), Nicotinamide adenine dinucleotide phosphate, beta-Nicotinamide adenine dinucleotide phosphate, TPN, Triphosphopyridine nucleotide, NADP(3-)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
NADP+ [cytosol]
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
NADP+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
NADP+ [cytosol]
Drug ADME (Bos taurus)
Atorvastatin ADME (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
NADP+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
NADP+ [cytosol]
Paracetamol ADME (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
NADP+ [cytosol]
Prednisone ADME (Bos taurus)
AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)
NADP+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)
NADP+ [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Bos taurus)
G6PD dimer [cytosol] (Bos taurus)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Bos taurus)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
NADP+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Bos taurus)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Bos taurus)
TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)
NADP+ [cytosol]
Hemostasis (Bos taurus)
Platelet homeostasis (Bos taurus)
Nitric oxide stimulates guanylate cyclase (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
NADP+ [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
ROS and RNS production in phagocytes (Bos taurus)
NOX2 generates superoxide anion from oxygen (Bos taurus)
NADP+ [cytosol]
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
NADP+ [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
ME1 tetramer decarboxylates MAL to PYR (Bos taurus)
NADP+ [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)
NADP+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
NADP+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
NADP+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
NADP+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
NADP+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
NADP+ [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
NADP+ [cytosol]
CBR3 reduces DOX to DOXOL (Bos taurus)
NADP+ [cytosol]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Eicosanoids (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
NADP+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
NADP+ [cytosol]
Endogenous sterols (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
NADP+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Bos taurus)
NADP+ [cytosol]
CYP21A2 21-hydroxylates PROG (Bos taurus)
NADP+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
NADP+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
NADP+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
NADP+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
NADP+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
NADP+ [cytosol]
Vitamins (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
NADP+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
NADP+ [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Glutathione conjugation (Bos taurus)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)
NADP+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Glutamate and glutamine metabolism (Bos taurus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
NADP+ [cytosol]
Metabolism of amine-derived hormones (Bos taurus)
Thyroxine biosynthesis (Bos taurus)
Regulation of thyroid hormone activity (Bos taurus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)
NADP+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Bos taurus)
NADP+ [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
NADP+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
NADP+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
NADP+ [cytosol]
Tryptophan catabolism (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
NADP+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)
NADP+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)
NADP+ [cytosol]
Fructose metabolism (Bos taurus)
Fructose biosynthesis (Bos taurus)
AKR1B1 reduces Glc to D-sorbitol (Bos taurus)
NADP+ [cytosol]
Pentose phosphate pathway (Bos taurus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)
NADP+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Bos taurus)
G6PD dimer [cytosol] (Bos taurus)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Bos taurus)
NADP+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)
NADP+ [cytosol]
ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)
NADP+ [cytosol]
Biosynthesis of D-series resolvins (Bos taurus)
ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)
NADP+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Bos taurus)
ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Bos taurus)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Bos taurus)
NADP+ [cytosol]
Biosynthesis of maresins (Bos taurus)
Biosynthesis of maresin-like SPMs (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
NADP+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
NADP+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
NADP+ [cytosol]
Biosynthesis of protectins (Bos taurus)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)
NADP+ [cytosol]
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
NADP+ [cytosol]
Biosynthesis of DPA-derived SPMs (Bos taurus)
Biosynthesis of DPAn-3 SPMs (Bos taurus)
Biosynthesis of DPAn-3-derived maresins (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)
NADP+ [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Bos taurus)
ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)
NADP+ [cytosol]
ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)
NADP+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
NADP+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
NADP+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
NADP+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
NADP+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Bos taurus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)
NADP+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Bos taurus)
NADP+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)
NADP+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
NADP+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
NADP+ [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Bos taurus)
NADP+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)
NADP+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)
NADP+ [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)
NADP+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)
NADP+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)
NADP+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)
NADP+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
NADP+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
NADP+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)
NADP+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)
NADP+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)
NADP+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
NADP+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)
NADP+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)
NADP+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)
NADP+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
NADP+ [cytosol]
Cholesterol biosynthesis (Bos taurus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)
NADP+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
NADP+ [cytosol]
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)
NADP+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
NADP+ [cytosol]
Reduction of desmosterol to cholesterol (Bos taurus)
NADP+ [cytosol]
Cholesterol biosynthesis via lathosterol (Bos taurus)
DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)
NADP+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)
NADP+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
NADP+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)
NADP+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)
NADP+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Bos taurus)
NADP+ [cytosol]
Squalene is oxidized to its epoxide (Bos taurus)
NADP+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)
NADP+ [cytosol]
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
NADP+ [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
NADP+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)
NADP+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)
NADP+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)
NADP+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)
NADP+ [cytosol]
Estrogen biosynthesis (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
NADP+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
NADP+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Bos taurus)
NADP+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
NADP+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)
NADP+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)
NADP+ [cytosol]
Glucocorticoid biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates PREG (Bos taurus)
NADP+ [cytosol]
CYP21A2 oxidises 17HPROG (Bos taurus)
NADP+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
NADP+ [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
NADP+ [cytosol]
Pregnenolone biosynthesis (Bos taurus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)
NADP+ [cytosol]
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
NADP+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
NADP+ [cytosol]
Sphingolipid metabolism (Bos taurus)
Sphingolipid de novo biosynthesis (Bos taurus)
KDSR reduces 3-ketosphingoid (Bos taurus)
NADP+ [cytosol]
Wax and plasmalogen biosynthesis (Bos taurus)
Plasmalogen biosynthesis (Bos taurus)
DHRS7B reduces GO3P to HXDG3P (Bos taurus)
NADP+ [cytosol]
Wax biosynthesis (Bos taurus)
FAR1 reduces PalmCoA to HXOL (Bos taurus)
NADP+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Bos taurus)
NADP+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
CYGB dioxygenates NO (Bos taurus)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
NADP+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
NADP+ [cytosol]
eNOS synthesizes NO (Bos taurus)
NADP+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
NADP+ [cytosol]
Nucleotide catabolism (Bos taurus)
Pyrimidine catabolism (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
NADP+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
NADP+ [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)
NADP+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme degradation (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
NADP+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
NADPH regeneration (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
NADP+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
NADP+ [cytosol]
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
NADP+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
NADP+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MMACHC decyanates CNCbl (Bos taurus)
NADP+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
NADP+ [cytosol]
Metabolism of folate and pterines (Bos taurus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)
NADP+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
NADP+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Bos taurus)
NADP+ [cytosol]
DHFR dimer reduces FOLA to DHF (Bos taurus)
NADP+ [cytosol]
DHFR2 reduces FOLA to DHF (Bos taurus)
NADP+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)
NADP+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
NADP+ [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
NADP+ [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)
NADP+ [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
SRD5A3 reduces pPNOL to DCHOL (Bos taurus)
NADP+ [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
NADP+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
NADP+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
NADP+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)
NADP+ [cytosol]
RDH12 reduces atRAL to atROL (Bos taurus)
NADP+ [cytosol]
The retinoid cycle in cones (daylight vision) (Bos taurus)
atRAL is reduced to atROL (Bos taurus)
NADP+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
NADP+ [cytosol]
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
AKR1C3 reduces atRAL to atROL (Bos taurus)
NADP+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
NADP+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
NADP+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)
NADP+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NADP+ [cytosol]
VEGFR2 mediated vascular permeability (Bos taurus)
eNOS synthesizes NO (Bos taurus)
NADP+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NADP+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
NADP+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
NADP+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)
NADP+ [cytosol]
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
NADP+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
Drug ADME (Caenorhabditis elegans)
Paracetamol ADME (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
NADP+ [cytosol]
Prednisone ADME (Caenorhabditis elegans)
AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)
NADP+ [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Caenorhabditis elegans)
G6PD dimer [cytosol] (Caenorhabditis elegans)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Caenorhabditis elegans)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
Hemostasis (Caenorhabditis elegans)
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
ME1 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
NADP+ [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
NADP+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
NADP+ [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
NADP+ [cytosol]
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Endogenous sterols (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
NADP+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
NADP+ [cytosol]
Vitamins (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
NADP+ [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Glutathione conjugation (Caenorhabditis elegans)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
NADP+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
NADP+ [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
NADP+ [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
AKR1A1 reduces D-glucuronate to L-gulonate (Caenorhabditis elegans)
NADP+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)
NADP+ [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose biosynthesis (Caenorhabditis elegans)
AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)
NADP+ [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)
NADP+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Caenorhabditis elegans)
G6PD dimer [cytosol] (Caenorhabditis elegans)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of maresins (Caenorhabditis elegans)
Biosynthesis of maresin-like SPMs (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
NADP+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
NADP+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
NADP+ [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Caenorhabditis elegans)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)
NADP+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
NADP+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
NADP+ [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)
NADP+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)
NADP+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)
NADP+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)
NADP+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)
NADP+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)
NADP+ [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
Cholesterol biosynthesis via desmosterol (Caenorhabditis elegans)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)
NADP+ [cytosol]
Reduction of desmosterol to cholesterol (Caenorhabditis elegans)
NADP+ [cytosol]
Cholesterol biosynthesis via lathosterol (Caenorhabditis elegans)
DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)
NADP+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)
NADP+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)
NADP+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of steroid hormones (Caenorhabditis elegans)
Androgen biosynthesis (Caenorhabditis elegans)
HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)
NADP+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
NADP+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
NADP+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
NADP+ [cytosol]
Estrogen biosynthesis (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
NADP+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
NADP+ [cytosol]
Pregnenolone biosynthesis (Caenorhabditis elegans)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)
NADP+ [cytosol]
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
NADP+ [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
KDSR reduces 3-ketosphingoid (Caenorhabditis elegans)
NADP+ [cytosol]
Wax and plasmalogen biosynthesis (Caenorhabditis elegans)
Plasmalogen biosynthesis (Caenorhabditis elegans)
DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)
NADP+ [cytosol]
Wax biosynthesis (Caenorhabditis elegans)
FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)
NADP+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
CYGB dioxygenates NO (Caenorhabditis elegans)
NADP+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
NADP+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Pyrimidine catabolism (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
NADP+ [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
NADPH regeneration (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of fat-soluble vitamins (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MMACHC decyanates CNCbl (Caenorhabditis elegans)
NADP+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)
NADP+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
NADP+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)
NADP+ [cytosol]
DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
NADP+ [cytosol]
DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
NADP+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)
NADP+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
NADP+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)
NADP+ [cytosol]
Synthesis of Dolichyl-phosphate (Caenorhabditis elegans)
SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)
NADP+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
NADP+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
NADP+ [cytosol]
The retinoid cycle in cones (daylight vision) (Caenorhabditis elegans)
atRAL is reduced to atROL (Caenorhabditis elegans)
NADP+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
NADP+ [cytosol]
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)
NADP+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)
NADP+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
NADP+ [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
NADP+ [cytosol]
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
NADP+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
NADP+ [cytosol]
Drug ADME (Canis familiaris)
Atorvastatin ADME (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
NADP+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
NADP+ [cytosol]
Paracetamol ADME (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
NADP+ [cytosol]
Prednisone ADME (Canis familiaris)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)
NADP+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)
NADP+ [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Canis familiaris)
G6PD dimer [cytosol] (Canis familiaris)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Canis familiaris)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
NADP+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Canis familiaris)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Canis familiaris)
TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)
NADP+ [cytosol]
Hemostasis (Canis familiaris)
Platelet homeostasis (Canis familiaris)
Nitric oxide stimulates guanylate cyclase (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
NADP+ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
ROS and RNS production in phagocytes (Canis familiaris)
NOX2 generates superoxide anion from oxygen (Canis familiaris)
NADP+ [cytosol]
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
NADP+ [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
ME1 tetramer decarboxylates MAL to PYR (Canis familiaris)
NADP+ [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)
NADP+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
NADP+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
NADP+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
NADP+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
NADP+ [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
NADP+ [cytosol]
CBR3 reduces DOX to DOXOL (Canis familiaris)
NADP+ [cytosol]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Eicosanoids (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
NADP+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
NADP+ [cytosol]
Endogenous sterols (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
NADP+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
NADP+ [cytosol]
CYP21A2 21-hydroxylates PROG (Canis familiaris)
NADP+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
NADP+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
NADP+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
NADP+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
NADP+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
NADP+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
NADP+ [cytosol]
Vitamins (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
NADP+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
NADP+ [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Glutathione conjugation (Canis familiaris)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)
NADP+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Glutamate and glutamine metabolism (Canis familiaris)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
NADP+ [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Thyroxine biosynthesis (Canis familiaris)
Regulation of thyroid hormone activity (Canis familiaris)
Thyroxine is deiodinated to triiodothyronine (Canis familiaris)
NADP+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
NADP+ [cytosol]
Tryptophan catabolism (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
NADP+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Formation of xylulose-5-phosphate (Canis familiaris)
AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)
NADP+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)
NADP+ [cytosol]
Fructose metabolism (Canis familiaris)
Fructose biosynthesis (Canis familiaris)
AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)
NADP+ [cytosol]
Pentose phosphate pathway (Canis familiaris)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)
NADP+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Canis familiaris)
G6PD dimer [cytosol] (Canis familiaris)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Canis familiaris)
NADP+ [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Canis familiaris)
NADP+ [cytosol]
ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of D-series resolvins (Canis familiaris)
ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of maresins (Canis familiaris)
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
NADP+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
NADP+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of protectins (Canis familiaris)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of DPA-derived SPMs (Canis familiaris)
Biosynthesis of DPAn-3 SPMs (Canis familiaris)
Biosynthesis of DPAn-3-derived maresins (Canis familiaris)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Canis familiaris)
NADP+ [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Canis familiaris)
ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)
NADP+ [cytosol]
ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)
NADP+ [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
NADP+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
NADP+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
NADP+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
NADP+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
PGE2 is converted to PGF2a by CBR1 (Canis familiaris)
NADP+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
NADP+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
NADP+ [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Canis familiaris)
NADP+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)
NADP+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)
NADP+ [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)
NADP+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)
NADP+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
NADP+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
NADP+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)
NADP+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
NADP+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)
NADP+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
NADP+ [cytosol]
Cholesterol biosynthesis (Canis familiaris)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)
NADP+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
NADP+ [cytosol]
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)
NADP+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
NADP+ [cytosol]
Reduction of desmosterol to cholesterol (Canis familiaris)
NADP+ [cytosol]
Cholesterol biosynthesis via lathosterol (Canis familiaris)
DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)
NADP+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)
NADP+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
NADP+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)
NADP+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)
NADP+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
NADP+ [cytosol]
Squalene is oxidized to its epoxide (Canis familiaris)
NADP+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)
NADP+ [cytosol]
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
NADP+ [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
NADP+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)
NADP+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)
NADP+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)
NADP+ [cytosol]
Estrogen biosynthesis (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
NADP+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
NADP+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)
NADP+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
NADP+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
NADP+ [cytosol]
Glucocorticoid biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
NADP+ [cytosol]
CYP21A2 oxidises 17HPROG (Canis familiaris)
NADP+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
NADP+ [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
NADP+ [cytosol]
Pregnenolone biosynthesis (Canis familiaris)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)
NADP+ [cytosol]
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
NADP+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
NADP+ [cytosol]
Sphingolipid metabolism (Canis familiaris)
Sphingolipid de novo biosynthesis (Canis familiaris)
KDSR reduces 3-ketosphingoid (Canis familiaris)
NADP+ [cytosol]
Wax and plasmalogen biosynthesis (Canis familiaris)
Plasmalogen biosynthesis (Canis familiaris)
DHRS7B reduces GO3P to HXDG3P (Canis familiaris)
NADP+ [cytosol]
Wax biosynthesis (Canis familiaris)
FAR1 reduces PalmCoA to HXOL (Canis familiaris)
NADP+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Canis familiaris)
NADP+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
CYGB dioxygenates NO (Canis familiaris)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
NADP+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
NADP+ [cytosol]
Nucleotide catabolism (Canis familiaris)
Pyrimidine catabolism (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
NADP+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
NADP+ [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)
NADP+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme degradation (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
NADP+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
NADPH regeneration (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
NADP+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
NADP+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MMACHC decyanates CNCbl (Canis familiaris)
NADP+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
NADP+ [cytosol]
Metabolism of folate and pterines (Canis familiaris)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)
NADP+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
NADP+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)
NADP+ [cytosol]
DHFR dimer reduces FOLA to DHF (Canis familiaris)
NADP+ [cytosol]
DHFR2 reduces FOLA to DHF (Canis familiaris)
NADP+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)
NADP+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
NADP+ [cytosol]
Nicotinate metabolism (Canis familiaris)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
NADP+ [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)
NADP+ [cytosol]
Synthesis of Dolichyl-phosphate (Canis familiaris)
SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)
NADP+ [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
NADP+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)
NADP+ [cytosol]
RDH12 reduces atRAL to atROL (Canis familiaris)
NADP+ [cytosol]
The retinoid cycle in cones (daylight vision) (Canis familiaris)
atRAL is reduced to atROL (Canis familiaris)
NADP+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
NADP+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
NADP+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)
NADP+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NADP+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NADP+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
NADP+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
NADP+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
NADP+ [cytosol]
Transport of small molecules (Canis familiaris)
Iron uptake and transport (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
NADP+ [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
NADP+ [cytosol]
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
NADP+ [cytosol]
Drug ADME (Danio rerio)
Atorvastatin ADME (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
NADP+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
NADP+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
NADP+ [cytosol]
Paracetamol ADME (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
NADP+ [cytosol]
Prednisone ADME (Danio rerio)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)
NADP+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)
NADP+ [cytosol]
Hemostasis (Danio rerio)
Factors involved in megakaryocyte development and platelet production (Danio rerio)
MICAL1 produces NADP+, H2O2 (Danio rerio)
NADP+ [cytosol]
Platelet homeostasis (Danio rerio)
Nitric oxide stimulates guanylate cyclase (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
NADP+ [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
ROS and RNS production in phagocytes (Danio rerio)
NOX2 generates superoxide anion from oxygen (Danio rerio)
NADP+ [cytosol]
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
NADP+ [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
ME1 tetramer decarboxylates MAL to PYR (Danio rerio)
NADP+ [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)
NADP+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
NADP+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
NADP+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
NADP+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
NADP+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
NADP+ [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
NADP+ [cytosol]
CBR3 reduces DOX to DOXOL (Danio rerio)
NADP+ [cytosol]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
NADP+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
NADP+ [cytosol]
Endogenous sterols (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
NADP+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Danio rerio)
NADP+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
NADP+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
NADP+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
NADP+ [cytosol]
Vitamins (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
NADP+ [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)
NADP+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Glutamate and glutamine metabolism (Danio rerio)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
NADP+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
NADP+ [cytosol]
Tryptophan catabolism (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
NADP+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Formation of xylulose-5-phosphate (Danio rerio)
AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)
NADP+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)
NADP+ [cytosol]
Fructose metabolism (Danio rerio)
Fructose biosynthesis (Danio rerio)
AKR1B1 reduces Glc to D-sorbitol (Danio rerio)
NADP+ [cytosol]
Pentose phosphate pathway (Danio rerio)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)
NADP+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)
NADP+ [cytosol]
ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)
NADP+ [cytosol]
Biosynthesis of D-series resolvins (Danio rerio)
ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)
NADP+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)
NADP+ [cytosol]
ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)
NADP+ [cytosol]
Biosynthesis of maresins (Danio rerio)
Biosynthesis of maresin-like SPMs (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
NADP+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
NADP+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
NADP+ [cytosol]
Biosynthesis of protectins (Danio rerio)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)
NADP+ [cytosol]
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
NADP+ [cytosol]
Biosynthesis of DPA-derived SPMs (Danio rerio)
Biosynthesis of DPAn-3 SPMs (Danio rerio)
Biosynthesis of DPAn-3-derived maresins (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)
NADP+ [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Danio rerio)
ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)
NADP+ [cytosol]
ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)
NADP+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
NADP+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
NADP+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
NADP+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
NADP+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)
PGE2 is converted to PGF2a by CBR1 (Danio rerio)
NADP+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
NADP+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
NADP+ [cytosol]
Fatty acyl-CoA biosynthesis (Danio rerio)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Danio rerio)
NADP+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Danio rerio)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)
NADP+ [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
CYP46A1 24-hydroxylates CHOL (Danio rerio)
NADP+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
NADP+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
NADP+ [cytosol]
Cholesterol biosynthesis (Danio rerio)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)
NADP+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)
NADP+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
NADP+ [cytosol]
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)
NADP+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
NADP+ [cytosol]
Reduction of desmosterol to cholesterol (Danio rerio)
NADP+ [cytosol]
Cholesterol biosynthesis via lathosterol (Danio rerio)
DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)
NADP+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)
NADP+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
NADP+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)
NADP+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)
NADP+ [cytosol]
Squalene is oxidized to its epoxide (Danio rerio)
NADP+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)
NADP+ [cytosol]
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
NADP+ [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
NADP+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
NADP+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)
NADP+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)
NADP+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)
NADP+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)
NADP+ [cytosol]
Estrogen biosynthesis (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
NADP+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
NADP+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)
NADP+ [cytosol]
Glucocorticoid biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates PREG (Danio rerio)
NADP+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
NADP+ [cytosol]
Pregnenolone biosynthesis (Danio rerio)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)
NADP+ [cytosol]
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
NADP+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
NADP+ [cytosol]
Wax and plasmalogen biosynthesis (Danio rerio)
Plasmalogen biosynthesis (Danio rerio)
DHRS7B reduces GO3P to HXDG3P (Danio rerio)
NADP+ [cytosol]
Wax biosynthesis (Danio rerio)
FAR2 reduces PalmCoA to HXOL (Danio rerio)
NADP+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
eNOS activation (Danio rerio)
CYGB dioxygenates NO (Danio rerio)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
NADP+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Pyrimidine catabolism (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
NADP+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
NADP+ [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)
NADP+ [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme degradation (Danio rerio)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
NADP+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
NADP+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
NADPH regeneration (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
NADP+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)
NADP+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
NADP+ [cytosol]
Metabolism of fat-soluble vitamins (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
NADP+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
NADP+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Danio rerio)
Cobalamin (Cbl) metabolism (Danio rerio)
MMACHC decyanates CNCbl (Danio rerio)
NADP+ [cytosol]
Metabolism of folate and pterines (Danio rerio)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)
NADP+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
NADP+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Danio rerio)
NADP+ [cytosol]
DHFR dimer reduces FOLA to DHF (Danio rerio)
NADP+ [cytosol]
DHFR2 reduces FOLA to DHF (Danio rerio)
NADP+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)
NADP+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
NADP+ [cytosol]
Nicotinate metabolism (Danio rerio)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)
NADP+ [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
GDP-fucose biosynthesis (Danio rerio)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)
NADP+ [cytosol]
Synthesis of Dolichyl-phosphate (Danio rerio)
SRD5A3 reduces pPNOL to DCHOL (Danio rerio)
NADP+ [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
NADP+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
NADP+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
NADP+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)
NADP+ [cytosol]
RDH12 reduces atRAL to atROL (Danio rerio)
NADP+ [cytosol]
The retinoid cycle in cones (daylight vision) (Danio rerio)
atRAL is reduced to atROL (Danio rerio)
NADP+ [cytosol]
Signal Transduction (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
NADP+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
NADP+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)
NADP+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NADP+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate NADPH Oxidases (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NADP+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
NADP+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
NADP+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)
NADP+ [cytosol]
Transport of small molecules (Danio rerio)
Iron uptake and transport (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
NADP+ [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
NADP+ [cytosol]
Drug ADME (Dictyostelium discoideum)
Paracetamol ADME (Dictyostelium discoideum)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
NADP+ [cytosol]
Prednisone ADME (Dictyostelium discoideum)
AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)
NADP+ [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Dictyostelium discoideum)
G6PD dimer [cytosol] (Dictyostelium discoideum)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Dictyostelium discoideum)
NADP+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
NADP+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Dictyostelium discoideum)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Dictyostelium discoideum)
TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)
NADP+ [cytosol]
Hemostasis (Dictyostelium discoideum)
Factors involved in megakaryocyte development and platelet production (Dictyostelium discoideum)
MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
NADP+ [cytosol]
Platelet homeostasis (Dictyostelium discoideum)
Nitric oxide stimulates guanylate cyclase (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
NADP+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
ROS and RNS production in phagocytes (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
NADP+ [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
NADP+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
NADP+ [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
NADP+ [cytosol]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
NADP+ [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
NADP+ [cytosol]
Vitamins (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
NADP+ [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glutathione conjugation (Dictyostelium discoideum)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Dictyostelium discoideum)
NADP+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Glutamate and glutamine metabolism (Dictyostelium discoideum)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
NADP+ [cytosol]
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Thyroxine biosynthesis (Dictyostelium discoideum)
Regulation of thyroid hormone activity (Dictyostelium discoideum)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)
NADP+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)
NADP+ [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
NADP+ [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
NADP+ [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Formation of xylulose-5-phosphate (Dictyostelium discoideum)
AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)
NADP+ [cytosol]
Fructose metabolism (Dictyostelium discoideum)
Fructose biosynthesis (Dictyostelium discoideum)
AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)
NADP+ [cytosol]
Pentose phosphate pathway (Dictyostelium discoideum)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)
NADP+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
NADP+ [cytosol]
G6PD dimer and tetramer [cytosol] (Dictyostelium discoideum)
G6PD dimer [cytosol] (Dictyostelium discoideum)
NADP+ [cytosol]
G6PD tetramer [cytosol] (Dictyostelium discoideum)
NADP+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)